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The map label for this gene is patB [H]

Identifier: 99082421

GI number: 99082421

Start: 2718493

End: 2719665

Strand: Direct

Name: patB [H]

Synonym: TM1040_2581

Alternate gene names: 99082421

Gene position: 2718493-2719665 (Clockwise)

Preceding gene: 99082414

Following gene: 99082423

Centisome position: 84.93

GC content: 59.76

Gene sequence:

>1173_bases
ATGGATTTTGACAAGATCATCGACCGCCGCGGCACCCATTGCGCCAAATGGGACATGATGGAGCCTCTCTATGGCGTCAC
GCCCGAGGATGGGTTGGCGATGTGGGTTGCAGATACGGATTTTCCAGTACCGGAAGCTGTCTCGGCCAAGATGCGCGAAA
TGGCCGATCACGGCATCTATGGTTATGTGAACTGCGAGGCGCAGTACAAGAGCGCGATTCAGTGGTGGATGGAAAGCCGC
CACGGATGGAGCGTGGATGCAGATGCGATCTTTACCACCACGGGTCTCGTGAACGGTGTCGGCATGTGCCTTGACACCTT
CACCCAGCCCGGGGACGGCATCGTGCTGTTCACCCCGGTCTATCACGCTTTTGCCAAGGTGATCCGTCTTGCGGGACGTG
AGGTGGTCGAATGCCCGATGGTGCAGGAAGACGGCGCCTACAAGATGGATTTCGACGCCTACGATGCGCAGATGACCGGC
AAGGAAAAGATGGTCATCCTGTGTTCGCCGCACAACCCCGGTGGCCGCGTCTGGACCCAAGACGAGCTCACGCAAGTTGC
CGCCTTCTGCAAGCGCCATGACCTGATGCTGATTTCGGACGAAATCCACCACGACCTGGTCTTTGGGGGGCGCAAGCATC
TCCCCATGGCGGTGGCCGCACCCGAAATCAGCGAGCGCCTGATCATGCTGACAGCCCCCTCCAAGACCTTCAACTTTGCC
GGGCTGCACACGGGGCAGGTCATCATCCCTGATGAGACGCTGCGCGAGCAGTTCCGTCGCCGCATGATGGCCATCTATCT
GCAGGGCAATACGGCAGGGGAATTTGCAACCATCGCCGCCTACTCCCCGGATGGCGCGGCCTATGTCGAAGAGCTGGTGC
CCTATATCGAGGCCAACAAGCGCCTGTTTGACGAAGCAGTGAATGCAATCCCAGGCCTACAATCGATGGAGCTGCAATCC
ACATATCTGGCGTGGGTCGACTTCTCCGGTACAGGCATGGAGCGCGAGGAGTTCACCCGCCGCGTTGAACAGGGTGCACG
GATCGCGGCCAACCACGGCACCACATTTGGCACCGGCGGTGAGAGCTTCTTGCGGTTCAACCTCGGCACACAGCGTGCAC
GGGTCGAAGAAGCCTGCGAGCGGCTGGCAAAGGCGTTCTCTGACTTGCAGTGA

Upstream 100 bases:

>100_bases
ACGGGAGTGGCCGAGCGTGTTTGTACCAGCACATTGGCGGGGCTTTGCAGCGCTCGCACAATCCCCTAGCTTCTGGCGCA
ATCACCACGGAGACAGATTT

Downstream 100 bases:

>100_bases
CACGCACATAAAGAAGGCGCGCGACGGGAAAACTGTCGCGCGCAACTTTGGGAGGGTCGCGATATTCTGGGTGCGGCTTA
GGGCCAATGACGCGGCTGAT

Product: aminotransferase, class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MDFDKIIDRRGTHCAKWDMMEPLYGVTPEDGLAMWVADTDFPVPEAVSAKMREMADHGIYGYVNCEAQYKSAIQWWMESR
HGWSVDADAIFTTTGLVNGVGMCLDTFTQPGDGIVLFTPVYHAFAKVIRLAGREVVECPMVQEDGAYKMDFDAYDAQMTG
KEKMVILCSPHNPGGRVWTQDELTQVAAFCKRHDLMLISDEIHHDLVFGGRKHLPMAVAAPEISERLIMLTAPSKTFNFA
GLHTGQVIIPDETLREQFRRRMMAIYLQGNTAGEFATIAAYSPDGAAYVEELVPYIEANKRLFDEAVNAIPGLQSMELQS
TYLAWVDFSGTGMEREEFTRRVEQGARIAANHGTTFGTGGESFLRFNLGTQRARVEEACERLAKAFSDLQ

Sequences:

>Translated_390_residues
MDFDKIIDRRGTHCAKWDMMEPLYGVTPEDGLAMWVADTDFPVPEAVSAKMREMADHGIYGYVNCEAQYKSAIQWWMESR
HGWSVDADAIFTTTGLVNGVGMCLDTFTQPGDGIVLFTPVYHAFAKVIRLAGREVVECPMVQEDGAYKMDFDAYDAQMTG
KEKMVILCSPHNPGGRVWTQDELTQVAAFCKRHDLMLISDEIHHDLVFGGRKHLPMAVAAPEISERLIMLTAPSKTFNFA
GLHTGQVIIPDETLREQFRRRMMAIYLQGNTAGEFATIAAYSPDGAAYVEELVPYIEANKRLFDEAVNAIPGLQSMELQS
TYLAWVDFSGTGMEREEFTRRVEQGARIAANHGTTFGTGGESFLRFNLGTQRARVEEACERLAKAFSDLQ
>Mature_390_residues
MDFDKIIDRRGTHCAKWDMMEPLYGVTPEDGLAMWVADTDFPVPEAVSAKMREMADHGIYGYVNCEAQYKSAIQWWMESR
HGWSVDADAIFTTTGLVNGVGMCLDTFTQPGDGIVLFTPVYHAFAKVIRLAGREVVECPMVQEDGAYKMDFDAYDAQMTG
KEKMVILCSPHNPGGRVWTQDELTQVAAFCKRHDLMLISDEIHHDLVFGGRKHLPMAVAAPEISERLIMLTAPSKTFNFA
GLHTGQVIIPDETLREQFRRRMMAIYLQGNTAGEFATIAAYSPDGAAYVEELVPYIEANKRLFDEAVNAIPGLQSMELQS
TYLAWVDFSGTGMEREEFTRRVEQGARIAANHGTTFGTGGESFLRFNLGTQRARVEEACERLAKAFSDLQ

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=345, Percent_Identity=24.0579710144928, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI56713254, Length=345, Percent_Identity=24.0579710144928, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI95147551, Length=254, Percent_Identity=21.6535433070866, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI169881279, Length=254, Percent_Identity=21.6535433070866, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI169881281, Length=188, Percent_Identity=25, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4507369, Length=359, Percent_Identity=21.1699164345404, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1787909, Length=390, Percent_Identity=29.7435897435897, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1786816, Length=319, Percent_Identity=24.4514106583072, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788722, Length=366, Percent_Identity=23.224043715847, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788627, Length=269, Percent_Identity=21.1895910780669, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567369, Length=231, Percent_Identity=21.6450216450216, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71994476, Length=182, Percent_Identity=25.2747252747253, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71994472, Length=182, Percent_Identity=25.2747252747253, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17567663, Length=352, Percent_Identity=21.5909090909091, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322401, Length=335, Percent_Identity=25.0746268656716, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI28573069, Length=325, Percent_Identity=23.3846153846154, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646114, Length=325, Percent_Identity=23.3846153846154, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28573067, Length=325, Percent_Identity=23.3846153846154, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28573065, Length=325, Percent_Identity=23.3846153846154, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI18859735, Length=361, Percent_Identity=21.8836565096953, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43615; Mature: 43615

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDKIIDRRGTHCAKWDMMEPLYGVTPEDGLAMWVADTDFPVPEAVSAKMREMADHGIY
CCHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCE
GYVNCEAQYKSAIQWWMESRHGWSVDADAIFTTTGLVNGVGMCLDTFTQPGDGIVLFTPV
EEEECCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEECHH
YHAFAKVIRLAGREVVECPMVQEDGAYKMDFDAYDAQMTGKEKMVILCSPHNPGGRVWTQ
HHHHHHHHHHHCCHHHCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCEECH
DELTQVAAFCKRHDLMLISDEIHHDLVFGGRKHLPMAVAAPEISERLIMLTAPSKTFNFA
HHHHHHHHHHHHCCEEEEECHHHHHHHCCCCCCCCEEEECCCCCCCEEEEECCCCCCEEC
GLHTGQVIIPDETLREQFRRRMMAIYLQGNTAGEFATIAAYSPDGAAYVEELVPYIEANK
CCCCCEEEECCHHHHHHHHHHEEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
RLFDEAVNAIPGLQSMELQSTYLAWVDFSGTGMEREEFTRRVEQGARIAANHGTTFGTGG
HHHHHHHHHCCCCCCEEECCEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCC
ESFLRFNLGTQRARVEEACERLAKAFSDLQ
CCEEEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFDKIIDRRGTHCAKWDMMEPLYGVTPEDGLAMWVADTDFPVPEAVSAKMREMADHGIY
CCHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCE
GYVNCEAQYKSAIQWWMESRHGWSVDADAIFTTTGLVNGVGMCLDTFTQPGDGIVLFTPV
EEEECCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEECHH
YHAFAKVIRLAGREVVECPMVQEDGAYKMDFDAYDAQMTGKEKMVILCSPHNPGGRVWTQ
HHHHHHHHHHHCCHHHCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCCCEECH
DELTQVAAFCKRHDLMLISDEIHHDLVFGGRKHLPMAVAAPEISERLIMLTAPSKTFNFA
HHHHHHHHHHHHCCEEEEECHHHHHHHCCCCCCCCEEEECCCCCCCEEEEECCCCCCEEC
GLHTGQVIIPDETLREQFRRRMMAIYLQGNTAGEFATIAAYSPDGAAYVEELVPYIEANK
CCCCCEEEECCHHHHHHHHHHEEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
RLFDEAVNAIPGLQSMELQSTYLAWVDFSGTGMEREEFTRRVEQGARIAANHGTTFGTGG
HHHHHHHHHCCCCCCEEECCEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCC
ESFLRFNLGTQRARVEEACERLAKAFSDLQ
CCEEEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]