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The map label for this gene is pphA [C]

Identifier: 99082862

GI number: 99082862

Start: 3190437

End: 3191171

Strand: Direct

Name: pphA [C]

Synonym: TM1040_3022

Alternate gene names: 99082862

Gene position: 3190437-3191171 (Clockwise)

Preceding gene: 99082861

Following gene: 99082866

Centisome position: 99.67

GC content: 59.46

Gene sequence:

>735_bases
ATGACCAAGCCCATCTACGCTATTGGTGACATCCACGGACAAACCGAACAACTGGAGCGCGCTCTCGAACTGATCGAACG
TGATGGCGGGGCAGAGGCCGAGATCGTCTTTGTAGGCGACTATGTGGATCGTGGTCCTGACAGCCGTGGCGTGATCGACC
GCCTCATGCAAGGGCAGGCCGATGGGCGCAACTGGACGTGCCTAAAGGGCAACCATGACCGTATGTTTTCTTGGTTTCTG
GAAGAATTCCCAAGAGAAGATCCGCATCTCCCCGTGGCGCTTTACTACTTGCAGGAGCGTATCGGGGGCGCTGAAACACT
GGCGTCCTACGGCATCAGCTGCGCGCCAGAGGATCGCACGTCCGTTGTGCATGAAGCGGCACGGGCAGCCGTGCCGCAAC
AGCATCTGAGCTGGATCGACTCGCTGCCGCTGTTCCACCAAACGGGCGCGCAGTTTTTTGTCCACGCCGGCATTCGCCCC
GGTGTTCCCCTGATGGATCAGGCTGAACAGGACATGCTCTGGATTCGCCAAGGTTTCCTGGAGCATACCGAGGCACATCC
ACACCTGATCGTCCACGGCCACACGGCTGAAAAGCACCCGGTCCATTATGGCAATCGTGTCGATATTGATTGTGGAGCGG
GCTATGGGCGCACGCTGGTGCCAGTGGTGTTCGAAGGAGATCGCGCATGGTGTCTGACGCCCGGGGGACGACAGCATCTT
GCGCCGGGCTCGTAA

Upstream 100 bases:

>100_bases
GCCTCACGAGGCAGGCACGCCATTGTGCGATCAGCTGCGCGCACCATTATTTGTAACGAGCCCGCGCGCCCTGACCGAAG
ATAAATGAAAGACGTTTCTT

Downstream 100 bases:

>100_bases
TCGAGGAAGGCCGACAGTTTTGCGGGAAATTTGTTATTCAGGCGCTCGCAAGAGTTGTATAACGGACTGCATGGCTAACG
CTTTGCGGTTTTGCATACCC

Product: bis(5'nucleosyl)-tetraphosphatase, ApaH

Products: A Protein; Orthophosphate. [C]

Alternate protein names: Serine/Threonine Protein Phosphatase; Bis(5Nucleosyl)-Tetraphosphatase ApaH; Serine/Threonine Protein Phosphatase Family Protein; Ser/Thr Protein Phosphatase Family Protein; Serine/Threonine Specific Protein Phosphatase Protein; Serine/Threonine Protein Phosphatase I; Diadenosine Tetraphosphatase; Diadenosine Tetraphosphatase-Like Protein; Phosphatase; Serinethreonine Protein Phosphatase; Phosphoprotein Phosphatase; Serine/Threonine Specific Protein Phosphatase; Calcineurin-Like Phosphoesterase; Bis(5-Nucleosyl)-Tetraphosphatase; Serine/Threonine Protein Phosphatase Protein; Protein Phosphatase; Serine/Threonine-Protein Phosphatase

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTKPIYAIGDIHGQTEQLERALELIERDGGAEAEIVFVGDYVDRGPDSRGVIDRLMQGQADGRNWTCLKGNHDRMFSWFL
EEFPREDPHLPVALYYLQERIGGAETLASYGISCAPEDRTSVVHEAARAAVPQQHLSWIDSLPLFHQTGAQFFVHAGIRP
GVPLMDQAEQDMLWIRQGFLEHTEAHPHLIVHGHTAEKHPVHYGNRVDIDCGAGYGRTLVPVVFEGDRAWCLTPGGRQHL
APGS

Sequences:

>Translated_244_residues
MTKPIYAIGDIHGQTEQLERALELIERDGGAEAEIVFVGDYVDRGPDSRGVIDRLMQGQADGRNWTCLKGNHDRMFSWFL
EEFPREDPHLPVALYYLQERIGGAETLASYGISCAPEDRTSVVHEAARAAVPQQHLSWIDSLPLFHQTGAQFFVHAGIRP
GVPLMDQAEQDMLWIRQGFLEHTEAHPHLIVHGHTAEKHPVHYGNRVDIDCGAGYGRTLVPVVFEGDRAWCLTPGGRQHL
APGS
>Mature_243_residues
TKPIYAIGDIHGQTEQLERALELIERDGGAEAEIVFVGDYVDRGPDSRGVIDRLMQGQADGRNWTCLKGNHDRMFSWFLE
EFPREDPHLPVALYYLQERIGGAETLASYGISCAPEDRTSVVHEAARAAVPQQHLSWIDSLPLFHQTGAQFFVHAGIRPG
VPLMDQAEQDMLWIRQGFLEHTEAHPHLIVHGHTAEKHPVHYGNRVDIDCGAGYGRTLVPVVFEGDRAWCLTPGGRQHLA
PGS

Specific function: Plays A Key Role In Signaling Protein Misfolding Via The Cpxr/Cpxa Transducing System. It Also Modulates The Phosphorylated Status Of Many Phosphoproteins In E. coli, Some Of Which Acting As Major Chaperones. Has Been Shown, In Vitro, To Act On Ser, Thr A

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.3.16 [C]

Molecular weight: Translated: 27216; Mature: 27085

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPIYAIGDIHGQTEQLERALELIERDGGAEAEIVFVGDYVDRGPDSRGVIDRLMQGQA
CCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHHCCCCCHHHHHHHHCCCC
DGRNWTCLKGNHDRMFSWFLEEFPREDPHLPVALYYLQERIGGAETLASYGISCAPEDRT
CCCCEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCHHH
SVVHEAARAAVPQQHLSWIDSLPLFHQTGAQFFVHAGIRPGVPLMDQAEQDMLWIRQGFL
HHHHHHHHHCCCHHHHHHHHCCCHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
EHTEAHPHLIVHGHTAEKHPVHYGNRVDIDCGAGYGRTLVPVVFEGDRAWCLTPGGRQHL
HHCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCC
APGS
CCCC
>Mature Secondary Structure 
TKPIYAIGDIHGQTEQLERALELIERDGGAEAEIVFVGDYVDRGPDSRGVIDRLMQGQA
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHHCCCCCHHHHHHHHCCCC
DGRNWTCLKGNHDRMFSWFLEEFPREDPHLPVALYYLQERIGGAETLASYGISCAPEDRT
CCCCEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCHHH
SVVHEAARAAVPQQHLSWIDSLPLFHQTGAQFFVHAGIRPGVPLMDQAEQDMLWIRQGFL
HHHHHHHHHCCCHHHHHHHHCCCHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
EHTEAHPHLIVHGHTAEKHPVHYGNRVDIDCGAGYGRTLVPVVFEGDRAWCLTPGGRQHL
HHCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCC
APGS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Phosphoprotein; H2O [C]

Specific reaction: A Phosphoprotein + H2O = A Protein + Orthophosphate. [C]

General reaction: Phosphoric ester hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA