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The map label for this gene is hisZ [H]

Identifier: 103486108

GI number: 103486108

Start: 625673

End: 626785

Strand: Reverse

Name: hisZ [H]

Synonym: Sala_0615

Alternate gene names: 103486108

Gene position: 626785-625673 (Counterclockwise)

Preceding gene: 103486109

Following gene: 103486101

Centisome position: 18.74

GC content: 71.52

Gene sequence:

>1113_bases
ATGACCAAGGCCCCTGCCCTGCTGCCCGAAGGCCTCCGCGACCGCCTCCCCCGACAGGCCGAGGCCGCGTCGCGCGTCAC
CCGCGCGCTGGTCGATGCGATGCGCGCGCATGGCTATGGCCGCGTGTCGCCGCCGCTCGCCGAGTTTCGCGAGACGCTGG
GCAGCGACGACGACCGCTCCGGCCGCGACCTGCTCCGCTTCACCGATCCGGTGTCGCAGCGCACGCTCGCGCTGCGCCCC
GACATCACGCGACAGGTCGGGCGGATCGCGACCTCGCTGCTCGCGGCATCACCGCGGCCGCTGCGCCTTTGCTATGCCGG
ACAAGTCGTGAAGTTGCGCGCCAGCCAGCTTCGACCCGCACGCGAGATGTTACAGGTCGGCGCCGAGCTGATCGGCAGCG
ACAGCGTCGCCGCCGCGCGCGAAATTGTGACCGTCGCGATCGACGCGCTCGAAGCCGCGGGCATCGGTCCCGTCACCATC
GACTTCACCCTGCCCGATGTCGTCGATCTGCTCGCGTTCGGACCGCTTCCGGTCACGGCCGACCTCCAGCAGCTCCGCGA
CGAACTCGATGCGAAGGACGCGGGCGCACTCGCGCGGATCGGCGCTGGCGCCTATCTGCCGCTGCTGCGCGCCACCGGCC
CGTTCGACCGGGCGATCACCGACCTGCGCGCTTTCGACACCAGCGGCGTCCTCGGCGGACGCATCGACGCGCTGGAAGCC
ATCGCGGCGCCGATCCGCGACCGCGTCACGCTGACGCTCGATCCGACCGAGCGCCACGGCTTCGCCTATCAAAGCTGGTT
CGGCTTCCAGATCTTCGTGCCCGGACAGGGCGACGCGGTCGGCCGCGGCGGCGCCTATGCGATCCCCGTCGGCGAGGCTG
AGGAGGCTGCGGTCGGCTTTTCGCTCTATCCCGATCCGCTGATCGACGCCGGGCTGGGCGCCGAAGATATGGCCGAGCGC
CGCATTTTCCTGCCGCTCGGTCACGATGCAGCGGTCGCGGCGAGCCTGCGCGCCGACGGCTGGCGTACCGTCGCTGCGCT
CACCGACGCCGACGACGCAACGCGGCTCGGCTGCGCCTATGTGCTGGGGGCCGACGGTCCTGTCGAGGCCTGA

Upstream 100 bases:

>100_bases
ACTGCGACTAGGCGGCAAGCCACCAAGTCTCGTTGCCTCTCCCGACGGGAGAGGATTAGCGATGCTTCCAATTGAGACTC
ACAGCCACTAAGGCCACCCC

Downstream 100 bases:

>100_bases
AAGTCCGAAAGCCCGAAACGCGGGATCCCCTGATTGCCTCCCGGCGGATCGAGCACGGTCAGGTCGAGATCGACCGGTTC
GCCGATCCATTGCGCCAGGC

Product: tRNA synthetase, class II (G, H, P and S)

Products: ATP; 5-phospho-alpha-D-ribose 1-diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MTKAPALLPEGLRDRLPRQAEAASRVTRALVDAMRAHGYGRVSPPLAEFRETLGSDDDRSGRDLLRFTDPVSQRTLALRP
DITRQVGRIATSLLAASPRPLRLCYAGQVVKLRASQLRPAREMLQVGAELIGSDSVAAAREIVTVAIDALEAAGIGPVTI
DFTLPDVVDLLAFGPLPVTADLQQLRDELDAKDAGALARIGAGAYLPLLRATGPFDRAITDLRAFDTSGVLGGRIDALEA
IAAPIRDRVTLTLDPTERHGFAYQSWFGFQIFVPGQGDAVGRGGAYAIPVGEAEEAAVGFSLYPDPLIDAGLGAEDMAER
RIFLPLGHDAAVAASLRADGWRTVAALTDADDATRLGCAYVLGADGPVEA

Sequences:

>Translated_370_residues
MTKAPALLPEGLRDRLPRQAEAASRVTRALVDAMRAHGYGRVSPPLAEFRETLGSDDDRSGRDLLRFTDPVSQRTLALRP
DITRQVGRIATSLLAASPRPLRLCYAGQVVKLRASQLRPAREMLQVGAELIGSDSVAAAREIVTVAIDALEAAGIGPVTI
DFTLPDVVDLLAFGPLPVTADLQQLRDELDAKDAGALARIGAGAYLPLLRATGPFDRAITDLRAFDTSGVLGGRIDALEA
IAAPIRDRVTLTLDPTERHGFAYQSWFGFQIFVPGQGDAVGRGGAYAIPVGEAEEAAVGFSLYPDPLIDAGLGAEDMAER
RIFLPLGHDAAVAASLRADGWRTVAALTDADDATRLGCAYVLGADGPVEA
>Mature_369_residues
TKAPALLPEGLRDRLPRQAEAASRVTRALVDAMRAHGYGRVSPPLAEFRETLGSDDDRSGRDLLRFTDPVSQRTLALRPD
ITRQVGRIATSLLAASPRPLRLCYAGQVVKLRASQLRPAREMLQVGAELIGSDSVAAAREIVTVAIDALEAAGIGPVTID
FTLPDVVDLLAFGPLPVTADLQQLRDELDAKDAGALARIGAGAYLPLLRATGPFDRAITDLRAFDTSGVLGGRIDALEAI
AAPIRDRVTLTLDPTERHGFAYQSWFGFQIFVPGQGDAVGRGGAYAIPVGEAEEAAVGFSLYPDPLIDAGLGAEDMAERR
IFLPLGHDAAVAASLRADGWRTVAALTDADDATRLGCAYVLGADGPVEA

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: 2.4.2.17

Molecular weight: Translated: 39137; Mature: 39006

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKAPALLPEGLRDRLPRQAEAASRVTRALVDAMRAHGYGRVSPPLAEFRETLGSDDDRS
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
GRDLLRFTDPVSQRTLALRPDITRQVGRIATSLLAASPRPLRLCYAGQVVKLRASQLRPA
CCHHHHHCCCHHHCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEHHHHHCCHH
REMLQVGAELIGSDSVAAAREIVTVAIDALEAAGIGPVTIDFTLPDVVDLLAFGPLPVTA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCCCCCH
DLQQLRDELDAKDAGALARIGAGAYLPLLRATGPFDRAITDLRAFDTSGVLGGRIDALEA
HHHHHHHHHCCCCCCHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHH
IAAPIRDRVTLTLDPTERHGFAYQSWFGFQIFVPGQGDAVGRGGAYAIPVGEAEEAAVGF
HHHCCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCCCCCCCCEEEEECCCCHHHEECC
SLYPDPLIDAGLGAEDMAERRIFLPLGHDAAVAASLRADGWRTVAALTDADDATRLGCAY
CCCCCHHHHCCCCHHHHHCCEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCHHCCEEE
VLGADGPVEA
EECCCCCCCC
>Mature Secondary Structure 
TKAPALLPEGLRDRLPRQAEAASRVTRALVDAMRAHGYGRVSPPLAEFRETLGSDDDRS
CCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
GRDLLRFTDPVSQRTLALRPDITRQVGRIATSLLAASPRPLRLCYAGQVVKLRASQLRPA
CCHHHHHCCCHHHCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEHHHHHCCHH
REMLQVGAELIGSDSVAAAREIVTVAIDALEAAGIGPVTIDFTLPDVVDLLAFGPLPVTA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCCCCCH
DLQQLRDELDAKDAGALARIGAGAYLPLLRATGPFDRAITDLRAFDTSGVLGGRIDALEA
HHHHHHHHHCCCCCCHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHH
IAAPIRDRVTLTLDPTERHGFAYQSWFGFQIFVPGQGDAVGRGGAYAIPVGEAEEAAVGF
HHHCCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCCCCCCCCEEEEECCCCHHHEECC
SLYPDPLIDAGLGAEDMAERRIFLPLGHDAAVAASLRADGWRTVAALTDADDATRLGCAY
CCCCCHHHHCCCCHHHHHCCEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCHHCCEEE
VLGADGPVEA
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 1-(5-phospho-D-ribosyl)-ATP; diphosphate

Specific reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA