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The map label for this gene is phoQ [H]

Identifier: 103486294

GI number: 103486294

Start: 808286

End: 809677

Strand: Direct

Name: phoQ [H]

Synonym: Sala_0802

Alternate gene names: 103486294

Gene position: 808286-809677 (Clockwise)

Preceding gene: 103486293

Following gene: 103486296

Centisome position: 24.16

GC content: 65.8

Gene sequence:

>1392_bases
ATGACGGAGAATGAAAAGGCGGAGGGTTTGGAACCCTCGTCGCGTCCGGCACCCGCCAGCCGCATGACCGGTTCGCTCGC
GCGGCGCATGATCGCGATTGCGGCGCTGTGGATTTCGCTGCTGCTGATTGGCGGCGGCTTCGCGCTCGACCGCGTGCTGA
CCAGCGCGATCACGCGCAATTTCGATTCGAGCCTCGAATATGTGCTGATCGCGATGATCCGCTCGTCAGAGATCGGCCCC
GACGGCGAGGTGCGGCTGATCGAACCGCTCGGCGACCAGCGGTTTCTGGAACCCTATAGCGGTCTTTACTGGCAGATCAG
CGGCGGTGGGCAGGAGCCCTATCGCTCGCGCTCGCTGTGGGAACGCACATTGAAGGCGCCGAGGTCGCATATCGACGACC
AGATTCATACCTATGACAGCGATCAGTTTGTGGACGAGGAATTGCGCATCCTCGAACGCAATGTGATCCTGCCGGGCAGC
GAAGTGAGCTGGCGCTACCAGATCGCCCAGTCGCGCGAGACGCTCGACGCGCAGATTGGCGCGGTGCGCAAGACACTGAT
CCCCAGTCTCGCGCTCCTCGGAATCGGGCTTATCATCCTTGCGGCGCTCCAGACCTTTTACGGCCTCTGGCCGCTACGCC
ACATCCGGCGTGCGATCGCGGCGATGCGCGGCGGCCAGAACCGCCGCGTCGACGCGCCGCTGCCGCGCGAGGTGCAACCG
ATGGTCGACGAACTCAACGCGCTGCTCGCGCATAATGAAAAGCAGGCGGAGGAGGCGCGGCTCCACGCCGGCAATCTCGC
TCATGCGCTGAAAACCCCCCTCACCGTGCTCGTCAACAGCGCGACGGGTTCGGATTCGGATCTTGCGAACATCGTCCGGC
GCGAGGCGGCGACGATGCAGCGTCAGGTCGATCACCATCTGGCGCGCGCGCGCGCCGTTGGGCGCCGCGGGGCCGCGCAG
TCGCGCGCGGTCGTGTGGGACAGCGTCCAGAGCGTCTCGCGGGCCGTCTTCGCCTTGTATCCCGATACGCGGCTCGATGC
CGCGGGGGACCGGACGGTGGTGGTGCAGGTCGAGCGGCAGGATCTGGATGAACTGGTTGGGAACCTGCTTGAAAATGCGG
CCAAATATGGCGGCGGCAGCGTGTTTGTGACGATCGCGCGCGACGGCGCGATGGCAGAGATCATCGTCGAGGATGACGGT
CCCGGCATTTCTCCCGCCGATCGCACGCGCATATTCGACCGCGGTGTGCGGCTCGACAGCGGCAAGCCCGGAACCGGCCT
TGGTCTGGCGATCGTGCGCGACGTCGCCGAAATCTATGGCGGCAGCATCGCGCTGGAAGCGAGCGAGGATCTGGGCGGGC
TGCTGGTGCGGTTGCGGCTGCCGGCGGGATAG

Upstream 100 bases:

>100_bases
TGACCATGCGCCATTCCTGTTTCCCTGCCGTCATCCCGGCGAAGGCCGGGATCTCGCCGGTGCGCGGTGACGACAGGGAG
AGATTCCGGCCTTTGCCGGA

Downstream 100 bases:

>100_bases
GGGTGTCGGTTTTGGGGTGGGGAGCTGCCATAGCCGTCTCCCCTTCAGGGGAGAGGGTTGGGAGAGGGGGACCATCCCAA
CCCCCTCTCAACTGCGGCTA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTENEKAEGLEPSSRPAPASRMTGSLARRMIAIAALWISLLLIGGGFALDRVLTSAITRNFDSSLEYVLIAMIRSSEIGP
DGEVRLIEPLGDQRFLEPYSGLYWQISGGGQEPYRSRSLWERTLKAPRSHIDDQIHTYDSDQFVDEELRILERNVILPGS
EVSWRYQIAQSRETLDAQIGAVRKTLIPSLALLGIGLIILAALQTFYGLWPLRHIRRAIAAMRGGQNRRVDAPLPREVQP
MVDELNALLAHNEKQAEEARLHAGNLAHALKTPLTVLVNSATGSDSDLANIVRREAATMQRQVDHHLARARAVGRRGAAQ
SRAVVWDSVQSVSRAVFALYPDTRLDAAGDRTVVVQVERQDLDELVGNLLENAAKYGGGSVFVTIARDGAMAEIIVEDDG
PGISPADRTRIFDRGVRLDSGKPGTGLGLAIVRDVAEIYGGSIALEASEDLGGLLVRLRLPAG

Sequences:

>Translated_463_residues
MTENEKAEGLEPSSRPAPASRMTGSLARRMIAIAALWISLLLIGGGFALDRVLTSAITRNFDSSLEYVLIAMIRSSEIGP
DGEVRLIEPLGDQRFLEPYSGLYWQISGGGQEPYRSRSLWERTLKAPRSHIDDQIHTYDSDQFVDEELRILERNVILPGS
EVSWRYQIAQSRETLDAQIGAVRKTLIPSLALLGIGLIILAALQTFYGLWPLRHIRRAIAAMRGGQNRRVDAPLPREVQP
MVDELNALLAHNEKQAEEARLHAGNLAHALKTPLTVLVNSATGSDSDLANIVRREAATMQRQVDHHLARARAVGRRGAAQ
SRAVVWDSVQSVSRAVFALYPDTRLDAAGDRTVVVQVERQDLDELVGNLLENAAKYGGGSVFVTIARDGAMAEIIVEDDG
PGISPADRTRIFDRGVRLDSGKPGTGLGLAIVRDVAEIYGGSIALEASEDLGGLLVRLRLPAG
>Mature_462_residues
TENEKAEGLEPSSRPAPASRMTGSLARRMIAIAALWISLLLIGGGFALDRVLTSAITRNFDSSLEYVLIAMIRSSEIGPD
GEVRLIEPLGDQRFLEPYSGLYWQISGGGQEPYRSRSLWERTLKAPRSHIDDQIHTYDSDQFVDEELRILERNVILPGSE
VSWRYQIAQSRETLDAQIGAVRKTLIPSLALLGIGLIILAALQTFYGLWPLRHIRRAIAAMRGGQNRRVDAPLPREVQPM
VDELNALLAHNEKQAEEARLHAGNLAHALKTPLTVLVNSATGSDSDLANIVRREAATMQRQVDHHLARARAVGRRGAAQS
RAVVWDSVQSVSRAVFALYPDTRLDAAGDRTVVVQVERQDLDELVGNLLENAAKYGGGSVFVTIARDGAMAEIIVEDDGP
GISPADRTRIFDRGVRLDSGKPGTGLGLAIVRDVAEIYGGSIALEASEDLGGLLVRLRLPAG

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=261, Percent_Identity=29.5019157088123, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=31.2775330396476, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789808, Length=237, Percent_Identity=29.957805907173, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786783, Length=304, Percent_Identity=25.3289473684211, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=30.9322033898305, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790551, Length=280, Percent_Identity=26.4285714285714, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790346, Length=249, Percent_Identity=26.1044176706827, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1789403, Length=346, Percent_Identity=28.3236994219653, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=29, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788393, Length=242, Percent_Identity=24.3801652892562, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50505; Mature: 50374

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENEKAEGLEPSSRPAPASRMTGSLARRMIAIAALWISLLLIGGGFALDRVLTSAITRN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
FDSSLEYVLIAMIRSSEIGPDGEVRLIEPLGDQRFLEPYSGLYWQISGGGQEPYRSRSLW
CCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHH
ERTLKAPRSHIDDQIHTYDSDQFVDEELRILERNVILPGSEVSWRYQIAQSRETLDAQIG
HHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHH
AVRKTLIPSLALLGIGLIILAALQTFYGLWPLRHIRRAIAAMRGGQNRRVDAPLPREVQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
MVDELNALLAHNEKQAEEARLHAGNLAHALKTPLTVLVNSATGSDSDLANIVRREAATMQ
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHH
RQVDHHLARARAVGRRGAAQSRAVVWDSVQSVSRAVFALYPDTRLDAAGDRTVVVQVERQ
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEEECHH
DLDELVGNLLENAAKYGGGSVFVTIARDGAMAEIIVEDDGPGISPADRTRIFDRGVRLDS
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCC
GKPGTGLGLAIVRDVAEIYGGSIALEASEDLGGLLVRLRLPAG
CCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCC
>Mature Secondary Structure 
TENEKAEGLEPSSRPAPASRMTGSLARRMIAIAALWISLLLIGGGFALDRVLTSAITRN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
FDSSLEYVLIAMIRSSEIGPDGEVRLIEPLGDQRFLEPYSGLYWQISGGGQEPYRSRSLW
CCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHH
ERTLKAPRSHIDDQIHTYDSDQFVDEELRILERNVILPGSEVSWRYQIAQSRETLDAQIG
HHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHH
AVRKTLIPSLALLGIGLIILAALQTFYGLWPLRHIRRAIAAMRGGQNRRVDAPLPREVQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
MVDELNALLAHNEKQAEEARLHAGNLAHALKTPLTVLVNSATGSDSDLANIVRREAATMQ
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHH
RQVDHHLARARAVGRRGAAQSRAVVWDSVQSVSRAVFALYPDTRLDAAGDRTVVVQVERQ
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEEECHH
DLDELVGNLLENAAKYGGGSVFVTIARDGAMAEIIVEDDGPGISPADRTRIFDRGVRLDS
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCC
GKPGTGLGLAIVRDVAEIYGGSIALEASEDLGGLLVRLRLPAG
CCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]