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The map label for this gene is lpd [H]

Identifier: 103485617

GI number: 103485617

Start: 117462

End: 118886

Strand: Reverse

Name: lpd [H]

Synonym: Sala_0121

Alternate gene names: 103485617

Gene position: 118886-117462 (Counterclockwise)

Preceding gene: 103485618

Following gene: 103485604

Centisome position: 3.55

GC content: 64.84

Gene sequence:

>1425_bases
ATGACCGATTTCGACTATGACGTGGCGATAATCGGCGCGGGCACCGCTGGAATGTCGGCGTACCGGGAAGCGCTCAAATA
TAGCGATCGCGTCGTCATGATCGATGGCGGCCCCTTGGGGACCACATGCGCCCGCGTTGGCTGCATGCCCTCCAAATTGC
TGATCGCTGCGGCAGAGGCGCGCCACCGTGCCGAAAGCGTCGGCCTGTTCGGACTTCGCGCCGGACCCGTCGAGGTCGAT
GGTGTGCAGGTCATGAACCGCGTCCGCGCCGAGCGCGACCACTTTGTTAGCTTCGCCACCGAGGCGATTGCGGGGTTTGC
ACCCGGAGGCCTGCTTCGCGAGCAGGCGCGTTTTGTCGATGACAATCGGCTCGAACTTGCGAGCGGCAAGCAGATCAGCG
CGCGCAGCATCGTGATCGCAACGGGCTCGCGGCCGGTCGTACCCGCAGGCCTGGAACCGGCGGGCGATCGGCTGATTTTC
AACGACCAACTGTTCGACTGGACCGATCTGCCGTCCTCGGTTGCAGTCTTCGGCACCGGCGCGATCGGGTTGGAGCTCGG
GCAGGCTTTGCATCGCCTCGGTGTCCGCACCCATATCTATGGGCGCGGCGGCAGCGTCGGCCCGCTCACCGATCCCGACG
TCGCGGCTTATGCGGCGGCACAGTTCTCGAGCGAAATTCCTATCGACTGGATGGCAGCCGATGCAAGCGTCGCGCGCGAC
GGGGACGCTGTGATCGTCCGGTCAGCGGGGGGCGAGGAGCGGTTCGATTATCTCCTCGCGGCCGCAGGCCGACGGGCCAA
TGTCGACAATCTCGGACTGGAAAACACCTCGCTCACGCTCGATGCCCATGGCGTCCCCACTTATGATCACCTGTCGATGC
GCGCCAGTTACAGCGACATCTTCATCGCGGGCGACTCGGCGGTCGATCTCTCGCTCCTTCACGAGGCCGCGGACGAAGGC
CGGGTGGCAGGCGAAAATGCCGCGCGCTATCCGCACAGCTATCGCCGCGCGCGCCGGACCCCGTTGACGATCGTCTTCAC
CGATCCCCAGATCGCCATCGCCGGGCGCAGCCATGCCGACCTTCTTCGCGACCGGATGGATTTCGCCATCGGCGAAGTGT
CGTTCGAAGACCAGGGACGGGCTCGCATATTGGGGCTCAACCGGGGATTGCTGCGCGTCTATGGCGATCGGCCGAGCGGG
TTGCTGCTTGGCGCCGAAATCTTCGGTCCAGCGGCGGAACATCTCGCTCATCTCCTCGCCTGGTCGATCGAGAGCCGGCT
CACCGTCGCCGAATTGCTCGAACGACCCTTCTATCATCCTGTCATTGAGGAAGGGCTGCGCACCGCGCTTCGCCACCTCA
ACCACCATCTCGGGTTCGGACCGAATCCGCCGCTGCGCTGCATCGACTGTGGTCCGGGAGGCTAG

Upstream 100 bases:

>100_bases
CTATTCCCGCAGGGCATAGAAACCATGCCCACGGGCCAACTGTTTTTGCGCGCTCGATGCGCGCAATATGCGCATCGTGT
AATCAGGAAGGGACAGCGGG

Downstream 100 bases:

>100_bases
GCCAAGCGGTGCCCGCCTTCGGCTCGGATAGAATATCGGCACCTTGCAACGGCGCAAATCCGGCAGAGCCTTTGCCCGAG
CCTGGATCGCGCACGGCCGA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MTDFDYDVAIIGAGTAGMSAYREALKYSDRVVMIDGGPLGTTCARVGCMPSKLLIAAAEARHRAESVGLFGLRAGPVEVD
GVQVMNRVRAERDHFVSFATEAIAGFAPGGLLREQARFVDDNRLELASGKQISARSIVIATGSRPVVPAGLEPAGDRLIF
NDQLFDWTDLPSSVAVFGTGAIGLELGQALHRLGVRTHIYGRGGSVGPLTDPDVAAYAAAQFSSEIPIDWMAADASVARD
GDAVIVRSAGGEERFDYLLAAAGRRANVDNLGLENTSLTLDAHGVPTYDHLSMRASYSDIFIAGDSAVDLSLLHEAADEG
RVAGENAARYPHSYRRARRTPLTIVFTDPQIAIAGRSHADLLRDRMDFAIGEVSFEDQGRARILGLNRGLLRVYGDRPSG
LLLGAEIFGPAAEHLAHLLAWSIESRLTVAELLERPFYHPVIEEGLRTALRHLNHHLGFGPNPPLRCIDCGPGG

Sequences:

>Translated_474_residues
MTDFDYDVAIIGAGTAGMSAYREALKYSDRVVMIDGGPLGTTCARVGCMPSKLLIAAAEARHRAESVGLFGLRAGPVEVD
GVQVMNRVRAERDHFVSFATEAIAGFAPGGLLREQARFVDDNRLELASGKQISARSIVIATGSRPVVPAGLEPAGDRLIF
NDQLFDWTDLPSSVAVFGTGAIGLELGQALHRLGVRTHIYGRGGSVGPLTDPDVAAYAAAQFSSEIPIDWMAADASVARD
GDAVIVRSAGGEERFDYLLAAAGRRANVDNLGLENTSLTLDAHGVPTYDHLSMRASYSDIFIAGDSAVDLSLLHEAADEG
RVAGENAARYPHSYRRARRTPLTIVFTDPQIAIAGRSHADLLRDRMDFAIGEVSFEDQGRARILGLNRGLLRVYGDRPSG
LLLGAEIFGPAAEHLAHLLAWSIESRLTVAELLERPFYHPVIEEGLRTALRHLNHHLGFGPNPPLRCIDCGPGG
>Mature_473_residues
TDFDYDVAIIGAGTAGMSAYREALKYSDRVVMIDGGPLGTTCARVGCMPSKLLIAAAEARHRAESVGLFGLRAGPVEVDG
VQVMNRVRAERDHFVSFATEAIAGFAPGGLLREQARFVDDNRLELASGKQISARSIVIATGSRPVVPAGLEPAGDRLIFN
DQLFDWTDLPSSVAVFGTGAIGLELGQALHRLGVRTHIYGRGGSVGPLTDPDVAAYAAAQFSSEIPIDWMAADASVARDG
DAVIVRSAGGEERFDYLLAAAGRRANVDNLGLENTSLTLDAHGVPTYDHLSMRASYSDIFIAGDSAVDLSLLHEAADEGR
VAGENAARYPHSYRRARRTPLTIVFTDPQIAIAGRSHADLLRDRMDFAIGEVSFEDQGRARILGLNRGLLRVYGDRPSGL
LLGAEIFGPAAEHLAHLLAWSIESRLTVAELLERPFYHPVIEEGLRTALRHLNHHLGFGPNPPLRCIDCGPGG

Specific function: Has chromate reductase activity [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=474, Percent_Identity=26.3713080168776, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=21.9088937093275, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=25.7019438444924, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1786307, Length=477, Percent_Identity=25.1572327044025, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789915, Length=339, Percent_Identity=28.3185840707965, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081717, Length=449, Percent_Identity=21.826280623608, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI32565766, Length=468, Percent_Identity=26.0683760683761, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17557007, Length=337, Percent_Identity=25.5192878338279, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71983419, Length=370, Percent_Identity=25.1351351351351, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71983429, Length=370, Percent_Identity=25.1351351351351, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=23.6170212765957, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=22.3175965665236, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325240, Length=478, Percent_Identity=21.7573221757322, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=26.0775862068966, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24640551, Length=501, Percent_Identity=27.5449101796407, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24640553, Length=501, Percent_Identity=27.5449101796407, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24640549, Length=501, Percent_Identity=27.1457085828343, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737741, Length=511, Percent_Identity=26.027397260274, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50779; Mature: 50648

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFDYDVAIIGAGTAGMSAYREALKYSDRVVMIDGGPLGTTCARVGCMPSKLLIAAAEA
CCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHH
RHRAESVGLFGLRAGPVEVDGVQVMNRVRAERDHFVSFATEAIAGFAPGGLLREQARFVD
HHHHHHCCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
DNRLELASGKQISARSIVIATGSRPVVPAGLEPAGDRLIFNDQLFDWTDLPSSVAVFGTG
CCCEEECCCCEEECCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECC
AIGLELGQALHRLGVRTHIYGRGGSVGPLTDPDVAAYAAAQFSSEIPIDWMAADASVARD
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCC
GDAVIVRSAGGEERFDYLLAAAGRRANVDNLGLENTSLTLDAHGVPTYDHLSMRASYSDI
CCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHEEEECCCEE
FIAGDSAVDLSLLHEAADEGRVAGENAARYPHSYRRARRTPLTIVFTDPQIAIAGRSHAD
EEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCEEEEECCCHHH
LLRDRMDFAIGEVSFEDQGRARILGLNRGLLRVYGDRPSGLLLGAEIFGPAAEHLAHLLA
HHHHHHHHHHCCCEECCCCCEEEEECCCCEEEEECCCCCCEEEEHHHHCHHHHHHHHHHH
WSIESRLTVAELLERPFYHPVIEEGLRTALRHLNHHLGFGPNPPLRCIDCGPGG
HHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
>Mature Secondary Structure 
TDFDYDVAIIGAGTAGMSAYREALKYSDRVVMIDGGPLGTTCARVGCMPSKLLIAAAEA
CCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHH
RHRAESVGLFGLRAGPVEVDGVQVMNRVRAERDHFVSFATEAIAGFAPGGLLREQARFVD
HHHHHHCCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
DNRLELASGKQISARSIVIATGSRPVVPAGLEPAGDRLIFNDQLFDWTDLPSSVAVFGTG
CCCEEECCCCEEECCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECC
AIGLELGQALHRLGVRTHIYGRGGSVGPLTDPDVAAYAAAQFSSEIPIDWMAADASVARD
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCC
GDAVIVRSAGGEERFDYLLAAAGRRANVDNLGLENTSLTLDAHGVPTYDHLSMRASYSDI
CCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHEEEECCCEE
FIAGDSAVDLSLLHEAADEGRVAGENAARYPHSYRRARRTPLTIVFTDPQIAIAGRSHAD
EEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCEEEEECCCHHH
LLRDRMDFAIGEVSFEDQGRARILGLNRGLLRVYGDRPSGLLLGAEIFGPAAEHLAHLLA
HHHHHHHHHHCCCEECCCCCEEEEECCCCEEEEECCCCCCEEEEHHHHCHHHHHHHHHHH
WSIESRLTVAELLERPFYHPVIEEGLRTALRHLNHHLGFGPNPPLRCIDCGPGG
HHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA