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The map label for this gene is ffh [H]

Identifier: 99082443

GI number: 99082443

Start: 2740131

End: 2741675

Strand: Direct

Name: ffh [H]

Synonym: TM1040_2603

Alternate gene names: 99082443

Gene position: 2740131-2741675 (Clockwise)

Preceding gene: 99082440

Following gene: 99082444

Centisome position: 85.6

GC content: 62.27

Gene sequence:

>1545_bases
ATGTTTGAAAATCTATCCGAACGCCTATCCGGTGTCTTCGACCGGCTGACAAAACAGGGCGCCCTCTCCGAGGACGACGT
CAAAACCGCCCTGCGCGAAGTGCGCGTCGCCCTCTTGGAGGCCGACGTCTCGCTGCCCGTGGCCCGCGATTTCGTCAAGA
AGGTTCAGGAGCAGGCCACCGGTCAGGCCGTCACCAAATCGGTGACACCGGGCCAGCAGGTCGTGAAGATCGTTCATGAT
GCGCTTGTCGAGACCCTGCGAGGCGACGAGGACCCCGGGGCGCTCAAGATCGACAACCCGCCCGCACCGATCCTGATGGT
CGGCCTGCAGGGCTCCGGCAAGACCACCACCACCGGTAAGCTTGCAAAGCGCCTCAAGGAAAAAGAGGGCAAGAAAGTGC
TTCTTGCCTCGCTCGACGTCTATCGCCCGGCAGCGATGGATCAGCTGGCGGTGCTTGGTACCCAGATCGGCGTCGACACC
CTGCCCATCGTCAAAGGCCAAAGCCCGGTCGACATCGCCAAACGCGCCAAACAGCAGGCCGCGCTTGGGGGCTATGACGT
CTATATGCTCGACACGGCCGGTCGTCTGCAAATCGACGAGACCCTCATGAAAGAGGTCGAAGACGTCCGCGACGTGGTCT
CCCCGCGCGAGACGCTTCTGGTGGTAGATGGTCTGACCGGTCAGGTTGCGGTCGAGGTCGCGGAAGAATTCGACAACAAG
ATCGGCATCTCCGGCGTCGTGCTGACCCGGATGGACGGCGACGGGCGCGGCGGTGCGGCGCTCTCGATGCGCGCCGTGAC
CGGCAAGCCCATCCGCTTTGTCGGCCTTGGCGAGAAGATGGACGCCATCGAGACCTTCGAGCCGGACCGGATCGCAGGCC
GCATCCTTGGCATGGGCGACATTGTGGCCCTCGTCGAGAAGGCGCAGGAAACCATCGAGGCTGAGCAGGCCGAGCGCATG
ATGAAGCGCATGATGAAAGGTCAGTTCAATATGAACGACCTGCGCATGCAGTTGGAGCAGATGCAGCAGATGGGCGGCAT
GCAGGGCATGATGCAGATGATGCCGGGCATGGGCAAAATGGCCAAACAGGTCGAAGAGTCCGGCTTTGACGACAAGATGG
TCAAGCGCCAGATCGCGATGATCCAGTCCATGACCAAGAAAGAGCGCGCAAACCCCGCGCTGCTGCAGGCCAGCCGCAAG
AAACGCATTGCAGCAGGCTCCGGCATGGAGGTCTCGGACCTCAACAAGCTCTTGAAGATGCACCGCCAGATGGCGGACGT
CATGAAGAAGATGGGCAAAATGGGCAAAGGCAAGATGCTGAAACAGGCCATGAAAGGCATGTTCGGCAAAGGCGGCATGC
CCGAGATGCCCGGTGGCATGCCCGGCGGTATGGATCCCTCGCAGATGGACCCCAAGGCGCTCGAGGCCGCAGCCAAGGCC
ATGGGCGGCAAGGGTGGTTTGCCCGGCGGTCTCGGCGGGCTGGGTGGCCTCGGTGGCGGCATGGGCCTGCCCGGTGGCCT
CTCTGGATTTGGCAAGAAGAAGTAA

Upstream 100 bases:

>100_bases
TGTACCCAGGCTTGCGATCTGGTGGCGAGTGATTGAGGTTCGTTTCACCGCTCCTTACATGAGGGGCACGCGTCATAAAC
CGGCAAAGGAGGCCGAAGGC

Downstream 100 bases:

>100_bases
CCCCCTCAGATGAGCTCAGCCCCCACCATAGAAACCGACCGACTGATCCTACGCCCGCATGTTGCGGCGGATCTCGAAGC
GTTCTGGTCCTTCTACCAGA

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MFENLSERLSGVFDRLTKQGALSEDDVKTALREVRVALLEADVSLPVARDFVKKVQEQATGQAVTKSVTPGQQVVKIVHD
ALVETLRGDEDPGALKIDNPPAPILMVGLQGSGKTTTTGKLAKRLKEKEGKKVLLASLDVYRPAAMDQLAVLGTQIGVDT
LPIVKGQSPVDIAKRAKQQAALGGYDVYMLDTAGRLQIDETLMKEVEDVRDVVSPRETLLVVDGLTGQVAVEVAEEFDNK
IGISGVVLTRMDGDGRGGAALSMRAVTGKPIRFVGLGEKMDAIETFEPDRIAGRILGMGDIVALVEKAQETIEAEQAERM
MKRMMKGQFNMNDLRMQLEQMQQMGGMQGMMQMMPGMGKMAKQVEESGFDDKMVKRQIAMIQSMTKKERANPALLQASRK
KRIAAGSGMEVSDLNKLLKMHRQMADVMKKMGKMGKGKMLKQAMKGMFGKGGMPEMPGGMPGGMDPSQMDPKALEAAAKA
MGGKGGLPGGLGGLGGLGGGMGLPGGLSGFGKKK

Sequences:

>Translated_514_residues
MFENLSERLSGVFDRLTKQGALSEDDVKTALREVRVALLEADVSLPVARDFVKKVQEQATGQAVTKSVTPGQQVVKIVHD
ALVETLRGDEDPGALKIDNPPAPILMVGLQGSGKTTTTGKLAKRLKEKEGKKVLLASLDVYRPAAMDQLAVLGTQIGVDT
LPIVKGQSPVDIAKRAKQQAALGGYDVYMLDTAGRLQIDETLMKEVEDVRDVVSPRETLLVVDGLTGQVAVEVAEEFDNK
IGISGVVLTRMDGDGRGGAALSMRAVTGKPIRFVGLGEKMDAIETFEPDRIAGRILGMGDIVALVEKAQETIEAEQAERM
MKRMMKGQFNMNDLRMQLEQMQQMGGMQGMMQMMPGMGKMAKQVEESGFDDKMVKRQIAMIQSMTKKERANPALLQASRK
KRIAAGSGMEVSDLNKLLKMHRQMADVMKKMGKMGKGKMLKQAMKGMFGKGGMPEMPGGMPGGMDPSQMDPKALEAAAKA
MGGKGGLPGGLGGLGGLGGGMGLPGGLSGFGKKK
>Mature_514_residues
MFENLSERLSGVFDRLTKQGALSEDDVKTALREVRVALLEADVSLPVARDFVKKVQEQATGQAVTKSVTPGQQVVKIVHD
ALVETLRGDEDPGALKIDNPPAPILMVGLQGSGKTTTTGKLAKRLKEKEGKKVLLASLDVYRPAAMDQLAVLGTQIGVDT
LPIVKGQSPVDIAKRAKQQAALGGYDVYMLDTAGRLQIDETLMKEVEDVRDVVSPRETLLVVDGLTGQVAVEVAEEFDNK
IGISGVVLTRMDGDGRGGAALSMRAVTGKPIRFVGLGEKMDAIETFEPDRIAGRILGMGDIVALVEKAQETIEAEQAERM
MKRMMKGQFNMNDLRMQLEQMQQMGGMQGMMQMMPGMGKMAKQVEESGFDDKMVKRQIAMIQSMTKKERANPALLQASRK
KRIAAGSGMEVSDLNKLLKMHRQMADVMKKMGKMGKGKMLKQAMKGMFGKGGMPEMPGGMPGGMDPSQMDPKALEAAAKA
MGGKGGLPGGLGGLGGLGGGMGLPGGLSGFGKKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=527, Percent_Identity=29.7912713472486, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI226371618, Length=455, Percent_Identity=30.7692307692308, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=31.4465408805031, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI295424842, Length=288, Percent_Identity=28.4722222222222, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI23308697, Length=288, Percent_Identity=28.4722222222222, Blast_Score=93, Evalue=8e-19,
Organism=Escherichia coli, GI1788963, Length=463, Percent_Identity=51.6198704103672, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1789874, Length=221, Percent_Identity=37.5565610859729, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17539958, Length=510, Percent_Identity=29.0196078431373, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=281, Percent_Identity=30.9608540925267, Blast_Score=97, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=456, Percent_Identity=31.5789473684211, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320498, Length=315, Percent_Identity=26.031746031746, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647949, Length=518, Percent_Identity=29.7297297297297, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24641198, Length=284, Percent_Identity=29.5774647887324, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 54965; Mature: 54965

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
8.4 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
8.4 %Met     (Mature Protein)
8.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLSERLSGVFDRLTKQGALSEDDVKTALREVRVALLEADVSLPVARDFVKKVQEQAT
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GQAVTKSVTPGQQVVKIVHDALVETLRGDEDPGALKIDNPPAPILMVGLQGSGKTTTTGK
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEECCCCCCCHHHH
LAKRLKEKEGKKVLLASLDVYRPAAMDQLAVLGTQIGVDTLPIVKGQSPVDIAKRAKQQA
HHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
ALGGYDVYMLDTAGRLQIDETLMKEVEDVRDVVSPRETLLVVDGLTGQVAVEVAEEFDNK
HCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCC
IGISGVVLTRMDGDGRGGAALSMRAVTGKPIRFVGLGEKMDAIETFEPDRIAGRILGMGD
CCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHCCCCHHHHHHHCCHHH
IVALVEKAQETIEAEQAERMMKRMMKGQFNMNDLRMQLEQMQQMGGMQGMMQMMPGMGKM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHH
AKQVEESGFDDKMVKRQIAMIQSMTKKERANPALLQASRKKRIAAGSGMEVSDLNKLLKM
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
HRQMADVMKKMGKMGKGKMLKQAMKGMFGKGGMPEMPGGMPGGMDPSQMDPKALEAAAKA
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
MGGKGGLPGGLGGLGGLGGGMGLPGGLSGFGKKK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFENLSERLSGVFDRLTKQGALSEDDVKTALREVRVALLEADVSLPVARDFVKKVQEQAT
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GQAVTKSVTPGQQVVKIVHDALVETLRGDEDPGALKIDNPPAPILMVGLQGSGKTTTTGK
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEECCCCCCCHHHH
LAKRLKEKEGKKVLLASLDVYRPAAMDQLAVLGTQIGVDTLPIVKGQSPVDIAKRAKQQA
HHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
ALGGYDVYMLDTAGRLQIDETLMKEVEDVRDVVSPRETLLVVDGLTGQVAVEVAEEFDNK
HCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCC
IGISGVVLTRMDGDGRGGAALSMRAVTGKPIRFVGLGEKMDAIETFEPDRIAGRILGMGD
CCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHCCCCHHHHHHHCCHHH
IVALVEKAQETIEAEQAERMMKRMMKGQFNMNDLRMQLEQMQQMGGMQGMMQMMPGMGKM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHH
AKQVEESGFDDKMVKRQIAMIQSMTKKERANPALLQASRKKRIAAGSGMEVSDLNKLLKM
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
HRQMADVMKKMGKMGKGKMLKQAMKGMFGKGGMPEMPGGMPGGMDPSQMDPKALEAAAKA
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
MGGKGGLPGGLGGLGGLGGGMGLPGGLSGFGKKK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]