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The map label for this gene is hbdA [H]

Identifier: 99082264

GI number: 99082264

Start: 2564427

End: 2565302

Strand: Reverse

Name: hbdA [H]

Synonym: TM1040_2424

Alternate gene names: 99082264

Gene position: 2565302-2564427 (Counterclockwise)

Preceding gene: 99082266

Following gene: 99082255

Centisome position: 80.14

GC content: 56.96

Gene sequence:

>876_bases
ATGGACGTGAAAAAAGTCGGAATTATTGGTGCAGGTCAGATGGGCAACGGTATCGCTCACGTCATGGCCCTGGCTGGATT
TGATGTTGTTCTCAACGACATAAGCCAACAAGCACTCGACAGCGCTCTGTCCCTGATCCAGAAGAACCTTGCCCGACAGG
CCAGCAAGGGCAAGATTGCCGACGCCGAGGTCGCCGCAGCCATGGGGCGGATTTCCACCAGCCTGACACTGGCGGATGTG
GGCAAGACCGATTTGGTGATCGAGGCCGCCACCGAGCGCGAAACCGTGAAGCAGGCGATCTTTGAGGATCTGCTGCCGCA
TCTGGAACCCCATACGATTCTAACGTCCAACACCTCGTCGATTTCGATCACGCGTCTGGCGAGCCGCACCGATCGGCCCG
AGCGTTTCATGGGGTTCCACTTCATGAATCCGGTACCGGTCATGCAACTCGTGGAACTCATTCGCGGCATCGCGACGGAT
GAGGAGACGTTCCAGACCTGTCAAACCGTGGTGGAAAAGCTGGGTAAAACAGCGGCAAGCGCCGAGGATTTCCCTGCCTT
TATCGTCAACCGCATCCTGATGCCGATGATCAACGAGGCGGTATACACGCTTTATGAGGGCGTGGGCAGCGTGCGTTCGA
TTGACGAGTCGATGAAGCTTGGCGCCAATCACCCGATGGGTCCGCTAGAGCTTGCAGATTTCATCGGTTTGGATACCTGT
CTTGCAATCATGAACGTCTTGCATGACGGGCTTGCGGATACAAAGTATCGCCCTTGCCCGCTGCTGACAAAATATGTCGA
GGCCGGCTGGCTGGGGCGTAAAACCCAGCGCGGATTCTACGACTACCGTGGCGAGGTTCCCGTTCCCACACGCTGA

Upstream 100 bases:

>100_bases
ATTTGCTGAAAACTGAGGCAATCGGCCTTGTTTCTGCGGACGCGAAGCCTTTAGTATCCGCCCGCAGGCATTGGGCAGGC
GCAAGGAAAGGCCATTCATC

Downstream 100 bases:

>100_bases
AGGCAGGGGCAGGTACAATTGCCCAGCCTGAACGCGATGGGCAAAGCCTCGATCCGGATAGGGTGGGGCTTGGGGTCTTT
TAGCGACCTGCGGGGATCAA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MDVKKVGIIGAGQMGNGIAHVMALAGFDVVLNDISQQALDSALSLIQKNLARQASKGKIADAEVAAAMGRISTSLTLADV
GKTDLVIEAATERETVKQAIFEDLLPHLEPHTILTSNTSSISITRLASRTDRPERFMGFHFMNPVPVMQLVELIRGIATD
EETFQTCQTVVEKLGKTAASAEDFPAFIVNRILMPMINEAVYTLYEGVGSVRSIDESMKLGANHPMGPLELADFIGLDTC
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKTQRGFYDYRGEVPVPTR

Sequences:

>Translated_291_residues
MDVKKVGIIGAGQMGNGIAHVMALAGFDVVLNDISQQALDSALSLIQKNLARQASKGKIADAEVAAAMGRISTSLTLADV
GKTDLVIEAATERETVKQAIFEDLLPHLEPHTILTSNTSSISITRLASRTDRPERFMGFHFMNPVPVMQLVELIRGIATD
EETFQTCQTVVEKLGKTAASAEDFPAFIVNRILMPMINEAVYTLYEGVGSVRSIDESMKLGANHPMGPLELADFIGLDTC
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKTQRGFYDYRGEVPVPTR
>Mature_291_residues
MDVKKVGIIGAGQMGNGIAHVMALAGFDVVLNDISQQALDSALSLIQKNLARQASKGKIADAEVAAAMGRISTSLTLADV
GKTDLVIEAATERETVKQAIFEDLLPHLEPHTILTSNTSSISITRLASRTDRPERFMGFHFMNPVPVMQLVELIRGIATD
EETFQTCQTVVEKLGKTAASAEDFPAFIVNRILMPMINEAVYTLYEGVGSVRSIDESMKLGANHPMGPLELADFIGLDTC
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKTQRGFYDYRGEVPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=42.7083333333333, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=41.1764705882353, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=32.8621908127208, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI68989263, Length=290, Percent_Identity=30.6896551724138, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI261878539, Length=290, Percent_Identity=30.6896551724138, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI115430219, Length=231, Percent_Identity=27.7056277056277, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787661, Length=286, Percent_Identity=39.5104895104895, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1790281, Length=264, Percent_Identity=34.469696969697, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788682, Length=266, Percent_Identity=34.5864661654135, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17553560, Length=293, Percent_Identity=43.3447098976109, Blast_Score=221, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=40.2777777777778, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=36.8055555555556, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=32.1554770318021, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17508953, Length=283, Percent_Identity=31.8021201413428, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=31.8021201413428, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=31.8021201413428, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=27.4647887323944, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71985930, Length=281, Percent_Identity=26.6903914590747, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24583077, Length=286, Percent_Identity=32.8671328671329, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24583079, Length=286, Percent_Identity=32.8671328671329, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI19921000, Length=286, Percent_Identity=32.8671328671329, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45549573, Length=235, Percent_Identity=28.936170212766, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI20129993, Length=248, Percent_Identity=27.4193548387097, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31694; Mature: 31694

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVKKVGIIGAGQMGNGIAHVMALAGFDVVLNDISQQALDSALSLIQKNLARQASKGKIA
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DAEVAAAMGRISTSLTLADVGKTDLVIEAATERETVKQAIFEDLLPHLEPHTILTSNTSS
HHHHHHHHHHHHHHEEHHHCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
ISITRLASRTDRPERFMGFHFMNPVPVMQLVELIRGIATDEETFQTCQTVVEKLGKTAAS
EEHHHHHHCCCCHHHHHCHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
AEDFPAFIVNRILMPMINEAVYTLYEGVGSVRSIDESMKLGANHPMGPLELADFIGLDTC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKTQRGFYDYRGEVPVPTR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHCCHHHCCCCCCCCCC
>Mature Secondary Structure
MDVKKVGIIGAGQMGNGIAHVMALAGFDVVLNDISQQALDSALSLIQKNLARQASKGKIA
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DAEVAAAMGRISTSLTLADVGKTDLVIEAATERETVKQAIFEDLLPHLEPHTILTSNTSS
HHHHHHHHHHHHHHEEHHHCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
ISITRLASRTDRPERFMGFHFMNPVPVMQLVELIRGIATDEETFQTCQTVVEKLGKTAAS
EEHHHHHHCCCCHHHHHCHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
AEDFPAFIVNRILMPMINEAVYTLYEGVGSVRSIDESMKLGANHPMGPLELADFIGLDTC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKTQRGFYDYRGEVPVPTR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]