Click here to switch to the map view.

The map label for this gene is msrA2 [H]

Identifier: 99082644

GI number: 99082644

Start: 2965650

End: 2966165

Strand: Direct

Name: msrA2 [H]

Synonym: TM1040_2804

Alternate gene names: 99082644

Gene position: 2965650-2966165 (Clockwise)

Preceding gene: 99082643

Following gene: 99082649

Centisome position: 92.65

GC content: 55.81

Gene sequence:

>516_bases
ATGACCACAACTGAACGCGCCGTTCTGGCAGGCGGCTGCTTCTGGGGCATGCAGGAGCTAATCCGTCATCGCAAGGGCGT
CCTCAGCACCCGCGTCGGCTATACCGGTGGTGATGTGCCCAATGCGACGTACAAGAACCACGGCACCCACGCAGAAGGCA
TCGAGATCACCTTTGATCCCGAACAGACCTCCTATCGCGAGATGTTGGAGTTCTTTTTTCAGATCCATGACCCAACAACG
GTCAATCGTCAGGGTAACGATATCGGTATGAGCTATCGCTCTGCGATCTACTACGTCGATGCGCGTCAAAAACAAATTGC
CGAGGACACGATTGCAGATGTCGAAGCTTCCGGAATTTGGCCCGGCAAGGTCGTGACCGAAGTGGAACCCGTTGGGGATT
TCTGGGAGGCAGAGGCAGAGCATCAAGACTACCTGCAGCGCCTGCCCAATGGCTATACCTGCCATTTTCCCCGTCCCGAC
TGGGTCCTGCCCAAACGGGATCAAGCTGCAGAATAA

Upstream 100 bases:

>100_bases
TGAGATATTGCATCAACTCGGCGTCCTTGCGCTTTATTCACCTCGACGACATGGAGGCTGAAGGCTATGGCGCCTACATC
AACCAAGTGGAGGACCACCG

Downstream 100 bases:

>100_bases
CTCTCGATAGAGCCTAGTTTCGTGGATTCTTACAACAAATAGGCCGCCTCCAGTTGGGGGCGGCTTTTGTTTGGTCGCTA
AGCATGTGCCACACGCGGGC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTTTERAVLAGGCFWGMQELIRHRKGVLSTRVGYTGGDVPNATYKNHGTHAEGIEITFDPEQTSYREMLEFFFQIHDPTT
VNRQGNDIGMSYRSAIYYVDARQKQIAEDTIADVEASGIWPGKVVTEVEPVGDFWEAEAEHQDYLQRLPNGYTCHFPRPD
WVLPKRDQAAE

Sequences:

>Translated_171_residues
MTTTERAVLAGGCFWGMQELIRHRKGVLSTRVGYTGGDVPNATYKNHGTHAEGIEITFDPEQTSYREMLEFFFQIHDPTT
VNRQGNDIGMSYRSAIYYVDARQKQIAEDTIADVEASGIWPGKVVTEVEPVGDFWEAEAEHQDYLQRLPNGYTCHFPRPD
WVLPKRDQAAE
>Mature_170_residues
TTTERAVLAGGCFWGMQELIRHRKGVLSTRVGYTGGDVPNATYKNHGTHAEGIEITFDPEQTSYREMLEFFFQIHDPTTV
NRQGNDIGMSYRSAIYYVDARQKQIAEDTIADVEASGIWPGKVVTEVEPVGDFWEAEAEHQDYLQRLPNGYTCHFPRPDW
VLPKRDQAAE

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=40.6451612903226, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=40.6451612903226, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI208609993, Length=105, Percent_Identity=40, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=39.4736842105263, Blast_Score=111, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=40.1360544217687, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=36.7469879518072, Blast_Score=106, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=37.2413793103448, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=38.2352941176471, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=36.734693877551, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19443; Mature: 19312

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTERAVLAGGCFWGMQELIRHRKGVLSTRVGYTGGDVPNATYKNHGTHAEGIEITFDP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
EQTSYREMLEFFFQIHDPTTVNRQGNDIGMSYRSAIYYVDARQKQIAEDTIADVEASGIW
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCC
PGKVVTEVEPVGDFWEAEAEHQDYLQRLPNGYTCHFPRPDWVLPKRDQAAE
CCCCEEECCCCCCHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTTERAVLAGGCFWGMQELIRHRKGVLSTRVGYTGGDVPNATYKNHGTHAEGIEITFDP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
EQTSYREMLEFFFQIHDPTTVNRQGNDIGMSYRSAIYYVDARQKQIAEDTIADVEASGIW
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCC
PGKVVTEVEPVGDFWEAEAEHQDYLQRLPNGYTCHFPRPDWVLPKRDQAAE
CCCCEEECCCCCCHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12835416 [H]