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The map label for this gene is cysG [H]

Identifier: 103485700

GI number: 103485700

Start: 218984

End: 219766

Strand: Direct

Name: cysG [H]

Synonym: Sala_0204

Alternate gene names: 103485700

Gene position: 218984-219766 (Clockwise)

Preceding gene: 103485699

Following gene: 103485702

Centisome position: 6.55

GC content: 75.1

Gene sequence:

>783_bases
ATGCACCAACTCCCCATCTTCCTGAACCTGACCGGCCGCACCGTCGTGCTGGTCGGCGAAGGGGAGGCGGCGGAGGCCAA
GGCGCGCCTCATCCAGCGCGCGGGCGGGCGCATCATCTCCGCGTGGGAGGCAGGCGCGACCATCGCCTTCGTCGCGCTGG
GCGACGAGGCCGCGGCGCGCGCCGCCGCCGACGCGCTCCGCGCCCACGGCCTGCTCGTCAATGTCGTCGACCGTCCCGAT
CTCTGCGATTTCACCACCCCGGCGATTGTCGACCGCGCCCCCGTCACCATCGCCATCGGCACCGGCGGCGCGTCGGCGGG
GCTCGCCAAAGCGATCCGCCAGCGCCTCGAGGCGCTGCTCCCCGCGCGGCTTGGCGACCTTGCCGGGGCGCTCTACGCCG
CGCGCGCCGCGATGAAGGCGCGCTGGCCTGTCGCCGCCGACCGCCGCCGTGCGATCGACGCCGCCCTCGCGCCCGGCGGC
GCGCTCGATCCGCTCGACGCCGGCGCGGCGGACCGAGTGGGCGAATGGCTCGCTGCCGCAGCGCCGGATCGGCCATCGCG
TCTCGAAACCATTCGCCTGACGAGCGCCGACCCGGACGAGCTCACGCTGCGCGCCGCGCGTCTGCTCGGCGAGGCCGATC
ATGTCTTTCACCCGCCGCACATCCCCGCCGCGATCCTGGCCCGCACCCGCGCCGACGCGGCGCGCCACATCGCCGCCGCA
CCGCCGCGGGAATCGCCGCCCGGCCTGTCGTTATGGCTGGAGATGCAGGTCATCGCGCTCTAG

Upstream 100 bases:

>100_bases
GGCAGGGGAGGGCAGGCGCTGCGTTTGACTGCCCCGTGCCCCTCCACCACTTCGCTGGTCCCCCTCCCCGTTCCGGGGAG
GATCTGTTAGGGCCTCCACC

Downstream 100 bases:

>100_bases
GCTGTATCGGCATTCAGCCCGGGGTAAGGGCTCCCGGGCCTTTCCGGCCTCGCGACACGAACGGAAAGATGGGGCGGCTC
GCGGGTCGTCGTCACCCCTC

Product: siroheme synthase-like protein

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MHQLPIFLNLTGRTVVLVGEGEAAEAKARLIQRAGGRIISAWEAGATIAFVALGDEAAARAAADALRAHGLLVNVVDRPD
LCDFTTPAIVDRAPVTIAIGTGGASAGLAKAIRQRLEALLPARLGDLAGALYAARAAMKARWPVAADRRRAIDAALAPGG
ALDPLDAGAADRVGEWLAAAAPDRPSRLETIRLTSADPDELTLRAARLLGEADHVFHPPHIPAAILARTRADAARHIAAA
PPRESPPGLSLWLEMQVIAL

Sequences:

>Translated_260_residues
MHQLPIFLNLTGRTVVLVGEGEAAEAKARLIQRAGGRIISAWEAGATIAFVALGDEAAARAAADALRAHGLLVNVVDRPD
LCDFTTPAIVDRAPVTIAIGTGGASAGLAKAIRQRLEALLPARLGDLAGALYAARAAMKARWPVAADRRRAIDAALAPGG
ALDPLDAGAADRVGEWLAAAAPDRPSRLETIRLTSADPDELTLRAARLLGEADHVFHPPHIPAAILARTRADAARHIAAA
PPRESPPGLSLWLEMQVIAL
>Mature_260_residues
MHQLPIFLNLTGRTVVLVGEGEAAEAKARLIQRAGGRIISAWEAGATIAFVALGDEAAARAAADALRAHGLLVNVVDRPD
LCDFTTPAIVDRAPVTIAIGTGGASAGLAKAIRQRLEALLPARLGDLAGALYAARAAMKARWPVAADRRRAIDAALAPGG
ALDPLDAGAADRVGEWLAAAAPDRPSRLETIRLTSADPDELTLRAARLLGEADHVFHPPHIPAAILARTRADAARHIAAA
PPRESPPGLSLWLEMQVIAL

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=265, Percent_Identity=29.4339622641509, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 27064; Mature: 27064

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQLPIFLNLTGRTVVLVGEGEAAEAKARLIQRAGGRIISAWEAGATIAFVALGDEAAAR
CCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCHHHHH
AAADALRAHGLLVNVVDRPDLCDFTTPAIVDRAPVTIAIGTGGASAGLAKAIRQRLEALL
HHHHHHHHCCEEEEECCCCCCCCCCCCHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
PARLGDLAGALYAARAAMKARWPVAADRRRAIDAALAPGGALDPLDAGAADRVGEWLAAA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
APDRPSRLETIRLTSADPDELTLRAARLLGEADHVFHPPHIPAAILARTRADAARHIAAA
CCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PPRESPPGLSLWLEMQVIAL
CCCCCCCCCEEEEEEEEEEC
>Mature Secondary Structure
MHQLPIFLNLTGRTVVLVGEGEAAEAKARLIQRAGGRIISAWEAGATIAFVALGDEAAAR
CCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCHHHHH
AAADALRAHGLLVNVVDRPDLCDFTTPAIVDRAPVTIAIGTGGASAGLAKAIRQRLEALL
HHHHHHHHCCEEEEECCCCCCCCCCCCHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
PARLGDLAGALYAARAAMKARWPVAADRRRAIDAALAPGGALDPLDAGAADRVGEWLAAA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
APDRPSRLETIRLTSADPDELTLRAARLLGEADHVFHPPHIPAAILARTRADAARHIAAA
CCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PPRESPPGLSLWLEMQVIAL
CCCCCCCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]