Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 99082088

GI number: 99082088

Start: 2361977

End: 2362825

Strand: Reverse

Name: nadC [H]

Synonym: TM1040_2248

Alternate gene names: 99082088

Gene position: 2362825-2361977 (Counterclockwise)

Preceding gene: 99082089

Following gene: 99082086

Centisome position: 73.82

GC content: 62.43

Gene sequence:

>849_bases
ATGAGCTTTGCCACTTTGCCCGACCTGATCCTTGAGCCATTGGTCAAATCCGCCCTGATGGAAGACCTCGGCTCTTATGG
CGATGTGACCACCCGCGCGGTGATCCCCGATGATGTTACCTATTCCGCCCGCCTGCGCGCCCGCGAAGAGGCGGTGGTCT
CTGGCATGCAGGTGGCCGCGCTGGCATTCCGGTTGGTGGATGCGACCCTTGAGGTGAAGACCCGCGTTGCAGATGGCGCT
GTGTGTCAGCCCGGCGATGTGCTGATGGAGATCGAGGGCAAGGCGGCGTCGATCCTGATGGGGGAGCGGGTTGCGCTCAA
CTTTGCGGGGCGTTTGACGGGGATCGCAACGCTCACGGCGGCCATGGTCGCTGAAACCCGTGGCACACAGGCACGTATCA
CCTGCACCCGCAAGACCACGCCGGGGCTGCGGATGGTCGAAAAGCTGGCGGTATTGCATGGCGGTGGCTTCAATCACCGC
TATTCGCTCTCGGATGCCATCCTCATCAAGGACAACCACATCGCTGCAGCGGGTGGTATTCGCGCGGTGCTGGATGCCAC
CAAGGCGCATGCCAGCCACATGATGGCGGTGGAAATCGAAGTGGACACGCTCGATCAGTTGCGCGAGGTGCTGGAGGTCG
GCGGTGCCTCCGTTGTGCTCTTGGACAATATGACGCCTGCTGAGCTGCGTGAGGCGGTCGAGATCAATGCCGGACGTCTG
GCGCTCGAGGCCAGCGGCAACGTCAAACGCGACACAGTGGCGGAAATTGCAGCCACGGGGGTGGATTTCATCTCCTCGGG
GGCGCTCACGCATTCGGCGCGCACCGTCGATCTGGGGCTTGATTTCTAA

Upstream 100 bases:

>100_bases
CCCTGCCTGCGCTTGCGCATCGCTCCCGCCTCACGTGGGAGGCAGCCAAAGCGCTCCGTGACAGCCTGTGTGATGCCAGT
GCATCCGACCCGGAGACCCC

Downstream 100 bases:

>100_bases
GCGCTCAGCCCACAGCCCTTGCTGGATGACAAGGCCTGAAGCACCGGGTCCGCGCGCAGCCGGTCGCGGGCAAAATCGAT
AAAGCTGCGCACCTTGGCTG

Product: nicotinate-nucleotide pyrophosphorylase [carboxylating]

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSFATLPDLILEPLVKSALMEDLGSYGDVTTRAVIPDDVTYSARLRAREEAVVSGMQVAALAFRLVDATLEVKTRVADGA
VCQPGDVLMEIEGKAASILMGERVALNFAGRLTGIATLTAAMVAETRGTQARITCTRKTTPGLRMVEKLAVLHGGGFNHR
YSLSDAILIKDNHIAAAGGIRAVLDATKAHASHMMAVEIEVDTLDQLREVLEVGGASVVLLDNMTPAELREAVEINAGRL
ALEASGNVKRDTVAEIAATGVDFISSGALTHSARTVDLGLDF

Sequences:

>Translated_282_residues
MSFATLPDLILEPLVKSALMEDLGSYGDVTTRAVIPDDVTYSARLRAREEAVVSGMQVAALAFRLVDATLEVKTRVADGA
VCQPGDVLMEIEGKAASILMGERVALNFAGRLTGIATLTAAMVAETRGTQARITCTRKTTPGLRMVEKLAVLHGGGFNHR
YSLSDAILIKDNHIAAAGGIRAVLDATKAHASHMMAVEIEVDTLDQLREVLEVGGASVVLLDNMTPAELREAVEINAGRL
ALEASGNVKRDTVAEIAATGVDFISSGALTHSARTVDLGLDF
>Mature_281_residues
SFATLPDLILEPLVKSALMEDLGSYGDVTTRAVIPDDVTYSARLRAREEAVVSGMQVAALAFRLVDATLEVKTRVADGAV
CQPGDVLMEIEGKAASILMGERVALNFAGRLTGIATLTAAMVAETRGTQARITCTRKTTPGLRMVEKLAVLHGGGFNHRY
SLSDAILIKDNHIAAAGGIRAVLDATKAHASHMMAVEIEVDTLDQLREVLEVGGASVVLLDNMTPAELREAVEINAGRLA
LEASGNVKRDTVAEIAATGVDFISSGALTHSARTVDLGLDF

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=282, Percent_Identity=34.3971631205674, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI1786299, Length=273, Percent_Identity=39.1941391941392, Blast_Score=163, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=280, Percent_Identity=31.0714285714286, Blast_Score=122, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29752; Mature: 29620

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFATLPDLILEPLVKSALMEDLGSYGDVTTRAVIPDDVTYSARLRAREEAVVSGMQVAA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LAFRLVDATLEVKTRVADGAVCQPGDVLMEIEGKAASILMGERVALNFAGRLTGIATLTA
HHHHHHHHHHHHEEEECCCCCCCCCCEEEEECCCEEEEEECCEEEEEHHHHHHHHHHHHH
AMVAETRGTQARITCTRKTTPGLRMVEKLAVLHGGGFNHRYSLSDAILIKDNHIAAAGGI
HHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCEEEEECCCEEECCCH
RAVLDATKAHASHMMAVEIEVDTLDQLREVLEVGGASVVLLDNMTPAELREAVEINAGRL
HHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEE
ALEASGNVKRDTVAEIAATGVDFISSGALTHSARTVDLGLDF
EEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCEEEEEECCC
>Mature Secondary Structure 
SFATLPDLILEPLVKSALMEDLGSYGDVTTRAVIPDDVTYSARLRAREEAVVSGMQVAA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LAFRLVDATLEVKTRVADGAVCQPGDVLMEIEGKAASILMGERVALNFAGRLTGIATLTA
HHHHHHHHHHHHEEEECCCCCCCCCCEEEEECCCEEEEEECCEEEEEHHHHHHHHHHHHH
AMVAETRGTQARITCTRKTTPGLRMVEKLAVLHGGGFNHRYSLSDAILIKDNHIAAAGGI
HHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCEEEEECCCEEECCCH
RAVLDATKAHASHMMAVEIEVDTLDQLREVLEVGGASVVLLDNMTPAELREAVEINAGRL
HHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEE
ALEASGNVKRDTVAEIAATGVDFISSGALTHSARTVDLGLDF
EEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]