Click here to switch to the map view.

The map label for this gene is cysG2 [H]

Identifier: 103486264

GI number: 103486264

Start: 778412

End: 779293

Strand: Reverse

Name: cysG2 [H]

Synonym: Sala_0772

Alternate gene names: 103486264

Gene position: 779293-778412 (Counterclockwise)

Preceding gene: 103486265

Following gene: 103486263

Centisome position: 23.3

GC content: 67.01

Gene sequence:

>882_bases
ATGACGGGGGAAACATGGCGGGGCAATTTTACCTTCATCACCGTCAATAAAGCCTGCTTTGCGCTTTCGGGACGCGCAAA
CCATGTTCGCAGCATGGAACAGACGACTCTCTCTGCGGGCAAGCTGTGGCTCGTCGGCGCCGGTCCCGGCGATCCTGACC
TGCTGACGCTGCGCGCCGCGCGGCTGCTCGAAAGCGCCGACCTTGTGGTCCACGACGGGCTGGTCGGCGAAGGCGTGCTT
GCCTTGATTCCGGCAGATGTGACGCGGATTTCGGTCGCCAAGCAGCGCAGCCGTCACACGATGAAGCAGGAATCGATCAA
CGAGTTGCTCGTCCGCGAAACGCTTGCCGGAAAGCAGGTCGTGCGCCTGAAGGGCGGCGATCCCTTCATCTTTGGCCGCG
GCGGCGAGGAACTCGATGCCGCGCGCGAGGCGGGCATCGCGGTCGAGGTCGTCCCCGGCATCACCGCCGCCGCAGGCTGC
GCGGCGCAGGCCGGCCTCCCCCTCACCCACCGCGAAGATGCCAGCGCGGTCAGCTTCGTCGCGGGTCAGTGCAAGGATCT
GACCGATCAGGACTGGTCGGGGTTGGCCGGGCATGGCCGTACCCTCGTCATCTACATGGGCCTCGCGACCGCATCCGCCA
TTGCCGACAAGCTGATTGCCGACGGCGTTTCGCCGGGCCTGCCGGTCGCGGTGGTCGAGCGCGGCACCACTGCCGACGCG
CGCGTGCTGCGCACATTGCTCACCGACCTCGGCGACCTCATCGCGCGCGAACGGGTGCAAAGCCCGGCGCTGATCATCGT
CGGCAAGGTCGCGGCGCGCGCCGATGCGCTCGACTGCCTCGGCGCGCCTGGCGTCGCCGCTCAAATAAGGGATTTCACAT
GA

Upstream 100 bases:

>100_bases
TGCGTGCCTCGATCGGCGTGGGCCTGCGCGATCCCGAAGGGTCGCAATTGGTGACGAAGAAGTATCTCTAAGACCACGTC
ATTGCGAGCGTAGCGAAGCA

Downstream 100 bases:

>100_bases
AATTGCTCACCGGCAACGACCTGAAAAGCGGCGCCGTCATCTGGTGGACCGGCCACGACTGGTCGATCCATGTCGAGGAT
GCCGCCGACGTCGGCGAGCA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTGETWRGNFTFITVNKACFALSGRANHVRSMEQTTLSAGKLWLVGAGPGDPDLLTLRAARLLESADLVVHDGLVGEGVL
ALIPADVTRISVAKQRSRHTMKQESINELLVRETLAGKQVVRLKGGDPFIFGRGGEELDAAREAGIAVEVVPGITAAAGC
AAQAGLPLTHREDASAVSFVAGQCKDLTDQDWSGLAGHGRTLVIYMGLATASAIADKLIADGVSPGLPVAVVERGTTADA
RVLRTLLTDLGDLIARERVQSPALIIVGKVAARADALDCLGAPGVAAQIRDFT

Sequences:

>Translated_293_residues
MTGETWRGNFTFITVNKACFALSGRANHVRSMEQTTLSAGKLWLVGAGPGDPDLLTLRAARLLESADLVVHDGLVGEGVL
ALIPADVTRISVAKQRSRHTMKQESINELLVRETLAGKQVVRLKGGDPFIFGRGGEELDAAREAGIAVEVVPGITAAAGC
AAQAGLPLTHREDASAVSFVAGQCKDLTDQDWSGLAGHGRTLVIYMGLATASAIADKLIADGVSPGLPVAVVERGTTADA
RVLRTLLTDLGDLIARERVQSPALIIVGKVAARADALDCLGAPGVAAQIRDFT
>Mature_292_residues
TGETWRGNFTFITVNKACFALSGRANHVRSMEQTTLSAGKLWLVGAGPGDPDLLTLRAARLLESADLVVHDGLVGEGVLA
LIPADVTRISVAKQRSRHTMKQESINELLVRETLAGKQVVRLKGGDPFIFGRGGEELDAAREAGIAVEVVPGITAAAGCA
AQAGLPLTHREDASAVSFVAGQCKDLTDQDWSGLAGHGRTLVIYMGLATASAIADKLIADGVSPGLPVAVVERGTTADAR
VLRTLLTDLGDLIARERVQSPALIIVGKVAARADALDCLGAPGVAAQIRDFT

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=239, Percent_Identity=49.3723849372385, Blast_Score=228, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6322922, Length=242, Percent_Identity=35.5371900826446, Blast_Score=126, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 30546; Mature: 30415

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGETWRGNFTFITVNKACFALSGRANHVRSMEQTTLSAGKLWLVGAGPGDPDLLTLRAA
CCCCEECCCEEEEEECCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
RLLESADLVVHDGLVGEGVLALIPADVTRISVAKQRSRHTMKQESINELLVRETLAGKQV
HHHHHCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
VRLKGGDPFIFGRGGEELDAAREAGIAVEVVPGITAAAGCAAQAGLPLTHREDASAVSFV
EEEECCCEEEECCCCCHHHHHHHCCCEEEECCCCHHHHCHHHHCCCCCCCCCCCHHHHHH
AGQCKDLTDQDWSGLAGHGRTLVIYMGLATASAIADKLIADGVSPGLPVAVVERGTTADA
HHCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHH
RVLRTLLTDLGDLIARERVQSPALIIVGKVAARADALDCLGAPGVAAQIRDFT
HHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHCCCCCCHHHCCCCC
>Mature Secondary Structure 
TGETWRGNFTFITVNKACFALSGRANHVRSMEQTTLSAGKLWLVGAGPGDPDLLTLRAA
CCCEECCCEEEEEECCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
RLLESADLVVHDGLVGEGVLALIPADVTRISVAKQRSRHTMKQESINELLVRETLAGKQV
HHHHHCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
VRLKGGDPFIFGRGGEELDAAREAGIAVEVVPGITAAAGCAAQAGLPLTHREDASAVSFV
EEEECCCEEEECCCCCHHHHHHHCCCEEEECCCCHHHHCHHHHCCCCCCCCCCCHHHHHH
AGQCKDLTDQDWSGLAGHGRTLVIYMGLATASAIADKLIADGVSPGLPVAVVERGTTADA
HHCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHH
RVLRTLLTDLGDLIARERVQSPALIIVGKVAARADALDCLGAPGVAAQIRDFT
HHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA