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The map label for this gene is apt

Identifier: 99082165

GI number: 99082165

Start: 2445634

End: 2446173

Strand: Direct

Name: apt

Synonym: TM1040_2325

Alternate gene names: 99082165

Gene position: 2445634-2446173 (Clockwise)

Preceding gene: 99082164

Following gene: 99082166

Centisome position: 76.4

GC content: 59.63

Gene sequence:

>540_bases
ATGAGCACCTCCAAAACCGTCAAGGACTACATCCGCACCATCGTCGATTTCCCCCATGAGGGGATCATGTTCCGCGATGT
GACCACATTGTTTGCCGACCCGCGCGGGTTTCGCATGGCCGTGGACCAGATGCTGCACCCCTATGCGGGCCAGCGCATCG
ACAAGGTCGTGGGGCTTGAGGCGCGGGGGTTCATCCTTGGCGGCGCCATCGCGCATCAACTGGGCACTGGGTTTGTGCCT
GTGCGCAAAAAGGGCAAACTGCCCGGCGCCACGATTTCGCAGGAATACAAGCTCGAATACGGCGAGGCGGTGGTGGAGCT
TCACAAGGATGCCATCCAACCGGGTGAAAAGATCCTCGTGGTGGATGATCTTCTGGCCACCGGCGGCACCGCGGGTGCGG
GCATCAAACTGATCGAAAAACTCGGCGGAGAGATCATCTCCTGCTCTTTCATCATCGACCTGCCGGAACTTGGCGGGCGC
AAGCATCTCCAAAGCCTTGGCATGGACGTGCATGTTCTGTGCGAATTCGAGGGGCTCTGA

Upstream 100 bases:

>100_bases
ATGACCGCCCCGCTTCGGCCACACCGCTAGGGTTTGGGCGCGGCGGACTTCATTACCACTGCGCCCGCCATCGCGAAGCC
AGATCAGGGATCACAGCCCC

Downstream 100 bases:

>100_bases
GCGTTTTTTTTCGCCGGGATCAGTCACGACGGATCACAGCTGCTCACGCAGGCGTGACTGGATTTTGGAAAAGCTCCCGG
CTTAGGGAGCTTTTTTCATG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MSTSKTVKDYIRTIVDFPHEGIMFRDVTTLFADPRGFRMAVDQMLHPYAGQRIDKVVGLEARGFILGGAIAHQLGTGFVP
VRKKGKLPGATISQEYKLEYGEAVVELHKDAIQPGEKILVVDDLLATGGTAGAGIKLIEKLGGEIISCSFIIDLPELGGR
KHLQSLGMDVHVLCEFEGL

Sequences:

>Translated_179_residues
MSTSKTVKDYIRTIVDFPHEGIMFRDVTTLFADPRGFRMAVDQMLHPYAGQRIDKVVGLEARGFILGGAIAHQLGTGFVP
VRKKGKLPGATISQEYKLEYGEAVVELHKDAIQPGEKILVVDDLLATGGTAGAGIKLIEKLGGEIISCSFIIDLPELGGR
KHLQSLGMDVHVLCEFEGL
>Mature_178_residues
STSKTVKDYIRTIVDFPHEGIMFRDVTTLFADPRGFRMAVDQMLHPYAGQRIDKVVGLEARGFILGGAIAHQLGTGFVPV
RKKGKLPGATISQEYKLEYGEAVVELHKDAIQPGEKILVVDDLLATGGTAGAGIKLIEKLGGEIISCSFIIDLPELGGRK
HLQSLGMDVHVLCEFEGL

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=165, Percent_Identity=44.2424242424242, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI71773201, Length=130, Percent_Identity=46.9230769230769, Blast_Score=127, Evalue=6e-30,
Organism=Escherichia coli, GI1786675, Length=172, Percent_Identity=52.3255813953488, Blast_Score=184, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17509087, Length=166, Percent_Identity=43.9759036144578, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=168, Percent_Identity=39.8809523809524, Blast_Score=118, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=168, Percent_Identity=36.3095238095238, Blast_Score=95, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17136334, Length=174, Percent_Identity=41.9540229885057, Blast_Score=129, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_SILST (Q1GE59)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614319.1
- ProteinModelPortal:   Q1GE59
- SMR:   Q1GE59
- STRING:   Q1GE59
- GeneID:   4078315
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2325
- NMPDR:   fig|292414.1.peg.686
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q1GE59
- ProtClustDB:   PRK02304
- BioCyc:   SSP292414:TM1040_2325-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19418; Mature: 19287

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSKTVKDYIRTIVDFPHEGIMFRDVTTLFADPRGFRMAVDQMLHPYAGQRIDKVVGLE
CCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHCCC
ARGFILGGAIAHQLGTGFVPVRKKGKLPGATISQEYKLEYGEAVVELHKDAIQPGEKILV
CCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
VDDLLATGGTAGAGIKLIEKLGGEIISCSFIIDLPELGGRKHLQSLGMDVHVLCEFEGL
EEHHHHCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure 
STSKTVKDYIRTIVDFPHEGIMFRDVTTLFADPRGFRMAVDQMLHPYAGQRIDKVVGLE
CCHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHCCC
ARGFILGGAIAHQLGTGFVPVRKKGKLPGATISQEYKLEYGEAVVELHKDAIQPGEKILV
CCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
VDDLLATGGTAGAGIKLIEKLGGEIISCSFIIDLPELGGRKHLQSLGMDVHVLCEFEGL
EEHHHHCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA