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The map label for this gene is zitB [H]

Identifier: 103485790

GI number: 103485790

Start: 294188

End: 295087

Strand: Reverse

Name: zitB [H]

Synonym: Sala_0295

Alternate gene names: 103485790

Gene position: 295087-294188 (Counterclockwise)

Preceding gene: 103485791

Following gene: 103485789

Centisome position: 8.82

GC content: 68.0

Gene sequence:

>900_bases
ATGTCGGACACCGCTCCCGCCCGGCATCGCCATGATTTTCTGGCCGCCGCGCACGACGACAATGCGCGGCGGACCCGATG
GGTCGTCGCGCTCACCGCCGCAATGATGGTCGGCGAGATCGCCGCGGGTTACTGGACCGGGTCGATGGCGCTGCTCGCCG
ATGGCTTTCACATGGCGACTCATGCCGGCGCGCTCGGACTCGCGGCGCTCGCCTATCGCTATGCGAGGAAACACCGGAAC
GATCCGCGTTTCAGCTTCGGCACGGGCAAGATCGGCGATCTTGCCGGTTTCGCCTCGGCGCTGATCCTCGGCGTCTTTGC
GATCGGTATCGCGGTCGAATCGACGCTGCGGCTGATCGATCCGGTGCGCGTGGATTTTGCGAGTGCAACGCTCGTCGCAG
TGCTGGGACTCGCGGTCAATATCGTCAGCGCGCTGCTGCTGATGGGCGGGCATCACGACCATCATCTTCACGACCATGGG
CACGACCACGCCCATGGCCATGACAATAATCTGCGGTCGGCCTATTTCCACGTCCTCGCCGATGCGCTGACCTCGCTGCT
CGCGATCGTTGCGCTGCTCGCCGGGCGCTATCTGGGGCTTGGCTGGATGGATCCCGCAATGGGCATCGTCGGGGCGATCG
TCATCGCGCGCTGGGCGTGGAGCCTGATGCGCGACACCGCGGCGATCCTGCTTGACACCCACGATGCGCCGGCCGCAGCG
GCGATCCGCGCGCGCGTCGAGGCGGCGGGCGCCGAAATCACCGACCTTCACGTCTGGCGCGTCGGCCCCGGCGCGCGCGC
CGCGATCGTCGAGGTCGCGGGGTCCGCTTGCTCCGCCGCGCTGCGCGAGCAGCTGGAGGGTGCGCCCGCCATCGCGCATC
TGACGATCGGGGTGCGTTGA

Upstream 100 bases:

>100_bases
GGATCATGTCGCGCTGCCGGGGCTCAGCGATGCGGAGCGCGCGACCGGGGCAGAGGATCTGCTCGCGGTGATCCGCCGCT
ACGCGAAATAGGGCGCCGCC

Downstream 100 bases:

>100_bases
TCCCGCCGCCTTATTGGCGGTCCGATACAATCGTCTTGCACCGACAGGCGATAGACGGGCATCGACGTTGCAAGGGCAGC
GGCGTCAAAGGGGGCAGCGA

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSDTAPARHRHDFLAAAHDDNARRTRWVVALTAAMMVGEIAAGYWTGSMALLADGFHMATHAGALGLAALAYRYARKHRN
DPRFSFGTGKIGDLAGFASALILGVFAIGIAVESTLRLIDPVRVDFASATLVAVLGLAVNIVSALLLMGGHHDHHLHDHG
HDHAHGHDNNLRSAYFHVLADALTSLLAIVALLAGRYLGLGWMDPAMGIVGAIVIARWAWSLMRDTAAILLDTHDAPAAA
AIRARVEAAGAEITDLHVWRVGPGARAAIVEVAGSACSAALREQLEGAPAIAHLTIGVR

Sequences:

>Translated_299_residues
MSDTAPARHRHDFLAAAHDDNARRTRWVVALTAAMMVGEIAAGYWTGSMALLADGFHMATHAGALGLAALAYRYARKHRN
DPRFSFGTGKIGDLAGFASALILGVFAIGIAVESTLRLIDPVRVDFASATLVAVLGLAVNIVSALLLMGGHHDHHLHDHG
HDHAHGHDNNLRSAYFHVLADALTSLLAIVALLAGRYLGLGWMDPAMGIVGAIVIARWAWSLMRDTAAILLDTHDAPAAA
AIRARVEAAGAEITDLHVWRVGPGARAAIVEVAGSACSAALREQLEGAPAIAHLTIGVR
>Mature_298_residues
SDTAPARHRHDFLAAAHDDNARRTRWVVALTAAMMVGEIAAGYWTGSMALLADGFHMATHAGALGLAALAYRYARKHRND
PRFSFGTGKIGDLAGFASALILGVFAIGIAVESTLRLIDPVRVDFASATLVAVLGLAVNIVSALLLMGGHHDHHLHDHGH
DHAHGHDNNLRSAYFHVLADALTSLLAIVALLAGRYLGLGWMDPAMGIVGAIVIARWAWSLMRDTAAILLDTHDAPAAAA
IRARVEAAGAEITDLHVWRVGPGARAAIVEVAGSACSAALREQLEGAPAIAHLTIGVR

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=343, Percent_Identity=25.0728862973761, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI222080086, Length=271, Percent_Identity=27.3062730627306, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI40255009, Length=271, Percent_Identity=27.3062730627306, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI21359890, Length=273, Percent_Identity=24.9084249084249, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1786966, Length=277, Percent_Identity=32.8519855595668, Blast_Score=91, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI32564488, Length=258, Percent_Identity=29.4573643410853, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17555796, Length=293, Percent_Identity=26.2798634812287, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17555794, Length=302, Percent_Identity=25.8278145695364, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI193210990, Length=303, Percent_Identity=26.7326732673267, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320411, Length=206, Percent_Identity=28.1553398058252, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323899, Length=145, Percent_Identity=30.3448275862069, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24656728, Length=284, Percent_Identity=28.169014084507, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24656724, Length=284, Percent_Identity=28.169014084507, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24656720, Length=284, Percent_Identity=28.169014084507, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24656715, Length=284, Percent_Identity=28.169014084507, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21357035, Length=284, Percent_Identity=28.169014084507, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24645863, Length=266, Percent_Identity=27.0676691729323, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 31491; Mature: 31359

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTAPARHRHDFLAAAHDDNARRTRWVVALTAAMMVGEIAAGYWTGSMALLADGFHMAT
CCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHH
HAGALGLAALAYRYARKHRNDPRFSFGTGKIGDLAGFASALILGVFAIGIAVESTLRLID
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVRVDFASATLVAVLGLAVNIVSALLLMGGHHDHHLHDHGHDHAHGHDNNLRSAYFHVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
DALTSLLAIVALLAGRYLGLGWMDPAMGIVGAIVIARWAWSLMRDTAAILLDTHDAPAAA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCHHH
AIRARVEAAGAEITDLHVWRVGPGARAAIVEVAGSACSAALREQLEGAPAIAHLTIGVR
HHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
SDTAPARHRHDFLAAAHDDNARRTRWVVALTAAMMVGEIAAGYWTGSMALLADGFHMAT
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHH
HAGALGLAALAYRYARKHRNDPRFSFGTGKIGDLAGFASALILGVFAIGIAVESTLRLID
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVRVDFASATLVAVLGLAVNIVSALLLMGGHHDHHLHDHGHDHAHGHDNNLRSAYFHVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
DALTSLLAIVALLAGRYLGLGWMDPAMGIVGAIVIARWAWSLMRDTAAILLDTHDAPAAA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCHHH
AIRARVEAAGAEITDLHVWRVGPGARAAIVEVAGSACSAALREQLEGAPAIAHLTIGVR
HHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]