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The map label for this gene is gpsA

Identifier: 99082670

GI number: 99082670

Start: 2999768

End: 3000730

Strand: Direct

Name: gpsA

Synonym: TM1040_2830

Alternate gene names: 99082670

Gene position: 2999768-3000730 (Clockwise)

Preceding gene: 99082669

Following gene: 99082671

Centisome position: 93.72

GC content: 62.2

Gene sequence:

>963_bases
ATGAGCGTCGCGGTCCTCGGCGCGGGCGCTTTTGGCACGGCATTGGCCATCTCCCTCGCGCGCAAGGCGCCGACAACGCT
CTGGTGCCGCAGCAAAGACCATGCAGACGAGATACGCAGCACGCGTGAAAACACCCGTCGCCTGCCGGGCGCGCCCTTGC
CCGATGCTCTGGCCGTCACGTCGGATATTGCCTGTCTTGGCGCCCATGACGTGATCCTGCTTGCTGTTCCGATGCAAAAA
ATGCGCGGTTTCCTGACCGCGCATCACGCAGCGCTTTCCGGCAAGACATTGGTAGCCTGCTGCAAAGGCATCGAGCTCGA
CAGTGGTCTTGGCCCGGTGGCGGTTCTGCGCGACACGGTGCCTGACGCAACTGCAGCCCTGCTGACGGGCCCAAGTTTCG
CGGCAGACATTGCCCTCGGCCTGCCAACCGCATTGACGCTGGCCTGCGATCCGGATGAGACCGGGAAAGCCCTGCAAGCC
ACCTTGTCCACCGATAACCTGCGCCTCTATCGCACCACCGACCTGACCGGAGCGGAGATCGGCGGCGCACTGAAGAACGT
CATCGCCATCGCCTGCGGAGCAGTGATCGGCGCAAGGCTCGGTGACAGTGCCCGCGCGGCGCTCATGACACGTGGCTATG
CAGAGATGCAGCGCTTGGCACTGGCCCGCGGTGCCCGGCCGGAAACGCTGGCAGGGCTTTCGGGGTTTGGTGACCTCACC
CTCACATGCGGTTCGGAACTGTCGCGCAATTTTCGCCTCGGTCTGAGCCTCGGCCGTGGAGAGGCCTTTGATCCCTCTAT
TACGGTGGAGGGCGCAGCAACGGCACGTGCCACCGCCAAAACGGCCCAAGAGATGGGATTGGAGATGCCAATCACGCAAA
CGGTAACCAATTTGTTGGATCAAAGGTTGACGATCTCCGACGCGGCGGATCAATTGCTTAAAAGGCCATTAAAAGAGGAA
TAA

Upstream 100 bases:

>100_bases
CCGGAGCGCGTGATGGCATGTCGCTTTCGGCACGTCCGCGCTGGCCGCTGGATAAAACCAGCCCAGCGCTGATCGGCAGC
GGCAAGAAAGGGGCCAAGGC

Downstream 100 bases:

>100_bases
AATGCTCATTGCATTGATTGCCCGCGACAAACCCGACCATCTGCAGACGCGCCTCGACAATCGTGCGGCGCATCTCGCCT
ATATCGAAGAGACCGGCGTT

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSVAVLGAGAFGTALAISLARKAPTTLWCRSKDHADEIRSTRENTRRLPGAPLPDALAVTSDIACLGAHDVILLAVPMQK
MRGFLTAHHAALSGKTLVACCKGIELDSGLGPVAVLRDTVPDATAALLTGPSFAADIALGLPTALTLACDPDETGKALQA
TLSTDNLRLYRTTDLTGAEIGGALKNVIAIACGAVIGARLGDSARAALMTRGYAEMQRLALARGARPETLAGLSGFGDLT
LTCGSELSRNFRLGLSLGRGEAFDPSITVEGAATARATAKTAQEMGLEMPITQTVTNLLDQRLTISDAADQLLKRPLKEE

Sequences:

>Translated_320_residues
MSVAVLGAGAFGTALAISLARKAPTTLWCRSKDHADEIRSTRENTRRLPGAPLPDALAVTSDIACLGAHDVILLAVPMQK
MRGFLTAHHAALSGKTLVACCKGIELDSGLGPVAVLRDTVPDATAALLTGPSFAADIALGLPTALTLACDPDETGKALQA
TLSTDNLRLYRTTDLTGAEIGGALKNVIAIACGAVIGARLGDSARAALMTRGYAEMQRLALARGARPETLAGLSGFGDLT
LTCGSELSRNFRLGLSLGRGEAFDPSITVEGAATARATAKTAQEMGLEMPITQTVTNLLDQRLTISDAADQLLKRPLKEE
>Mature_319_residues
SVAVLGAGAFGTALAISLARKAPTTLWCRSKDHADEIRSTRENTRRLPGAPLPDALAVTSDIACLGAHDVILLAVPMQKM
RGFLTAHHAALSGKTLVACCKGIELDSGLGPVAVLRDTVPDATAALLTGPSFAADIALGLPTALTLACDPDETGKALQAT
LSTDNLRLYRTTDLTGAEIGGALKNVIAIACGAVIGARLGDSARAALMTRGYAEMQRLALARGARPETLAGLSGFGDLTL
TCGSELSRNFRLGLSLGRGEAFDPSITVEGAATARATAKTAQEMGLEMPITQTVTNLLDQRLTISDAADQLLKRPLKEE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=352, Percent_Identity=24.4318181818182, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI24307999, Length=282, Percent_Identity=25.886524822695, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790037, Length=329, Percent_Identity=38.9057750759878, Blast_Score=187, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17507425, Length=271, Percent_Identity=28.0442804428044, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32564403, Length=272, Percent_Identity=25.7352941176471, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32564399, Length=264, Percent_Identity=26.1363636363636, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193210136, Length=273, Percent_Identity=25.6410256410256, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320181, Length=290, Percent_Identity=27.5862068965517, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324513, Length=369, Percent_Identity=23.8482384823848, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136204, Length=346, Percent_Identity=23.9884393063584, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136202, Length=346, Percent_Identity=23.9884393063584, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17136200, Length=346, Percent_Identity=23.9884393063584, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45551945, Length=240, Percent_Identity=25.8333333333333, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281362270, Length=240, Percent_Identity=25.8333333333333, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648969, Length=193, Percent_Identity=27.979274611399, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_SILST (Q1GCQ4)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614824.1
- ProteinModelPortal:   Q1GCQ4
- SMR:   Q1GCQ4
- STRING:   Q1GCQ4
- GeneID:   4076649
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2830
- NMPDR:   fig|292414.1.peg.1733
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   AKGIEHG
- ProtClustDB:   PRK00094
- BioCyc:   SSP292414:TM1040_2830-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 33156; Mature: 33024

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 185-185 BINDING 102-102 BINDING 102-102 BINDING 134-134 BINDING 249-249 BINDING 270-270

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVAVLGAGAFGTALAISLARKAPTTLWCRSKDHADEIRSTRENTRRLPGAPLPDALAVT
CCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
SDIACLGAHDVILLAVPMQKMRGFLTAHHAALSGKTLVACCKGIELDSGLGPVAVLRDTV
HHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHCC
PDATAALLTGPSFAADIALGLPTALTLACDPDETGKALQATLSTDNLRLYRTTDLTGAEI
CCHHHHHHCCCCHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCHHH
GGALKNVIAIACGAVIGARLGDSARAALMTRGYAEMQRLALARGARPETLAGLSGFGDLT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCHHHCCCCCCCEE
LTCGSELSRNFRLGLSLGRGEAFDPSITVEGAATARATAKTAQEMGLEMPITQTVTNLLD
EECCHHHCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
QRLTISDAADQLLKRPLKEE
CCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SVAVLGAGAFGTALAISLARKAPTTLWCRSKDHADEIRSTRENTRRLPGAPLPDALAVT
CEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
SDIACLGAHDVILLAVPMQKMRGFLTAHHAALSGKTLVACCKGIELDSGLGPVAVLRDTV
HHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHCC
PDATAALLTGPSFAADIALGLPTALTLACDPDETGKALQATLSTDNLRLYRTTDLTGAEI
CCHHHHHHCCCCHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCHHH
GGALKNVIAIACGAVIGARLGDSARAALMTRGYAEMQRLALARGARPETLAGLSGFGDLT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCHHHCCCCCCCEE
LTCGSELSRNFRLGLSLGRGEAFDPSITVEGAATARATAKTAQEMGLEMPITQTVTNLLD
EECCHHHCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
QRLTISDAADQLLKRPLKEE
CCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA