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The map label for this gene is aroC

Identifier: 99082659

GI number: 99082659

Start: 2983051

End: 2984163

Strand: Direct

Name: aroC

Synonym: TM1040_2819

Alternate gene names: 99082659

Gene position: 2983051-2984163 (Clockwise)

Preceding gene: 99082651

Following gene: 99082660

Centisome position: 93.19

GC content: 59.12

Gene sequence:

>1113_bases
ATGTCCATGAATTCTTTTGGCCACCTTTTTCGAGTCACCACCTGGGGTGAAAGCCATGGGCCCGCTTTGGGCGCTACGGT
TGATGGCTGCCCGCCAAATGTCGCAGTCTCGGAAGAGATGCTTCAACACTGGCTCGACAAGCGCCGCCCCGGTCAGAACA
AGAACACCACCCAGCGCAATGAGCCTGACGCGGTGAGAATCCTCTCTGGTGTGTTTGAGGGAAAATCGACCGGCACGCCG
ATTCAATTGATGATTGAAAACACCGACCAGCGCTCACGGGATTATGGCGAGATCGCCCAGACATTCCGCCCAGGACATGC
GGACATTACTTACTTTCAGAAATACGGCAACCGCGACTATCGCGGTGGTGGACGATCCTCTGCACGCGAAACCGCAGCGC
GGGTGGCAGCAGGTGGCGTAGCGCGCGAAGCCCTCAAGTCCTTGGCCCCGGGGATCGAGATCAAGGGCTATATGACCCGC
ATGGGGGAAATGGAAATCGACCGCGCGCGGTTTGACTGGTCTGCCATCGATCAGAACGACTTCTGGATTCCCGATGCCGC
CGCTGTTCAGGACTGGGAAGACTATCTGCAGGCCCTTCGCAAGCAGCACGACTCGGTTGGCGCTGTTGTCGAAGTGGTCG
CGCGCGGCGTACCCGCAGGCATCGGAGCGCCAATCTACGGCAAGCTCGACACCGATCTCGCAGCGGCAATGATGTCGATC
AACGCTGTCAAAGCCGTCGAAATCGGCGAAGGCATGAATGCTGCGTTGTTGAAGGGCTCCGAGAACGCGGATGAGATCTT
CATGGGCAATGACGGTGCGCCTGTCTACTCGTCGAATCACGCGGGTGGTATCTTGGGAGGAATCTCAACGGGCCAAGATG
TGGTGATCCGTTTCGCCGTGAAGCCGACCTCGTCCATTTTGACCCCGCGCCAGTCGATTCGCAAAGACGGGACGGCTGCC
GAAGTCATCACCAAGGGCCGCCATGATCCCTGTGTCGGTATCCGCGCAGTGCCCGTGGCAGAGGCCATGATGGCCTTTGT
GATTCTCGATCACATCCTGTTGCACCGCGGGCAGATTGGCGAGAATCAGGGCGTGATCGGCGCGCCCGACTGA

Upstream 100 bases:

>100_bases
CTGTGCTGGTTTTTGCGCTTATCTGACCTGTTGCGACGCGGGTCTCTTTTCCCGGGCAGGCTTTCTCGCTAAAGGATCAA
ATCAAAGGAGATCCGCGCGC

Downstream 100 bases:

>100_bases
ACCAATCAAGAGCGCGCGTTCTGCGGGCTCTCGCGAACAGCCGCCGCACATAGAGCGGACCCACAGAGATAGCTAGCGGA
GTGGCACACGGGGGGTGTTG

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSMNSFGHLFRVTTWGESHGPALGATVDGCPPNVAVSEEMLQHWLDKRRPGQNKNTTQRNEPDAVRILSGVFEGKSTGTP
IQLMIENTDQRSRDYGEIAQTFRPGHADITYFQKYGNRDYRGGGRSSARETAARVAAGGVAREALKSLAPGIEIKGYMTR
MGEMEIDRARFDWSAIDQNDFWIPDAAAVQDWEDYLQALRKQHDSVGAVVEVVARGVPAGIGAPIYGKLDTDLAAAMMSI
NAVKAVEIGEGMNAALLKGSENADEIFMGNDGAPVYSSNHAGGILGGISTGQDVVIRFAVKPTSSILTPRQSIRKDGTAA
EVITKGRHDPCVGIRAVPVAEAMMAFVILDHILLHRGQIGENQGVIGAPD

Sequences:

>Translated_370_residues
MSMNSFGHLFRVTTWGESHGPALGATVDGCPPNVAVSEEMLQHWLDKRRPGQNKNTTQRNEPDAVRILSGVFEGKSTGTP
IQLMIENTDQRSRDYGEIAQTFRPGHADITYFQKYGNRDYRGGGRSSARETAARVAAGGVAREALKSLAPGIEIKGYMTR
MGEMEIDRARFDWSAIDQNDFWIPDAAAVQDWEDYLQALRKQHDSVGAVVEVVARGVPAGIGAPIYGKLDTDLAAAMMSI
NAVKAVEIGEGMNAALLKGSENADEIFMGNDGAPVYSSNHAGGILGGISTGQDVVIRFAVKPTSSILTPRQSIRKDGTAA
EVITKGRHDPCVGIRAVPVAEAMMAFVILDHILLHRGQIGENQGVIGAPD
>Mature_369_residues
SMNSFGHLFRVTTWGESHGPALGATVDGCPPNVAVSEEMLQHWLDKRRPGQNKNTTQRNEPDAVRILSGVFEGKSTGTPI
QLMIENTDQRSRDYGEIAQTFRPGHADITYFQKYGNRDYRGGGRSSARETAARVAAGGVAREALKSLAPGIEIKGYMTRM
GEMEIDRARFDWSAIDQNDFWIPDAAAVQDWEDYLQALRKQHDSVGAVVEVVARGVPAGIGAPIYGKLDTDLAAAMMSIN
AVKAVEIGEGMNAALLKGSENADEIFMGNDGAPVYSSNHAGGILGGISTGQDVVIRFAVKPTSSILTPRQSIRKDGTAAE
VITKGRHDPCVGIRAVPVAEAMMAFVILDHILLHRGQIGENQGVIGAPD

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=358, Percent_Identity=59.2178770949721, Blast_Score=404, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321290, Length=369, Percent_Identity=39.2953929539295, Blast_Score=271, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_SILST (Q1GCR5)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614813.1
- ProteinModelPortal:   Q1GCR5
- SMR:   Q1GCR5
- STRING:   Q1GCR5
- GeneID:   4076638
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2819
- NMPDR:   fig|292414.1.peg.1723
- eggNOG:   COG0082
- HOGENOM:   HBG292336
- OMA:   SRFTTQR
- PhylomeDB:   Q1GCR5
- ProtClustDB:   PRK05382
- BioCyc:   SSP292414:TM1040_2819-MONOMER
- HAMAP:   MF_00300_B
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 39799; Mature: 39668

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMNSFGHLFRVTTWGESHGPALGATVDGCPPNVAVSEEMLQHWLDKRRPGQNKNTTQRN
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
EPDAVRILSGVFEGKSTGTPIQLMIENTDQRSRDYGEIAQTFRPGHADITYFQKYGNRDY
CCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCC
RGGGRSSARETAARVAAGGVAREALKSLAPGIEIKGYMTRMGEMEIDRARFDWSAIDQND
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHCCCCHHHHHCCHHCCCCCC
FWIPDAAAVQDWEDYLQALRKQHDSVGAVVEVVARGVPAGIGAPIYGKLDTDLAAAMMSI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
NAVKAVEIGEGMNAALLKGSENADEIFMGNDGAPVYSSNHAGGILGGISTGQDVVIRFAV
HHHEEEECCCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCCCEEEEEEEE
KPTSSILTPRQSIRKDGTAAEVITKGRHDPCVGIRAVPVAEAMMAFVILDHILLHRGQIG
CCCHHHCCCHHHHHCCCCHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCC
ENQGVIGAPD
CCCCCCCCCC
>Mature Secondary Structure 
SMNSFGHLFRVTTWGESHGPALGATVDGCPPNVAVSEEMLQHWLDKRRPGQNKNTTQRN
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
EPDAVRILSGVFEGKSTGTPIQLMIENTDQRSRDYGEIAQTFRPGHADITYFQKYGNRDY
CCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCC
RGGGRSSARETAARVAAGGVAREALKSLAPGIEIKGYMTRMGEMEIDRARFDWSAIDQND
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHCCCCHHHHHCCHHCCCCCC
FWIPDAAAVQDWEDYLQALRKQHDSVGAVVEVVARGVPAGIGAPIYGKLDTDLAAAMMSI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
NAVKAVEIGEGMNAALLKGSENADEIFMGNDGAPVYSSNHAGGILGGISTGQDVVIRFAV
HHHEEEECCCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCCCEEEEEEEE
KPTSSILTPRQSIRKDGTAAEVITKGRHDPCVGIRAVPVAEAMMAFVILDHILLHRGQIG
CCCHHHCCCHHHHHCCCCHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCC
ENQGVIGAPD
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA