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The map label for this gene is folK [H]

Identifier: 99082407

GI number: 99082407

Start: 2709688

End: 2710257

Strand: Reverse

Name: folK [H]

Synonym: TM1040_2567

Alternate gene names: 99082407

Gene position: 2710257-2709688 (Counterclockwise)

Preceding gene: 99082415

Following gene: 99082406

Centisome position: 84.67

GC content: 55.09

Gene sequence:

>570_bases
ATGGCCGAAAACCGGTCAACTTATCTTGTGGCTATGGGAAGTAACCTCGAGGATGAGGGTACTATACCATTAGAAATCCT
GCAAATGTGCCTTGCGGAGTTATCGGGCGAAGGTTTCGACCTAGTGGCTGTTTCTCGTTTCTATGCAACGCCTTGCTTTC
CAGCGGGCGCCGGGCCTGATTATGTGAATGCGGCAATTGTATTGCGCGGCGCTTTTTCTGCGGACGAGACATTGCGCAGA
CTTCACAAAATCGAGACCAAGTTTCACCGCAGAAGGCAACAGCGCTGGGGCATGCGGACACTTGATCTAGATCTTTTGGC
TGTGGATCAGGAAATTGCGCCCGATATTCAGACGTTTAGCCATTGGCACTCGCTGCCTCAAAGCGAGCAGAGGACGAAAG
CACCCGAGCATTTGATTCTGCCGCACCCGCGTGTGCAGGACCGTGCGTTTGTGCTTGTGCCGCTTCGGGATATTGCCCCA
GACTGGGTGCATCCGGTTCTCGAGCTGAGCGTCCGGGAGATGCTGAAACGATGTCCGGCCTCTGATGTGGCCGAGGTGCG
CGCCCTCTGA

Upstream 100 bases:

>100_bases
CGTGAGTGAGTTAAATAAATCTCCGGCGCCGCGGGTGGACTTAATTTAGGTTATTTGGCACTCCCCGCAAGGGTCAGGTC
TTATGGAATTGGGGACAATC

Downstream 100 bases:

>100_bases
GAGAGGGGCGTTTTGTAGCATTCGTGCAATTGTGATCGTCTCCGACTTGTCAAGTCCCGTGATTCATCCTAGAAGCACTC
CCTCTGGACCCAGAACTGTA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MAENRSTYLVAMGSNLEDEGTIPLEILQMCLAELSGEGFDLVAVSRFYATPCFPAGAGPDYVNAAIVLRGAFSADETLRR
LHKIETKFHRRRQQRWGMRTLDLDLLAVDQEIAPDIQTFSHWHSLPQSEQRTKAPEHLILPHPRVQDRAFVLVPLRDIAP
DWVHPVLELSVREMLKRCPASDVAEVRAL

Sequences:

>Translated_189_residues
MAENRSTYLVAMGSNLEDEGTIPLEILQMCLAELSGEGFDLVAVSRFYATPCFPAGAGPDYVNAAIVLRGAFSADETLRR
LHKIETKFHRRRQQRWGMRTLDLDLLAVDQEIAPDIQTFSHWHSLPQSEQRTKAPEHLILPHPRVQDRAFVLVPLRDIAP
DWVHPVLELSVREMLKRCPASDVAEVRAL
>Mature_188_residues
AENRSTYLVAMGSNLEDEGTIPLEILQMCLAELSGEGFDLVAVSRFYATPCFPAGAGPDYVNAAIVLRGAFSADETLRRL
HKIETKFHRRRQQRWGMRTLDLDLLAVDQEIAPDIQTFSHWHSLPQSEQRTKAPEHLILPHPRVQDRAFVLVPLRDIAPD
WVHPVLELSVREMLKRCPASDVAEVRAL

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=168, Percent_Identity=34.5238095238095, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 21391; Mature: 21260

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENRSTYLVAMGSNLEDEGTIPLEILQMCLAELSGEGFDLVAVSRFYATPCFPAGAGPD
CCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCH
YVNAAIVLRGAFSADETLRRLHKIETKFHRRRQQRWGMRTLDLDLLAVDQEIAPDIQTFS
HHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHEECCHHHCCHHHHHH
HWHSLPQSEQRTKAPEHLILPHPRVQDRAFVLVPLRDIAPDWVHPVLELSVREMLKRCPA
HHHCCCCCHHHHCCCCCEECCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCC
SDVAEVRAL
CCHHHHHCC
>Mature Secondary Structure 
AENRSTYLVAMGSNLEDEGTIPLEILQMCLAELSGEGFDLVAVSRFYATPCFPAGAGPD
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCH
YVNAAIVLRGAFSADETLRRLHKIETKFHRRRQQRWGMRTLDLDLLAVDQEIAPDIQTFS
HHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHEECCHHHCCHHHHHH
HWHSLPQSEQRTKAPEHLILPHPRVQDRAFVLVPLRDIAPDWVHPVLELSVREMLKRCPA
HHHCCCCCHHHHCCCCCEECCCCCCCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHCCC
SDVAEVRAL
CCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]