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The map label for this gene is hvrB [H]

Identifier: 99082381

GI number: 99082381

Start: 2682482

End: 2683366

Strand: Reverse

Name: hvrB [H]

Synonym: TM1040_2541

Alternate gene names: 99082381

Gene position: 2683366-2682482 (Counterclockwise)

Preceding gene: 99082382

Following gene: 99082380

Centisome position: 83.83

GC content: 64.86

Gene sequence:

>885_bases
ATGAACTGGCGCGACATGCCCCCCTTGTCGGCCCTGAGGGCTTTTGCGGCCTTTGCGGAGACCGGCAACCTGCAACAGGC
AGGCGAGCAGCTGAACGTCAGCCACGCTGCCATCAGTCAGCAATTGCGCCACCTTGAGACGCATATGGGGGTGCCGCTTC
TGGACCGCTCTGGCCGCTCGCTGCGTCTGACGAGCGAGGGCGAGCAGCTAGCACAGGCGCTGGCGCTTGGGTTTGGCGCG
ATTCGCAGCGCCGTGCAGGACCTGACCTCACGCGGCGCAGGGCAGCCTCTGCATGTTACCTGCACGCCAATGTTTGCGAC
TCATTGGCTGATGCCACGGCTGGCGGGGTTCCGTCAGGCCTACCCCGATGTCGATCTGGTGATCGACCCCACCGGCGAAG
TGGTGCGTCTTGCCCCAGGTGGGATCGATATTGCCCTGCGCTATGGAACAGGCACATGGCCGGGGCTCGAGGCAGAGATG
CTGCTCGCTTCGCCGATGGTCGTGGTGGCTGCGCCGGGTCTCTTGGATAAACGCGCCGTCACAACGCCGGAGGACCTGCT
GGACCTGCCCTGGCTTGAGGAAATCGGCACCAATGAGGCGTCGGTCTGGCTGCGCTCCCGAGGCGTTCAAGATGGCGTTA
AGGCGGGGCGAGTCGTTTTGCCGGGCAACTTGTTGATGGAAGCGCTGCGCGCGGGGCAGGGGGTTGCGGTGTCGGTGCGT
GAATTCGTCGCGCTCGATGTGGCGGCGGGCCGCCTGACCGAGCTTTTCTGCGAAGAAAAGGGCCGTGGCTATCACATAGT
GCACCGCCCGTGCTTGCTGCGTCCGGGTGCGCGGCATTTCGTCAACTGGCTGCGGCGAGAGCGCGACTCTACGCCCTTGA
TCTGA

Upstream 100 bases:

>100_bases
CTTGATAGGGGCAGGGTGGAAGGAAACTGCGCTCATGCTTGCCCGAGTGCGCCTGATATGCGAGTCAGGAAGAAATTCAA
CGTGTAAGTAAGGCTTACAT

Downstream 100 bases:

>100_bases
CCGTACAGTTCTTGTGCGGCGCTCGCAGCGCCAGCGACAGATGGGCAAAATGCACATGCGAGATGCGATTTTTGATCCAC
GTCAAAGTCTCGACCGCTGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNWRDMPPLSALRAFAAFAETGNLQQAGEQLNVSHAAISQQLRHLETHMGVPLLDRSGRSLRLTSEGEQLAQALALGFGA
IRSAVQDLTSRGAGQPLHVTCTPMFATHWLMPRLAGFRQAYPDVDLVIDPTGEVVRLAPGGIDIALRYGTGTWPGLEAEM
LLASPMVVVAAPGLLDKRAVTTPEDLLDLPWLEEIGTNEASVWLRSRGVQDGVKAGRVVLPGNLLMEALRAGQGVAVSVR
EFVALDVAAGRLTELFCEEKGRGYHIVHRPCLLRPGARHFVNWLRRERDSTPLI

Sequences:

>Translated_294_residues
MNWRDMPPLSALRAFAAFAETGNLQQAGEQLNVSHAAISQQLRHLETHMGVPLLDRSGRSLRLTSEGEQLAQALALGFGA
IRSAVQDLTSRGAGQPLHVTCTPMFATHWLMPRLAGFRQAYPDVDLVIDPTGEVVRLAPGGIDIALRYGTGTWPGLEAEM
LLASPMVVVAAPGLLDKRAVTTPEDLLDLPWLEEIGTNEASVWLRSRGVQDGVKAGRVVLPGNLLMEALRAGQGVAVSVR
EFVALDVAAGRLTELFCEEKGRGYHIVHRPCLLRPGARHFVNWLRRERDSTPLI
>Mature_294_residues
MNWRDMPPLSALRAFAAFAETGNLQQAGEQLNVSHAAISQQLRHLETHMGVPLLDRSGRSLRLTSEGEQLAQALALGFGA
IRSAVQDLTSRGAGQPLHVTCTPMFATHWLMPRLAGFRQAYPDVDLVIDPTGEVVRLAPGGIDIALRYGTGTWPGLEAEM
LLASPMVVVAAPGLLDKRAVTTPEDLLDLPWLEEIGTNEASVWLRSRGVQDGVKAGRVVLPGNLLMEALRAGQGVAVSVR
EFVALDVAAGRLTELFCEEKGRGYHIVHRPCLLRPGARHFVNWLRRERDSTPLI

Specific function: Functions as a low-light activator of ahcY expression (gene for S-adenosyl-L-homocysteine hydrolase) and as a high-light activator of a uncharacterized 21.6 kDa protein in the ahcY-hvrB intergenic region (orf5). It is also a negative regulator of its own

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789173, Length=270, Percent_Identity=33.7037037037037, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786401, Length=258, Percent_Identity=29.8449612403101, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786448, Length=288, Percent_Identity=27.0833333333333, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788706, Length=296, Percent_Identity=25, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI157672245, Length=163, Percent_Identity=35.5828220858896, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87081978, Length=267, Percent_Identity=27.3408239700375, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788748, Length=176, Percent_Identity=28.4090909090909, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789639, Length=191, Percent_Identity=28.7958115183246, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790208, Length=180, Percent_Identity=29.4444444444444, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787589, Length=234, Percent_Identity=26.4957264957265, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787128, Length=257, Percent_Identity=24.5136186770428, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693193, Length=259, Percent_Identity=26.2548262548263, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789204, Length=253, Percent_Identity=28.4584980237154, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32010; Mature: 32010

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWRDMPPLSALRAFAAFAETGNLQQAGEQLNVSHAAISQQLRHLETHMGVPLLDRSGRS
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEECCCCCE
LRLTSEGEQLAQALALGFGAIRSAVQDLTSRGAGQPLHVTCTPMFATHWLMPRLAGFRQA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHH
YPDVDLVIDPTGEVVRLAPGGIDIALRYGTGTWPGLEAEMLLASPMVVVAAPGLLDKRAV
CCCCEEEECCCCCEEEECCCCEEEEEEECCCCCCCCCHHHHHHCCEEEEECCCCCCCCCC
TTPEDLLDLPWLEEIGTNEASVWLRSRGVQDGVKAGRVVLPGNLLMEALRAGQGVAVSVR
CCHHHHHCCCCHHHHCCCHHHHHHHHCCCHHHHHCCCEEECHHHHHHHHHCCCCCEEHHH
EFVALDVAAGRLTELFCEEKGRGYHIVHRPCLLRPGARHFVNWLRRERDSTPLI
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNWRDMPPLSALRAFAAFAETGNLQQAGEQLNVSHAAISQQLRHLETHMGVPLLDRSGRS
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEECCCCCE
LRLTSEGEQLAQALALGFGAIRSAVQDLTSRGAGQPLHVTCTPMFATHWLMPRLAGFRQA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHH
YPDVDLVIDPTGEVVRLAPGGIDIALRYGTGTWPGLEAEMLLASPMVVVAAPGLLDKRAV
CCCCEEEECCCCCEEEECCCCEEEEEEECCCCCCCCCHHHHHHCCEEEEECCCCCCCCCC
TTPEDLLDLPWLEEIGTNEASVWLRSRGVQDGVKAGRVVLPGNLLMEALRAGQGVAVSVR
CCHHHHHCCCCHHHHCCCHHHHHHHHCCCHHHHHCCCEEECHHHHHHHHHCCCCCEEHHH
EFVALDVAAGRLTELFCEEKGRGYHIVHRPCLLRPGARHFVNWLRRERDSTPLI
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8282711 [H]