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The map label for this gene is lysA [H]

Identifier: 103485699

GI number: 103485699

Start: 217574

End: 218833

Strand: Direct

Name: lysA [H]

Synonym: Sala_0203

Alternate gene names: 103485699

Gene position: 217574-218833 (Clockwise)

Preceding gene: 103485698

Following gene: 103485700

Centisome position: 6.5

GC content: 66.83

Gene sequence:

>1260_bases
ATGGATCATTTTGAATATCGTGACGGCGTCCTCCACGCCGAAGACATCCCGCTGCCGCGTATTGCCAAGGAAATCGGCAC
CCCCGTCTATGTCTATTCGCGCGCGACGCTCGAACGCCACGCGCAGGTGTTCGCCGACGCGCTCAGGGATATTCCCAGGA
AGCACATCGCCTTTGCGATCAAGTGCAACCCCAACCTTGGCGTGCTGCGCGTCCTCGCGCGGCAGGGCTATGGCGCCGAC
GTCGTGTCGGGCGGCGAACTCGAACGCGCGCTCGCCGCGGGCATGGCGGCGGAGGACATCGTTTTTTCTGGGGTCGGCAA
GACGCGCGCCGAGCTGGCGCAGGGGCTCGACCGCGGCATCGGCCAGTTCAACATCGAGCATGAACCCGAGGGCGTCGCGC
TGTCCGAAATCGCGGTGGCGAAGGAAATGACCGCGCGCGCGGTGCTGCGCGTCAATCCCGACGTCGATGCCGGCACCCAC
GCCAAGATTTCGACCGGCAAGGCCGAAAACAAGTTCGGCGTCGGCATCGATTCGGCGCCCGCGATCTTCGACCGGCTCTC
GGCGTTGCCGGGGCTCAAGATGCGCGGCGTCGCGCTCCATATCGGCAGCCAGCTCACCAGCCTCGATCCGTTGGAGGCCG
CGTTCGAGCGCGTCGGCCGCCTCGTCGCCGACCTGCGCGCTGCGGGGCACAGCATCACCCACGTCGACCTCGGCGGCGGC
CTTGGTGTCCCCTATCGGCCGGAGGACAATCCCCCGACTCCGGCCGAATATGGCGCGATGGTCGCACGCGTGACAAAGGA
TTGGGACGTCACCCTGATGTTCGAGCCCGGCCGCGTCATTGCGGGCAACACCGGCGTGCTCCTGACCGAAGTGCTGTGGG
TCAAGCCCGGCGCGACCCACCCCTTCGTCATCGTCGACGCCGCGATGAACGACCTTGCGCGCCCCGCGCTCTACGATGCC
TGGCATGATTTTGTCGCGGTGAAGCCGACGGGTGAAAAAATGATCGCGTCGATCGTCGGCCCGGTGTGCGAAACGGGCGA
CACCTTCGCGCGCGACCGCGAAATCGACGCGGTTCAGCCGGGCGCCCTCGCGGTGTTCCGTACCGCGGGCGCTTATGGTG
CGACCATGGCCTCGACCTACAACAGCCGCAGCCTCGTGCCCGAGGTGCTCGTCGATGGTGATCGCTACATCACCGTCGCC
GACCGCATCGCCGCGGGCACGATCATGGCGGCGGAGCGCGTCCCCGACTGGATCGATTGA

Upstream 100 bases:

>100_bases
ATCGGTGTAGCTCCGTTCCCAGGGGCATCTCGATCTTTCGACCGGCTCAAGACAGGCTTCGCTCGATGCGAACGGGAACA
TAGGACCAGGATTTCCTTCG

Downstream 100 bases:

>100_bases
ATCGGTCCTCCCCCGCAGGGGGAGGGGGACCACCCGAAGGGTGGTGGAGGGGCAGGGGAGGGCAGGCGCTGCGTTTGACT
GCCCCGTGCCCCTCCACCAC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MDHFEYRDGVLHAEDIPLPRIAKEIGTPVYVYSRATLERHAQVFADALRDIPRKHIAFAIKCNPNLGVLRVLARQGYGAD
VVSGGELERALAAGMAAEDIVFSGVGKTRAELAQGLDRGIGQFNIEHEPEGVALSEIAVAKEMTARAVLRVNPDVDAGTH
AKISTGKAENKFGVGIDSAPAIFDRLSALPGLKMRGVALHIGSQLTSLDPLEAAFERVGRLVADLRAAGHSITHVDLGGG
LGVPYRPEDNPPTPAEYGAMVARVTKDWDVTLMFEPGRVIAGNTGVLLTEVLWVKPGATHPFVIVDAAMNDLARPALYDA
WHDFVAVKPTGEKMIASIVGPVCETGDTFARDREIDAVQPGALAVFRTAGAYGATMASTYNSRSLVPEVLVDGDRYITVA
DRIAAGTIMAAERVPDWID

Sequences:

>Translated_419_residues
MDHFEYRDGVLHAEDIPLPRIAKEIGTPVYVYSRATLERHAQVFADALRDIPRKHIAFAIKCNPNLGVLRVLARQGYGAD
VVSGGELERALAAGMAAEDIVFSGVGKTRAELAQGLDRGIGQFNIEHEPEGVALSEIAVAKEMTARAVLRVNPDVDAGTH
AKISTGKAENKFGVGIDSAPAIFDRLSALPGLKMRGVALHIGSQLTSLDPLEAAFERVGRLVADLRAAGHSITHVDLGGG
LGVPYRPEDNPPTPAEYGAMVARVTKDWDVTLMFEPGRVIAGNTGVLLTEVLWVKPGATHPFVIVDAAMNDLARPALYDA
WHDFVAVKPTGEKMIASIVGPVCETGDTFARDREIDAVQPGALAVFRTAGAYGATMASTYNSRSLVPEVLVDGDRYITVA
DRIAAGTIMAAERVPDWID
>Mature_419_residues
MDHFEYRDGVLHAEDIPLPRIAKEIGTPVYVYSRATLERHAQVFADALRDIPRKHIAFAIKCNPNLGVLRVLARQGYGAD
VVSGGELERALAAGMAAEDIVFSGVGKTRAELAQGLDRGIGQFNIEHEPEGVALSEIAVAKEMTARAVLRVNPDVDAGTH
AKISTGKAENKFGVGIDSAPAIFDRLSALPGLKMRGVALHIGSQLTSLDPLEAAFERVGRLVADLRAAGHSITHVDLGGG
LGVPYRPEDNPPTPAEYGAMVARVTKDWDVTLMFEPGRVIAGNTGVLLTEVLWVKPGATHPFVIVDAAMNDLARPALYDA
WHDFVAVKPTGEKMIASIVGPVCETGDTFARDREIDAVQPGALAVFRTAGAYGATMASTYNSRSLVPEVLVDGDRYITVA
DRIAAGTIMAAERVPDWID

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=365, Percent_Identity=24.3835616438356, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789203, Length=399, Percent_Identity=34.3358395989975, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17562780, Length=388, Percent_Identity=22.680412371134, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322664, Length=369, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24586472, Length=390, Percent_Identity=23.5897435897436, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44772; Mature: 44772

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFEYRDGVLHAEDIPLPRIAKEIGTPVYVYSRATLERHAQVFADALRDIPRKHIAFAI
CCCCCCCCCCEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEE
KCNPNLGVLRVLARQGYGADVVSGGELERALAAGMAAEDIVFSGVGKTRAELAQGLDRGI
EECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHEECCCHHHHHHHHHHHHCC
GQFNIEHEPEGVALSEIAVAKEMTARAVLRVNPDVDAGTHAKISTGKAENKFGVGIDSAP
CCEECCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCHH
AIFDRLSALPGLKMRGVALHIGSQLTSLDPLEAAFERVGRLVADLRAAGHSITHVDLGGG
HHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LGVPYRPEDNPPTPAEYGAMVARVTKDWDVTLMFEPGRVIAGNTGVLLTEVLWVKPGATH
CCCCCCCCCCCCCCHHHHHHHHEEECCCEEEEEECCCEEEECCCCEEEEEEEEECCCCCC
PFVIVDAAMNDLARPALYDAWHDFVAVKPTGEKMIASIVGPVCETGDTFARDREIDAVQP
CEEEEECHHHHHHCHHHHHHHHCEEEECCCHHHHHHHHHHHHHCCCCCHHCCCCCCCCCC
GALAVFRTAGAYGATMASTYNSRSLVPEVLVDGDRYITVADRIAAGTIMAAERVPDWID
CCEEEEECCCCCCHHHHHCCCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDHFEYRDGVLHAEDIPLPRIAKEIGTPVYVYSRATLERHAQVFADALRDIPRKHIAFAI
CCCCCCCCCCEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEE
KCNPNLGVLRVLARQGYGADVVSGGELERALAAGMAAEDIVFSGVGKTRAELAQGLDRGI
EECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHEECCCHHHHHHHHHHHHCC
GQFNIEHEPEGVALSEIAVAKEMTARAVLRVNPDVDAGTHAKISTGKAENKFGVGIDSAP
CCEECCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCHH
AIFDRLSALPGLKMRGVALHIGSQLTSLDPLEAAFERVGRLVADLRAAGHSITHVDLGGG
HHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LGVPYRPEDNPPTPAEYGAMVARVTKDWDVTLMFEPGRVIAGNTGVLLTEVLWVKPGATH
CCCCCCCCCCCCCCHHHHHHHHEEECCCEEEEEECCCEEEECCCCEEEEEEEEECCCCCC
PFVIVDAAMNDLARPALYDAWHDFVAVKPTGEKMIASIVGPVCETGDTFARDREIDAVQP
CEEEEECHHHHHHCHHHHHHHHCEEEECCCHHHHHHHHHHHHHCCCCCHHCCCCCCCCCC
GALAVFRTAGAYGATMASTYNSRSLVPEVLVDGDRYITVADRIAAGTIMAAERVPDWID
CCEEEEECCCCCCHHHHHCCCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA