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The map label for this gene is mtnP [H]

Identifier: 99082164

GI number: 99082164

Start: 2444645

End: 2445517

Strand: Direct

Name: mtnP [H]

Synonym: TM1040_2324

Alternate gene names: 99082164

Gene position: 2444645-2445517 (Clockwise)

Preceding gene: 99082163

Following gene: 99082165

Centisome position: 76.37

GC content: 64.49

Gene sequence:

>873_bases
ATGACAGAGACATTGATTGCCGTGATCGGCGGCTCCGGCATTTACGAGATCGACGGGCTGGAAGGCGCCGCGTGGACCAC
CGTCGAAACCCCTTGGGGCACGCCCTCGGACCAGATCCTCACCGGGCGGCTTGAGGGTGTCAAAATGGCGTTCCTGCCGC
GCCATGGCCGGGGTCATGTGCATGCCCCAAGCGATGTGCCCTACCGGGCCAATATCGACGCCCTGAAACGTCTCGGGGCC
ACGGATGTGATCTCCGTCTCTGCCTGCGGCTCCTTTCGCGAGCACATGGCGCCCGGCGATTTTGTCATCGTGGATCAGTT
CATCGACCGCACGTTTGCGCGCGCCAAGAGCTTCTTTTCCTCGGGCTGCGTGGCGCATGTGGCGCTGGCGCATCCGACCT
GCCCACGTCTGAGCGATGCGGTCGAAGCCGCCGCAGGCGCAGCCGGGATCAACACACATCGTGGCGGCACCTATCTGGCG
ATGGAGGGGCCGCAGTTTTCCACGCTTGCGGAATCCAAGATGTACCGCGAGCACTGGGGCGCGGATGTGATCGGCATGAC
CAATATGCCAGAGGCAAAACTCGCCCGTGAGGCCGAGCTCTGCTATGCCTCCGTGGCCATGGTCACCGATTACGACAGCT
GGCACCCCGACCACGGCGAGGTGGATGTGACCGCCGTCATCGCCACCCTCAAAGGCAACTCTGAAAAAGGGCGCGCCTTG
ATCAAGGGCCTGCCCGCACGTCTGGGCGCAGAGCGCGCGCCCTGCCCCCATGGCTGTGACCGCGCGCTGGAGTATGCCAT
CATGACCGCGCCCGAAAAACGGGACCCGGCGCTTTTGGCCAAGCTGGATGCCGTCGCAGGACGCGTGCTCTGA

Upstream 100 bases:

>100_bases
CTTCATCTTTTTCAAAATACCTCCGCCGGAGGCATCCCATGCTTGCCAAGCCGCGCCCTGCTCGGCCATAGGTCAAAAAA
GACCCGCAGGAGGGACCCCC

Downstream 100 bases:

>100_bases
GGCAGATGACACTTGCATGACCGCCCCGCTTCGGCCACACCGCTAGGGTTTGGGCGCGGCGGACTTCATTACCACTGCGC
CCGCCATCGCGAAGCCAGAT

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MTETLIAVIGGSGIYEIDGLEGAAWTTVETPWGTPSDQILTGRLEGVKMAFLPRHGRGHVHAPSDVPYRANIDALKRLGA
TDVISVSACGSFREHMAPGDFVIVDQFIDRTFARAKSFFSSGCVAHVALAHPTCPRLSDAVEAAAGAAGINTHRGGTYLA
MEGPQFSTLAESKMYREHWGADVIGMTNMPEAKLAREAELCYASVAMVTDYDSWHPDHGEVDVTAVIATLKGNSEKGRAL
IKGLPARLGAERAPCPHGCDRALEYAIMTAPEKRDPALLAKLDAVAGRVL

Sequences:

>Translated_290_residues
MTETLIAVIGGSGIYEIDGLEGAAWTTVETPWGTPSDQILTGRLEGVKMAFLPRHGRGHVHAPSDVPYRANIDALKRLGA
TDVISVSACGSFREHMAPGDFVIVDQFIDRTFARAKSFFSSGCVAHVALAHPTCPRLSDAVEAAAGAAGINTHRGGTYLA
MEGPQFSTLAESKMYREHWGADVIGMTNMPEAKLAREAELCYASVAMVTDYDSWHPDHGEVDVTAVIATLKGNSEKGRAL
IKGLPARLGAERAPCPHGCDRALEYAIMTAPEKRDPALLAKLDAVAGRVL
>Mature_289_residues
TETLIAVIGGSGIYEIDGLEGAAWTTVETPWGTPSDQILTGRLEGVKMAFLPRHGRGHVHAPSDVPYRANIDALKRLGAT
DVISVSACGSFREHMAPGDFVIVDQFIDRTFARAKSFFSSGCVAHVALAHPTCPRLSDAVEAAAGAAGINTHRGGTYLAM
EGPQFSTLAESKMYREHWGADVIGMTNMPEAKLAREAELCYASVAMVTDYDSWHPDHGEVDVTAVIATLKGNSEKGRALI
KGLPARLGAERAPCPHGCDRALEYAIMTAPEKRDPALLAKLDAVAGRVL

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=269, Percent_Identity=43.8661710037175, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71980569, Length=243, Percent_Identity=38.2716049382716, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323045, Length=296, Percent_Identity=36.8243243243243, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20130079, Length=251, Percent_Identity=41.0358565737052, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI221459247, Length=255, Percent_Identity=35.2941176470588, Blast_Score=157, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 30924; Mature: 30793

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETLIAVIGGSGIYEIDGLEGAAWTTVETPWGTPSDQILTGRLEGVKMAFLPRHGRGHV
CCCEEEEEECCCCEEEECCCCCCEEEEEECCCCCCCCCEEEECCCCEEEEEECCCCCCCE
HAPSDVPYRANIDALKRLGATDVISVSACGSFREHMAPGDFVIVDQFIDRTFARAKSFFS
ECCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
SGCVAHVALAHPTCPRLSDAVEAAAGAAGINTHRGGTYLAMEGPQFSTLAESKMYREHWG
CCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCC
ADVIGMTNMPEAKLAREAELCYASVAMVTDYDSWHPDHGEVDVTAVIATLKGNSEKGRAL
CCEEECCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEEEEEECCCCHHHHHH
IKGLPARLGAERAPCPHGCDRALEYAIMTAPEKRDPALLAKLDAVAGRVL
HHCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TETLIAVIGGSGIYEIDGLEGAAWTTVETPWGTPSDQILTGRLEGVKMAFLPRHGRGHV
CCEEEEEECCCCEEEECCCCCCEEEEEECCCCCCCCCEEEECCCCEEEEEECCCCCCCE
HAPSDVPYRANIDALKRLGATDVISVSACGSFREHMAPGDFVIVDQFIDRTFARAKSFFS
ECCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHH
SGCVAHVALAHPTCPRLSDAVEAAAGAAGINTHRGGTYLAMEGPQFSTLAESKMYREHWG
CCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCC
ADVIGMTNMPEAKLAREAELCYASVAMVTDYDSWHPDHGEVDVTAVIATLKGNSEKGRAL
CCEEECCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEEEEEECCCCHHHHHH
IKGLPARLGAERAPCPHGCDRALEYAIMTAPEKRDPALLAKLDAVAGRVL
HHCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA