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The map label for this gene is ethA [H]

Identifier: 103486208

GI number: 103486208

Start: 720136

End: 721647

Strand: Reverse

Name: ethA [H]

Synonym: Sala_0715

Alternate gene names: 103486208

Gene position: 721647-720136 (Counterclockwise)

Preceding gene: 103486211

Following gene: 103486206

Centisome position: 21.57

GC content: 61.51

Gene sequence:

>1512_bases
ATGATGGCGAACACGGCGAGTCCCGTGGATCAGGATGTGCTGATCGTCGGCGCAGGCATTTCGGGGATCGGCATGGCGGT
CCATCTTCAGATGCATTGCCCCGACCGCAGCTTCGCACTCGTCGAGCGCCGCGCGCAGCTCGGCGGCACCTGGGATCTGT
TCCGCTACCCCGGCATCCGGTCGGACAGCGACATGCATACGCTGGGCTTCATCTTCGAACCGTGGAAGCATGAAAAGTCG
ATCGCCGACGGTCCAGCGATCCTCGAATATCTCAATCGCATCGTCGACGAGCGCCACATCCGCGAACACATCCGCTTCGA
CCGCAAGGTCGTTGGCGCCGATTGGGACAGCGCCGCCGCGTGCTGGACGGTGACGATGGAGGACGGCGAGGGCCGGACCT
CGACGACGACCGCGCGCTGGCTCTACCTCGGCGCGGGCTATTATGATTATGACGAGCCGTTCGACGCCAATTTCGCGGGG
CGCGAGGATTTCAAGGGCCGGATCGTTCATCCGCAATTCTGGCCCAAGGATCTCGATTACAAGGACAAAAGGGTCGTCGT
GATCGGATCGGGCGCCACCGCAGTTACCATCGTGCCCTCGATGCAGGAGGCCGCGCATGTCACGATGCTCCAGCGCACGC
CGACCTGGTATTTCATCCGCCCCGCGAAGGACGGTTTGGCCAATTTCCTGCGCAAGATCCTGCCTGAAAAGCTGGCGTAC
AAGATCACGCGCTACAAGAATGTCCGGCTTCAGGACATCGCCTTCCGCCGCGCGCGCGAAAAGCCCGAGAAGGTCAAGGA
GTTCCTGACCAGAAAACTGAAGGCCAGCCTGGGCGACCATTATGACGCGGAGGCCTTCACTCCGCCTTACAACCCGTGGG
AGCAGCGGCTCTGCCTCGTCCCTGACGCTGATTTCTTCGAGGCGATGAAGGCGGGCAAGGCGTCGGTCGTTACCGATCAT
GTCGAGCGGTTCGACGCGACGGGCATCCAGCTCAAATCGGGCAAACATCTCGACGCCGACATCATCATCACCGCGACCGG
ATTGAAGCTGGCGGTGGCGGGCAAGATTCCGGTGCGCATCGACGGCGAGCGCGTCGATTGGCACGAGCATTTCTATTACA
AGGCGTGCATGTTCTCGAACGTCCCGAACTTCTCGGCGGTGTTCGGCTATCTCAACGCCAGCTGGACGCTGCGCGCCGAC
ATCGTGTCCGAATATGTGTGCCGCGTGCTCAATCATATGAAGGCGACGAACACGCTGGTCGCGACCCCCGTGCTTGCCGA
TCCGTCGAGCCTGGAGGAAGAAAATGTCTTCGATTTCTCGTCGGGCTATATCCAGCGGTCGCTGCACATCATGCCCAAAA
GCACGGCGTCGCTGCCGTGGCGGCTCAGCCAGAATTATGTGCAGGATCGCATCGACATGCGCACCGGCGCGATCGACGAC
GGCATATTGACCTTCACCAATGCGAAGGCAAAGGCCCCGGCCGCGCCAACCGAACTCGAAGCCGCCGAGTGA

Upstream 100 bases:

>100_bases
CCGAGCCGCACCAACTCGTCGCAGTTTCCGTAAACGTCAATTCGATTGCAAAATGCAACGCGGTGCGTAAGCTGCCCGCA
TAAGACGACTGGGAGATGAC

Downstream 100 bases:

>100_bases
GGGTCAATCGACGTGATCGGGCTTGCCTTTGGTCGAGCCCCTGGCGAAATCTTCGAGCTGTTTTTCGGTCATGCTTTCGG
CCATTTCTTTCGATGCGCCT

Product: monooxygenase flavin-binding family protein

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MMANTASPVDQDVLIVGAGISGIGMAVHLQMHCPDRSFALVERRAQLGGTWDLFRYPGIRSDSDMHTLGFIFEPWKHEKS
IADGPAILEYLNRIVDERHIREHIRFDRKVVGADWDSAAACWTVTMEDGEGRTSTTTARWLYLGAGYYDYDEPFDANFAG
REDFKGRIVHPQFWPKDLDYKDKRVVVIGSGATAVTIVPSMQEAAHVTMLQRTPTWYFIRPAKDGLANFLRKILPEKLAY
KITRYKNVRLQDIAFRRAREKPEKVKEFLTRKLKASLGDHYDAEAFTPPYNPWEQRLCLVPDADFFEAMKAGKASVVTDH
VERFDATGIQLKSGKHLDADIIITATGLKLAVAGKIPVRIDGERVDWHEHFYYKACMFSNVPNFSAVFGYLNASWTLRAD
IVSEYVCRVLNHMKATNTLVATPVLADPSSLEEENVFDFSSGYIQRSLHIMPKSTASLPWRLSQNYVQDRIDMRTGAIDD
GILTFTNAKAKAPAAPTELEAAE

Sequences:

>Translated_503_residues
MMANTASPVDQDVLIVGAGISGIGMAVHLQMHCPDRSFALVERRAQLGGTWDLFRYPGIRSDSDMHTLGFIFEPWKHEKS
IADGPAILEYLNRIVDERHIREHIRFDRKVVGADWDSAAACWTVTMEDGEGRTSTTTARWLYLGAGYYDYDEPFDANFAG
REDFKGRIVHPQFWPKDLDYKDKRVVVIGSGATAVTIVPSMQEAAHVTMLQRTPTWYFIRPAKDGLANFLRKILPEKLAY
KITRYKNVRLQDIAFRRAREKPEKVKEFLTRKLKASLGDHYDAEAFTPPYNPWEQRLCLVPDADFFEAMKAGKASVVTDH
VERFDATGIQLKSGKHLDADIIITATGLKLAVAGKIPVRIDGERVDWHEHFYYKACMFSNVPNFSAVFGYLNASWTLRAD
IVSEYVCRVLNHMKATNTLVATPVLADPSSLEEENVFDFSSGYIQRSLHIMPKSTASLPWRLSQNYVQDRIDMRTGAIDD
GILTFTNAKAKAPAAPTELEAAE
>Mature_503_residues
MMANTASPVDQDVLIVGAGISGIGMAVHLQMHCPDRSFALVERRAQLGGTWDLFRYPGIRSDSDMHTLGFIFEPWKHEKS
IADGPAILEYLNRIVDERHIREHIRFDRKVVGADWDSAAACWTVTMEDGEGRTSTTTARWLYLGAGYYDYDEPFDANFAG
REDFKGRIVHPQFWPKDLDYKDKRVVVIGSGATAVTIVPSMQEAAHVTMLQRTPTWYFIRPAKDGLANFLRKILPEKLAY
KITRYKNVRLQDIAFRRAREKPEKVKEFLTRKLKASLGDHYDAEAFTPPYNPWEQRLCLVPDADFFEAMKAGKASVVTDH
VERFDATGIQLKSGKHLDADIIITATGLKLAVAGKIPVRIDGERVDWHEHFYYKACMFSNVPNFSAVFGYLNASWTLRAD
IVSEYVCRVLNHMKATNTLVATPVLADPSSLEEENVFDFSSGYIQRSLHIMPKSTASLPWRLSQNYVQDRIDMRTGAIDD
GILTFTNAKAKAPAAPTELEAAE

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI25150462, Length=228, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17555726, Length=269, Percent_Identity=22.6765799256506, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 56793; Mature: 56793

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMANTASPVDQDVLIVGAGISGIGMAVHLQMHCPDRSFALVERRAQLGGTWDLFRYPGIR
CCCCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEHHCCCCCC
SDSDMHTLGFIFEPWKHEKSIADGPAILEYLNRIVDERHIREHIRFDRKVVGADWDSAAA
CCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCE
CWTVTMEDGEGRTSTTTARWLYLGAGYYDYDEPFDANFAGREDFKGRIVHPQFWPKDLDY
EEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
KDKRVVVIGSGATAVTIVPSMQEAAHVTMLQRTPTWYFIRPAKDGLANFLRKILPEKLAY
CCCEEEEEECCCEEEEEECCHHHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHH
KITRYKNVRLQDIAFRRAREKPEKVKEFLTRKLKASLGDHYDAEAFTPPYNPWEQRLCLV
HHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCEEEC
PDADFFEAMKAGKASVVTDHVERFDATGIQLKSGKHLDADIIITATGLKLAVAGKIPVRI
CCCHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCEEEEEECCCEEEE
DGERVDWHEHFYYKACMFSNVPNFSAVFGYLNASWTLRADIVSEYVCRVLNHMKATNTLV
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCEE
ATPVLADPSSLEEENVFDFSSGYIQRSLHIMPKSTASLPWRLSQNYVQDRIDMRTGAIDD
ECCEECCCCCCCCCCCEECCCCHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GILTFTNAKAKAPAAPTELEAAE
CEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMANTASPVDQDVLIVGAGISGIGMAVHLQMHCPDRSFALVERRAQLGGTWDLFRYPGIR
CCCCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEHHCCCCCC
SDSDMHTLGFIFEPWKHEKSIADGPAILEYLNRIVDERHIREHIRFDRKVVGADWDSAAA
CCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCE
CWTVTMEDGEGRTSTTTARWLYLGAGYYDYDEPFDANFAGREDFKGRIVHPQFWPKDLDY
EEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
KDKRVVVIGSGATAVTIVPSMQEAAHVTMLQRTPTWYFIRPAKDGLANFLRKILPEKLAY
CCCEEEEEECCCEEEEEECCHHHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHH
KITRYKNVRLQDIAFRRAREKPEKVKEFLTRKLKASLGDHYDAEAFTPPYNPWEQRLCLV
HHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCEEEC
PDADFFEAMKAGKASVVTDHVERFDATGIQLKSGKHLDADIIITATGLKLAVAGKIPVRI
CCCHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCEEEEEECCCEEEE
DGERVDWHEHFYYKACMFSNVPNFSAVFGYLNASWTLRADIVSEYVCRVLNHMKATNTLV
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCEE
ATPVLADPSSLEEENVFDFSSGYIQRSLHIMPKSTASLPWRLSQNYVQDRIDMRTGAIDD
ECCEECCCCCCCCCCCEECCCCHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GILTFTNAKAKAPAAPTELEAAE
CEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]