Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 103486185

GI number: 103486185

Start: 698389

End: 700392

Strand: Direct

Name: thrS

Synonym: Sala_0692

Alternate gene names: 103486185

Gene position: 698389-700392 (Clockwise)

Preceding gene: 103486184

Following gene: 103486186

Centisome position: 20.88

GC content: 65.47

Gene sequence:

>2004_bases
ATGTCCGACATGATCCGCGTCACCCTTCCCGATGGCTCTGCCCGTGAAGTCGCGCGCGGGACCACCCCGGCCGAGATCGC
GGCCGCCATCGGCCCCGGCCTTGCCAAGGCGGCGCTGGCGGCAAAAATCGACGGCGAACTGCGCGACATCATGCGACCGC
TGGAGGAAGACACGAACCTGGCGCTGGTCACCAGCCGCGACGAGGCCGATGCGCTCGAACTCGCGCGCCACGATTATGCG
CATGTCCTCGCCGAAGCGGTGCAGACGCTGTTTCCGGGCACGCAGATCACCTTTGGTCCCGCGACGAGCGACGGCTTTTA
TTACGACTTCGCGCCGACCGCTGAACATGGCCCATTCCGCGACGAGGAACTGCCGCTGATCGAGGAGGAGATGCGCCGCA
TCATCGCCGCCGACAAGCCGCTGCGCCGCGAGGTGTGGGACCGCGACGCGCTGATCGCCCGCTGGAAGAAGGACGGCGAG
ACGTTCAAGGCCGAATGGGCGGCCGAGCTGCCCGCGGGCGAGGAGATCAGCGTTTACTGGTCGGGCGACGACTGGATGGA
CATGTGCCGCGGGCCGCATCTGGCGTCGACGGGCAAGCTCGACCCGGCGGCGTTCAAGCTCACGCGGGTTTCGGGCGCCT
ATTGGCGCGGCGACCAGAAAAATGCGCAGCTTTCGCGCATCTATGGCACCGGCTGGCTGAACAGGAAGCAGCTCGCCGAG
CATCTTGTCCGGCTGGAGGAAGCGGCCAAGCGCGACCATCGTCGGCTGGGGCAGGAGATGGACCTGTTCCACCTGCAACA
GGAGGCGCATGGTTCGGTCTTCTGGCATCCCAATGGCTTCGTCGTGTGGCGCGAGCTCGAGGCCTATATGCGCCGCGCGA
TCGACGCCGCGGGCTATCGCGAGGTCAAGACGCCGCAGGTGATGGACGCGCGCCAGTGGGAACAGTCGGGCCACTGGGGC
AAATATCGCGAAAATATGTTCGTCATCCCCGACGAGGTGCCGAACACCGAGGATGAAGGCCCGATCGTCTCCGACGATGC
CGAGTGGATGGCGCTGAAGCCGATGAATTGCCCGGCGCATGTGCTGATCTTCCGCCAGGGCATGAAAAGCTATCGCGACC
TGCCGCTGCGGCTTTACGAAAATGGCTGCTGCCACCGCAACGAACCCCACGGTGCGCTGCACGGGCTGATGCGCGTGCGC
CAGTTCACCCAGGACGACGCGCATATCTTCTGCCGCGAAGATCAGATCGTCGAGGAAGTCCGCAATTTCTGCGCGCTCGC
CGACCGCATCTACAAGGATTTCGGCTTCACCTATGCGATCAAGCTGGCGCTGCGTCCCGAAAAGCGCTTCGGCAGCGACG
CGATGTGGGACAAGTCCGAGGATGAGCTGCGCAACGCGGTGATCGAGGCGGGGCTTGCGACCGAGCAATATGGCTGGGAG
GAACTGCCCGGCGAAGGCGCCTTCTATGCGCCCAAGCTCGAATGGCATCTGACCGACGCGATCGGCCGGACGTGGCAGGT
CGGCACGATCCAGTCCGACCGCGTGCTCCCCGACCGGCTCGACGCCTCCTATATTGGCGAGGATGGCGAGCGGCATCGCC
CGGTGATGCTCCACCGCGCGATCTTCGGCAGCTATGAACGCTTTATCGGCATTTTGATCGAGCATTTCGTCGGCCGCTTC
CCGACCTGGCTCGCGCCGGTGCAGGCAGTCGTCGCGACGATCGTCAGCGACGCCGACGATTATGCGAAGGCCGCGACCGC
ACGGCTCGTCGCCGCGGGCATCCGCACCGAGAGCGATCTGCGCAACGAAAAGATCAACTACAAGGTGCGCGAACACAGCC
TCGCCAAAGTCCCCCACCTGCTCGTCGTCGGCAAGCGCGAGGCCGAGGAAGGCACCGTCGCGATCCGCACGCTGGGGCAG
GACGGCCAGCGCATCATGCCGCTCGCCGAAGCGATCGCGATGCTGAAGACCCAGGCGACCCCGCCGGACCTCAAGGTCCG
GTGA

Upstream 100 bases:

>100_bases
AGTATCATTGCAACCCCCGTTGCGAATCCCGCCCTTGCCGCTCCTATCGCTTGCTGGCAAAGGGGCGCCGCACTTTTGCG
CAAGAAAGGCCGTTTTTTCG

Downstream 100 bases:

>100_bases
GCGCGGTCGGCTTCGGTCGCCACGCGGCGGACGAGCGGCTGCCGCGGCATCGCCATGCCCATGGCTATATCGCGGTCGTG
CTCGGCGGCGGATATGAAGA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MSDMIRVTLPDGSAREVARGTTPAEIAAAIGPGLAKAALAAKIDGELRDIMRPLEEDTNLALVTSRDEADALELARHDYA
HVLAEAVQTLFPGTQITFGPATSDGFYYDFAPTAEHGPFRDEELPLIEEEMRRIIAADKPLRREVWDRDALIARWKKDGE
TFKAEWAAELPAGEEISVYWSGDDWMDMCRGPHLASTGKLDPAAFKLTRVSGAYWRGDQKNAQLSRIYGTGWLNRKQLAE
HLVRLEEAAKRDHRRLGQEMDLFHLQQEAHGSVFWHPNGFVVWRELEAYMRRAIDAAGYREVKTPQVMDARQWEQSGHWG
KYRENMFVIPDEVPNTEDEGPIVSDDAEWMALKPMNCPAHVLIFRQGMKSYRDLPLRLYENGCCHRNEPHGALHGLMRVR
QFTQDDAHIFCREDQIVEEVRNFCALADRIYKDFGFTYAIKLALRPEKRFGSDAMWDKSEDELRNAVIEAGLATEQYGWE
ELPGEGAFYAPKLEWHLTDAIGRTWQVGTIQSDRVLPDRLDASYIGEDGERHRPVMLHRAIFGSYERFIGILIEHFVGRF
PTWLAPVQAVVATIVSDADDYAKAATARLVAAGIRTESDLRNEKINYKVREHSLAKVPHLLVVGKREAEEGTVAIRTLGQ
DGQRIMPLAEAIAMLKTQATPPDLKVR

Sequences:

>Translated_667_residues
MSDMIRVTLPDGSAREVARGTTPAEIAAAIGPGLAKAALAAKIDGELRDIMRPLEEDTNLALVTSRDEADALELARHDYA
HVLAEAVQTLFPGTQITFGPATSDGFYYDFAPTAEHGPFRDEELPLIEEEMRRIIAADKPLRREVWDRDALIARWKKDGE
TFKAEWAAELPAGEEISVYWSGDDWMDMCRGPHLASTGKLDPAAFKLTRVSGAYWRGDQKNAQLSRIYGTGWLNRKQLAE
HLVRLEEAAKRDHRRLGQEMDLFHLQQEAHGSVFWHPNGFVVWRELEAYMRRAIDAAGYREVKTPQVMDARQWEQSGHWG
KYRENMFVIPDEVPNTEDEGPIVSDDAEWMALKPMNCPAHVLIFRQGMKSYRDLPLRLYENGCCHRNEPHGALHGLMRVR
QFTQDDAHIFCREDQIVEEVRNFCALADRIYKDFGFTYAIKLALRPEKRFGSDAMWDKSEDELRNAVIEAGLATEQYGWE
ELPGEGAFYAPKLEWHLTDAIGRTWQVGTIQSDRVLPDRLDASYIGEDGERHRPVMLHRAIFGSYERFIGILIEHFVGRF
PTWLAPVQAVVATIVSDADDYAKAATARLVAAGIRTESDLRNEKINYKVREHSLAKVPHLLVVGKREAEEGTVAIRTLGQ
DGQRIMPLAEAIAMLKTQATPPDLKVR
>Mature_666_residues
SDMIRVTLPDGSAREVARGTTPAEIAAAIGPGLAKAALAAKIDGELRDIMRPLEEDTNLALVTSRDEADALELARHDYAH
VLAEAVQTLFPGTQITFGPATSDGFYYDFAPTAEHGPFRDEELPLIEEEMRRIIAADKPLRREVWDRDALIARWKKDGET
FKAEWAAELPAGEEISVYWSGDDWMDMCRGPHLASTGKLDPAAFKLTRVSGAYWRGDQKNAQLSRIYGTGWLNRKQLAEH
LVRLEEAAKRDHRRLGQEMDLFHLQQEAHGSVFWHPNGFVVWRELEAYMRRAIDAAGYREVKTPQVMDARQWEQSGHWGK
YRENMFVIPDEVPNTEDEGPIVSDDAEWMALKPMNCPAHVLIFRQGMKSYRDLPLRLYENGCCHRNEPHGALHGLMRVRQ
FTQDDAHIFCREDQIVEEVRNFCALADRIYKDFGFTYAIKLALRPEKRFGSDAMWDKSEDELRNAVIEAGLATEQYGWEE
LPGEGAFYAPKLEWHLTDAIGRTWQVGTIQSDRVLPDRLDASYIGEDGERHRPVMLHRAIFGSYERFIGILIEHFVGRFP
TWLAPVQAVVATIVSDADDYAKAATARLVAAGIRTESDLRNEKINYKVREHSLAKVPHLLVVGKREAEEGTVAIRTLGQD
GQRIMPLAEAIAMLKTQATPPDLKVR

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=658, Percent_Identity=37.6899696048632, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI38570111, Length=659, Percent_Identity=35.8118361153263, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI20070344, Length=648, Percent_Identity=38.1172839506173, Blast_Score=407, Evalue=1e-113,
Organism=Escherichia coli, GI1788013, Length=660, Percent_Identity=45.7575757575758, Blast_Score=593, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI71984184, Length=639, Percent_Identity=39.2801251956182, Blast_Score=443, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71984192, Length=639, Percent_Identity=39.2801251956182, Blast_Score=442, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322112, Length=649, Percent_Identity=36.517719568567, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6322654, Length=411, Percent_Identity=36.0097323600973, Blast_Score=253, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24583842, Length=654, Percent_Identity=37.4617737003058, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI28574141, Length=654, Percent_Identity=37.4617737003058, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24583839, Length=654, Percent_Identity=37.4617737003058, Blast_Score=431, Evalue=1e-121,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_SPHAL (Q1GVA9)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_615746.1
- ProteinModelPortal:   Q1GVA9
- SMR:   Q1GVA9
- GeneID:   4081951
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_0692
- NMPDR:   fig|317655.9.peg.640
- HOGENOM:   HBG352811
- OMA:   ARDRPFT
- ProtClustDB:   PRK00413
- BioCyc:   SALA317655:SALA_0692-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 75595; Mature: 75464

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMIRVTLPDGSAREVARGTTPAEIAAAIGPGLAKAALAAKIDGELRDIMRPLEEDTNL
CCCCEEEECCCCCHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCCCE
ALVTSRDEADALELARHDYAHVLAEAVQTLFPGTQITFGPATSDGFYYDFAPTAEHGPFR
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCCCCCCCC
DEELPLIEEEMRRIIAADKPLRREVWDRDALIARWKKDGETFKAEWAAELPAGEEISVYW
CCCCCHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHCCCCEEEHHHHHCCCCCCEEEEEE
SGDDWMDMCRGPHLASTGKLDPAAFKLTRVSGAYWRGDQKNAQLSRIYGTGWLNRKQLAE
CCCCHHHHHCCCCCCCCCCCCHHHEEEEECCCCEECCCCCCCEEEEEECCCCCCHHHHHH
HLVRLEEAAKRDHRRLGQEMDLFHLQQEAHGSVFWHPNGFVVWRELEAYMRRAIDAAGYR
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCCEEEHHHHHHHHHHHHHHCCCC
EVKTPQVMDARQWEQSGHWGKYRENMFVIPDEVPNTEDEGPIVSDDAEWMALKPMNCPAH
CCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCEECCCCCEEEEECCCCCHH
VLIFRQGMKSYRDLPLRLYENGCCHRNEPHGALHGLMRVRQFTQDDAHIFCREDQIVEEV
HHHHHHHHHHHHCCCHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
RNFCALADRIYKDFGFTYAIKLALRPEKRFGSDAMWDKSEDELRNAVIEAGLATEQYGWE
HHHHHHHHHHHHHCCCEEEEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHH
ELPGEGAFYAPKLEWHLTDAIGRTWQVGTIQSDRVLPDRLDASYIGEDGERHRPVMLHRA
HCCCCCCEECCCEEEEEHHHHCCEEEECCCCCCCCCHHHCCHHHCCCCCCCCCCHHHHHH
IFGSYERFIGILIEHFVGRFPTWLAPVQAVVATIVSDADDYAKAATARLVAAGIRTESDL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHH
RNEKINYKVREHSLAKVPHLLVVGKREAEEGTVAIRTLGQDGQRIMPLAEAIAMLKTQAT
CCCCCCEEEHHHHHHHCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
PPDLKVR
CCCCCCC
>Mature Secondary Structure 
SDMIRVTLPDGSAREVARGTTPAEIAAAIGPGLAKAALAAKIDGELRDIMRPLEEDTNL
CCCEEEECCCCCHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCCCE
ALVTSRDEADALELARHDYAHVLAEAVQTLFPGTQITFGPATSDGFYYDFAPTAEHGPFR
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCCCCCCCC
DEELPLIEEEMRRIIAADKPLRREVWDRDALIARWKKDGETFKAEWAAELPAGEEISVYW
CCCCCHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHCCCCEEEHHHHHCCCCCCEEEEEE
SGDDWMDMCRGPHLASTGKLDPAAFKLTRVSGAYWRGDQKNAQLSRIYGTGWLNRKQLAE
CCCCHHHHHCCCCCCCCCCCCHHHEEEEECCCCEECCCCCCCEEEEEECCCCCCHHHHHH
HLVRLEEAAKRDHRRLGQEMDLFHLQQEAHGSVFWHPNGFVVWRELEAYMRRAIDAAGYR
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCCEEEHHHHHHHHHHHHHHCCCC
EVKTPQVMDARQWEQSGHWGKYRENMFVIPDEVPNTEDEGPIVSDDAEWMALKPMNCPAH
CCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCEECCCCCEEEEECCCCCHH
VLIFRQGMKSYRDLPLRLYENGCCHRNEPHGALHGLMRVRQFTQDDAHIFCREDQIVEEV
HHHHHHHHHHHHCCCHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHH
RNFCALADRIYKDFGFTYAIKLALRPEKRFGSDAMWDKSEDELRNAVIEAGLATEQYGWE
HHHHHHHHHHHHHCCCEEEEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHH
ELPGEGAFYAPKLEWHLTDAIGRTWQVGTIQSDRVLPDRLDASYIGEDGERHRPVMLHRA
HCCCCCCEECCCEEEEEHHHHCCEEEECCCCCCCCCHHHCCHHHCCCCCCCCCCHHHHHH
IFGSYERFIGILIEHFVGRFPTWLAPVQAVVATIVSDADDYAKAATARLVAAGIRTESDL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHH
RNEKINYKVREHSLAKVPHLLVVGKREAEEGTVAIRTLGQDGQRIMPLAEAIAMLKTQAT
CCCCCCEEEHHHHHHHCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
PPDLKVR
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA