Click here to switch to the map view.

The map label for this gene is sufS [H]

Identifier: 103486162

GI number: 103486162

Start: 678557

End: 679801

Strand: Reverse

Name: sufS [H]

Synonym: Sala_0669

Alternate gene names: 103486162

Gene position: 679801-678557 (Counterclockwise)

Preceding gene: 103486163

Following gene: 103486161

Centisome position: 20.32

GC content: 66.43

Gene sequence:

>1245_bases
GTGAGCAATCTCCCTTCCCCGTTCGCATCGAGCGAAGTCGGGATGCCCATCGGTAACGCACGCCTTCAGGGTGTCTCGAC
TTCGCTCGACACGAACGGGATCAGAGATCAGTTCCCCGGCCTCACCCCCGGCTGGCACTATCTCGACACCGCCGCGACGG
CGCAGAAGCCGCAGGCGGTGATCGATGCCACCCTCGCCGCGATGGGCCGCGACTATGCGACCGTGCATCGCGGCGTCTAT
GCGCGTTCGGCCGACATGACGCTTGCCTATGAGGCGGCGCGGCGGCGGATCGCGGCCTTTATCGGCGCGAAGGACGACCA
GATCGCCTTTGTGCGCGGCGCGACCGAGGCGATCAACCTGGTTGCCTATTCGCACCCGAAAAAGGGCCGCGTGCTGCTCT
CCACGCTCGAGCATCACAGCAATATCGTGCCGTGGCAGCTCGCGGGCTGGCAGGTCGATGTCTGCCCGCTGACCGCCGAC
GGCTGCATCGACCTCGATGCCGCCGAAAAGCTGCTGACCCGCGGTCATAATATGGTCGCCTTCGCGCATGTCTCGAACGT
GCTCGGCAGTCCGCTCGACGTCGCGCGCGCGGCGGAGCTGGCGCACAAGGTTGGCGCCGAGCTGCTGATCGACGGGTGCC
AGGCGGTGCCGCGGCTGCCCGTCGACGTCGCGGCGCTGGGGTGCGACTATTACGTCTTTTCGGGGCACAAGCTCTATGGT
CCGACCGGTATCGGCGTGCTGTGGAGCGACAAGCTCGACGCCTTGCCGCCGTGGCAGGGCGGCGGGTCGATGATCGACCG
GGTGACGTTCGAGCGCACGACCTATGCCCCCGCCCCCACCCGCTTCGAGGCTGGAACGCCCGCAATCGTCGAGGCGCTGG
GGCTCGCGGCGGCGGTCGATTATGTCGAGACGATCGGGATCGATGCGATCCACGCGCACGAATGCGCGCTCGTCACCTCG
CTGCGCGACCAACTCGCGCGGCGCAACAGCATCACCCTTTATGGCCCTGAAAACAGCGCCGGAATCGTCAGCTTTTCGAT
GGCGGGGGTTCATCCGCACGACATCGGCACTATCTTGGACGAAAGCGGGGTCGCGATCCGCGCCGGGCATCATTGCGCGC
AGCCGCTGATGGACCATCTGGGCGTGCCCGCGACCGCGCGCGCGAGTTTCGGTTTGTACAGCAATGACGACGATGTGGCG
GCGCTGATCGACGGCCTCGCCCGCGTCGAAAGGATTTTCGGATGA

Upstream 100 bases:

>100_bases
AGAAGATATTGCTCCAGGCCTTTGTCGCGGGCGTGTTCGACGGGGCGGTGGATGAGGCGCGGTTGCAGGAGCTGGCGCTG
GCGAAGCTGGGGGAACTGGT

Downstream 100 bases:

>100_bases
GCGAGGAGCGGACAATCAGGATCGAGGAAGTCGCGCACGTCGAGGCGCCGCCCAAAGCGCGCGTCGCCGATGCCGAGACG
GCGCCCGAGAAGCTCGAACG

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSNLPSPFASSEVGMPIGNARLQGVSTSLDTNGIRDQFPGLTPGWHYLDTAATAQKPQAVIDATLAAMGRDYATVHRGVY
ARSADMTLAYEAARRRIAAFIGAKDDQIAFVRGATEAINLVAYSHPKKGRVLLSTLEHHSNIVPWQLAGWQVDVCPLTAD
GCIDLDAAEKLLTRGHNMVAFAHVSNVLGSPLDVARAAELAHKVGAELLIDGCQAVPRLPVDVAALGCDYYVFSGHKLYG
PTGIGVLWSDKLDALPPWQGGGSMIDRVTFERTTYAPAPTRFEAGTPAIVEALGLAAAVDYVETIGIDAIHAHECALVTS
LRDQLARRNSITLYGPENSAGIVSFSMAGVHPHDIGTILDESGVAIRAGHHCAQPLMDHLGVPATARASFGLYSNDDDVA
ALIDGLARVERIFG

Sequences:

>Translated_414_residues
MSNLPSPFASSEVGMPIGNARLQGVSTSLDTNGIRDQFPGLTPGWHYLDTAATAQKPQAVIDATLAAMGRDYATVHRGVY
ARSADMTLAYEAARRRIAAFIGAKDDQIAFVRGATEAINLVAYSHPKKGRVLLSTLEHHSNIVPWQLAGWQVDVCPLTAD
GCIDLDAAEKLLTRGHNMVAFAHVSNVLGSPLDVARAAELAHKVGAELLIDGCQAVPRLPVDVAALGCDYYVFSGHKLYG
PTGIGVLWSDKLDALPPWQGGGSMIDRVTFERTTYAPAPTRFEAGTPAIVEALGLAAAVDYVETIGIDAIHAHECALVTS
LRDQLARRNSITLYGPENSAGIVSFSMAGVHPHDIGTILDESGVAIRAGHHCAQPLMDHLGVPATARASFGLYSNDDDVA
ALIDGLARVERIFG
>Mature_413_residues
SNLPSPFASSEVGMPIGNARLQGVSTSLDTNGIRDQFPGLTPGWHYLDTAATAQKPQAVIDATLAAMGRDYATVHRGVYA
RSADMTLAYEAARRRIAAFIGAKDDQIAFVRGATEAINLVAYSHPKKGRVLLSTLEHHSNIVPWQLAGWQVDVCPLTADG
CIDLDAAEKLLTRGHNMVAFAHVSNVLGSPLDVARAAELAHKVGAELLIDGCQAVPRLPVDVAALGCDYYVFSGHKLYGP
TGIGVLWSDKLDALPPWQGGGSMIDRVTFERTTYAPAPTRFEAGTPAIVEALGLAAAVDYVETIGIDAIHAHECALVTSL
RDQLARRNSITLYGPENSAGIVSFSMAGVHPHDIGTILDESGVAIRAGHHCAQPLMDHLGVPATARASFGLYSNDDDVAA
LIDGLARVERIFG

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=210, Percent_Identity=29.5238095238095, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=44.3069306930693, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1789175, Length=387, Percent_Identity=41.8604651162791, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI48994898, Length=168, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=396, Percent_Identity=25, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI193211090, Length=338, Percent_Identity=26.3313609467456, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319831, Length=227, Percent_Identity=26.8722466960352, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI20129463, Length=226, Percent_Identity=32.3008849557522, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 43917; Mature: 43786

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLPSPFASSEVGMPIGNARLQGVSTSLDTNGIRDQFPGLTPGWHYLDTAATAQKPQAV
CCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHCCCCHHH
IDATLAAMGRDYATVHRGVYARSADMTLAYEAARRRIAAFIGAKDDQIAFVRGATEAINL
HHHHHHHHCCCHHHHHHCCEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCHHHEEE
VAYSHPKKGRVLLSTLEHHSNIVPWQLAGWQVDVCPLTADGCIDLDAAEKLLTRGHNMVA
EEECCCCCCHHHHHHHHHCCCCCCEEECCEEEEEEEECCCCCCCHHHHHHHHHCCCCEEE
FAHVSNVLGSPLDVARAAELAHKVGAELLIDGCQAVPRLPVDVAALGCDYYVFSGHKLYG
EEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEECCCEEEC
PTGIGVLWSDKLDALPPWQGGGSMIDRVTFERTTYAPAPTRFEAGTPAIVEALGLAAAVD
CCCCEEEECCCCCCCCCCCCCCHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YVETIGIDAIHAHECALVTSLRDQLARRNSITLYGPENSAGIVSFSMAGVHPHDIGTILD
HHHHHCCCEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCHHHHHHHHC
ESGVAIRAGHHCAQPLMDHLGVPATARASFGLYSNDDDVAALIDGLARVERIFG
CCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNLPSPFASSEVGMPIGNARLQGVSTSLDTNGIRDQFPGLTPGWHYLDTAATAQKPQAV
CCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHCCCCHHH
IDATLAAMGRDYATVHRGVYARSADMTLAYEAARRRIAAFIGAKDDQIAFVRGATEAINL
HHHHHHHHCCCHHHHHHCCEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCHHHEEE
VAYSHPKKGRVLLSTLEHHSNIVPWQLAGWQVDVCPLTADGCIDLDAAEKLLTRGHNMVA
EEECCCCCCHHHHHHHHHCCCCCCEEECCEEEEEEEECCCCCCCHHHHHHHHHCCCCEEE
FAHVSNVLGSPLDVARAAELAHKVGAELLIDGCQAVPRLPVDVAALGCDYYVFSGHKLYG
EEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEECCCEEEC
PTGIGVLWSDKLDALPPWQGGGSMIDRVTFERTTYAPAPTRFEAGTPAIVEALGLAAAVD
CCCCEEEECCCCCCCCCCCCCCHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YVETIGIDAIHAHECALVTSLRDQLARRNSITLYGPENSAGIVSFSMAGVHPHDIGTILD
HHHHHCCCEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCHHHHHHHHC
ESGVAIRAGHHCAQPLMDHLGVPATARASFGLYSNDDDVAALIDGLARVERIFG
CCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA