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The map label for this gene is lpsI [H]

Identifier: 99082180

GI number: 99082180

Start: 2462335

End: 2463039

Strand: Direct

Name: lpsI [H]

Synonym: TM1040_2340

Alternate gene names: 99082180

Gene position: 2462335-2463039 (Clockwise)

Preceding gene: 99082179

Following gene: 99082181

Centisome position: 76.93

GC content: 59.29

Gene sequence:

>705_bases
ATGAAGAAGGTTTACGGCTCTGCCGCTGAGGCCCTCGACGGGGTGCTGTTTGACGGCATGACAATTGCGGCAGGCGGCTT
TGGCCTCTGCGGCATCCCGGAGTTGCTGCTTGAGGCGATCAAAGACGCGGGCACCAAGGATCTGACATTTGCGTCCAACA
ACGCAGGCGTTGATGACTTTGGCATTGGAATCCTGCTGCAGACCAAGCAGGTCAAAAAGATGATGTCGTCCTATGTGGGC
GAGAACGCGGAATTCATGCGTCAGTATCTCTCGGGCGAACTGGAGCTGGAATTCAACCCCCAAGGCACGCTGGCCGAACG
CATGCGCGCAGGCGGCTGCGGCATTCCCGGGTTTTACACCAAGACCGGCGTCGGCACCCAGATCGCCGAAGGCAAGGAGG
TCAAGGTCTTTGACGGCGAGGAATACATCCTCGAGCGCGGCATCTTTGCGGATCTGTCCATCGTCAAAGCCTGGAAGGCG
GATGAAACCGGCAACCTCGTGTTCCGCAAGACCGCCCGCAATTTCAATCCGCCCGCCGCGATGTGCGGCAAGATCTGTGT
GGTCGAAGTGGAAGAGATCGTGCCCACCGGCAGCCTTGATCCCGATCACATCCACCTGCCCGGCGTCTACGTGCACCGCC
TGATCCAGGGCGAACACGAAAAACGTATCGAAAAAGTGACCACCCGCCCGCGTGAGGAGGCTTGA

Upstream 100 bases:

>100_bases
TTGGCATGGGTAGAAATACGCAGACCATTGCGTATTCGTTGACTCGACAGCACAACTGGGGCGATTAGCTTGACCCAGAG
GAAATGGAAGGGAGAGTTCC

Downstream 100 bases:

>100_bases
TCCATGGCTTGGGACCGCAACCAAATGGCCGCGCGCGCGGCACAGGAACTCGAAGACGGCATGTATGTAAACCTCGGCAT
CGGGATTCCGACGCTGGTCG

Product: 3-oxoacid CoA-transferase, subunit A

Products: NA

Alternate protein names: Succinyl CoA:3-oxoacid CoA-transferase; OXCT A [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKKVYGSAAEALDGVLFDGMTIAAGGFGLCGIPELLLEAIKDAGTKDLTFASNNAGVDDFGIGILLQTKQVKKMMSSYVG
ENAEFMRQYLSGELELEFNPQGTLAERMRAGGCGIPGFYTKTGVGTQIAEGKEVKVFDGEEYILERGIFADLSIVKAWKA
DETGNLVFRKTARNFNPPAAMCGKICVVEVEEIVPTGSLDPDHIHLPGVYVHRLIQGEHEKRIEKVTTRPREEA

Sequences:

>Translated_234_residues
MKKVYGSAAEALDGVLFDGMTIAAGGFGLCGIPELLLEAIKDAGTKDLTFASNNAGVDDFGIGILLQTKQVKKMMSSYVG
ENAEFMRQYLSGELELEFNPQGTLAERMRAGGCGIPGFYTKTGVGTQIAEGKEVKVFDGEEYILERGIFADLSIVKAWKA
DETGNLVFRKTARNFNPPAAMCGKICVVEVEEIVPTGSLDPDHIHLPGVYVHRLIQGEHEKRIEKVTTRPREEA
>Mature_234_residues
MKKVYGSAAEALDGVLFDGMTIAAGGFGLCGIPELLLEAIKDAGTKDLTFASNNAGVDDFGIGILLQTKQVKKMMSSYVG
ENAEFMRQYLSGELELEFNPQGTLAERMRAGGCGIPGFYTKTGVGTQIAEGKEVKVFDGEEYILERGIFADLSIVKAWKA
DETGNLVFRKTARNFNPPAAMCGKICVVEVEEIVPTGSLDPDHIHLPGVYVHRLIQGEHEKRIEKVTTRPREEA

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=246, Percent_Identity=55.2845528455285, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI11545841, Length=250, Percent_Identity=48.8, Blast_Score=228, Evalue=3e-60,
Organism=Escherichia coli, GI1788551, Length=208, Percent_Identity=43.75, Blast_Score=187, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17531517, Length=240, Percent_Identity=52.5, Blast_Score=257, Evalue=4e-69,
Organism=Drosophila melanogaster, GI21358325, Length=250, Percent_Identity=51.6, Blast_Score=254, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24655794, Length=250, Percent_Identity=51.6, Blast_Score=254, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012792
- InterPro:   IPR004165
- InterPro:   IPR004163 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: =2.8.3.5 [H]

Molecular weight: Translated: 25447; Mature: 25447

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS01273 COA_TRANSF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVYGSAAEALDGVLFDGMTIAAGGFGLCGIPELLLEAIKDAGTKDLTFASNNAGVDDF
CCCCCCHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCC
GIGILLQTKQVKKMMSSYVGENAEFMRQYLSGELELEFNPQGTLAERMRAGGCGIPGFYT
CCEEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCCCCC
KTGVGTQIAEGKEVKVFDGEEYILERGIFADLSIVKAWKADETGNLVFRKTARNFNPPAA
CCCCCCCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHH
MCGKICVVEVEEIVPTGSLDPDHIHLPGVYVHRLIQGEHEKRIEKVTTRPREEA
HHCCEEEEEHHHHCCCCCCCCCCEECCHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKVYGSAAEALDGVLFDGMTIAAGGFGLCGIPELLLEAIKDAGTKDLTFASNNAGVDDF
CCCCCCHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCC
GIGILLQTKQVKKMMSSYVGENAEFMRQYLSGELELEFNPQGTLAERMRAGGCGIPGFYT
CCEEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCCCCC
KTGVGTQIAEGKEVKVFDGEEYILERGIFADLSIVKAWKADETGNLVFRKTARNFNPPAA
CCCCCCCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHH
MCGKICVVEVEEIVPTGSLDPDHIHLPGVYVHRLIQGEHEKRIEKVTTRPREEA
HHCCEEEEEHHHHCCCCCCCCCCEECCHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9385134; 11589581 [H]