Click here to switch to the map view.

The map label for this gene is qor [C]

Identifier: 103485604

GI number: 103485604

Start: 105651

End: 106676

Strand: Reverse

Name: qor [C]

Synonym: Sala_0107

Alternate gene names: 103485604

Gene position: 106676-105651 (Counterclockwise)

Preceding gene: 103485617

Following gene: 103485603

Centisome position: 3.19

GC content: 63.65

Gene sequence:

>1026_bases
ATGGAGACATTGATGAAAGCCGTTGGTTACAAGGTCCCGGGACCCATCGCCGAGGATGCTGCGCTGGTCGACATCGAGCT
GCCCCAGCCTGTCGCGGCAGGATATGATATCCTGGTTGAGGTGAAGGCCGTCTCGGTGAACCCGGTCGACTATAAGGTCC
GCGGCAGCTCGCCGCCAGCCGATGGTGAATGGAAGGTGCTGGGGTGGGATGCGTCCGGGATCGTGCGCGAGGTCGGCCCC
GACGTGACGCAGTTCCAGCCGGGCGACGAGGTCTATTATGCCGGATCGATCACCCGGCCCGGCACCAATGTCGAGTTCCA
TCTTGTCGACGCCCGGATCGTCGGTCGCAAACCCGCCTCGCTCGACTGGGCGGAAGCAGCAGCGCTGCCGCTAACGACGT
TGACCGCCTGGGAGGCGATGTTCGATCGCCTCGACGTGGCGAAGCCAGTCCCCGGTGCGGCGCCGGCGATCCTCATCATC
GGTGGCGCGGGTGGGGTCGGGTCGATCGCGATCCAGATCGCGCGCCAGCGCACAGACCTCACCGTCATCACCACCGCCTC
CCGAGCGGAAACCCAGGAGTGGGTGAAGGAGCTTGGCGCGCACCATGTCATCGACCATAGGCGCCCGCTCGCGGCACAGA
TTGCCGAGCTTGGCATCGGCGCTCCCGCGTTCGTCTTTTCGACCACGCATACAGAGCAGCATGCCGCCGACATCGCCGAG
CTGATCGCGCCGCAAGGGCGGTTCGCGCTGATCGACGATCCCACGGCATTCGACATCATGCTGTTCAAGCGCAAGGCGGT
GTCGATACACCATGAGCTGATGTTCACCCGGTCGATCTACGGCACGCCCGATATGCATGAGCAGGGCAAGATCCTCGACG
CGCTGGCCGTGCTGGTCGATGAGGGCAAAATCCGTACGACACTGACCGAGCGACTGTCGCCGATCAATGCTGCCAATCTG
AAGACAGTGCACGCACTGATCGAAAGTGGCGCGGCGAAAGGCAAGACCGTCCTCGAAGGATTCTGA

Upstream 100 bases:

>100_bases
GGTGCACATCTTCATAGTCCTGCGTGCGAAACCCTTGAACCCCGTGCGAATTTTCGAAGAAGTGGCGCTCTGATCGATCG
AGACTTCGGGGCGCAGCAAG

Downstream 100 bases:

>100_bases
TCTTTTCCAGTCCAAGTAACGCCGGACGATAACGCCGCGGCGAAGGAAATCCCATGACCAAGTCCATTGCCACTGCCTCG
ATCAACCGTGAAACCGCAGT

Product: zinc-binding alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
METLMKAVGYKVPGPIAEDAALVDIELPQPVAAGYDILVEVKAVSVNPVDYKVRGSSPPADGEWKVLGWDASGIVREVGP
DVTQFQPGDEVYYAGSITRPGTNVEFHLVDARIVGRKPASLDWAEAAALPLTTLTAWEAMFDRLDVAKPVPGAAPAILII
GGAGGVGSIAIQIARQRTDLTVITTASRAETQEWVKELGAHHVIDHRRPLAAQIAELGIGAPAFVFSTTHTEQHAADIAE
LIAPQGRFALIDDPTAFDIMLFKRKAVSIHHELMFTRSIYGTPDMHEQGKILDALAVLVDEGKIRTTLTERLSPINAANL
KTVHALIESGAAKGKTVLEGF

Sequences:

>Translated_341_residues
METLMKAVGYKVPGPIAEDAALVDIELPQPVAAGYDILVEVKAVSVNPVDYKVRGSSPPADGEWKVLGWDASGIVREVGP
DVTQFQPGDEVYYAGSITRPGTNVEFHLVDARIVGRKPASLDWAEAAALPLTTLTAWEAMFDRLDVAKPVPGAAPAILII
GGAGGVGSIAIQIARQRTDLTVITTASRAETQEWVKELGAHHVIDHRRPLAAQIAELGIGAPAFVFSTTHTEQHAADIAE
LIAPQGRFALIDDPTAFDIMLFKRKAVSIHHELMFTRSIYGTPDMHEQGKILDALAVLVDEGKIRTTLTERLSPINAANL
KTVHALIESGAAKGKTVLEGF
>Mature_341_residues
METLMKAVGYKVPGPIAEDAALVDIELPQPVAAGYDILVEVKAVSVNPVDYKVRGSSPPADGEWKVLGWDASGIVREVGP
DVTQFQPGDEVYYAGSITRPGTNVEFHLVDARIVGRKPASLDWAEAAALPLTTLTAWEAMFDRLDVAKPVPGAAPAILII
GGAGGVGSIAIQIARQRTDLTVITTASRAETQEWVKELGAHHVIDHRRPLAAQIAELGIGAPAFVFSTTHTEQHAADIAE
LIAPQGRFALIDDPTAFDIMLFKRKAVSIHHELMFTRSIYGTPDMHEQGKILDALAVLVDEGKIRTTLTERLSPINAANL
KTVHALIESGAAKGKTVLEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=338, Percent_Identity=31.3609467455621, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI194239674, Length=208, Percent_Identity=29.8076923076923, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI13236495, Length=208, Percent_Identity=29.8076923076923, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI194239676, Length=208, Percent_Identity=29.8076923076923, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71987554, Length=216, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17507255, Length=325, Percent_Identity=27.0769230769231, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36495; Mature: 36495

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLMKAVGYKVPGPIAEDAALVDIELPQPVAAGYDILVEVKAVSVNPVDYKVRGSSPPA
CHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCC
DGEWKVLGWDASGIVREVGPDVTQFQPGDEVYYAGSITRPGTNVEFHLVDARIVGRKPAS
CCCEEEEEECCCCHHHHHCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEEECCCCCC
LDWAEAAALPLTTLTAWEAMFDRLDVAKPVPGAAPAILIIGGAGGVGSIAIQIARQRTDL
CCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCE
TVITTASRAETQEWVKELGAHHVIDHRRPLAAQIAELGIGAPAFVFSTTHTEQHAADIAE
EEEEECCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
LIAPQGRFALIDDPTAFDIMLFKRKAVSIHHELMFTRSIYGTPDMHEQGKILDALAVLVD
HHCCCCCEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
EGKIRTTLTERLSPINAANLKTVHALIESGAAKGKTVLEGF
CCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHCCC
>Mature Secondary Structure
METLMKAVGYKVPGPIAEDAALVDIELPQPVAAGYDILVEVKAVSVNPVDYKVRGSSPPA
CHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCC
DGEWKVLGWDASGIVREVGPDVTQFQPGDEVYYAGSITRPGTNVEFHLVDARIVGRKPAS
CCCEEEEEECCCCHHHHHCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEEECCCCCC
LDWAEAAALPLTTLTAWEAMFDRLDVAKPVPGAAPAILIIGGAGGVGSIAIQIARQRTDL
CCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCE
TVITTASRAETQEWVKELGAHHVIDHRRPLAAQIAELGIGAPAFVFSTTHTEQHAADIAE
EEEEECCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
LIAPQGRFALIDDPTAFDIMLFKRKAVSIHHELMFTRSIYGTPDMHEQGKILDALAVLVD
HHCCCCCEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
EGKIRTTLTERLSPINAANLKTVHALIESGAAKGKTVLEGF
CCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]