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The map label for this gene is kynA

Identifier: 99082066

GI number: 99082066

Start: 2337273

End: 2338112

Strand: Reverse

Name: kynA

Synonym: TM1040_2226

Alternate gene names: 99082066

Gene position: 2338112-2337273 (Counterclockwise)

Preceding gene: 99082069

Following gene: 99082065

Centisome position: 73.04

GC content: 58.21

Gene sequence:

>840_bases
ATGAGCGATTCCGCCTATAATCCCGGCCAGGACGGGGCAAAGATGGGCTTTGCCGATGCCATGTCTTATGGCGATTACCT
GCATCTGGATGCGCTCCTGGATCAGCAGCACTGCAAGAGCGATGCCCATGACGAGATGCTGTTCATTATCCAGCATCAGA
CCAGCGAGCTATGGATGAAGCTTGCCTTGCACGAGCTGCAGGCGGCGCGTGAGGCCTTGCAGCAGGGGCAGACTGCCGAA
ATGTTCAAGATGCTCGCGCGGGTGAGCCGGATTTTTGAGCAGCTCAACAGCGCCTGGGATGTGCTGCGCACCATGACGCC
CGCCGATTACACCCGATTTCGCGAGGCTCTGGGGCCGTCCTCGGGGTTTCAGTCCTATCAATATCGTCTGATCGAATATG
TTCTGGGCAATCGCAATCCCAACATGCTGCGCCCGCATGAGCATGTGCCAGAGGTGCATGCGCTCCTCAGTGCGGAGCTG
GCGCGCCCGAGTTTTTATGACGAGGTGAACCGGTATCTGTTTCAGACGCTGGACGGTCACACCGAAAACCTCCCCGCGCC
GAGACTGGATGCGCCGCATGCTCTGGATGAGACGATCCAAGAGCGCTGGCTCAAGGTTTACGGCGACATCGACACCTATT
GGACCCTTTATGAACTGGCCGAGAAGCTGGTTGATCTTGAGGATTATTTCCGCCGTTGGCGTTTCAACCACGTCACCACG
GTGGAGCGCGTGATTGGCTTCAAGCGCGGCACCGGCGGCACCTCTGGGGTGCAATATCTGCGCCGGATGCTGAGCGTGGA
GCTGTTTCCTGAACTTTGGACCCTGAGAGGCGATCTCTGA

Upstream 100 bases:

>100_bases
TCTTGCGTCCGGTCCGGTGGCACAATACCGTCTGGCCGACGCTGTCCCCTGACGGGCGATCCCAGATCGGGCGCCCGTGA
TCCTGAAAGAGAGGTCCACC

Downstream 100 bases:

>100_bases
CATGACAAACCTGCCCAAAAAATACCTCTTCGATATTCCCGAGGGCATGATCTATCTCGATGGAAACTCGCTTGGCCCCC
TGCCAAAGGGCGCGGCAGAG

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MSDSAYNPGQDGAKMGFADAMSYGDYLHLDALLDQQHCKSDAHDEMLFIIQHQTSELWMKLALHELQAAREALQQGQTAE
MFKMLARVSRIFEQLNSAWDVLRTMTPADYTRFREALGPSSGFQSYQYRLIEYVLGNRNPNMLRPHEHVPEVHALLSAEL
ARPSFYDEVNRYLFQTLDGHTENLPAPRLDAPHALDETIQERWLKVYGDIDTYWTLYELAEKLVDLEDYFRRWRFNHVTT
VERVIGFKRGTGGTSGVQYLRRMLSVELFPELWTLRGDL

Sequences:

>Translated_279_residues
MSDSAYNPGQDGAKMGFADAMSYGDYLHLDALLDQQHCKSDAHDEMLFIIQHQTSELWMKLALHELQAAREALQQGQTAE
MFKMLARVSRIFEQLNSAWDVLRTMTPADYTRFREALGPSSGFQSYQYRLIEYVLGNRNPNMLRPHEHVPEVHALLSAEL
ARPSFYDEVNRYLFQTLDGHTENLPAPRLDAPHALDETIQERWLKVYGDIDTYWTLYELAEKLVDLEDYFRRWRFNHVTT
VERVIGFKRGTGGTSGVQYLRRMLSVELFPELWTLRGDL
>Mature_278_residues
SDSAYNPGQDGAKMGFADAMSYGDYLHLDALLDQQHCKSDAHDEMLFIIQHQTSELWMKLALHELQAAREALQQGQTAEM
FKMLARVSRIFEQLNSAWDVLRTMTPADYTRFREALGPSSGFQSYQYRLIEYVLGNRNPNMLRPHEHVPEVHALLSAELA
RPSFYDEVNRYLFQTLDGHTENLPAPRLDAPHALDETIQERWLKVYGDIDTYWTLYELAEKLVDLEDYFRRWRFNHVTTV
ERVIGFKRGTGGTSGVQYLRRMLSVELFPELWTLRGDL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family

Homologues:

Organism=Homo sapiens, GI5032165, Length=144, Percent_Identity=40.9722222222222, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17552370, Length=344, Percent_Identity=28.1976744186047, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32564651, Length=146, Percent_Identity=36.3013698630137, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17530891, Length=174, Percent_Identity=40.2298850574713, Blast_Score=100, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): T23O_SILST (Q1GEF8)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614220.1
- ProteinModelPortal:   Q1GEF8
- SMR:   Q1GEF8
- STRING:   Q1GEF8
- GeneID:   4078217
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2226
- NMPDR:   fig|292414.1.peg.591
- eggNOG:   COG3483
- HOGENOM:   HBG647485
- OMA:   HWELYEL
- ProtClustDB:   CLSK751681
- BioCyc:   SSP292414:TM1040_2226-MONOMER
- InterPro:   IPR004981
- PANTHER:   PTHR10138

Pfam domain/function: PF03301 Trp_dioxygenase

EC number: =1.13.11.11

Molecular weight: Translated: 32455; Mature: 32324

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: BINDING 110-110 BINDING 114-114 BINDING 121-121 BINDING 251-251

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSAYNPGQDGAKMGFADAMSYGDYLHLDALLDQQHCKSDAHDEMLFIIQHQTSELWMK
CCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHH
LALHELQAAREALQQGQTAEMFKMLARVSRIFEQLNSAWDVLRTMTPADYTRFREALGPS
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
SGFQSYQYRLIEYVLGNRNPNMLRPHEHVPEVHALLSAELARPSFYDEVNRYLFQTLDGH
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
TENLPAPRLDAPHALDETIQERWLKVYGDIDTYWTLYELAEKLVDLEDYFRRWRFNHVTT
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VERVIGFKRGTGGTSGVQYLRRMLSVELFPELWTLRGDL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDSAYNPGQDGAKMGFADAMSYGDYLHLDALLDQQHCKSDAHDEMLFIIQHQTSELWMK
CCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHH
LALHELQAAREALQQGQTAEMFKMLARVSRIFEQLNSAWDVLRTMTPADYTRFREALGPS
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
SGFQSYQYRLIEYVLGNRNPNMLRPHEHVPEVHALLSAELARPSFYDEVNRYLFQTLDGH
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
TENLPAPRLDAPHALDETIQERWLKVYGDIDTYWTLYELAEKLVDLEDYFRRWRFNHVTT
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VERVIGFKRGTGGTSGVQYLRRMLSVELFPELWTLRGDL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA