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The map label for this gene is pyrD

Identifier: 103486173

GI number: 103486173

Start: 688516

End: 689586

Strand: Direct

Name: pyrD

Synonym: Sala_0680

Alternate gene names: 103486173

Gene position: 688516-689586 (Clockwise)

Preceding gene: 103486158

Following gene: 103486174

Centisome position: 20.58

GC content: 71.71

Gene sequence:

>1071_bases
ATGTCGCTTTTCGCTTCGCTCACCGACGCCGCCTATGCGCTCGCCCGCCCGCTCGTCCACGCCACCGATGGCGAGGCCGC
GCATAATCTGACGCTCGCCGCGCTCCAGCCGCTGCCGCGCGCGCGCCATGCCCTGACCAGCCCGATGCTCGCGACCGAGC
TTGCCGGACTGCGCTTCCCCAACCCGGTCGGGCTGGCCCCCGGTTTCGACAAGGACGCGCGCGTCGCGCATGCGATGCCG
CATTTCGGCTTCGGCTTTGTCGAGGTCGGCACGCTCACCCCGCTGCCGCAGGAGGGCAATCCGCGCCCACGGCTGTTCCG
GCTGGTCGAGGATCGCGCGATCATCAACCGCATGGGCTTCAACAATGGCGGACAGGTCGCCGCCGCCGAGCGCATCGCCT
GCCTGCGCCGCCATGGGCTGCCGGTGCCGCTCGGCATCAATATCGGCGCGAACAAGGACAGCGCCGACCGCATCGCCGAC
TATGCGAAGGGCACGGCGGCGATGGCGCCGCTCGCCGATTATCTTACCGTCAATATCAGCTCGCCGAACACGCCCGGACT
GCGCGCGCTGCAGGACAGGGGGGCGCTCGAGGCGCTGCTCGACGGCGTCGCCGCGGCGCAGCCGGCGGGGGCGGCGAAGC
CCGTCTTCCTGAAGGTCGCACCCGACCTCGAACCCGCCGACATCGACGACATTGTGGCGGTGGCGCTCGATAGGGGGCTC
GCGGCGGTGATCGTGTCGAACACGACCGTAGCCCGGCCGCCGCTGGCCTCGCGCCACGCCGTCGAAGCCGGTGGCCTGTC
GGGCGCGCCGCTCGCGCAGCTCGCGCTTCAGTGCGTGCAGGATTTCCGCGCCGCGAGCGGCGGCAGGCTGCCGCTGATCG
CCGCGGGCGGGATCGCCTCTGCCGAACAGGCCTGGGAACGCATTCGCGCGGGAGCAAGCCTGGTGCAGGTCTATTCGGCG
ATGGTCTTTGAAGGGCCGGGTCTTGCGAGCCGCATCGCACGCGGGCTGGAGACGCTGGCGGCGCGCGACGGGTTTGCGCG
GGTGAGCGACGCGGTGGGGGCGGGCGCCTGA

Upstream 100 bases:

>100_bases
CAGACGAGCGAGGGTGCGAAGGTGCGACACGATTTTCTCCCGGTTTTTGCGGATATGGCGGGGGCTTGCCATAGCGCCGC
CGGGCGCGCAATGGCGGGCC

Downstream 100 bases:

>100_bases
GCCCATGCGCTCTCCCCCCGCAGCGGAGAGAGCGATCAAGCGCCCTTGCACTCCCTCTGTCTCCGCGCCAATGTCGCGTG
CATGCTGAACCGTCTCCTCG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSLFASLTDAAYALARPLVHATDGEAAHNLTLAALQPLPRARHALTSPMLATELAGLRFPNPVGLAPGFDKDARVAHAMP
HFGFGFVEVGTLTPLPQEGNPRPRLFRLVEDRAIINRMGFNNGGQVAAAERIACLRRHGLPVPLGINIGANKDSADRIAD
YAKGTAAMAPLADYLTVNISSPNTPGLRALQDRGALEALLDGVAAAQPAGAAKPVFLKVAPDLEPADIDDIVAVALDRGL
AAVIVSNTTVARPPLASRHAVEAGGLSGAPLAQLALQCVQDFRAASGGRLPLIAAGGIASAEQAWERIRAGASLVQVYSA
MVFEGPGLASRIARGLETLAARDGFARVSDAVGAGA

Sequences:

>Translated_356_residues
MSLFASLTDAAYALARPLVHATDGEAAHNLTLAALQPLPRARHALTSPMLATELAGLRFPNPVGLAPGFDKDARVAHAMP
HFGFGFVEVGTLTPLPQEGNPRPRLFRLVEDRAIINRMGFNNGGQVAAAERIACLRRHGLPVPLGINIGANKDSADRIAD
YAKGTAAMAPLADYLTVNISSPNTPGLRALQDRGALEALLDGVAAAQPAGAAKPVFLKVAPDLEPADIDDIVAVALDRGL
AAVIVSNTTVARPPLASRHAVEAGGLSGAPLAQLALQCVQDFRAASGGRLPLIAAGGIASAEQAWERIRAGASLVQVYSA
MVFEGPGLASRIARGLETLAARDGFARVSDAVGAGA
>Mature_355_residues
SLFASLTDAAYALARPLVHATDGEAAHNLTLAALQPLPRARHALTSPMLATELAGLRFPNPVGLAPGFDKDARVAHAMPH
FGFGFVEVGTLTPLPQEGNPRPRLFRLVEDRAIINRMGFNNGGQVAAAERIACLRRHGLPVPLGINIGANKDSADRIADY
AKGTAAMAPLADYLTVNISSPNTPGLRALQDRGALEALLDGVAAAQPAGAAKPVFLKVAPDLEPADIDDIVAVALDRGLA
AVIVSNTTVARPPLASRHAVEAGGLSGAPLAQLALQCVQDFRAASGGRLPLIAAGGIASAEQAWERIRAGASLVQVYSAM
VFEGPGLASRIARGLETLAARDGFARVSDAVGAGA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=345, Percent_Identity=46.9565217391304, Blast_Score=289, Evalue=2e-78,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=38.9221556886228, Blast_Score=209, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17509475, Length=366, Percent_Identity=43.4426229508197, Blast_Score=285, Evalue=2e-77,
Organism=Drosophila melanogaster, GI281361352, Length=348, Percent_Identity=41.6666666666667, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI17137316, Length=348, Percent_Identity=41.6666666666667, Blast_Score=265, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_SPHAL (Q1GVC1)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_615734.1
- ProteinModelPortal:   Q1GVC1
- SMR:   Q1GVC1
- GeneID:   4082977
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_0680
- NMPDR:   fig|317655.9.peg.631
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- ProtClustDB:   PRK05286
- BioCyc:   SALA317655:SALA_0680-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36684; Mature: 36553

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFASLTDAAYALARPLVHATDGEAAHNLTLAALQPLPRARHALTSPMLATELAGLRFP
CCHHHHHHHHHHHHHHHHHCCCCCCHHHCEEHHHHCCCHHHHHHHHCCHHHHHHHCCCCC
NPVGLAPGFDKDARVAHAMPHFGFGFVEVGTLTPLPQEGNPRPRLFRLVEDRAIINRMGF
CCCCCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
NNGGQVAAAERIACLRRHGLPVPLGINIGANKDSADRIADYAKGTAAMAPLADYLTVNIS
CCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHCEEEEEEEC
SPNTPGLRALQDRGALEALLDGVAAAQPAGAAKPVFLKVAPDLEPADIDDIVAVALDRGL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCE
AAVIVSNTTVARPPLASRHAVEAGGLSGAPLAQLALQCVQDFRAASGGRLPLIAAGGIAS
EEEEEECCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCH
AEQAWERIRAGASLVQVYSAMVFEGPGLASRIARGLETLAARDGFARVSDAVGAGA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SLFASLTDAAYALARPLVHATDGEAAHNLTLAALQPLPRARHALTSPMLATELAGLRFP
CHHHHHHHHHHHHHHHHHCCCCCCHHHCEEHHHHCCCHHHHHHHHCCHHHHHHHCCCCC
NPVGLAPGFDKDARVAHAMPHFGFGFVEVGTLTPLPQEGNPRPRLFRLVEDRAIINRMGF
CCCCCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
NNGGQVAAAERIACLRRHGLPVPLGINIGANKDSADRIADYAKGTAAMAPLADYLTVNIS
CCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHCEEEEEEEC
SPNTPGLRALQDRGALEALLDGVAAAQPAGAAKPVFLKVAPDLEPADIDDIVAVALDRGL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCE
AAVIVSNTTVARPPLASRHAVEAGGLSGAPLAQLALQCVQDFRAASGGRLPLIAAGGIAS
EEEEEECCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCH
AEQAWERIRAGASLVQVYSAMVFEGPGLASRIARGLETLAARDGFARVSDAVGAGA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA