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The map label for this gene is moeA [H]

Identifier: 103486323

GI number: 103486323

Start: 839060

End: 840250

Strand: Reverse

Name: moeA [H]

Synonym: Sala_0833

Alternate gene names: 103486323

Gene position: 840250-839060 (Counterclockwise)

Preceding gene: 103486324

Following gene: 103486322

Centisome position: 25.12

GC content: 75.4

Gene sequence:

>1191_bases
ATGAGCGCACTGCTCCCCGTCGAGGAGGCGCAGGCGCGCCTGCTCGCGCTGCGCGCGCCGCTGGGACGCGAGACGGTCGC
GCTCGCCGACGCGCATGGCCGCTATCTCGCCGCCGATGTCCTGGCGGAGCGCGACCAGCCCGCGGCGCCGCTGTCGGCGA
TGGACGGCTATGCGATCCGCTTCGACGACCTGCCCGGCCCATGGACGGTGACCGGCGAGGTTGCGGCAGGCAGCGCTCCC
GACCGCGCCGTCGGCGCGGGCGAGGCGCAGCGCATCTTCACCGGCGCGGTCGTTCCGCCCGGCGCCGATACGGTGATCGT
GCAGGAGGATGTTGCGCGCGAGGGCGACCGGCTGACCCTGACCGGCGACGGGCCGGACAGCCGCGGCCGCCACATCCGCG
CGCGCGCCGCCGATTTCGCCGCCGGCGACGCGCTGCTCGCGGCGGGTTCGCGATTGACACCCGGCGCCATCGCCACCGCC
GCGATGAGCGGCGCGGGCGCGCTTTCCGTCGCTATCCGCCCGCGCGTCGCGATCCTCACCACCGGCGACGAACTGGTCGC
GCCGGGTCGCGCGCCCGGCCCCGGTCAGATCCCCGACAGCAACGGCGTGATGCTCGCCGCCATGCTCGCGGGCGAGGCCG
CCGCGCCCGTGCAGCCGCGCCACATCCGCGACGACCGCGCGACGCTCGCAAAGATTCTGAAGGAGCTGGCGCGGAGTCAC
GACGTCATCGTCACCGTCGGCGGCGCGTCGGTCGGCGATCACGACCATGTCCGCGGCGCGCTGGGTGACGCGGGCGGGCG
GCTCGATTTCTGGAGGATCGCGATGAAGCCCGGCAAGCCGCTGATCGCCGGCACGCTCGGCGACGCGATCCTGCTCGGCC
TGCCCGGCAATCCCTCGTCGGCCTTCGTCACCGCGACGCTCTTCCTCCTCCCGCTCGTCCGCCACCTCGCGGGTGCGCGC
GCGCCGTTGCCGCCGGTACAGCGCGCGCCGCTCGCCGCACCGCTCGACGCCGGCGGCACGCGCCGCGACTATCTGCGCGC
GCGGGTCGAGCGGGGCGTGCTGACCCCGCTCGTCGGACAGGAAAGCGGCCGCACCCTCCCCCTCGCCGCCGCCAATGCGC
TGCTCATCCGCGACATCGGCGCCCCCGCGCGCGATGCCGGCGACGCGGCGGACTATATCGCCATCGCTTGA

Upstream 100 bases:

>100_bases
CCCTTTACGACATGGCGAAGGCGCTCGACCGTACAATGGTGATCGGCGACATCCGCCTGCTCGAAAAAAGCGGCGGCCGT
TCGGGCGACTGGCGCGCCGC

Downstream 100 bases:

>100_bases
CAAGTTCCGCTTTGTTCCACTATCGTTCCCGCTATGTCCGGCCTGACGCTCCAGGCCTTCATGGAGAACGACCGATGTTG
ACCGCGAAGCAGCATGAACT

Product: MoeA-likedomain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSALLPVEEAQARLLALRAPLGRETVALADAHGRYLAADVLAERDQPAAPLSAMDGYAIRFDDLPGPWTVTGEVAAGSAP
DRAVGAGEAQRIFTGAVVPPGADTVIVQEDVAREGDRLTLTGDGPDSRGRHIRARAADFAAGDALLAAGSRLTPGAIATA
AMSGAGALSVAIRPRVAILTTGDELVAPGRAPGPGQIPDSNGVMLAAMLAGEAAAPVQPRHIRDDRATLAKILKELARSH
DVIVTVGGASVGDHDHVRGALGDAGGRLDFWRIAMKPGKPLIAGTLGDAILLGLPGNPSSAFVTATLFLLPLVRHLAGAR
APLPPVQRAPLAAPLDAGGTRRDYLRARVERGVLTPLVGQESGRTLPLAAANALLIRDIGAPARDAGDAADYIAIA

Sequences:

>Translated_396_residues
MSALLPVEEAQARLLALRAPLGRETVALADAHGRYLAADVLAERDQPAAPLSAMDGYAIRFDDLPGPWTVTGEVAAGSAP
DRAVGAGEAQRIFTGAVVPPGADTVIVQEDVAREGDRLTLTGDGPDSRGRHIRARAADFAAGDALLAAGSRLTPGAIATA
AMSGAGALSVAIRPRVAILTTGDELVAPGRAPGPGQIPDSNGVMLAAMLAGEAAAPVQPRHIRDDRATLAKILKELARSH
DVIVTVGGASVGDHDHVRGALGDAGGRLDFWRIAMKPGKPLIAGTLGDAILLGLPGNPSSAFVTATLFLLPLVRHLAGAR
APLPPVQRAPLAAPLDAGGTRRDYLRARVERGVLTPLVGQESGRTLPLAAANALLIRDIGAPARDAGDAADYIAIA
>Mature_395_residues
SALLPVEEAQARLLALRAPLGRETVALADAHGRYLAADVLAERDQPAAPLSAMDGYAIRFDDLPGPWTVTGEVAAGSAPD
RAVGAGEAQRIFTGAVVPPGADTVIVQEDVAREGDRLTLTGDGPDSRGRHIRARAADFAAGDALLAAGSRLTPGAIATAA
MSGAGALSVAIRPRVAILTTGDELVAPGRAPGPGQIPDSNGVMLAAMLAGEAAAPVQPRHIRDDRATLAKILKELARSHD
VIVTVGGASVGDHDHVRGALGDAGGRLDFWRIAMKPGKPLIAGTLGDAILLGLPGNPSSAFVTATLFLLPLVRHLAGARA
PLPPVQRAPLAAPLDAGGTRRDYLRARVERGVLTPLVGQESGRTLPLAAANALLIRDIGAPARDAGDAADYIAIA

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=396, Percent_Identity=33.3333333333333, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI66932975, Length=396, Percent_Identity=33.3333333333333, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI1787049, Length=355, Percent_Identity=35.7746478873239, Blast_Score=187, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI25147659, Length=333, Percent_Identity=30.9309309309309, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=364, Percent_Identity=25, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136978, Length=278, Percent_Identity=33.4532374100719, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24638841, Length=278, Percent_Identity=33.4532374100719, Blast_Score=138, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 40402; Mature: 40270

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALLPVEEAQARLLALRAPLGRETVALADAHGRYLAADVLAERDQPAAPLSAMDGYAIR
CCCCCCHHHHHHHHHHEECCCCCCEEEEECCCCCEEEHHHHHCCCCCCCCHHHCCCCEEE
FDDLPGPWTVTGEVAAGSAPDRAVGAGEAQRIFTGAVVPPGADTVIVQEDVAREGDRLTL
ECCCCCCEEEEECEECCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEHHHHCCCCEEEE
TGDGPDSRGRHIRARAADFAAGDALLAAGSRLTPGAIATAAMSGAGALSVAIRPRVAILT
ECCCCCCCCCEEEEECCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCEEEEEE
TGDELVAPGRAPGPGQIPDSNGVMLAAMLAGEAAAPVQPRHIRDDRATLAKILKELARSH
CCCCEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
DVIVTVGGASVGDHDHVRGALGDAGGRLDFWRIAMKPGKPLIAGTLGDAILLGLPGNPSS
CEEEEECCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCCCCH
AFVTATLFLLPLVRHLAGARAPLPPVQRAPLAAPLDAGGTRRDYLRARVERGVLTPLVGQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
ESGRTLPLAAANALLIRDIGAPARDAGDAADYIAIA
CCCCEEEHHHCCEEEEEECCCCCCCCCCCCCEEEEC
>Mature Secondary Structure 
SALLPVEEAQARLLALRAPLGRETVALADAHGRYLAADVLAERDQPAAPLSAMDGYAIR
CCCCCHHHHHHHHHHEECCCCCCEEEEECCCCCEEEHHHHHCCCCCCCCHHHCCCCEEE
FDDLPGPWTVTGEVAAGSAPDRAVGAGEAQRIFTGAVVPPGADTVIVQEDVAREGDRLTL
ECCCCCCEEEEECEECCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEHHHHCCCCEEEE
TGDGPDSRGRHIRARAADFAAGDALLAAGSRLTPGAIATAAMSGAGALSVAIRPRVAILT
ECCCCCCCCCEEEEECCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCEEEEEE
TGDELVAPGRAPGPGQIPDSNGVMLAAMLAGEAAAPVQPRHIRDDRATLAKILKELARSH
CCCCEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
DVIVTVGGASVGDHDHVRGALGDAGGRLDFWRIAMKPGKPLIAGTLGDAILLGLPGNPSS
CEEEEECCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCCCCH
AFVTATLFLLPLVRHLAGARAPLPPVQRAPLAAPLDAGGTRRDYLRARVERGVLTPLVGQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
ESGRTLPLAAANALLIRDIGAPARDAGDAADYIAIA
CCCCEEEHHHCCEEEEEECCCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840 [H]