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The map label for this gene is nhaA [H]

Identifier: 99082363

GI number: 99082363

Start: 2663516

End: 2664313

Strand: Reverse

Name: nhaA [H]

Synonym: TM1040_2523

Alternate gene names: 99082363

Gene position: 2664313-2663516 (Counterclockwise)

Preceding gene: 99082364

Following gene: 99082362

Centisome position: 83.24

GC content: 62.66

Gene sequence:

>798_bases
ATGAGTTTTCGATTGCCCTTCACAAAACGCCCGCCCCAAGTGGCGGTGGTGCGCCTGTCCGGAGCCATTGGCATGGCTGG
GCGCGGAAGCCTGAACGACTCCACGCTCGCTCCGGTCTTGGAACGCGCTTTTACGAAGGGCAAGCCGAAGGCCGTCGCCC
TTGAGATCAATTCCCCCGGCGGCAGCCCGGTGCAGAGCGCGCTGATCGGGGCGCGTATTCGCCGCTTGGCTGAGGAACGC
GACGTTCCTGTGATCGCTTTCGTCGAGGACGTGGCGGCCTCGGGCGGCTATTGGCTCGCTGCGGCTGCGGACGAGATCTA
TGCGGATGCGAGCTCGGTTGTTGGGTCGATCGGCGTGATTTCCGCGGGCTTTGGCGCGCATGTGTTCTTGGCGCGACAGG
GGCTGGAGCGCCGCGTGCACACTGCTGGCGAGAGCAAAAGCATGCTCGATCCTTTCCGCCCGGAAAACGAAGAGGATGTG
GCGCGCCTGAAGGGGCTGTTGAACGATATCCACGCTAATTTCATCGATCATGTGACCGACCGTCGGGGAGAGAAGCTCTC
CACCGAGGAAAAGCTCTTTACCGGAGAGATCTGGCTGGCGCGGCGCGCCAAGGAGCTCGGTTTGATCGACGGCATCGGCC
ATCTGAGGCCAGTTCTGCAAGAGCGGTTTGGGGACAAGGTGCGCCTGCGCCGCCACGGTATCAAAAAGCCCTTCCTGAGC
CGGTTTGGCCTGTCCATGGCCGAAGATGCGTTGGCAGCGGTTGAGGAGCGCGCCCAGTTTGCGCGTTTTGGCCTTTGA

Upstream 100 bases:

>100_bases
GTTGCATTTTTACCCGTTGCAGGGCCGCAAACGTAACAACGAAATAATTCCTCCCTCCCGATACCTTGTTTCCAAGGGGT
GGGCATTCTACATCGGCGCC

Downstream 100 bases:

>100_bases
CGTGATCCTCAAGATCGTCTCTCTGTTTCTGGTTGTCATGGCTGTCCTCGCCATGTTCGGGCGTTTGCGTTTTCCGGGAC
AAAAGAAACTCAATTCGGCT

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSFRLPFTKRPPQVAVVRLSGAIGMAGRGSLNDSTLAPVLERAFTKGKPKAVALEINSPGGSPVQSALIGARIRRLAEER
DVPVIAFVEDVAASGGYWLAAAADEIYADASSVVGSIGVISAGFGAHVFLARQGLERRVHTAGESKSMLDPFRPENEEDV
ARLKGLLNDIHANFIDHVTDRRGEKLSTEEKLFTGEIWLARRAKELGLIDGIGHLRPVLQERFGDKVRLRRHGIKKPFLS
RFGLSMAEDALAAVEERAQFARFGL

Sequences:

>Translated_265_residues
MSFRLPFTKRPPQVAVVRLSGAIGMAGRGSLNDSTLAPVLERAFTKGKPKAVALEINSPGGSPVQSALIGARIRRLAEER
DVPVIAFVEDVAASGGYWLAAAADEIYADASSVVGSIGVISAGFGAHVFLARQGLERRVHTAGESKSMLDPFRPENEEDV
ARLKGLLNDIHANFIDHVTDRRGEKLSTEEKLFTGEIWLARRAKELGLIDGIGHLRPVLQERFGDKVRLRRHGIKKPFLS
RFGLSMAEDALAAVEERAQFARFGL
>Mature_264_residues
SFRLPFTKRPPQVAVVRLSGAIGMAGRGSLNDSTLAPVLERAFTKGKPKAVALEINSPGGSPVQSALIGARIRRLAEERD
VPVIAFVEDVAASGGYWLAAAADEIYADASSVVGSIGVISAGFGAHVFLARQGLERRVHTAGESKSMLDPFRPENEEDVA
RLKGLLNDIHANFIDHVTDRRGEKLSTEEKLFTGEIWLARRAKELGLIDGIGHLRPVLQERFGDKVRLRRHGIKKPFLSR
FGLSMAEDALAAVEERAQFARFGL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=245, Percent_Identity=32.2448979591837, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788064, Length=209, Percent_Identity=31.1004784688995, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 28818; Mature: 28687

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFRLPFTKRPPQVAVVRLSGAIGMAGRGSLNDSTLAPVLERAFTKGKPKAVALEINSPG
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCC
GSPVQSALIGARIRRLAEERDVPVIAFVEDVAASGGYWLAAAADEIYADASSVVGSIGVI
CCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHH
SAGFGAHVFLARQGLERRVHTAGESKSMLDPFRPENEEDVARLKGLLNDIHANFIDHVTD
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RRGEKLSTEEKLFTGEIWLARRAKELGLIDGIGHLRPVLQERFGDKVRLRRHGIKKPFLS
HCCCCCCCHHHHHHHHHHHHHHHHHHCHHHCHHHHHHHHHHHCCCHHHHHHHCCCHHHHH
RFGLSMAEDALAAVEERAQFARFGL
HHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFRLPFTKRPPQVAVVRLSGAIGMAGRGSLNDSTLAPVLERAFTKGKPKAVALEINSPG
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCC
GSPVQSALIGARIRRLAEERDVPVIAFVEDVAASGGYWLAAAADEIYADASSVVGSIGVI
CCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHH
SAGFGAHVFLARQGLERRVHTAGESKSMLDPFRPENEEDVARLKGLLNDIHANFIDHVTD
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RRGEKLSTEEKLFTGEIWLARRAKELGLIDGIGHLRPVLQERFGDKVRLRRHGIKKPFLS
HCCCCCCCHHHHHHHHHHHHHHHHHHCHHHCHHHHHHHHHHHCCCHHHHHHHCCCHHHHH
RFGLSMAEDALAAVEERAQFARFGL
HHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA