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The map label for this gene is trpC [H]

Identifier: 103486325

GI number: 103486325

Start: 841089

End: 841874

Strand: Reverse

Name: trpC [H]

Synonym: Sala_0835

Alternate gene names: 103486325

Gene position: 841874-841089 (Counterclockwise)

Preceding gene: 103486326

Following gene: 103486324

Centisome position: 25.17

GC content: 67.05

Gene sequence:

>786_bases
ATGAACAAACTCACCCAGATCCTCGCCACCAAGGCGACCGAAGTCGCCGAACGCCGCGCCCTGCGCTCGCTCGCCGACCT
TGATGCGATCGACGCCGGGCCGGTGCGCGGCTTTGCCGCCGCCGTGCAGGCGAAAATCGACGCCGGCGGCTATGGCCTGA
TCGCCGAAATCAAGAAAGCATCGCCATCCAAGGGATTGATTCGCAAAGATTTCAACCCCGCCGATCATGCGCGCGCCTAT
GCCGCGGGCGGCGCCGCCTGCCTGTCGGTGCTCACCGACGCGCCCTGGTTTCAGGGGCATGAGGATTATCTGGTCGCCGC
GCGCGCCGCCTGCGCGCTGCCCGTGCTGCGCAAGGATTTCATGATCGACCCGTGGCAGGTGGCCGAGGCGCGGTCGATCG
GCGCCGACGCGATCCTCATCATCGTCGCGGCGCTCGACGACGGCGCGATGCGCGAGATTGAAGCGGCGGCAATCGAGCGC
GGCATGGACGTGCTGGTCGAGGTCCATGACGAAGCCGAACTGGACCGCGCGCTCACGCAGCTGCAATCGCGCCTGATCGG
CGTCAACAACCGCGACCTTCGCACCTTCGAAACCGACCTTGGCGTCACCGAACGGCTGGCCAAACTTGTCCCCGCGGATA
CGCTCCTCGTCGGCGAAAGTGGCATCGCAACCCACGCCGACTGCCAGCGCCTCGCCGACAGCGGCGTCCGGGCCTTCCTC
GTCGGCGAAAGCCTGATGCGTCAGGCCGACGTCACGGCGGTAACAAGGGCGCTGCTCGAAGGCTGA

Upstream 100 bases:

>100_bases
GAGCCGAAGGCGACGCGGCAATCTCCAGCTTTCGTCCATCAAAATCGCTAGCTGGAGGTTGCTTCGCTACGCTCGCAATG
ACGATAATTTTGAGCCCGAA

Downstream 100 bases:

>100_bases
GGCCCGCTTTGGAGTGGGGCGCGGCCATGAAGCCCTCTCCCCTTCAGGGGAGAGGGTTGGGAGAGGGGGACCATCCAAAC
CCCTCTCAACTCCGGCTAGC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MNKLTQILATKATEVAERRALRSLADLDAIDAGPVRGFAAAVQAKIDAGGYGLIAEIKKASPSKGLIRKDFNPADHARAY
AAGGAACLSVLTDAPWFQGHEDYLVAARAACALPVLRKDFMIDPWQVAEARSIGADAILIIVAALDDGAMREIEAAAIER
GMDVLVEVHDEAELDRALTQLQSRLIGVNNRDLRTFETDLGVTERLAKLVPADTLLVGESGIATHADCQRLADSGVRAFL
VGESLMRQADVTAVTRALLEG

Sequences:

>Translated_261_residues
MNKLTQILATKATEVAERRALRSLADLDAIDAGPVRGFAAAVQAKIDAGGYGLIAEIKKASPSKGLIRKDFNPADHARAY
AAGGAACLSVLTDAPWFQGHEDYLVAARAACALPVLRKDFMIDPWQVAEARSIGADAILIIVAALDDGAMREIEAAAIER
GMDVLVEVHDEAELDRALTQLQSRLIGVNNRDLRTFETDLGVTERLAKLVPADTLLVGESGIATHADCQRLADSGVRAFL
VGESLMRQADVTAVTRALLEG
>Mature_261_residues
MNKLTQILATKATEVAERRALRSLADLDAIDAGPVRGFAAAVQAKIDAGGYGLIAEIKKASPSKGLIRKDFNPADHARAY
AAGGAACLSVLTDAPWFQGHEDYLVAARAACALPVLRKDFMIDPWQVAEARSIGADAILIIVAALDDGAMREIEAAAIER
GMDVLVEVHDEAELDRALTQLQSRLIGVNNRDLRTFETDLGVTERLAKLVPADTLLVGESGIATHADCQRLADSGVRAFL
VGESLMRQADVTAVTRALLEG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=258, Percent_Identity=39.5348837209302, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322638, Length=216, Percent_Identity=40.7407407407407, Blast_Score=158, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 27782; Mature: 27782

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLTQILATKATEVAERRALRSLADLDAIDAGPVRGFAAAVQAKIDAGGYGLIAEIKKA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHC
SPSKGLIRKDFNPADHARAYAAGGAACLSVLTDAPWFQGHEDYLVAARAACALPVLRKDF
CCCCCCHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MIDPWQVAEARSIGADAILIIVAALDDGAMREIEAAAIERGMDVLVEVHDEAELDRALTQ
CCCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCHHEEEECCHHHHHHHHHH
LQSRLIGVNNRDLRTFETDLGVTERLAKLVPADTLLVGESGIATHADCQRLADSGVRAFL
HHHHHCCCCCCCCHHHHHHCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCEEEE
VGESLMRQADVTAVTRALLEG
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKLTQILATKATEVAERRALRSLADLDAIDAGPVRGFAAAVQAKIDAGGYGLIAEIKKA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHC
SPSKGLIRKDFNPADHARAYAAGGAACLSVLTDAPWFQGHEDYLVAARAACALPVLRKDF
CCCCCCHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MIDPWQVAEARSIGADAILIIVAALDDGAMREIEAAAIERGMDVLVEVHDEAELDRALTQ
CCCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCHHEEEECCHHHHHHHHHH
LQSRLIGVNNRDLRTFETDLGVTERLAKLVPADTLLVGESGIATHADCQRLADSGVRAFL
HHHHHCCCCCCCCHHHHHHCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCEEEE
VGESLMRQADVTAVTRALLEG
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA