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The map label for this gene is edd [H]

Identifier: 103485687

GI number: 103485687

Start: 202109

End: 204100

Strand: Direct

Name: edd [H]

Synonym: Sala_0191

Alternate gene names: 103485687

Gene position: 202109-204100 (Clockwise)

Preceding gene: 103485686

Following gene: 103485688

Centisome position: 6.04

GC content: 67.92

Gene sequence:

>1992_bases
TTGGCGCGCAGCGCCTGGGCGCAGTTGGATGAGGGTCGCTGCCGTCGCTTTCGCCGCTGCCGTTCACACCCTCACCCAGC
TTCGACTAGCGAGCAAGCTCGCAAGTCTGCGCATCCCTCTCCCCCAAGGGGGGAGGATTTTGGAATTGTCATGACCCCCC
TCCATCCCACCATCGCCGCCGTCACCGACCGCATCATCGCCCGCAGCGCCCCGCGCCGCGCCGCATATCTCGACCTGATG
GACCGTCAGCGCGACGCCGGCACCAACCGCGGCAATCTGTCGTGCGGCAATCTCGCCCACGGCTTCGCCGCCGCGGGCGA
TGACAAGCCCGTCATCCGCACCGGCGCCGCGATGAATATCGGCATCGTCACCGCCTATAACGACATGCTTTCGGCGCATC
AGCCCTATGGCCGCTATCCCGAACAGATCAAACTCTTCGCGCGCGAGGTCGGCGTGACGGCGCAGGTCGCGGGCGGCGTG
CCGGCGATGTGCGACGGGGTGACGCAGGGGCAGGCGGGCATGGACCTGTCGCTGTTCAGCCGCGACAATATCGCGCAGGG
CACCGTCATCGCCCTCAGCCATGCGATGTTCGAGGGCGCGCTCCTGCTCGGCATCTGCGACAAGATCGTCCCCGGCCTGC
TCATCGGCGCGCTGCGGTTCGGCCATCTGCCGCAGATCCTTGTTCCCGCCGGGCCGATGCCGTCGGGGCTCGCGAACAAG
GAAAAGCAGCGCGTGCGCCAGCTTTATGCAGAGGGCAAGGCGACCCGTGACGAACTGCTGGAGGCCGAGGCGGCGAGCTA
TCATGGCGCGGGCACCTGCACCTTCTATGGCACCGCCAACTCGAACCAGATGATGATGGAGCTGATGGGGCTGCACATCC
CCGGCAGCGCCTTCACCAATCCGGGAACGAAGCTGCGGCAGGCGCTGACGCGCGCCGCGACGCACCGGATTGCGCAGATC
GGCTGGGACGGCGACGATTATCGCCCGCTTGGCCGCTGCATCGACGAAAAGGCGATCGTCAACGCCGCGATCGGCCTGCT
CGCGACGGGCGGCTCGACGAACCATGCGATCCATCTGCCCGCGATCGCCCGCGCCGCAGGGATCATCATCGACTGGCAGG
ATTTCGACGAGCTCAGCCACGCGGTGCCGCTGCTCGCGCGCGTCTATCCGAACGGCGCGGGCGACGTGAACCAGTTTCAC
GCCGCGGGCGGCATCGGCTTCGTCGTGCGCGAGCTGCTGGGTGCGGGATTGCTGCACGGCGATGTGCTCACCGTTGGCGG
GACGATGGCGGACTATGCCGCCGAACCCGTGCTGGTGAATGACGAACTTCACTGGCAAGCCGCCCCCGGCCAGAGCCGCG
ACGACACTATGCTGCGCCCCGTCGCCGATCCTTTCTCGCCCGATGGGGGGATGCGCCTGCTGACCGGCAATCTCGGCCGC
GCGATCATCAAGACGAGCGCGGTCGCCGAAGATCGCTGGACGATCGAGGCGCCGGCCCGGATCTTCGACGACCAGAATCA
GGTTCTCGCGGCCTTCAAGGCAGGCGAGCTTGATCGCGACGTTGTCGTCGTCGTCCGCTTTCAGGGGCCGCGTGCGAACG
GCATGCCCGAACTCCACAAGCTGACCCCGGCGCTCGGCGTGCTTCAGGACAAGGGCTACCGCGTCGCGCTGCTGACCGAT
GGCCGCATGTCGGGCGCCAGCGGCAAGGTTCCCGCCGTCATTCATCTGTCGCCCGAAGCCTTGCCCGGCCCTGACGGGAT
GAGTGGCCCGCTCGCCTATCTCCGGGACGGCGACATGGTGCGTGTCTGCGCGGTGAGGGGCGAAGTCGCCGCGCTGGTTG
ACGAAACCGAATGGGCTGCGCGAAGTCCCGCTGCCGCGCCGCCCCCCGCGGTGGGTGTCGGCCGCGAGCTGTTCGCGCTG
TTCCGCCATCACGCCGACGAGGCGGAGAAGGGCGGATCGGCGGTGCTCGCGGCGATGGAGGCTGTGACTTAA

Upstream 100 bases:

>100_bases
GCCGAGTTCGGCGATCGCGCTGATCGAGCGCGACGGGGCGAGCTGGCATGATTGAGCGCACCCCAAACCTTCTCCCCTTG
GGGGAGAAGGATACGAAGCC

Downstream 100 bases:

>100_bases
TCCGTCGCCCCCGCGAAGGCGGGGGCCGCTACCGGCCTTGGGCCACCTTGCCACCGGCCCCCGCCTTCGCGGGGGCGACG
AACGAAATTGGAGTGAACAT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:

>663_residues
MARSAWAQLDEGRCRRFRRCRSHPHPASTSEQARKSAHPSPPRGEDFGIVMTPLHPTIAAVTDRIIARSAPRRAAYLDLM
DRQRDAGTNRGNLSCGNLAHGFAAAGDDKPVIRTGAAMNIGIVTAYNDMLSAHQPYGRYPEQIKLFAREVGVTAQVAGGV
PAMCDGVTQGQAGMDLSLFSRDNIAQGTVIALSHAMFEGALLLGICDKIVPGLLIGALRFGHLPQILVPAGPMPSGLANK
EKQRVRQLYAEGKATRDELLEAEAASYHGAGTCTFYGTANSNQMMMELMGLHIPGSAFTNPGTKLRQALTRAATHRIAQI
GWDGDDYRPLGRCIDEKAIVNAAIGLLATGGSTNHAIHLPAIARAAGIIIDWQDFDELSHAVPLLARVYPNGAGDVNQFH
AAGGIGFVVRELLGAGLLHGDVLTVGGTMADYAAEPVLVNDELHWQAAPGQSRDDTMLRPVADPFSPDGGMRLLTGNLGR
AIIKTSAVAEDRWTIEAPARIFDDQNQVLAAFKAGELDRDVVVVVRFQGPRANGMPELHKLTPALGVLQDKGYRVALLTD
GRMSGASGKVPAVIHLSPEALPGPDGMSGPLAYLRDGDMVRVCAVRGEVAALVDETEWAARSPAAAPPPAVGVGRELFAL
FRHHADEAEKGGSAVLAAMEAVT

Sequences:

>Translated_663_residues
MARSAWAQLDEGRCRRFRRCRSHPHPASTSEQARKSAHPSPPRGEDFGIVMTPLHPTIAAVTDRIIARSAPRRAAYLDLM
DRQRDAGTNRGNLSCGNLAHGFAAAGDDKPVIRTGAAMNIGIVTAYNDMLSAHQPYGRYPEQIKLFAREVGVTAQVAGGV
PAMCDGVTQGQAGMDLSLFSRDNIAQGTVIALSHAMFEGALLLGICDKIVPGLLIGALRFGHLPQILVPAGPMPSGLANK
EKQRVRQLYAEGKATRDELLEAEAASYHGAGTCTFYGTANSNQMMMELMGLHIPGSAFTNPGTKLRQALTRAATHRIAQI
GWDGDDYRPLGRCIDEKAIVNAAIGLLATGGSTNHAIHLPAIARAAGIIIDWQDFDELSHAVPLLARVYPNGAGDVNQFH
AAGGIGFVVRELLGAGLLHGDVLTVGGTMADYAAEPVLVNDELHWQAAPGQSRDDTMLRPVADPFSPDGGMRLLTGNLGR
AIIKTSAVAEDRWTIEAPARIFDDQNQVLAAFKAGELDRDVVVVVRFQGPRANGMPELHKLTPALGVLQDKGYRVALLTD
GRMSGASGKVPAVIHLSPEALPGPDGMSGPLAYLRDGDMVRVCAVRGEVAALVDETEWAARSPAAAPPPAVGVGRELFAL
FRHHADEAEKGGSAVLAAMEAVT
>Mature_662_residues
ARSAWAQLDEGRCRRFRRCRSHPHPASTSEQARKSAHPSPPRGEDFGIVMTPLHPTIAAVTDRIIARSAPRRAAYLDLMD
RQRDAGTNRGNLSCGNLAHGFAAAGDDKPVIRTGAAMNIGIVTAYNDMLSAHQPYGRYPEQIKLFAREVGVTAQVAGGVP
AMCDGVTQGQAGMDLSLFSRDNIAQGTVIALSHAMFEGALLLGICDKIVPGLLIGALRFGHLPQILVPAGPMPSGLANKE
KQRVRQLYAEGKATRDELLEAEAASYHGAGTCTFYGTANSNQMMMELMGLHIPGSAFTNPGTKLRQALTRAATHRIAQIG
WDGDDYRPLGRCIDEKAIVNAAIGLLATGGSTNHAIHLPAIARAAGIIIDWQDFDELSHAVPLLARVYPNGAGDVNQFHA
AGGIGFVVRELLGAGLLHGDVLTVGGTMADYAAEPVLVNDELHWQAAPGQSRDDTMLRPVADPFSPDGGMRLLTGNLGRA
IIKTSAVAEDRWTIEAPARIFDDQNQVLAAFKAGELDRDVVVVVRFQGPRANGMPELHKLTPALGVLQDKGYRVALLTDG
RMSGASGKVPAVIHLSPEALPGPDGMSGPLAYLRDGDMVRVCAVRGEVAALVDETEWAARSPAAAPPPAVGVGRELFALF
RHHADEAEKGGSAVLAAMEAVT

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=606, Percent_Identity=56.1056105610561, Blast_Score=678, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=528, Percent_Identity=30.3030303030303, Blast_Score=177, Evalue=3e-45,
Organism=Escherichia coli, GI1786464, Length=504, Percent_Identity=31.3492063492063, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI2367371, Length=490, Percent_Identity=29.5918367346939, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322476, Length=486, Percent_Identity=30.2469135802469, Blast_Score=171, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 70327; Mature: 70196

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSAWAQLDEGRCRRFRRCRSHPHPASTSEQARKSAHPSPPRGEDFGIVMTPLHPTIAA
CCCCHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCEEECCCCHHHHH
VTDRIIARSAPRRAAYLDLMDRQRDAGTNRGNLSCGNLAHGFAAAGDDKPVIRTGAAMNI
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCCCEEEECCEEEE
GIVTAYNDMLSAHQPYGRYPEQIKLFAREVGVTAQVAGGVPAMCDGVTQGQAGMDLSLFS
EEEEEEHHHHHCCCCCCCCHHHHHHHHHHHCCEEEECCCCCHHHCCCCCCCCCCEEEEEC
RDNIAQGTVIALSHAMFEGALLLGICDKIVPGLLIGALRFGHLPQILVPAGPMPSGLANK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHH
EKQRVRQLYAEGKATRDELLEAEAASYHGAGTCTFYGTANSNQMMMELMGLHIPGSAFTN
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCC
PGTKLRQALTRAATHRIAQIGWDGDDYRPLGRCIDEKAIVNAAIGLLATGGSTNHAIHLP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEECC
AIARAAGIIIDWQDFDELSHAVPLLARVYPNGAGDVNQFHAAGGIGFVVRELLGAGLLHG
HHHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCC
DVLTVGGTMADYAAEPVLVNDELHWQAAPGQSRDDTMLRPVADPFSPDGGMRLLTGNLGR
CEEEECCCHHHHCCCCEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCH
AIIKTSAVAEDRWTIEAPARIFDDQNQVLAAFKAGELDRDVVVVVRFQGPRANGMPELHK
HHHHHHHHCCCCEEEECCHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCHHHH
LTPALGVLQDKGYRVALLTDGRMSGASGKVPAVIHLSPEALPGPDGMSGPLAYLRDGDMV
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCEE
RVCAVRGEVAALVDETEWAARSPAAAPPPAVGVGRELFALFRHHADEAEKGGSAVLAAME
EEEEECCCHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
AVT
HCC
>Mature Secondary Structure 
ARSAWAQLDEGRCRRFRRCRSHPHPASTSEQARKSAHPSPPRGEDFGIVMTPLHPTIAA
CCCHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCEEECCCCHHHHH
VTDRIIARSAPRRAAYLDLMDRQRDAGTNRGNLSCGNLAHGFAAAGDDKPVIRTGAAMNI
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCCCEEEECCEEEE
GIVTAYNDMLSAHQPYGRYPEQIKLFAREVGVTAQVAGGVPAMCDGVTQGQAGMDLSLFS
EEEEEEHHHHHCCCCCCCCHHHHHHHHHHHCCEEEECCCCCHHHCCCCCCCCCCEEEEEC
RDNIAQGTVIALSHAMFEGALLLGICDKIVPGLLIGALRFGHLPQILVPAGPMPSGLANK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHH
EKQRVRQLYAEGKATRDELLEAEAASYHGAGTCTFYGTANSNQMMMELMGLHIPGSAFTN
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCC
PGTKLRQALTRAATHRIAQIGWDGDDYRPLGRCIDEKAIVNAAIGLLATGGSTNHAIHLP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEECC
AIARAAGIIIDWQDFDELSHAVPLLARVYPNGAGDVNQFHAAGGIGFVVRELLGAGLLHG
HHHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCC
DVLTVGGTMADYAAEPVLVNDELHWQAAPGQSRDDTMLRPVADPFSPDGGMRLLTGNLGR
CEEEECCCHHHHCCCCEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCH
AIIKTSAVAEDRWTIEAPARIFDDQNQVLAAFKAGELDRDVVVVVRFQGPRANGMPELHK
HHHHHHHHCCCCEEEECCHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCHHHH
LTPALGVLQDKGYRVALLTDGRMSGASGKVPAVIHLSPEALPGPDGMSGPLAYLRDGDMV
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCEE
RVCAVRGEVAALVDETEWAARSPAAAPPPAVGVGRELFALFRHHADEAEKGGSAVLAAME
EEEEECCCHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
AVT
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]