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The map label for this gene is kynU [H]

Identifier: 99082065

GI number: 99082065

Start: 2336081

End: 2337271

Strand: Reverse

Name: kynU [H]

Synonym: TM1040_2225

Alternate gene names: 99082065

Gene position: 2337271-2336081 (Counterclockwise)

Preceding gene: 99082066

Following gene: 99082055

Centisome position: 73.02

GC content: 61.63

Gene sequence:

>1191_bases
ATGACAAACCTGCCCAAAAAATACCTCTTCGATATTCCCGAGGGCATGATCTATCTCGATGGAAACTCGCTTGGCCCCCT
GCCAAAGGGCGCGGCAGAGCGGGCCGCCAAGGTGCTGACCCAGGAATGGGGCACACAGTTGATCAAGGCCTGGAACACCG
CCGACTGGATGGCGCTGCCGCAAAAAGTGGGCGATCGTATCGCGGGGTTCATCGGCGCAGCACCGGGCAGCGTGGCCACG
GGCGATACGCTTTCGATCAAGGTTTATCAGGCGCTCGCGGCGGCGCTCAAGATGCGCCCCGAGCGCCGGGTGATCCTGTC
GGACACGGGCAATTTTCCGACCGATCTCTACATGGCGCAGGGGCTGATCTCCACCATCGGCAAGGACTATGAACTGCGCA
CCGTTGCCCCCGAAGAGGTCGCGGATGCGATCACCGATGATGTGGCGGTGGTGATGCTGACGGAGGTGGACTATCGCTCT
GGCCGCCGTCACGACATGATGGAGATGACAGCACGCGCGCATCAGAACGGCGCGGTGATGATCTGGGACCTCGCCCATAG
CGCAGGCGCGCTGCCGGTGGATCTGACGGCCTGCAATGCAGAATTCGCGGTGGGCTGCACCTACAAGTATTTCAACGGGG
GACCCGGTGCGCCTGCCTTTATCTATGCGCGGCCCGACATTGTGCTTGAGGTGGACCCTGCGCTTGCGGGCTGGCTTGGT
CATGATGCGCCTTTTGCGATGGAGCCCGATTATCGTCCGGCGATGACCACGGAGCGTCTGCGCGTTGGCACGCCCTCGAT
TGTGCAGCTCTCGATCCTTGATACGGCACTGGATGTTTGGGACGGGGTCTCGATGGAAGAGATCCGCGGCGCGTCCGTGG
CCCTGTGCGAGACGTTCATTGCCGAAGTCGAGGCCCGCTGCCCGGAACTGACGCTTGCCTCCCCCAGAGAGGCAGCGCTG
CGAGGGTCGCAGGTCTCCTTTGCCTTTGAGGATGGCTATGCGGTGGTACAGGCGTTGATTGATCGCGGCGTCATCGGCGA
TTTCCGCGCGCCCAACATCATGCGCTTTGGTTTCACACCGCTCTATCTCGATCAGGCGGATGTGGTGCAAGCCGCCGAGA
TCCTTGAGGATGTGATGAAGCGAGAGAGTTGGAAAGATCCCAAGTATCAGGTGCGCTCGCGCGTGACCTGA

Upstream 100 bases:

>100_bases
AAGCGCGGCACCGGCGGCACCTCTGGGGTGCAATATCTGCGCCGGATGCTGAGCGTGGAGCTGTTTCCTGAACTTTGGAC
CCTGAGAGGCGATCTCTGAC

Downstream 100 bases:

>100_bases
CCTGCGATGGCACACCCTTCGGAACAATAAAGCGTTGCGGCCGGGCGGGGATGCTCCCGCCCCCGTGCAGACCCTTGCTG
GCGCAAGTCTCCGCTTGGGG

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MTNLPKKYLFDIPEGMIYLDGNSLGPLPKGAAERAAKVLTQEWGTQLIKAWNTADWMALPQKVGDRIAGFIGAAPGSVAT
GDTLSIKVYQALAAALKMRPERRVILSDTGNFPTDLYMAQGLISTIGKDYELRTVAPEEVADAITDDVAVVMLTEVDYRS
GRRHDMMEMTARAHQNGAVMIWDLAHSAGALPVDLTACNAEFAVGCTYKYFNGGPGAPAFIYARPDIVLEVDPALAGWLG
HDAPFAMEPDYRPAMTTERLRVGTPSIVQLSILDTALDVWDGVSMEEIRGASVALCETFIAEVEARCPELTLASPREAAL
RGSQVSFAFEDGYAVVQALIDRGVIGDFRAPNIMRFGFTPLYLDQADVVQAAEILEDVMKRESWKDPKYQVRSRVT

Sequences:

>Translated_396_residues
MTNLPKKYLFDIPEGMIYLDGNSLGPLPKGAAERAAKVLTQEWGTQLIKAWNTADWMALPQKVGDRIAGFIGAAPGSVAT
GDTLSIKVYQALAAALKMRPERRVILSDTGNFPTDLYMAQGLISTIGKDYELRTVAPEEVADAITDDVAVVMLTEVDYRS
GRRHDMMEMTARAHQNGAVMIWDLAHSAGALPVDLTACNAEFAVGCTYKYFNGGPGAPAFIYARPDIVLEVDPALAGWLG
HDAPFAMEPDYRPAMTTERLRVGTPSIVQLSILDTALDVWDGVSMEEIRGASVALCETFIAEVEARCPELTLASPREAAL
RGSQVSFAFEDGYAVVQALIDRGVIGDFRAPNIMRFGFTPLYLDQADVVQAAEILEDVMKRESWKDPKYQVRSRVT
>Mature_395_residues
TNLPKKYLFDIPEGMIYLDGNSLGPLPKGAAERAAKVLTQEWGTQLIKAWNTADWMALPQKVGDRIAGFIGAAPGSVATG
DTLSIKVYQALAAALKMRPERRVILSDTGNFPTDLYMAQGLISTIGKDYELRTVAPEEVADAITDDVAVVMLTEVDYRSG
RRHDMMEMTARAHQNGAVMIWDLAHSAGALPVDLTACNAEFAVGCTYKYFNGGPGAPAFIYARPDIVLEVDPALAGWLGH
DAPFAMEPDYRPAMTTERLRVGTPSIVQLSILDTALDVWDGVSMEEIRGASVALCETFIAEVEARCPELTLASPREAALR
GSQVSFAFEDGYAVVQALIDRGVIGDFRAPNIMRFGFTPLYLDQADVVQAAEILEDVMKRESWKDPKYQVRSRVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=410, Percent_Identity=25.3658536585366, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI74101437, Length=224, Percent_Identity=25, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17550466, Length=399, Percent_Identity=25.31328320802, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323261, Length=419, Percent_Identity=28.4009546539379, Blast_Score=139, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 43244; Mature: 43113

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLPKKYLFDIPEGMIYLDGNSLGPLPKGAAERAAKVLTQEWGTQLIKAWNTADWMALP
CCCCCCHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
QKVGDRIAGFIGAAPGSVATGDTLSIKVYQALAAALKMRPERRVILSDTGNFPTDLYMAQ
HHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
GLISTIGKDYELRTVAPEEVADAITDDVAVVMLTEVDYRSGRRHDMMEMTARAHQNGAVM
HHHHHHCCCCEEEECCHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEE
IWDLAHSAGALPVDLTACNAEFAVGCTYKYFNGGPGAPAFIYARPDIVLEVDPALAGWLG
EEEECCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCEEEEECCCEEEEECHHHHHHCC
HDAPFAMEPDYRPAMTTERLRVGTPSIVQLSILDTALDVWDGVSMEEIRGASVALCETFI
CCCCCCCCCCCCCCCCCCCEECCCCCEEEEEHHHHHHHHHCCCCHHHHCCCHHHHHHHHH
AEVEARCPELTLASPREAALRGSQVSFAFEDGYAVVQALIDRGVIGDFRAPNIMRFGFTP
HHHHHCCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCEEEECCCE
LYLDQADVVQAAEILEDVMKRESWKDPKYQVRSRVT
EEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
>Mature Secondary Structure 
TNLPKKYLFDIPEGMIYLDGNSLGPLPKGAAERAAKVLTQEWGTQLIKAWNTADWMALP
CCCCCHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
QKVGDRIAGFIGAAPGSVATGDTLSIKVYQALAAALKMRPERRVILSDTGNFPTDLYMAQ
HHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
GLISTIGKDYELRTVAPEEVADAITDDVAVVMLTEVDYRSGRRHDMMEMTARAHQNGAVM
HHHHHHCCCCEEEECCHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEE
IWDLAHSAGALPVDLTACNAEFAVGCTYKYFNGGPGAPAFIYARPDIVLEVDPALAGWLG
EEEECCCCCCCEEEEEECCCCEEEEEEEEECCCCCCCCEEEEECCCEEEEECHHHHHHCC
HDAPFAMEPDYRPAMTTERLRVGTPSIVQLSILDTALDVWDGVSMEEIRGASVALCETFI
CCCCCCCCCCCCCCCCCCCEECCCCCEEEEEHHHHHHHHHCCCCHHHHCCCHHHHHHHHH
AEVEARCPELTLASPREAALRGSQVSFAFEDGYAVVQALIDRGVIGDFRAPNIMRFGFTP
HHHHHCCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCEEEECCCE
LYLDQADVVQAAEILEDVMKRESWKDPKYQVRSRVT
EEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA