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The map label for this gene is ilvC

Identifier: 99082143

GI number: 99082143

Start: 2421204

End: 2422226

Strand: Direct

Name: ilvC

Synonym: TM1040_2303

Alternate gene names: 99082143

Gene position: 2421204-2422226 (Clockwise)

Preceding gene: 99082139

Following gene: 99082144

Centisome position: 75.64

GC content: 60.22

Gene sequence:

>1023_bases
ATGCGTGTGTACTACGACCGCGACTGCGACGTGAACCTCATCAAAGAAAAGAAAGTCGCCATCCTCGGCTATGGCTCGCA
AGGTCACGCGCATGCGCTGAACCTGCGTGATTCCGGCGCCAAGAACCTCGTGATCGCCCTGCGCGAAGGCTCCCCTTCCG
CCAAGAAAGCCGAAGCCGAAGGCCTGCAGGTCATGGGTATCGCCGAAGCCGCGGCCTGGTGTGACGTGATCATGTTCACC
ATGCCCGACGAACTGCAGGCAGAGACCTACAAGAAATACGTCCACGACAACATCAAGCCGGGCGCGGCGATTGCATTCGC
CCACGGCCTGAACGTGCACTTCGGCCTGATCGAGCCCAAAGAAGGCGTCGACGTCATCATGATGGCGCCCAAAGGCCCCG
GCCACACCGTGCGCGGCGAATACACCAAAGGCGGCGGCGTGCCCTGCCTCGTGGCCGTTCACAACGACGCATCCGGCTCT
GCACTTGAAACTGCGCTGTCTTACTGCTCCGCGATTGGTGGCGGTCGCTCCGGCATCATCGAGACCAACTTCCGCGAAGA
GTGTGAAACCGACCTCTTCGGCGAGCAGGCAGTCCTGTGTGGCGGTCTCGTCGAGCTGATCCGCTGCGGCTTTGAAACCC
TCGTCGAGGCAGGCTACGCGCCGGAAATGGCCTATTTCGAGTGTCTGCACGAAGTGAAGCTGATCGTGGACCTGATCTAT
GAAGGCGGCATCGCCAACATGGACTACTCGATCTCCAACACTGCGGAATACGGCCAGTATGTCACCGGCCCGCGCATCCT
GAAGTACGACGAGACCAAAGCCCGCATGAAAGAAGTCCTCGCCGACATCCAGCAGGGCAAATTCGTACGCGACTTCATGC
TGGAAAACGCTGTAGGCCAGCCCACCATCAAAGCGTCCCGCCGTGCCAACGACGAGCACGCGATCGAGGCCACCGGCGCC
AAGCTGCGTGAAATGATGCCCTGGATCTCTGCCGGCAAGATGGTCGACAAGTCCAAGAACTAA

Upstream 100 bases:

>100_bases
GCGAATCTTTGTGAATTTATACTGCAATCGCTCTCGTATTCCGCGGCCTGCCACCTATGCTCGTCAGCAGATTAGAAACT
CAGGTCAAAGGATTGATCCG

Downstream 100 bases:

>100_bases
GGCCTGCGATTGCGGAGCTCAGGCTCCACAACCCGGACCTCTGCAGGGCGCCTCGGGAAACCGGGGCGCCTTCTCCACGT
CACAGGGCTGCCGCGCGCCG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MRVYYDRDCDVNLIKEKKVAILGYGSQGHAHALNLRDSGAKNLVIALREGSPSAKKAEAEGLQVMGIAEAAAWCDVIMFT
MPDELQAETYKKYVHDNIKPGAAIAFAHGLNVHFGLIEPKEGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHNDASGS
ALETALSYCSAIGGGRSGIIETNFREECETDLFGEQAVLCGGLVELIRCGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMDYSISNTAEYGQYVTGPRILKYDETKARMKEVLADIQQGKFVRDFMLENAVGQPTIKASRRANDEHAIEATGA
KLREMMPWISAGKMVDKSKN

Sequences:

>Translated_340_residues
MRVYYDRDCDVNLIKEKKVAILGYGSQGHAHALNLRDSGAKNLVIALREGSPSAKKAEAEGLQVMGIAEAAAWCDVIMFT
MPDELQAETYKKYVHDNIKPGAAIAFAHGLNVHFGLIEPKEGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHNDASGS
ALETALSYCSAIGGGRSGIIETNFREECETDLFGEQAVLCGGLVELIRCGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMDYSISNTAEYGQYVTGPRILKYDETKARMKEVLADIQQGKFVRDFMLENAVGQPTIKASRRANDEHAIEATGA
KLREMMPWISAGKMVDKSKN
>Mature_340_residues
MRVYYDRDCDVNLIKEKKVAILGYGSQGHAHALNLRDSGAKNLVIALREGSPSAKKAEAEGLQVMGIAEAAAWCDVIMFT
MPDELQAETYKKYVHDNIKPGAAIAFAHGLNVHFGLIEPKEGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHNDASGS
ALETALSYCSAIGGGRSGIIETNFREECETDLFGEQAVLCGGLVELIRCGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMDYSISNTAEYGQYVTGPRILKYDETKARMKEVLADIQQGKFVRDFMLENAVGQPTIKASRRANDEHAIEATGA
KLREMMPWISAGKMVDKSKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=321, Percent_Identity=33.0218068535826, Blast_Score=138, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6323387, Length=269, Percent_Identity=33.0855018587361, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_SILST (Q1GE81)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614297.1
- ProteinModelPortal:   Q1GE81
- SMR:   Q1GE81
- STRING:   Q1GE81
- GeneID:   4078487
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2303
- NMPDR:   fig|292414.1.peg.665
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q1GE81
- ProtClustDB:   PRK05479
- BioCyc:   SSP292414:TM1040_2303-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36993; Mature: 36993

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDCDVNLIKEKKVAILGYGSQGHAHALNLRDSGAKNLVIALREGSPSAKKAEAE
CCEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCHHHHHC
GLQVMGIAEAAAWCDVIMFTMPDELQAETYKKYVHDNIKPGAAIAFAHGLNVHFGLIEPK
CEEEEEHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEEECCC
EGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHNDASGSALETALSYCSAIGGGRSGII
CCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEE
ETNFREECETDLFGEQAVLCGGLVELIRCGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMDYSISNTAEYGQYVTGPRILKYDETKARMKEVLADIQQGKFVRDFMLENAVGQ
CCCCCCCCCCCCCCHHHCCCCCCCEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
PTIKASRRANDEHAIEATGAKLREMMPWISAGKMVDKSKN
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRVYYDRDCDVNLIKEKKVAILGYGSQGHAHALNLRDSGAKNLVIALREGSPSAKKAEAE
CCEEECCCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCHHHHHC
GLQVMGIAEAAAWCDVIMFTMPDELQAETYKKYVHDNIKPGAAIAFAHGLNVHFGLIEPK
CEEEEEHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEEECCC
EGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHNDASGSALETALSYCSAIGGGRSGII
CCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEE
ETNFREECETDLFGEQAVLCGGLVELIRCGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMDYSISNTAEYGQYVTGPRILKYDETKARMKEVLADIQQGKFVRDFMLENAVGQ
CCCCCCCCCCCCCCHHHCCCCCCCEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
PTIKASRRANDEHAIEATGAKLREMMPWISAGKMVDKSKN
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA