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The map label for this gene is gcp

Identifier: 99082669

GI number: 99082669

Start: 2998674

End: 2999771

Strand: Direct

Name: gcp

Synonym: TM1040_2829

Alternate gene names: 99082669

Gene position: 2998674-2999771 (Clockwise)

Preceding gene: 99082665

Following gene: 99082670

Centisome position: 93.68

GC content: 60.47

Gene sequence:

>1098_bases
ATGACTCAGACGCTCACACTTCTTGGACTGGAAAGCAGTTGCGACGACACAGCAGCCGCCGTTGTACGACAGACGACAGG
CGCCAAGGCGGAAATCCTGTCGTCGATCGTGTTCGGCCAGACCGAGCTTCACAGCGCGTATGGCGGCGTGGTGCCCGAGA
TCGCCGCGCGCGCCCATGCTGAAAAACTCGACAGTTGCGTGCGCGACGCTCTCGCCGAGGCCGGCCTCACCCTAGGCGAC
CTGGATGCCATCGCCGTCACCGCAGGCCCAGGGCTGATCGGGGGCGTGATGTCTGGCGTGATGTGCGCAAAAGGGATCTC
TGCTGCCACCGGACTGCCACTGATCGGAGTGAATCACCTTGCCGGGCATGCTCTGACGCCGCGCCTGACTGACGATATCA
CCTATCCCTACTTGATGCTGCTGGTGTCAGGTGGCCATTGCCAATATCTGATCGCACGCGGGCCAGAGACGTTCTCGCGC
CTTGGCGGCACAATAGACGATGCACCCGGCGAAGCCTTTGACAAGACCGCGCGACTTCTTGGGTTGCCACAACCCGGAGG
ACCGTCTGTACAGGCGGAGGCAGAGCATGGCGATCCGGAGCGGTTCCGCTTTCCACGCCCTCTGCTTGATCGCCCTGATT
GCAACCTGTCTTTTTCGGGGTTGAAAACCGCCTTGATGCGAATGCGGGACCAGATCATCGCAGAAAAGGGAGGCCTGACA
CGTCAGGATCGCGCCGATCTCTGTGCTGGTTTTCAGGCGGCAATCGTTGACACACTTGTGGAAAAAACCCGTCGCGCCCT
CCGGCTCTATCTCGAGGATAAGCCCCAGCACCCAACGTTGGCCGTGGCCGGAGGTGTCGCTGCCAATACTGAAATCCGGA
ACGGATTGATGGCTCTATGCTTTGAGTTAGAGACTGATTTTCTCGCACCCCCTTTGGCGCTTTGCACCGATAACGCAGCG
ATGATCGCCTATGCAGGACTGGAGCGCTACAAAACCGGAGCGCGTGATGGCATGTCGCTTTCGGCACGTCCGCGCTGGCC
GCTGGATAAAACCAGCCCAGCGCTGATCGGCAGCGGCAAGAAAGGGGCCAAGGCATGA

Upstream 100 bases:

>100_bases
AACAGAGATAGGCCCTTCCTGTTCACCTCGGCGCTCCCGGGATTGTTTGCCTCACCTCATGGTGGTAGCTGCGCAGTACA
AAGGATGCAACGGTAGGGCC

Downstream 100 bases:

>100_bases
GCGTCGCGGTCCTCGGCGCGGGCGCTTTTGGCACGGCATTGGCCATCTCCCTCGCGCGCAAGGCGCCGACAACGCTCTGG
TGCCGCAGCAAAGACCATGC

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MTQTLTLLGLESSCDDTAAAVVRQTTGAKAEILSSIVFGQTELHSAYGGVVPEIAARAHAEKLDSCVRDALAEAGLTLGD
LDAIAVTAGPGLIGGVMSGVMCAKGISAATGLPLIGVNHLAGHALTPRLTDDITYPYLMLLVSGGHCQYLIARGPETFSR
LGGTIDDAPGEAFDKTARLLGLPQPGGPSVQAEAEHGDPERFRFPRPLLDRPDCNLSFSGLKTALMRMRDQIIAEKGGLT
RQDRADLCAGFQAAIVDTLVEKTRRALRLYLEDKPQHPTLAVAGGVAANTEIRNGLMALCFELETDFLAPPLALCTDNAA
MIAYAGLERYKTGARDGMSLSARPRWPLDKTSPALIGSGKKGAKA

Sequences:

>Translated_365_residues
MTQTLTLLGLESSCDDTAAAVVRQTTGAKAEILSSIVFGQTELHSAYGGVVPEIAARAHAEKLDSCVRDALAEAGLTLGD
LDAIAVTAGPGLIGGVMSGVMCAKGISAATGLPLIGVNHLAGHALTPRLTDDITYPYLMLLVSGGHCQYLIARGPETFSR
LGGTIDDAPGEAFDKTARLLGLPQPGGPSVQAEAEHGDPERFRFPRPLLDRPDCNLSFSGLKTALMRMRDQIIAEKGGLT
RQDRADLCAGFQAAIVDTLVEKTRRALRLYLEDKPQHPTLAVAGGVAANTEIRNGLMALCFELETDFLAPPLALCTDNAA
MIAYAGLERYKTGARDGMSLSARPRWPLDKTSPALIGSGKKGAKA
>Mature_364_residues
TQTLTLLGLESSCDDTAAAVVRQTTGAKAEILSSIVFGQTELHSAYGGVVPEIAARAHAEKLDSCVRDALAEAGLTLGDL
DAIAVTAGPGLIGGVMSGVMCAKGISAATGLPLIGVNHLAGHALTPRLTDDITYPYLMLLVSGGHCQYLIARGPETFSRL
GGTIDDAPGEAFDKTARLLGLPQPGGPSVQAEAEHGDPERFRFPRPLLDRPDCNLSFSGLKTALMRMRDQIIAEKGGLTR
QDRADLCAGFQAAIVDTLVEKTRRALRLYLEDKPQHPTLAVAGGVAANTEIRNGLMALCFELETDFLAPPLALCTDNAAM
IAYAGLERYKTGARDGMSLSARPRWPLDKTSPALIGSGKKGAKA

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=363, Percent_Identity=36.0881542699724, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI8923380, Length=342, Percent_Identity=30.7017543859649, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1789445, Length=346, Percent_Identity=44.2196531791908, Blast_Score=276, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17557464, Length=332, Percent_Identity=33.7349397590361, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71995670, Length=340, Percent_Identity=28.5294117647059, Blast_Score=104, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6320099, Length=368, Percent_Identity=30.4347826086957, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322891, Length=352, Percent_Identity=28.4090909090909, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20129063, Length=344, Percent_Identity=36.9186046511628, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI21357207, Length=336, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_SILST (Q1GCQ5)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614823.1
- ProteinModelPortal:   Q1GCQ5
- SMR:   Q1GCQ5
- STRING:   Q1GCQ5
- MEROPS:   M22.001
- GeneID:   4076648
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2829
- NMPDR:   fig|292414.1.peg.1732
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q1GCQ5
- ProtClustDB:   PRK09604
- BioCyc:   SSP292414:TM1040_2829-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 38361; Mature: 38230

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTLTLLGLESSCDDTAAAVVRQTTGAKAEILSSIVFGQTELHSAYGGVVPEIAARAHA
CCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHH
EKLDSCVRDALAEAGLTLGDLDAIAVTAGPGLIGGVMSGVMCAKGISAATGLPLIGVNHL
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHCCCCEEEHHHH
AGHALTPRLTDDITYPYLMLLVSGGHCQYLIARGPETFSRLGGTIDDAPGEAFDKTARLL
CCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHH
GLPQPGGPSVQAEAEHGDPERFRFPRPLLDRPDCNLSFSGLKTALMRMRDQIIAEKGGLT
CCCCCCCCCEEECCCCCCHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCC
RQDRADLCAGFQAAIVDTLVEKTRRALRLYLEDKPQHPTLAVAGGVAANTEIRNGLMALC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHH
FELETDFLAPPLALCTDNAAMIAYAGLERYKTGARDGMSLSARPRWPLDKTSPALIGSGK
HHHHHHHCCCCHHHHCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCC
KGAKA
CCCCC
>Mature Secondary Structure 
TQTLTLLGLESSCDDTAAAVVRQTTGAKAEILSSIVFGQTELHSAYGGVVPEIAARAHA
CCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHH
EKLDSCVRDALAEAGLTLGDLDAIAVTAGPGLIGGVMSGVMCAKGISAATGLPLIGVNHL
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHCCCCEEEHHHH
AGHALTPRLTDDITYPYLMLLVSGGHCQYLIARGPETFSRLGGTIDDAPGEAFDKTARLL
CCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHH
GLPQPGGPSVQAEAEHGDPERFRFPRPLLDRPDCNLSFSGLKTALMRMRDQIIAEKGGLT
CCCCCCCCCEEECCCCCCHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCC
RQDRADLCAGFQAAIVDTLVEKTRRALRLYLEDKPQHPTLAVAGGVAANTEIRNGLMALC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHH
FELETDFLAPPLALCTDNAAMIAYAGLERYKTGARDGMSLSARPRWPLDKTSPALIGSGK
HHHHHHHCCCCHHHHCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCC
KGAKA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA