Click here to switch to the map view.

The map label for this gene is 99082462

Identifier: 99082462

GI number: 99082462

Start: 2754850

End: 2756106

Strand: Direct

Name: 99082462

Synonym: TM1040_2622

Alternate gene names: NA

Gene position: 2754850-2756106 (Clockwise)

Preceding gene: 99082461

Following gene: 99082463

Centisome position: 86.06

GC content: 62.53

Gene sequence:

>1257_bases
ATGCCTTTGAAAAAGTCCTGGGTGACGTCGGCCAATTCCGCTGACCACCCTTTTCCGCTGAACAACCTTCCCTATGGCGT
GTTTTCAACCCCCGACAGTGATCCGCGCTGTGGGGTCGCCATCGGCGATATGATCCTCGATCTTGCTGCGGCAGAGGCGG
CGGGGCTGATCGACCTCGCAGATGAGCCAATGTTCGAAATGCCCTTCTGGAACGAGTTTATGGAAGAAGGCCCCGCGGTC
TGGGCCGCGTTGCGCACCCGCCTGATCGCGCTTCTGGAAGAGGGCTCGGACGCGCAAAACAAGGTCGAGCCTTGTCTCGT
ACCGATGTCAGGCGCTGAGATGCATATGCCAATCATGGTGTCGGAATACACCGATTTCTATGCCGGGCGTCATCACGCCA
CCAATGTCGGCACCATGTTTCGGGGCGCCGAGAACGCGCTGCCGCCAAACTGGCTGCATATTCCGATCGGATACAATGGT
CGTGCCTCCTCGGTTGTGGTCTCCGGCACCGATGTGCGCCGTCCCTGGGGTCAGCTCAAGGGGCCAAATGACGACGCACC
CCGTTGGGCCCCCTGTGCGCGCTTTGACATCGAACTGGAGATGGGAGCCATCGTCGGGACACCCTCCGACGGGCCGATCA
CGGTGCAGGACGCGGACGATCACATCTTTGGCTATGTGCTGCTGAACGACTGGTCCGCCCGCGATATTCAGGCTTGGGAA
TACCAGCCGCTCGGCCCTTTTCAGGCCAAGGCGACCGCCACCACCATCAGCCCCTGGATCGTCACCAAGGCCGCATTGGA
GCCCTTCCGCTGCGACACCCCCGCGCGGGAGGTCGAGCTTCTCGATCACCTCAAGGACTGTGGCCCGATGCTCTATGACA
TCGACCTTGCCGTGACCCTGCGCCCCGAGGGGGGCGAAGAGGCCACCATCGCACGCACCAACTACAAGGAAATGTACTAT
TCCGCCGCGCAGCAACTGGCCCATCACACCACATCGGGCTGCCCGATGAACGCGGGCGACCTGCTGGGTTCCGGCACCAT
CTCCGGTCCGAACAAGGACGAACGCGGCTCGCTCCTCGAACTCAGCTGGGGTGGCAAGGAGCCTCTCACCCTGCCTTCGG
GCGATACCCGCAGCTTTATCGAGGATGGCGACACGCTGACCCTCAAAGGCGCGGCCAAGGGCGAGGGCTACACCATCGGC
TTTGGCGACTGCACCGGCACGGTGCTGCCCGCCCTCAGCGATCCGTTTGCACGCTGA

Upstream 100 bases:

>100_bases
CCCCCTCTGCGGCCCCAATTGGGGCCGCATTCACCCCCGAGATATTTGTAAAAAGCTGAAGGAGGGCCAGCAGAGCCCTC
ACCACCAAAAAGGAACGCGC

Downstream 100 bases:

>100_bases
CGGTTCCATCTTTCCTCAAATACCTCCGCCGGAGGCACCCCAACCTGACCTCCGGCGGACCAGACAAAAAGGATACGCAA
CCATGGCCAAGGCCTTCGCA

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MPLKKSWVTSANSADHPFPLNNLPYGVFSTPDSDPRCGVAIGDMILDLAAAEAAGLIDLADEPMFEMPFWNEFMEEGPAV
WAALRTRLIALLEEGSDAQNKVEPCLVPMSGAEMHMPIMVSEYTDFYAGRHHATNVGTMFRGAENALPPNWLHIPIGYNG
RASSVVVSGTDVRRPWGQLKGPNDDAPRWAPCARFDIELEMGAIVGTPSDGPITVQDADDHIFGYVLLNDWSARDIQAWE
YQPLGPFQAKATATTISPWIVTKAALEPFRCDTPAREVELLDHLKDCGPMLYDIDLAVTLRPEGGEEATIARTNYKEMYY
SAAQQLAHHTTSGCPMNAGDLLGSGTISGPNKDERGSLLELSWGGKEPLTLPSGDTRSFIEDGDTLTLKGAAKGEGYTIG
FGDCTGTVLPALSDPFAR

Sequences:

>Translated_418_residues
MPLKKSWVTSANSADHPFPLNNLPYGVFSTPDSDPRCGVAIGDMILDLAAAEAAGLIDLADEPMFEMPFWNEFMEEGPAV
WAALRTRLIALLEEGSDAQNKVEPCLVPMSGAEMHMPIMVSEYTDFYAGRHHATNVGTMFRGAENALPPNWLHIPIGYNG
RASSVVVSGTDVRRPWGQLKGPNDDAPRWAPCARFDIELEMGAIVGTPSDGPITVQDADDHIFGYVLLNDWSARDIQAWE
YQPLGPFQAKATATTISPWIVTKAALEPFRCDTPAREVELLDHLKDCGPMLYDIDLAVTLRPEGGEEATIARTNYKEMYY
SAAQQLAHHTTSGCPMNAGDLLGSGTISGPNKDERGSLLELSWGGKEPLTLPSGDTRSFIEDGDTLTLKGAAKGEGYTIG
FGDCTGTVLPALSDPFAR
>Mature_417_residues
PLKKSWVTSANSADHPFPLNNLPYGVFSTPDSDPRCGVAIGDMILDLAAAEAAGLIDLADEPMFEMPFWNEFMEEGPAVW
AALRTRLIALLEEGSDAQNKVEPCLVPMSGAEMHMPIMVSEYTDFYAGRHHATNVGTMFRGAENALPPNWLHIPIGYNGR
ASSVVVSGTDVRRPWGQLKGPNDDAPRWAPCARFDIELEMGAIVGTPSDGPITVQDADDHIFGYVLLNDWSARDIQAWEY
QPLGPFQAKATATTISPWIVTKAALEPFRCDTPAREVELLDHLKDCGPMLYDIDLAVTLRPEGGEEATIARTNYKEMYYS
AAQQLAHHTTSGCPMNAGDLLGSGTISGPNKDERGSLLELSWGGKEPLTLPSGDTRSFIEDGDTLTLKGAAKGEGYTIGF
GDCTGTVLPALSDPFAR

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=417, Percent_Identity=48.6810551558753, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17568863, Length=420, Percent_Identity=48.5714285714286, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24657182, Length=416, Percent_Identity=46.1538461538462, Blast_Score=374, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 45275; Mature: 45144

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLKKSWVTSANSADHPFPLNNLPYGVFSTPDSDPRCGVAIGDMILDLAAAEAAGLIDLA
CCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEHHHHHHHHHHHHHCCEEECC
DEPMFEMPFWNEFMEEGPAVWAALRTRLIALLEEGSDAQNKVEPCLVPMSGAEMHMPIMV
CCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEECCEEE
SEYTDFYAGRHHATNVGTMFRGAENALPPNWLHIPIGYNGRASSVVVSGTDVRRPWGQLK
ECHHHHHCCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHCC
GPNDDAPRWAPCARFDIELEMGAIVGTPSDGPITVQDADDHIFGYVLLNDWSARDIQAWE
CCCCCCCCCCCCEEEEEEEEECEEEECCCCCCEEEECCCCCEEEEEEEECCCCCCCCCEE
YQPLGPFQAKATATTISPWIVTKAALEPFRCDTPAREVELLDHLKDCGPMLYDIDLAVTL
CCCCCCCCCCCEEEECCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEE
RPEGGEEATIARTNYKEMYYSAAQQLAHHTTSGCPMNAGDLLGSGTISGPNKDERGSLLE
CCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEE
LSWGGKEPLTLPSGDTRSFIEDGDTLTLKGAAKGEGYTIGFGDCTGTVLPALSDPFAR
EECCCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCCEEEEECCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
PLKKSWVTSANSADHPFPLNNLPYGVFSTPDSDPRCGVAIGDMILDLAAAEAAGLIDLA
CCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEHHHHHHHHHHHHHCCEEECC
DEPMFEMPFWNEFMEEGPAVWAALRTRLIALLEEGSDAQNKVEPCLVPMSGAEMHMPIMV
CCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEECCEEE
SEYTDFYAGRHHATNVGTMFRGAENALPPNWLHIPIGYNGRASSVVVSGTDVRRPWGQLK
ECHHHHHCCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHCC
GPNDDAPRWAPCARFDIELEMGAIVGTPSDGPITVQDADDHIFGYVLLNDWSARDIQAWE
CCCCCCCCCCCCEEEEEEEEECEEEECCCCCCEEEECCCCCEEEEEEEECCCCCCCCCEE
YQPLGPFQAKATATTISPWIVTKAALEPFRCDTPAREVELLDHLKDCGPMLYDIDLAVTL
CCCCCCCCCCCEEEECCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEE
RPEGGEEATIARTNYKEMYYSAAQQLAHHTTSGCPMNAGDLLGSGTISGPNKDERGSLLE
CCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEE
LSWGGKEPLTLPSGDTRSFIEDGDTLTLKGAAKGEGYTIGFGDCTGTVLPALSDPFAR
EECCCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCCEEEEECCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA