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The map label for this gene is parC [H]

Identifier: 99082272

GI number: 99082272

Start: 2571061

End: 2573409

Strand: Direct

Name: parC [H]

Synonym: TM1040_2432

Alternate gene names: 99082272

Gene position: 2571061-2573409 (Clockwise)

Preceding gene: 99082265

Following gene: 99082273

Centisome position: 80.32

GC content: 59.94

Gene sequence:

>2349_bases
ATGACCGACATCGTTGATGATCCCACTTCCCCCGAGATGCCCGCAAATGGCGAATTGCGCGAACCTTTGCGCCGCGCCAT
TGGCGAACGATATCTGACCTATGCGCTTAGCACGATCATGCACCGGGCCTTGCCCGATGCGCGTGACGGCCTGAAGCCTG
TGCACCGGCGCATCCTTTACGCCATGAGCCGATTGCGCCTGTCGTCATCGGGCGGTTTTTTGAAATCGGCCAAGATTTCT
GGCGACACGATGGGGGATTTCCACCCCCATGGGGACGCGGCGATTTACGACGCCATGGCGCGTCTGGCGCAGGATTTTGC
GGTGCGCTATCCGCTGGTTGATGGTCAAGGTAACTTTGGCAACATCGACGGCGACAACCCTGCGGCCTCGCGCTACACCG
AGGCGCGGATGACCTTCATCGCCGAAGCGATGCTCGAAGGGCTGGGCGAGGACGCGGTAGATTTTCGCGATAATTACGAT
GGCCGCCTGCAAGAACCGAGTGTCCTGCCTGCGACTTTCCCGAATATTCTCGCCAATGGCGCCAGCGGTATCGCAGTGGG
GATGGCCACCAATATTCCCCCGCATAACATATCCGAACTGATCGACGCCTGTGTCCACCTGATCAAAGCGCCCAATGCTG
CTGATGACACGCTGCTTCAGTATGTGCCCGGACCGGATTTTCCCACCGGCGGCACCATTGTAGAGCCGAAAGAGAACATC
GCGCAGGCCTATCGCACAGGGCGTGGCTCGTTCCGGTTGCGAGCCAAGCACGAGATCGAGGATCTGGGTCGGGGCCAGTG
GCAGGTTGTTGTCACCGAAATCCCTTATCAGGTGCAGAAATCCAAGCTCATCGAGAAAATCGCAGAGCTGATCCAAACCA
AGAAAGTGCCGATTCTCGCGGATGTGCGCGATGAAAGCGCCGAAGACATCCGCATTATCCTCGAACCCAAGTCCAAGAAC
GTCGACCCGGAGGTTCTGATGGGTCTGATGCATCGCAACTCCGATCTGGAGGTGCGATTCTCACTCAACATGAACGTGCT
GATCGACGGCGTGACGCCCAAGGTCTGCTCGATGAAGGAGGTGCTGCGCGCCTTTCTGGATCATCGCCGCGATGTGCTTC
AGCGCCGTTCGCGCCACCGGATGGCAAAGATCGACCACCGGCTTGAAGTGCTCGATGGTTTCATCATCGCGTTTTTGAAC
CTCGACCGGGTGATCGACATCATCCGCTATGACGAGGACCCCAAAGCCGCGCTGATGCGCGAAAACTGGGATCGCGAACA
CCCCCGCGCCTTTACCGAGGCCGAGTATGTCACGCCTGCCGCAGGTGACGGCGAACTCTCCGAGGTGCAAGCTGAGGCGA
TCCTGAACATGCGTCTGCGCAGCCTGCGCAAGCTCGAAGAGATCGAACTCACCCGCGAGCGTGACGCCCTGCGCGAAGAA
CGTGCGGGCCTCGTGGAACTTCTGGGCAGCGAAGAGCTGCAGTGGAAGAAGATCACCGAGCAGCTGCGCGAGACCAAGAA
GCAGTTCGGCAAAAACTATGAAGGCGGCGCACGGCGGACGCAATTTGCCGAAGCGGGTGAAATCGAGGACGTGCCGCTCG
AGGCCATGATCGACCGAGAACCGATCACCGTGGTCTGCTCGCAGATGGGCTGGATTCGCGCGATGACTGGCCATATCGAC
CTCAGTCGTGAGCTGAAGTTCAAAGACGGCGACGGGCCGCGTTTTATCTTCCACGCGGAGACCACGGACCGGCTGTTGGT
CTTTGGTTCAAATGGGCGGTTTTATACGCTCTCGGCCGCGAACCTTCCCGGCGGGCGCGGCATGGGGGAACCTGTGCGCC
TGATGGTCGATCTGCCCAACGAGGTCGAGATTGTCGATCTCTTCATTCACAACCCCGAGGGTCGGCTTCTGGTGGCATCG
GATGCGGGCAACGGGTTTGTCTGCGCCGAGAAAGACATCGTCGCCCAGACCCGAGGCGGCAAGCAGGTGCTGAACGTCAA
GGATGACGAGCGGGCCAAGATCTGTATCCCCGTCGCCGGGGATCACGTCGCGGTGGTCTCGGAGAATGGCAAGTTTCTCG
TCTTTGCGATCGAAGAGATGCCCGAACTCACACGCGGCAAGGGTGTGCGCCTGCAGAAATACAACATGGCGCGCGGGCGC
CAGGGCGCGCTCGAACTTGATGGTGGGCTGGCGGATGTCACCACCTTCAACTGGGACGAAGGGCTGCACTGGGAGATGGG
TGGTGGCAAAATTCGTCACGAGACCGACCTCACCCAGTGGCTGGGCAAGCGCGCGGGCATCGGCAAGCGCCCCCCCTACG
GCTTCCCCAAGGACTACAAATTCAAATAG

Upstream 100 bases:

>100_bases
CCTGTCAATTCAAGGCATGAACGCCACGCCAAGGCGCTCTTCTGTGGAAAACCAGCGTTGCCCGCTTGCCGCCTGACGAG
GGGGGAAGTATCAGAATTAA

Downstream 100 bases:

>100_bases
CGGCAATATATTGCCGGAAAACATGTGGCCCCCGCGCAACCGCGCGAGGGTTCGCTTTTGTGCGGGTTTACCGGAAGGGA
AATCCCGGTCTATCACTTGG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 782; Mature: 781

Protein sequence:

>782_residues
MTDIVDDPTSPEMPANGELREPLRRAIGERYLTYALSTIMHRALPDARDGLKPVHRRILYAMSRLRLSSSGGFLKSAKIS
GDTMGDFHPHGDAAIYDAMARLAQDFAVRYPLVDGQGNFGNIDGDNPAASRYTEARMTFIAEAMLEGLGEDAVDFRDNYD
GRLQEPSVLPATFPNILANGASGIAVGMATNIPPHNISELIDACVHLIKAPNAADDTLLQYVPGPDFPTGGTIVEPKENI
AQAYRTGRGSFRLRAKHEIEDLGRGQWQVVVTEIPYQVQKSKLIEKIAELIQTKKVPILADVRDESAEDIRIILEPKSKN
VDPEVLMGLMHRNSDLEVRFSLNMNVLIDGVTPKVCSMKEVLRAFLDHRRDVLQRRSRHRMAKIDHRLEVLDGFIIAFLN
LDRVIDIIRYDEDPKAALMRENWDREHPRAFTEAEYVTPAAGDGELSEVQAEAILNMRLRSLRKLEEIELTRERDALREE
RAGLVELLGSEELQWKKITEQLRETKKQFGKNYEGGARRTQFAEAGEIEDVPLEAMIDREPITVVCSQMGWIRAMTGHID
LSRELKFKDGDGPRFIFHAETTDRLLVFGSNGRFYTLSAANLPGGRGMGEPVRLMVDLPNEVEIVDLFIHNPEGRLLVAS
DAGNGFVCAEKDIVAQTRGGKQVLNVKDDERAKICIPVAGDHVAVVSENGKFLVFAIEEMPELTRGKGVRLQKYNMARGR
QGALELDGGLADVTTFNWDEGLHWEMGGGKIRHETDLTQWLGKRAGIGKRPPYGFPKDYKFK

Sequences:

>Translated_782_residues
MTDIVDDPTSPEMPANGELREPLRRAIGERYLTYALSTIMHRALPDARDGLKPVHRRILYAMSRLRLSSSGGFLKSAKIS
GDTMGDFHPHGDAAIYDAMARLAQDFAVRYPLVDGQGNFGNIDGDNPAASRYTEARMTFIAEAMLEGLGEDAVDFRDNYD
GRLQEPSVLPATFPNILANGASGIAVGMATNIPPHNISELIDACVHLIKAPNAADDTLLQYVPGPDFPTGGTIVEPKENI
AQAYRTGRGSFRLRAKHEIEDLGRGQWQVVVTEIPYQVQKSKLIEKIAELIQTKKVPILADVRDESAEDIRIILEPKSKN
VDPEVLMGLMHRNSDLEVRFSLNMNVLIDGVTPKVCSMKEVLRAFLDHRRDVLQRRSRHRMAKIDHRLEVLDGFIIAFLN
LDRVIDIIRYDEDPKAALMRENWDREHPRAFTEAEYVTPAAGDGELSEVQAEAILNMRLRSLRKLEEIELTRERDALREE
RAGLVELLGSEELQWKKITEQLRETKKQFGKNYEGGARRTQFAEAGEIEDVPLEAMIDREPITVVCSQMGWIRAMTGHID
LSRELKFKDGDGPRFIFHAETTDRLLVFGSNGRFYTLSAANLPGGRGMGEPVRLMVDLPNEVEIVDLFIHNPEGRLLVAS
DAGNGFVCAEKDIVAQTRGGKQVLNVKDDERAKICIPVAGDHVAVVSENGKFLVFAIEEMPELTRGKGVRLQKYNMARGR
QGALELDGGLADVTTFNWDEGLHWEMGGGKIRHETDLTQWLGKRAGIGKRPPYGFPKDYKFK
>Mature_781_residues
TDIVDDPTSPEMPANGELREPLRRAIGERYLTYALSTIMHRALPDARDGLKPVHRRILYAMSRLRLSSSGGFLKSAKISG
DTMGDFHPHGDAAIYDAMARLAQDFAVRYPLVDGQGNFGNIDGDNPAASRYTEARMTFIAEAMLEGLGEDAVDFRDNYDG
RLQEPSVLPATFPNILANGASGIAVGMATNIPPHNISELIDACVHLIKAPNAADDTLLQYVPGPDFPTGGTIVEPKENIA
QAYRTGRGSFRLRAKHEIEDLGRGQWQVVVTEIPYQVQKSKLIEKIAELIQTKKVPILADVRDESAEDIRIILEPKSKNV
DPEVLMGLMHRNSDLEVRFSLNMNVLIDGVTPKVCSMKEVLRAFLDHRRDVLQRRSRHRMAKIDHRLEVLDGFIIAFLNL
DRVIDIIRYDEDPKAALMRENWDREHPRAFTEAEYVTPAAGDGELSEVQAEAILNMRLRSLRKLEEIELTRERDALREER
AGLVELLGSEELQWKKITEQLRETKKQFGKNYEGGARRTQFAEAGEIEDVPLEAMIDREPITVVCSQMGWIRAMTGHIDL
SRELKFKDGDGPRFIFHAETTDRLLVFGSNGRFYTLSAANLPGGRGMGEPVRLMVDLPNEVEIVDLFIHNPEGRLLVASD
AGNGFVCAEKDIVAQTRGGKQVLNVKDDERAKICIPVAGDHVAVVSENGKFLVFAIEEMPELTRGKGVRLQKYNMARGRQ
GALELDGGLADVTTFNWDEGLHWEMGGGKIRHETDLTQWLGKRAGIGKRPPYGFPKDYKFK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=476, Percent_Identity=23.109243697479, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1789396, Length=730, Percent_Identity=38.6301369863014, Blast_Score=501, Evalue=1e-142,
Organism=Escherichia coli, GI1788562, Length=718, Percent_Identity=38.4401114206128, Blast_Score=439, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI212645845, Length=368, Percent_Identity=26.3586956521739, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=510, Percent_Identity=22.156862745098, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=410, Percent_Identity=22.1951219512195, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=407, Percent_Identity=25.0614250614251, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 87506; Mature: 87375

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIVDDPTSPEMPANGELREPLRRAIGERYLTYALSTIMHRALPDARDGLKPVHRRILY
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
AMSRLRLSSSGGFLKSAKISGDTMGDFHPHGDAAIYDAMARLAQDFAVRYPLVDGQGNFG
HHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCC
NIDGDNPAASRYTEARMTFIAEAMLEGLGEDAVDFRDNYDGRLQEPSVLPATFPNILANG
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHCC
ASGIAVGMATNIPPHNISELIDACVHLIKAPNAADDTLLQYVPGPDFPTGGTIVEPKENI
CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHEECCCCCCCCCCEEECCHHHH
AQAYRTGRGSFRLRAKHEIEDLGRGQWQVVVTEIPYQVQKSKLIEKIAELIQTKKVPILA
HHHHHCCCCCEEEEECCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEE
DVRDESAEDIRIILEPKSKNVDPEVLMGLMHRNSDLEVRFSLNMNVLIDGVTPKVCSMKE
ECCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEECCEEEEECCCCCHHHHHH
VLRAFLDHRRDVLQRRSRHRMAKIDHRLEVLDGFIIAFLNLDRVIDIIRYDEDPKAALMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ENWDREHPRAFTEAEYVTPAAGDGELSEVQAEAILNMRLRSLRKLEEIELTRERDALREE
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAGLVELLGSEELQWKKITEQLRETKKQFGKNYEGGARRTQFAEAGEIEDVPLEAMIDRE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHCCCC
PITVVCSQMGWIRAMTGHIDLSRELKFKDGDGPRFIFHAETTDRLLVFGSNGRFYTLSAA
CHHHHHHHCCHHEEECCCEEECEEEEEECCCCCEEEEEECCCCEEEEEECCCCEEEEEEC
NLPGGRGMGEPVRLMVDLPNEVEIVDLFIHNPEGRLLVASDAGNGFVCAEKDIVAQTRGG
CCCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCEEEEECCCCCEEEECCHHHHCCCCC
KQVLNVKDDERAKICIPVAGDHVAVVSENGKFLVFAIEEMPELTRGKGVRLQKYNMARGR
CEEECCCCCCCCEEEEEECCCEEEEEECCCCEEEEEHHHCCHHHCCCCCEEEEECCCCCC
QGALELDGGLADVTTFNWDEGLHWEMGGGKIRHETDLTQWLGKRAGIGKRPPYGFPKDYK
CCCEEECCCEEEEEEECCCCCCEEECCCCEEECHHHHHHHHHHHCCCCCCCCCCCCCCCC
FK
CC
>Mature Secondary Structure 
TDIVDDPTSPEMPANGELREPLRRAIGERYLTYALSTIMHRALPDARDGLKPVHRRILY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
AMSRLRLSSSGGFLKSAKISGDTMGDFHPHGDAAIYDAMARLAQDFAVRYPLVDGQGNFG
HHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCC
NIDGDNPAASRYTEARMTFIAEAMLEGLGEDAVDFRDNYDGRLQEPSVLPATFPNILANG
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHCC
ASGIAVGMATNIPPHNISELIDACVHLIKAPNAADDTLLQYVPGPDFPTGGTIVEPKENI
CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHHHEECCCCCCCCCCEEECCHHHH
AQAYRTGRGSFRLRAKHEIEDLGRGQWQVVVTEIPYQVQKSKLIEKIAELIQTKKVPILA
HHHHHCCCCCEEEEECCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEE
DVRDESAEDIRIILEPKSKNVDPEVLMGLMHRNSDLEVRFSLNMNVLIDGVTPKVCSMKE
ECCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEECCEEEEECCCCCHHHHHH
VLRAFLDHRRDVLQRRSRHRMAKIDHRLEVLDGFIIAFLNLDRVIDIIRYDEDPKAALMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ENWDREHPRAFTEAEYVTPAAGDGELSEVQAEAILNMRLRSLRKLEEIELTRERDALREE
HCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAGLVELLGSEELQWKKITEQLRETKKQFGKNYEGGARRTQFAEAGEIEDVPLEAMIDRE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHCCCC
PITVVCSQMGWIRAMTGHIDLSRELKFKDGDGPRFIFHAETTDRLLVFGSNGRFYTLSAA
CHHHHHHHCCHHEEECCCEEECEEEEEECCCCCEEEEEECCCCEEEEEECCCCEEEEEEC
NLPGGRGMGEPVRLMVDLPNEVEIVDLFIHNPEGRLLVASDAGNGFVCAEKDIVAQTRGG
CCCCCCCCCCCEEEEEECCCCEEEEEEEEECCCCCEEEEECCCCCEEEECCHHHHCCCCC
KQVLNVKDDERAKICIPVAGDHVAVVSENGKFLVFAIEEMPELTRGKGVRLQKYNMARGR
CEEECCCCCCCCEEEEEECCCEEEEEECCCCEEEEEHHHCCHHHCCCCCEEEEECCCCCC
QGALELDGGLADVTTFNWDEGLHWEMGGGKIRHETDLTQWLGKRAGIGKRPPYGFPKDYK
CCCEEECCCEEEEEEECCCCCCEEECCCCEEECHHHHHHHHHHHCCCCCCCCCCCCCCCC
FK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]