Click here to switch to the map view.

The map label for this gene is msrA2 [H]

Identifier: 103485669

GI number: 103485669

Start: 177591

End: 178280

Strand: Direct

Name: msrA2 [H]

Synonym: Sala_0173

Alternate gene names: 103485669

Gene position: 177591-178280 (Clockwise)

Preceding gene: 103485668

Following gene: 103485670

Centisome position: 5.31

GC content: 68.7

Gene sequence:

>690_bases
ATGATGGCGCGGCGCGGCGGCCCCGCTCTGCGCGCGCTTGCAGCGCTCGCCCCGGCGGTGCTCCTCGCGCAATGCGCGCC
GGCGCAGGCCGAAAATGTCGTCAAGCTCCCCGCCGCGCTTACCGACCCGGCGGTGCCCGCGAAGCGGGCGACCGCCGTGC
TCGCGGGCGGTTGCTTCTGGGGCGTCGAGGGCGTTTTTTCGCATGTGAAAGGCGTGATCTCGGTCGAATCGGGCTATCAT
GGCGGCAGCGCGGCGACCGCGCGCTACGAGCTGACGCATGACGGCACGTCGGGTCATGCCGAGGCGGTGCGTATCGTCTA
TGATCCCACGCAGGTCAGTTACGGCACCTTGCTGCGCATCCTGTTTTCGGTGGTCGCCGACCCGACGCTCAAGGACCGGC
AGGGCCCCGACGTCGGATCGCAATATCGCGCCGCGATCGTTCCGCTCGACGCGACGCAACGCCAGGTCGCGACCGCCTAT
CTGGCGCAGATCGGGCGCGGCGGATATTTCGCCAGGCCACTTGTCGTGCCGATCGAGCGTTACAAACGCTTTTACCCTGC
CGAGCCGACCCATCAGGACTTCATGCGCCGCAACCCGCGCAACCCCTATATCGTCCGCTGGGATGCCCCCAAGCTGGCGG
CGCTGAAGCGGCTGTTCCCCGACAGGCTGCGCGCGACGCCCGCGCCTTGA

Upstream 100 bases:

>100_bases
TCTCCATGCTCCGTTCCGACTGGTTTTTGACCATGCTTGCCGGCTTTGCGATCGGCGCGACCTATATCGTGCTCAGCCAG
CCGGCGCTGCCCATCCCCGC

Downstream 100 bases:

>100_bases
CGCGGCGGGCCGACTGGTTCCACAATTGGTCGCGGCGAAAGAATCGTTCGTCGCAAATCGCTGGTCCGGCGTAGACGGCT
GCGCGACCAACGGAGCAACC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MMARRGGPALRALAALAPAVLLAQCAPAQAENVVKLPAALTDPAVPAKRATAVLAGGCFWGVEGVFSHVKGVISVESGYH
GGSAATARYELTHDGTSGHAEAVRIVYDPTQVSYGTLLRILFSVVADPTLKDRQGPDVGSQYRAAIVPLDATQRQVATAY
LAQIGRGGYFARPLVVPIERYKRFYPAEPTHQDFMRRNPRNPYIVRWDAPKLAALKRLFPDRLRATPAP

Sequences:

>Translated_229_residues
MMARRGGPALRALAALAPAVLLAQCAPAQAENVVKLPAALTDPAVPAKRATAVLAGGCFWGVEGVFSHVKGVISVESGYH
GGSAATARYELTHDGTSGHAEAVRIVYDPTQVSYGTLLRILFSVVADPTLKDRQGPDVGSQYRAAIVPLDATQRQVATAY
LAQIGRGGYFARPLVVPIERYKRFYPAEPTHQDFMRRNPRNPYIVRWDAPKLAALKRLFPDRLRATPAP
>Mature_229_residues
MMARRGGPALRALAALAPAVLLAQCAPAQAENVVKLPAALTDPAVPAKRATAVLAGGCFWGVEGVFSHVKGVISVESGYH
GGSAATARYELTHDGTSGHAEAVRIVYDPTQVSYGTLLRILFSVVADPTLKDRQGPDVGSQYRAAIVPLDATQRQVATAY
LAQIGRGGYFARPLVVPIERYKRFYPAEPTHQDFMRRNPRNPYIVRWDAPKLAALKRLFPDRLRATPAP

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=37.1069182389937, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=37.1069182389937, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=37.962962962963, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1790665, Length=158, Percent_Identity=41.7721518987342, Blast_Score=113, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=29.8780487804878, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664627, Length=155, Percent_Identity=31.6129032258064, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664631, Length=155, Percent_Identity=30.9677419354839, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24712; Mature: 24712

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMARRGGPALRALAALAPAVLLAQCAPAQAENVVKLPAALTDPAVPAKRATAVLAGGCFW
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHCCCCCCHHHHHHHHCCHHHH
GVEGVFSHVKGVISVESGYHGGSAATARYELTHDGTSGHAEAVRIVYDPTQVSYGTLLRI
HHHHHHHHHHHEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHH
LFSVVADPTLKDRQGPDVGSQYRAAIVPLDATQRQVATAYLAQIGRGGYFARPLVVPIER
HHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEEEHHH
YKRFYPAEPTHQDFMRRNPRNPYIVRWDAPKLAALKRLFPDRLRATPAP
HHHCCCCCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHCHHHHCCCCCC
>Mature Secondary Structure
MMARRGGPALRALAALAPAVLLAQCAPAQAENVVKLPAALTDPAVPAKRATAVLAGGCFW
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHCCCCCCHHHHHHHHCCHHHH
GVEGVFSHVKGVISVESGYHGGSAATARYELTHDGTSGHAEAVRIVYDPTQVSYGTLLRI
HHHHHHHHHHHEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHH
LFSVVADPTLKDRQGPDVGSQYRAAIVPLDATQRQVATAYLAQIGRGGYFARPLVVPIER
HHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEEEHHH
YKRFYPAEPTHQDFMRRNPRNPYIVRWDAPKLAALKRLFPDRLRATPAP
HHHCCCCCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]