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The map label for this gene is ilvD

Identifier: 99082326

GI number: 99082326

Start: 2625094

End: 2626938

Strand: Direct

Name: ilvD

Synonym: TM1040_2486

Alternate gene names: 99082326

Gene position: 2625094-2626938 (Clockwise)

Preceding gene: 99082325

Following gene: 99082328

Centisome position: 82.01

GC content: 60.98

Gene sequence:

>1845_bases
ATGCCGATGTACCGATCAAGAACCTCCACCCACGGTCGCAACATGGCCGGCGCTCGTGGCCTCTGGCGCGCCACTGGCAT
GACCGAAAGCGACTTCGGCAAGCCGATCATCGCCATCGTGAACTCCTTCACCCAATTCGTCCCCGGCCACGTTCACCTCA
AGGATCTGGGGCAGATGGTGGCCCGTGAGGTTGAGTCCGCTGGCGGTGTGGCCAAGGAGTTCAACACCATCGCTGTGGAC
GACGGCATCGCCATGGGCCACGATGGCATGCTCTATTCGCTCCCCTCGCGCGAGGTGATCGCGGATTCGGTTGAGTATAT
GGTCAACGCCCATTGCGCCGACGCGATGGTCTGTATCTCCAACTGCGACAAGATCACCCCCGGCATGATGATGGCCGCAA
TGCGCCTCAACATCCCGGTGATCTTTGTGTCCGGTGGCCCGATGGAAGCGGGCAAGATCGACATCGACTCCCTTGATGCC
AAGAAAATCGACCTCGTGGACGCAATGGTTGCCGCCGCAAGCGACAAGCTGACCGACGAGGAAGTCCAGCACATCGAGGA
AAACGCCTGCCCCACATGTGGCTCCTGCTCTGGCATGTTCACCGCAAACTCGATGAACTGTCTGGCCGAAGCCCTTGGGC
TTGCGCTGCCCGGCAATGGCTCCACCCTGGCCACCCACTCGGATCGCAAGCAATTGTTCCTCGAGGCGGGGCGCAAGATC
GTCGAGATCACCAAGCGCCACTATGAGCAGAACGAAAAAGGCCTGCTGCCGCGCGAAATCGCCACCTTTGAGGCGTTTGA
GAACGCCATGAGCCTTGATATTGCCATGGGCGGCTCCACCAATACCGTTTTGCACCTCCTCGCCATCGCGCATGAGGGCA
AGGTAGACTTCACCATGCAAGACATCGACCGGCTGAGCCGCAAGGTGCCCTGCCTGTGTAAAGTCGCGCCCAATATCGAG
AACGTCCATATGGAGGACGTTCACCGCGCCGGTGGGATCTTCTCGATCCTCGGGGAGCTGTCCCGTGCAGGCCTCCTGCA
CAATGACGTCCCGACGGTCCACAGCGACAGCATGGGTGAAGCCATCGCCCATTGGGACATCGCTGTGGCGGACAACCAAG
CGGCGAAGGACCTCTTCAAGGCCGCTCCCGGCGGAGTGCGTACGACGCAGGCCTTCAGCCAGTCCAACCGCTTCAAGGAT
CTCGACATCGACCGCAAGGGCGGCGTTATCCGCTCCAAGGAACATGCCTTCAGCCAGGACGGCGGCCTCGCGGTGCTCTT
TGGGAATATCGCACTGGATGGCTGCATCGTGAAAACGGCGGGCGTGGACGCCTCGATCCTGAAGTTCACCGGCAAAGCCT
ATGTCTGCGAGAGCCAGGACCAGGCCGTCAATGATATCCTCACCGGCAAAGTTCAGGCGGGCGATGTAGTTGTCATCCGC
TATGAGGGGCCGCGCGGGGGACCGGGCATGCAGGAAATGCTCTACCCAACGTCCTACCTCAAATCCAAGGGGCTCGGAAA
AGACTGTGCTCTGTTGACCGATGGGCGTTTCTCCGGCGGCACGTCGGGGCTTTCCATTGGCCACGTCTCGCCCGAAGCCG
CCGAAGGTGGCACCATCGGCCTCGTGGAGCATGGCGACACCATCGAGATCGATATCCCCAACCGTTCCATCCATCTGGCG
GTGGATGAGGCCACCCTTGCAGCGCGCCGCGCCGCGCAGGATGAGAAAGGCTGGAAACCTGTTGCCAAGCGTAAACGCAA
GGTATCAACCGCGCTCAAGGCTTACGCCTTGCTGGCCACATCTGCAGCCAAAGGCGCTGTGCGCCAACTGCCAGACGACG
AGTAA

Upstream 100 bases:

>100_bases
GCGGCCCCTTGAGTAATTTCGTGACCACAAACCGCCCCGACATGTTGCCTTTACTGCGCGAATAGTGTCCCTGTGGGCAA
AAATATAGGGAACCAGCAAT

Downstream 100 bases:

>100_bases
TCAACGCGGTTGATCGCAACGCAAAGGCCCCTCAAGCGCAAGGCTGAGGGGCCTTTTTTACCTTCGGAGTCAGCGCCACG
GGTCACGGGCCGCAGAGCCG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 614; Mature: 613

Protein sequence:

>614_residues
MPMYRSRTSTHGRNMAGARGLWRATGMTESDFGKPIIAIVNSFTQFVPGHVHLKDLGQMVAREVESAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREVIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKIDIDSLDA
KKIDLVDAMVAAASDKLTDEEVQHIEENACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHSDRKQLFLEAGRKI
VEITKRHYEQNEKGLLPREIATFEAFENAMSLDIAMGGSTNTVLHLLAIAHEGKVDFTMQDIDRLSRKVPCLCKVAPNIE
NVHMEDVHRAGGIFSILGELSRAGLLHNDVPTVHSDSMGEAIAHWDIAVADNQAAKDLFKAAPGGVRTTQAFSQSNRFKD
LDIDRKGGVIRSKEHAFSQDGGLAVLFGNIALDGCIVKTAGVDASILKFTGKAYVCESQDQAVNDILTGKVQAGDVVVIR
YEGPRGGPGMQEMLYPTSYLKSKGLGKDCALLTDGRFSGGTSGLSIGHVSPEAAEGGTIGLVEHGDTIEIDIPNRSIHLA
VDEATLAARRAAQDEKGWKPVAKRKRKVSTALKAYALLATSAAKGAVRQLPDDE

Sequences:

>Translated_614_residues
MPMYRSRTSTHGRNMAGARGLWRATGMTESDFGKPIIAIVNSFTQFVPGHVHLKDLGQMVAREVESAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREVIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKIDIDSLDA
KKIDLVDAMVAAASDKLTDEEVQHIEENACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHSDRKQLFLEAGRKI
VEITKRHYEQNEKGLLPREIATFEAFENAMSLDIAMGGSTNTVLHLLAIAHEGKVDFTMQDIDRLSRKVPCLCKVAPNIE
NVHMEDVHRAGGIFSILGELSRAGLLHNDVPTVHSDSMGEAIAHWDIAVADNQAAKDLFKAAPGGVRTTQAFSQSNRFKD
LDIDRKGGVIRSKEHAFSQDGGLAVLFGNIALDGCIVKTAGVDASILKFTGKAYVCESQDQAVNDILTGKVQAGDVVVIR
YEGPRGGPGMQEMLYPTSYLKSKGLGKDCALLTDGRFSGGTSGLSIGHVSPEAAEGGTIGLVEHGDTIEIDIPNRSIHLA
VDEATLAARRAAQDEKGWKPVAKRKRKVSTALKAYALLATSAAKGAVRQLPDDE
>Mature_613_residues
PMYRSRTSTHGRNMAGARGLWRATGMTESDFGKPIIAIVNSFTQFVPGHVHLKDLGQMVAREVESAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSREVIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKIDIDSLDAK
KIDLVDAMVAAASDKLTDEEVQHIEENACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHSDRKQLFLEAGRKIV
EITKRHYEQNEKGLLPREIATFEAFENAMSLDIAMGGSTNTVLHLLAIAHEGKVDFTMQDIDRLSRKVPCLCKVAPNIEN
VHMEDVHRAGGIFSILGELSRAGLLHNDVPTVHSDSMGEAIAHWDIAVADNQAAKDLFKAAPGGVRTTQAFSQSNRFKDL
DIDRKGGVIRSKEHAFSQDGGLAVLFGNIALDGCIVKTAGVDASILKFTGKAYVCESQDQAVNDILTGKVQAGDVVVIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKDCALLTDGRFSGGTSGLSIGHVSPEAAEGGTIGLVEHGDTIEIDIPNRSIHLAV
DEATLAARRAAQDEKGWKPVAKRKRKVSTALKAYALLATSAAKGAVRQLPDDE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=611, Percent_Identity=72.6677577741408, Blast_Score=915, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=502, Percent_Identity=32.6693227091633, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786464, Length=569, Percent_Identity=32.1616871704745, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1788157, Length=538, Percent_Identity=29.9256505576208, Blast_Score=192, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6322476, Length=604, Percent_Identity=38.5761589403974, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_SILST (Q1GDP8)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614480.1
- STRING:   Q1GDP8
- GeneID:   4076851
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2486
- NMPDR:   fig|292414.1.peg.795
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   Q1GDP8
- ProtClustDB:   PRK12448
- BioCyc:   SSP292414:TM1040_2486-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65523; Mature: 65391

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMYRSRTSTHGRNMAGARGLWRATGMTESDFGKPIIAIVNSFTQFVPGHVHLKDLGQMV
CCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREVESAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREVIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKIDIDSLDAKKIDLVDAMVAAASDKLTDE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCHH
EVQHIEENACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHSDRKQLFLEAGRKI
HHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEECCHHHHHHHHHCHHH
VEITKRHYEQNEKGLLPREIATFEAFENAMSLDIAMGGSTNTVLHLLAIAHEGKVDFTMQ
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCCEEEHH
DIDRLSRKVPCLCKVAPNIENVHMEDVHRAGGIFSILGELSRAGLLHNDVPTVHSDSMGE
HHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
AIAHWDIAVADNQAAKDLFKAAPGGVRTTQAFSQSNRFKDLDIDRKGGVIRSKEHAFSQD
HHHHEEEEECCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECHHHCCCCC
GGLAVLFGNIALDGCIVKTAGVDASILKFTGKAYVCESQDQAVNDILTGKVQAGDVVVIR
CCEEEEEECEEECCEEEEECCCCHHHHEECCCEEEECCCHHHHHHHHCCCEECCCEEEEE
YEGPRGGPGMQEMLYPTSYLKSKGLGKDCALLTDGRFSGGTSGLSIGHVSPEAAEGGTIG
ECCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEE
LVEHGDTIEIDIPNRSIHLAVDEATLAARRAAQDEKGWKPVAKRKRKVSTALKAYALLAT
EEECCCEEEEEECCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SAAKGAVRQLPDDE
HHHHHHHHCCCCCC
>Mature Secondary Structure 
PMYRSRTSTHGRNMAGARGLWRATGMTESDFGKPIIAIVNSFTQFVPGHVHLKDLGQMV
CCCCCCCCCCCCCCCCCCCHHHCCCCCHHHCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREVESAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREVIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKIDIDSLDAKKIDLVDAMVAAASDKLTDE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCHH
EVQHIEENACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHSDRKQLFLEAGRKI
HHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEECCHHHHHHHHHCHHH
VEITKRHYEQNEKGLLPREIATFEAFENAMSLDIAMGGSTNTVLHLLAIAHEGKVDFTMQ
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCCEEEHH
DIDRLSRKVPCLCKVAPNIENVHMEDVHRAGGIFSILGELSRAGLLHNDVPTVHSDSMGE
HHHHHHHCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
AIAHWDIAVADNQAAKDLFKAAPGGVRTTQAFSQSNRFKDLDIDRKGGVIRSKEHAFSQD
HHHHEEEEECCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECHHHCCCCC
GGLAVLFGNIALDGCIVKTAGVDASILKFTGKAYVCESQDQAVNDILTGKVQAGDVVVIR
CCEEEEEECEEECCEEEEECCCCHHHHEECCCEEEECCCHHHHHHHHCCCEECCCEEEEE
YEGPRGGPGMQEMLYPTSYLKSKGLGKDCALLTDGRFSGGTSGLSIGHVSPEAAEGGTIG
ECCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEE
LVEHGDTIEIDIPNRSIHLAVDEATLAARRAAQDEKGWKPVAKRKRKVSTALKAYALLAT
EEECCCEEEEEECCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SAAKGAVRQLPDDE
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA