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The map label for this gene is phbA [H]

Identifier: 99082866

GI number: 99082866

Start: 3194450

End: 3195625

Strand: Direct

Name: phbA [H]

Synonym: TM1040_3026

Alternate gene names: 99082866

Gene position: 3194450-3195625 (Clockwise)

Preceding gene: 99082862

Following gene: 99082869

Centisome position: 99.8

GC content: 59.86

Gene sequence:

>1176_bases
ATGACAGATATTGTGATTCTGGATGGCGCCCGCACTGCGATCGGAACCTTTGGTGGCGCGCTGGCCCAGACGGCGCCGAT
AGATCTTGGAGCGACGGTCGCCAAAGCTGCGATGGAGCGGTCTGGTGTCGATCCTGCTCAGATCGGCACTGTTGTCTATG
GTCATGTGATCAACACCGAACCACGTGATATGTATCTGTCGCGGGTGGCAGCGATGCAGGCGGGAATTCCAGAAAGCACG
CCTGCGATGAATGTGAACCGCCTCTGCGGGTCCGGCGCGCAAGCCATCGTATCAGGAATCCAAGCCTTGATGCTGGGAGA
TGCTGAATACGCTCTGACCGGCGGAGCAGAAAGCATGTCGCGCAGTCCATTCATCACGCCTTCGACCCGCTGGGGGCAAA
AGATGGGTGACGTGAAATCGCTCGACATGATGCTGGGCGCTCTGAATTGCCCGTTTGGGACTGGCCACATGGGAGTGACG
GCAGAGAATGTCGCAGATGAGCATGAGATCACGCGCGCTCAGATGGATGAGTTCGCGCTGGTTAGCCAGACCCGGGCCGC
TGCCGCCATCGAGGCCGGCTACTTCCAAAGCCAGATCGTGCCGGTTGATGTCAAGGTGAAGCGGGACATGGTTCCGTTCG
AAGTCGATGAGCATCCAAAGGGCACATCGATGGAGGCGCTCTCCGGGCTGCGTCCGGTGTTCAAGAAGGATGGGCGTGTG
ACGGCTGGCAATGCGTCGGGAATCAACGATGGCGCGGCTGCATTGGTGCTCGCCACAGCCGAGGCGGCTGAGAAATCCGG
TCTGAAACCCAAGGCCCGTATCCTCGGATATGCCCATGCAGGCGTTCGTCCGGAGGTCATGGGCGTAGGTCCGATTCCGG
CTGTAGAGCAGCTTCTGAAGCGGATTGATATGACTGTTGGTGACTTTGACCTCATTGAATCCAACGAGGCCTTTGCGGCG
CAGGCTCTGGCCGTCAACAAGGCACTTGGGTTGGACAGTGCCAAGGTAAATCCGAATGGCGGCGCAATTGCCCTGGGCCA
TCCGGTCGGCGCAACCGGCGCCATCATCACTGTCAAAGCGCTCTATGAGCTGGAGCGCACTGGCGGGCGCCGTGCGATCA
TCACCATGTGTATCGGGGGCGGGCAGGGGATCGCCCTCGCGATCGAACGGATCTGA

Upstream 100 bases:

>100_bases
TAGTGGCGCGACCTTCCAAGCCTGTCAATGACGGGACGTTCTGCGCGACAGGTTCATGCTGCAGGTGCATACTGTCGCGA
ACGGACACGAGGAGTGAGAG

Downstream 100 bases:

>100_bases
CCCGAAGGTTCGAGCGAACGTGGAGGGGCTTTGCCCCTTTGCGCGTCCGCGCATTCACCCCAAGATATTTTCAGTTAGAA
GAAGGTACAGACCCGTTCTG

Product: beta-ketothiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTDIVILDGARTAIGTFGGALAQTAPIDLGATVAKAAMERSGVDPAQIGTVVYGHVINTEPRDMYLSRVAAMQAGIPEST
PAMNVNRLCGSGAQAIVSGIQALMLGDAEYALTGGAESMSRSPFITPSTRWGQKMGDVKSLDMMLGALNCPFGTGHMGVT
AENVADEHEITRAQMDEFALVSQTRAAAAIEAGYFQSQIVPVDVKVKRDMVPFEVDEHPKGTSMEALSGLRPVFKKDGRV
TAGNASGINDGAAALVLATAEAAEKSGLKPKARILGYAHAGVRPEVMGVGPIPAVEQLLKRIDMTVGDFDLIESNEAFAA
QALAVNKALGLDSAKVNPNGGAIALGHPVGATGAIITVKALYELERTGGRRAIITMCIGGGQGIALAIERI

Sequences:

>Translated_391_residues
MTDIVILDGARTAIGTFGGALAQTAPIDLGATVAKAAMERSGVDPAQIGTVVYGHVINTEPRDMYLSRVAAMQAGIPEST
PAMNVNRLCGSGAQAIVSGIQALMLGDAEYALTGGAESMSRSPFITPSTRWGQKMGDVKSLDMMLGALNCPFGTGHMGVT
AENVADEHEITRAQMDEFALVSQTRAAAAIEAGYFQSQIVPVDVKVKRDMVPFEVDEHPKGTSMEALSGLRPVFKKDGRV
TAGNASGINDGAAALVLATAEAAEKSGLKPKARILGYAHAGVRPEVMGVGPIPAVEQLLKRIDMTVGDFDLIESNEAFAA
QALAVNKALGLDSAKVNPNGGAIALGHPVGATGAIITVKALYELERTGGRRAIITMCIGGGQGIALAIERI
>Mature_390_residues
TDIVILDGARTAIGTFGGALAQTAPIDLGATVAKAAMERSGVDPAQIGTVVYGHVINTEPRDMYLSRVAAMQAGIPESTP
AMNVNRLCGSGAQAIVSGIQALMLGDAEYALTGGAESMSRSPFITPSTRWGQKMGDVKSLDMMLGALNCPFGTGHMGVTA
ENVADEHEITRAQMDEFALVSQTRAAAAIEAGYFQSQIVPVDVKVKRDMVPFEVDEHPKGTSMEALSGLRPVFKKDGRVT
AGNASGINDGAAALVLATAEAAEKSGLKPKARILGYAHAGVRPEVMGVGPIPAVEQLLKRIDMTVGDFDLIESNEAFAAQ
ALAVNKALGLDSAKVNPNGGAIALGHPVGATGAIITVKALYELERTGGRRAIITMCIGGGQGIALAIERI

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=388, Percent_Identity=45.1030927835052, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=43.9897698209719, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=39.1414141414141, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4557237, Length=399, Percent_Identity=37.34335839599, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=29.5508274231678, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=31.2820512820513, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=48.9949748743719, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=43.3673469387755, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=43.3915211970075, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI48994986, Length=405, Percent_Identity=38.7654320987654, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=31.219512195122, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=44.2159383033419, Blast_Score=346, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=35.6589147286822, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17535921, Length=400, Percent_Identity=36.75, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=30.8235294117647, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=28.498727735369, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=36.1111111111111, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=36.5, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=46.0559796437659, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=46.5473145780051, Blast_Score=337, Evalue=6e-93,
Organism=Drosophila melanogaster, GI24640423, Length=398, Percent_Identity=37.6884422110553, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI17137578, Length=438, Percent_Identity=32.4200913242009, Blast_Score=184, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40465; Mature: 40334

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIVILDGARTAIGTFGGALAQTAPIDLGATVAKAAMERSGVDPAQIGTVVYGHVINTE
CCEEEEECCCCHHHHHHCHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHEEEEEEECCC
PRDMYLSRVAAMQAGIPESTPAMNVNRLCGSGAQAIVSGIQALMLGDAEYALTGGAESMS
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHHC
RSPFITPSTRWGQKMGDVKSLDMMLGALNCPFGTGHMGVTAENVADEHEITRAQMDEFAL
CCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHH
VSQTRAAAAIEAGYFQSQIVPVDVKVKRDMVPFEVDEHPKGTSMEALSGLRPVFKKDGRV
HHHHHHHHHHHHCCHHCEEEEEEEEEECCCCCEECCCCCCCCCHHHHHCCCHHHHCCCCE
TAGNASGINDGAAALVLATAEAAEKSGLKPKARILGYAHAGVRPEVMGVGPIPAVEQLLK
EECCCCCCCCCCEEEEEEEHHHHHHCCCCCHHHEEEEECCCCCCCEEECCCCHHHHHHHH
RIDMTVGDFDLIESNEAFAAQALAVNKALGLDSAKVNPNGGAIALGHPVGATGAIITVKA
HHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEECCCCCEEEECCCCCCCCCEEEHHH
LYELERTGGRRAIITMCIGGGQGIALAIERI
HHHHHHCCCCEEEEEEEECCCCEEEEEEECC
>Mature Secondary Structure 
TDIVILDGARTAIGTFGGALAQTAPIDLGATVAKAAMERSGVDPAQIGTVVYGHVINTE
CEEEEECCCCHHHHHHCHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHEEEEEEECCC
PRDMYLSRVAAMQAGIPESTPAMNVNRLCGSGAQAIVSGIQALMLGDAEYALTGGAESMS
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHHC
RSPFITPSTRWGQKMGDVKSLDMMLGALNCPFGTGHMGVTAENVADEHEITRAQMDEFAL
CCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHH
VSQTRAAAAIEAGYFQSQIVPVDVKVKRDMVPFEVDEHPKGTSMEALSGLRPVFKKDGRV
HHHHHHHHHHHHCCHHCEEEEEEEEEECCCCCEECCCCCCCCCHHHHHCCCHHHHCCCCE
TAGNASGINDGAAALVLATAEAAEKSGLKPKARILGYAHAGVRPEVMGVGPIPAVEQLLK
EECCCCCCCCCCEEEEEEEHHHHHHCCCCCHHHEEEEECCCCCCCEEECCCCHHHHHHHH
RIDMTVGDFDLIESNEAFAAQALAVNKALGLDSAKVNPNGGAIALGHPVGATGAIITVKA
HHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEECCCCCEEEECCCCCCCCCEEEHHH
LYELERTGGRRAIITMCIGGGQGIALAIERI
HHHHHHCCCCEEEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7763384 [H]