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The map label for this gene is ctaB

Identifier: 99082175

GI number: 99082175

Start: 2454126

End: 2455067

Strand: Reverse

Name: ctaB

Synonym: TM1040_2335

Alternate gene names: 99082175

Gene position: 2455067-2454126 (Counterclockwise)

Preceding gene: 99082176

Following gene: 99082174

Centisome position: 76.7

GC content: 60.83

Gene sequence:

>942_bases
ATGACAGACGCTAGCATCAATGCAAGCATGACCCGCGAAGAGGAGGCTTCCCTTGGCGATTACTTCGCGCTGCTGAAGCC
GCGGGTGATGTCCCTTGTCGTGTTCACCGCCTTTGTTGGCCTGATGGCTGCGCCCATCGGAGTGCATCCGGTGATCGGCT
TCTGTGCGATCCTGTTCATTGCCATCGGCGGCGGGGCGTCTGGCGCGCTCAATATGTGGTGGGACGCCGACATCGATCAG
GTGATGAAGCGCACCAAGGGCCGCCCGATCCCGGCTGGCAAAGTCGACAAGGGCGAAGCGCTGAGTCTCGGCCTTGCGCT
GTCGGGCCTGTCGGTGATCATGCTGGCGCTTGCGACCAACGTGTTTGCAGGGGCGTTCTTGGCGTTCACCATCTTCTTTT
ACGTGGTGATCTACACCATGTGGCTCAAGCGGGCGACGCCGCAGAACATCGTCATCGGTGGCGCGGCAGGGGCGTTTCCG
CCTGTGATCGGCTGGATCGCGGCCACCGGCAGCATGTCGGTCGAGCCCTGGCTGATGTTTGCACTGACCTTCCTGTGGAC
GCCGCCGCATTTCTGGGCGCTCGCGCTTTTTATGCGCAATGATTACGACATGGCCGATGTGCCGATGCTGACCGTGACCC
ATGGGCGGCGCTCCACGCGCAAGCACATCCTGGTCTACACCGTAATTCTCGCGGCCTTTGCGCTGACCACCGCCTTCACC
AGCGTCGGAGGGCCGATCTATCTCACTACAGCTGTTGTGCTCAATGCGCTGTTCCTGAAAGGCGCGGTCCAGATCTGGCG
CCGCGATGAGGAGATCTGCGAGAGCGACAACTTCAAGATCGAACGCTCCTTCTTCAAACTGTCGCTGCTCTACCTCTTCC
TCCACTTTGGCGCGATTCTCGCCGAGGCGCTGTTGAAACCCTATGGGCTGGGAGGCTGGTAA

Upstream 100 bases:

>100_bases
GCGCGTCCGCTATCTGCTGAGAGAGCCGCGTGCTGACGGATGAGACCAAGAGCGACCACGCGCTTTGCGTGGTCGTCCAT
GACCTGAAAGAGCCCGAGAC

Downstream 100 bases:

>100_bases
GATGAGCCTGCGCAAGGAACATGAAATCCACAACCGCCGCAAAGGGCGCAACGTGGGTGTTGGCCTGTTGCTAGGGGGAT
TCGTCGTGCTGGTTCTGGCG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTDASINASMTREEEASLGDYFALLKPRVMSLVVFTAFVGLMAAPIGVHPVIGFCAILFIAIGGGASGALNMWWDADIDQ
VMKRTKGRPIPAGKVDKGEALSLGLALSGLSVIMLALATNVFAGAFLAFTIFFYVVIYTMWLKRATPQNIVIGGAAGAFP
PVIGWIAATGSMSVEPWLMFALTFLWTPPHFWALALFMRNDYDMADVPMLTVTHGRRSTRKHILVYTVILAAFALTTAFT
SVGGPIYLTTAVVLNALFLKGAVQIWRRDEEICESDNFKIERSFFKLSLLYLFLHFGAILAEALLKPYGLGGW

Sequences:

>Translated_313_residues
MTDASINASMTREEEASLGDYFALLKPRVMSLVVFTAFVGLMAAPIGVHPVIGFCAILFIAIGGGASGALNMWWDADIDQ
VMKRTKGRPIPAGKVDKGEALSLGLALSGLSVIMLALATNVFAGAFLAFTIFFYVVIYTMWLKRATPQNIVIGGAAGAFP
PVIGWIAATGSMSVEPWLMFALTFLWTPPHFWALALFMRNDYDMADVPMLTVTHGRRSTRKHILVYTVILAAFALTTAFT
SVGGPIYLTTAVVLNALFLKGAVQIWRRDEEICESDNFKIERSFFKLSLLYLFLHFGAILAEALLKPYGLGGW
>Mature_312_residues
TDASINASMTREEEASLGDYFALLKPRVMSLVVFTAFVGLMAAPIGVHPVIGFCAILFIAIGGGASGALNMWWDADIDQV
MKRTKGRPIPAGKVDKGEALSLGLALSGLSVIMLALATNVFAGAFLAFTIFFYVVIYTMWLKRATPQNIVIGGAAGAFPP
VIGWIAATGSMSVEPWLMFALTFLWTPPHFWALALFMRNDYDMADVPMLTVTHGRRSTRKHILVYTVILAAFALTTAFTS
VGGPIYLTTAVVLNALFLKGAVQIWRRDEEICESDNFKIERSFFKLSLLYLFLHFGAILAEALLKPYGLGGW

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=207, Percent_Identity=34.7826086956522, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1786631, Length=180, Percent_Identity=33.8888888888889, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71998235, Length=205, Percent_Identity=30.7317073170732, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6325085, Length=303, Percent_Identity=24.7524752475248, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921064, Length=276, Percent_Identity=26.8115942028986, Blast_Score=94, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_SILST (Q1GE49)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614329.1
- STRING:   Q1GE49
- GeneID:   4078325
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2335
- NMPDR:   fig|292414.1.peg.696
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   LLKPRIM
- PhylomeDB:   Q1GE49
- ProtClustDB:   PRK04375
- BioCyc:   SSP292414:TM1040_2335-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 34148; Mature: 34017

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10796454)-; HASH(0x11ac0c50)-; HASH(0x116e2ec4)-; HASH(0x11ac09a4)-; HASH(0x11ac440c)-; HASH(0x11ab6d70)-; HASH(0x11ac0bfc)-; HASH(0x11adadfc)-; HASH(0x11adad54)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDASINASMTREEEASLGDYFALLKPRVMSLVVFTAFVGLMAAPIGVHPVIGFCAILFI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AIGGGASGALNMWWDADIDQVMKRTKGRPIPAGKVDKGEALSLGLALSGLSVIMLALATN
HHCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VFAGAFLAFTIFFYVVIYTMWLKRATPQNIVIGGAAGAFPPVIGWIAATGSMSVEPWLMF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHH
ALTFLWTPPHFWALALFMRNDYDMADVPMLTVTHGRRSTRKHILVYTVILAAFALTTAFT
HHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
SVGGPIYLTTAVVLNALFLKGAVQIWRRDEEICESDNFKIERSFFKLSLLYLFLHFGAIL
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AEALLKPYGLGGW
HHHHHCCCCCCCH
>Mature Secondary Structure 
TDASINASMTREEEASLGDYFALLKPRVMSLVVFTAFVGLMAAPIGVHPVIGFCAILFI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AIGGGASGALNMWWDADIDQVMKRTKGRPIPAGKVDKGEALSLGLALSGLSVIMLALATN
HHCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VFAGAFLAFTIFFYVVIYTMWLKRATPQNIVIGGAAGAFPPVIGWIAATGSMSVEPWLMF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCHHHHHH
ALTFLWTPPHFWALALFMRNDYDMADVPMLTVTHGRRSTRKHILVYTVILAAFALTTAFT
HHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
SVGGPIYLTTAVVLNALFLKGAVQIWRRDEEICESDNFKIERSFFKLSLLYLFLHFGAIL
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AEALLKPYGLGGW
HHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA