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The map label for this gene is cobH [H]

Identifier: 99082052

GI number: 99082052

Start: 2325365

End: 2325994

Strand: Direct

Name: cobH [H]

Synonym: TM1040_2212

Alternate gene names: 99082052

Gene position: 2325365-2325994 (Clockwise)

Preceding gene: 99082051

Following gene: 99082053

Centisome position: 72.65

GC content: 63.65

Gene sequence:

>630_bases
ATGCTGCACACCTATGAAACCGACGGCGCCAAGATCTATGCCGAGAGCTTTGCGACCATCCGCGCAGAGGCCAATCTGGC
GCGGTTCACCAAGGATGAAGAGGTCGTGGCCGTGCGCATGATCCACGCCGCAGGCATGGTCGGGCTCGAAGAGCACGTGC
GCTTTTCAGAGGGCATGGCCAAAACCGCCCGTGCCGCGCTGGCAGACGGCGCGCCGATCCTGTGTGATGCCTACATGGTT
TCTGAGGGCATCACCCGCCCGCGCCTGCCTGCGGACAACGAGGTGATCTGCACTCTGCGCGACCCCAAGGTTCCTGAGAT
GGCGCGTGAGATGGGCAACACCCGCTCTGCCGCCGCGCTGGAGCTTTGGCGCCCCAAACTCGACGGCGCAGTGGTCGCCA
TCGGCAATGCGCCAACTGCGCTGTTTCATCTTCTGAACATGCTCAAGGACCCCGCTTGTCCGCGTCCCGCAGCGATCATC
GGCTGCCCGGTGGGATTCGTCGGCGCGCGCGAATCCAAGGACGCCCTGATGGAGGACCTGCCTGTGCCGTCGATGATCGT
CGAAGGACGTCTTGGTGGGTCTGCCATCACCGTGGCAGCGGTCAATGCGCTTGCCTCCTGGAAAGAATGA

Upstream 100 bases:

>100_bases
CTCATCCGCAAGGGCCGCGCCAGCGACGCCCCCTTGCGTTCCGACCTCACTGCGCGCACCCTGCGCGCCGCGCCGCACAT
CCTGACGAAAGACACCTGAC

Downstream 100 bases:

>100_bases
CGGGGAAGGACCGATCATGAACGTGCCCAAAGCCGGCAAAGTCATCTGTGCGGGCCTCGGCCCGGGCGACCCGGAGCTGA
TGAGCGTCAAAAGCTGGCGC

Product: precorrin-8X methylmutase

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MLHTYETDGAKIYAESFATIRAEANLARFTKDEEVVAVRMIHAAGMVGLEEHVRFSEGMAKTARAALADGAPILCDAYMV
SEGITRPRLPADNEVICTLRDPKVPEMAREMGNTRSAAALELWRPKLDGAVVAIGNAPTALFHLLNMLKDPACPRPAAII
GCPVGFVGARESKDALMEDLPVPSMIVEGRLGGSAITVAAVNALASWKE

Sequences:

>Translated_209_residues
MLHTYETDGAKIYAESFATIRAEANLARFTKDEEVVAVRMIHAAGMVGLEEHVRFSEGMAKTARAALADGAPILCDAYMV
SEGITRPRLPADNEVICTLRDPKVPEMAREMGNTRSAAALELWRPKLDGAVVAIGNAPTALFHLLNMLKDPACPRPAAII
GCPVGFVGARESKDALMEDLPVPSMIVEGRLGGSAITVAAVNALASWKE
>Mature_209_residues
MLHTYETDGAKIYAESFATIRAEANLARFTKDEEVVAVRMIHAAGMVGLEEHVRFSEGMAKTARAALADGAPILCDAYMV
SEGITRPRLPADNEVICTLRDPKVPEMAREMGNTRSAAALELWRPKLDGAVVAIGNAPTALFHLLNMLKDPACPRPAAII
GCPVGFVGARESKDALMEDLPVPSMIVEGRLGGSAITVAAVNALASWKE

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: =5.4.1.2 [H]

Molecular weight: Translated: 22313; Mature: 22313

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHTYETDGAKIYAESFATIRAEANLARFTKDEEVVAVRMIHAAGMVGLEEHVRFSEGMA
CCCEEECCCCEEEEHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
KTARAALADGAPILCDAYMVSEGITRPRLPADNEVICTLRDPKVPEMAREMGNTRSAAAL
HHHHHHHCCCCCCEEHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHH
ELWRPKLDGAVVAIGNAPTALFHLLNMLKDPACPRPAAIIGCPVGFVGARESKDALMEDL
HHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHC
PVPSMIVEGRLGGSAITVAAVNALASWKE
CCCCEEEECCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLHTYETDGAKIYAESFATIRAEANLARFTKDEEVVAVRMIHAAGMVGLEEHVRFSEGMA
CCCEEECCCCEEEEHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
KTARAALADGAPILCDAYMVSEGITRPRLPADNEVICTLRDPKVPEMAREMGNTRSAAAL
HHHHHHHCCCCCCEEHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHH
ELWRPKLDGAVVAIGNAPTALFHLLNMLKDPACPRPAAIIGCPVGFVGARESKDALMEDL
HHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHC
PVPSMIVEGRLGGSAITVAAVNALASWKE
CCCCEEEECCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 1732194 [H]