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The map label for this gene is nhaA

Identifier: 103486093

GI number: 103486093

Start: 608902

End: 610176

Strand: Reverse

Name: nhaA

Synonym: Sala_0600

Alternate gene names: 103486093

Gene position: 610176-608902 (Counterclockwise)

Preceding gene: 103486099

Following gene: 103486092

Centisome position: 18.24

GC content: 64.78

Gene sequence:

>1275_bases
ATGGCCCGCAGTTTTCCGCCCCCTTCCGCCTTACGCGATTTCCTCGAAAGCGAGAGCGCAGGCGGGATCCTGCTTATTTT
CGCAGCCATTTTGGCAATGATTGTTGCCAATTCACCGCTGGCGACGCTGTATCACGACCTGATCCATGCCGTGACGGGAC
CGGTTCTGACCGACAAGCTCGGCCCGATGACGGTGCATCTTTGGATCAACGACGGGCTGATGGCGGTGTTTTTCCTGCTC
GTCGGGCTGGAGATCAAGCGCGAGTTCGTCGATGGACGGCTGGCGAGCTGGGATCGCCGACGCCTGCCCTTCATCGCCGC
CGCCGCCGGCATGGCGGTGCCCGCCGCGCTTTATATGTTTTTCGTCGGCGACGAGCCCGGTCTGGCGCAGGGCTGGGCGA
TTCCCGCAGCGACCGACATCGCCTTTGCGATGGGCGTGCTCGCGCTGCTCGGCAGGCGCGCGCCGACCTCGCTCAAGCTA
TTCCTCGTCACTGTCGCGATCGTCGATGACATGGGCGCGGTCGCGATCATCGCGCTTTTCTATACCGCCAAGATCAACCT
GCTCGCGCTCGGCGCCGCGGCGGCGATCCTTGGCATCATGTTCGCGTGCAACCGTGGCGGCGTGAAGAACCTGCTCGTCT
ATATGGCGCTCTTCCTGCTGCTCTGGTATGCGATGCTGCTGTCGGGCGTCCATGCGACGATCGCCGGCGTGCTCGCAGCA
ATGGCCATCCCTTTCGAGCGCACGCCGGGCGCGCCCGACAGTCAGACCTCGCCGCTGCACCGGCTCGAACATGCGCTGCA
CCCGACGGTTGCCTTTGCCATCGTGCCGCTGTTCGGCTTCGCCAATGCGGGCGTCGATGTGCGTGCGCTGGGGCTCGACC
AGCTCTTTGCGCCCCTGCCGCTCGGCATCGCCGCGGGATTGTTCCTCGGCAAGCAGATCGGCATTTTCGGCAGCGTCTGG
CTGGCGGTCAAACTCGGCATCGCGGGGAGACTGCGCGGCGCGACCTGGCTCCAGGTCTATGCCGTCTCCATGCTGTGCGG
GATCGGTTTCACGATGAGCCTGTTCATCGGCAGCCTCGCCTTTCCCGGCAACGCGCTGCTGATCGAGGAGGCGAAGATCG
GTATCCTGATGGGATCGCTCGCATCGGCGCTCGTCGGCTTTGCCGTGCTGCGCCTCGCCCCGCTCCATCCCGAACATAAT
GCCGTCGAATCGGCATCGAAAGGCGAAATTGCCGTCGACGGCGACGTGCGCGACACGTCCGAAGCGGCCCGCTAG

Upstream 100 bases:

>100_bases
CTAGGCAAGAGTGCTAATCAAGCGCCTCCGTTTGTAAAGCAGCGCATGCGCCGTTAAGCAATTGTCACAATAGTTGACGA
ACGAAGGAAATAGTCGACCC

Downstream 100 bases:

>100_bases
GCAAGCGATATGACAAAACTGCTCCCGCTTTCGCTGGTCGCGGCCACGATACTCGCCGGATGTGCCGCCGGTCCCGCCAA
AGCGCCTTCGGGCGAGCCGG

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MARSFPPPSALRDFLESESAGGILLIFAAILAMIVANSPLATLYHDLIHAVTGPVLTDKLGPMTVHLWINDGLMAVFFLL
VGLEIKREFVDGRLASWDRRRLPFIAAAAGMAVPAALYMFFVGDEPGLAQGWAIPAATDIAFAMGVLALLGRRAPTSLKL
FLVTVAIVDDMGAVAIIALFYTAKINLLALGAAAAILGIMFACNRGGVKNLLVYMALFLLLWYAMLLSGVHATIAGVLAA
MAIPFERTPGAPDSQTSPLHRLEHALHPTVAFAIVPLFGFANAGVDVRALGLDQLFAPLPLGIAAGLFLGKQIGIFGSVW
LAVKLGIAGRLRGATWLQVYAVSMLCGIGFTMSLFIGSLAFPGNALLIEEAKIGILMGSLASALVGFAVLRLAPLHPEHN
AVESASKGEIAVDGDVRDTSEAAR

Sequences:

>Translated_424_residues
MARSFPPPSALRDFLESESAGGILLIFAAILAMIVANSPLATLYHDLIHAVTGPVLTDKLGPMTVHLWINDGLMAVFFLL
VGLEIKREFVDGRLASWDRRRLPFIAAAAGMAVPAALYMFFVGDEPGLAQGWAIPAATDIAFAMGVLALLGRRAPTSLKL
FLVTVAIVDDMGAVAIIALFYTAKINLLALGAAAAILGIMFACNRGGVKNLLVYMALFLLLWYAMLLSGVHATIAGVLAA
MAIPFERTPGAPDSQTSPLHRLEHALHPTVAFAIVPLFGFANAGVDVRALGLDQLFAPLPLGIAAGLFLGKQIGIFGSVW
LAVKLGIAGRLRGATWLQVYAVSMLCGIGFTMSLFIGSLAFPGNALLIEEAKIGILMGSLASALVGFAVLRLAPLHPEHN
AVESASKGEIAVDGDVRDTSEAAR
>Mature_423_residues
ARSFPPPSALRDFLESESAGGILLIFAAILAMIVANSPLATLYHDLIHAVTGPVLTDKLGPMTVHLWINDGLMAVFFLLV
GLEIKREFVDGRLASWDRRRLPFIAAAAGMAVPAALYMFFVGDEPGLAQGWAIPAATDIAFAMGVLALLGRRAPTSLKLF
LVTVAIVDDMGAVAIIALFYTAKINLLALGAAAAILGIMFACNRGGVKNLLVYMALFLLLWYAMLLSGVHATIAGVLAAM
AIPFERTPGAPDSQTSPLHRLEHALHPTVAFAIVPLFGFANAGVDVRALGLDQLFAPLPLGIAAGLFLGKQIGIFGSVWL
AVKLGIAGRLRGATWLQVYAVSMLCGIGFTMSLFIGSLAFPGNALLIEEAKIGILMGSLASALVGFAVLRLAPLHPEHNA
VESASKGEIAVDGDVRDTSEAAR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=388, Percent_Identity=51.0309278350515, Blast_Score=312, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_SPHAL (Q1GVK1)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_615654.1
- ProteinModelPortal:   Q1GVK1
- SMR:   Q1GVK1
- GeneID:   4080628
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_0600
- NMPDR:   fig|317655.9.peg.556
- HOGENOM:   HBG665619
- OMA:   LTWTHIT
- ProtClustDB:   CLSK753820
- BioCyc:   SALA317655:SALA_0600-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 44574; Mature: 44442

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf878f20)-; HASH(0x111114c8)-; HASH(0x111111b0)-; HASH(0x11161748)-; HASH(0x11117ae4)-; HASH(0x1115f208)-; HASH(0x11117a54)-; HASH(0x1115ef20)-; HASH(0x1115ef38)-; HASH(0x111673bc)-; HASH(0x11111210)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSFPPPSALRDFLESESAGGILLIFAAILAMIVANSPLATLYHDLIHAVTGPVLTDKL
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHCCC
GPMTVHLWINDGLMAVFFLLVGLEIKREFVDGRLASWDRRRLPFIAAAAGMAVPAALYMF
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHH
FVGDEPGLAQGWAIPAATDIAFAMGVLALLGRRAPTSLKLFLVTVAIVDDMGAVAIIALF
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
YTAKINLLALGAAAAILGIMFACNRGGVKNLLVYMALFLLLWYAMLLSGVHATIAGVLAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAIPFERTPGAPDSQTSPLHRLEHALHPTVAFAIVPLFGFANAGVDVRALGLDQLFAPLP
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHCCC
LGIAAGLFLGKQIGIFGSVWLAVKLGIAGRLRGATWLQVYAVSMLCGIGFTMSLFIGSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPGNALLIEEAKIGILMGSLASALVGFAVLRLAPLHPEHNAVESASKGEIAVDGDVRDTS
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEECCCCCCCH
EAAR
HHCH
>Mature Secondary Structure 
ARSFPPPSALRDFLESESAGGILLIFAAILAMIVANSPLATLYHDLIHAVTGPVLTDKL
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHCCC
GPMTVHLWINDGLMAVFFLLVGLEIKREFVDGRLASWDRRRLPFIAAAAGMAVPAALYMF
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHH
FVGDEPGLAQGWAIPAATDIAFAMGVLALLGRRAPTSLKLFLVTVAIVDDMGAVAIIALF
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
YTAKINLLALGAAAAILGIMFACNRGGVKNLLVYMALFLLLWYAMLLSGVHATIAGVLAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAIPFERTPGAPDSQTSPLHRLEHALHPTVAFAIVPLFGFANAGVDVRALGLDQLFAPLP
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHCCC
LGIAAGLFLGKQIGIFGSVWLAVKLGIAGRLRGATWLQVYAVSMLCGIGFTMSLFIGSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPGNALLIEEAKIGILMGSLASALVGFAVLRLAPLHPEHNAVESASKGEIAVDGDVRDTS
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEECCCCCCCH
EAAR
HHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA