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The map label for this gene is cobI [H]

Identifier: 99082053

GI number: 99082053

Start: 2326011

End: 2326742

Strand: Direct

Name: cobI [H]

Synonym: TM1040_2213

Alternate gene names: 99082053

Gene position: 2326011-2326742 (Clockwise)

Preceding gene: 99082052

Following gene: 99082054

Centisome position: 72.67

GC content: 63.52

Gene sequence:

>732_bases
ATGAACGTGCCCAAAGCCGGCAAAGTCATCTGTGCGGGCCTCGGCCCGGGCGACCCGGAGCTGATGAGCGTCAAAAGCTG
GCGCGCCCTGCAAGGCGCGACCCATGTGGCCTATTTCCGCAAGGCAGGCCGCGCCGGGCAAGCCCGCGCCATCGTCGAGG
GCCTCTTGCCTGCGGGCGTCACCGAATACCCAATGGAATACCCGGTCACCACAGAGATCCATTTCTCCGACCCGGAATAT
AACCGCCAGCTTGCGGCCTTTTATGACCAATGGGCCGACACATTGGCCGAGATCGCAGCCACGCAAACCGTGGTGGTGCT
GTGCGAAGGCGATCCCTTTCTCTATGGATCGTTCATGCATCTGCATACCCGGCTCGAAGGACGCGCCGAGGTCGAGATCA
TCCCCGGCATCACCGGCATGTCAGGTTGCTGGACCGCCACCGGTCAGCCGATCACCTGGGGCGATGATGTCCTGACGGTC
GCGATGGCGACGCTGTCCGAAGACGAACTGACCCAGCGCATCCGGCAGACCGACGCGCTGGTCGTCATGAAAATCGGTCG
CAACCTGCCTAAGCTGCGCCGCGCACTCGAGGCTGCTGGCCGGTTGCAGGACGCTTGGCTTGTGGAGCGCGGCACCATGC
CGGCCCAGACGGTGCAAAAGCTCACCGATGTCGACGGCGAGGTGCCGTATTTCTCGATCGTGATCCTGCACGGAGAAGGA
CGCCGCCCATGA

Upstream 100 bases:

>100_bases
CCGTCGATGATCGTCGAAGGACGTCTTGGTGGGTCTGCCATCACCGTGGCAGCGGTCAATGCGCTTGCCTCCTGGAAAGA
ATGACGGGGAAGGACCGATC

Downstream 100 bases:

>100_bases
ATGACACCCCAAAAGGCTGGGTGGTGATTGCAGGCCTTGGCCCCGGCGCCGAGAGCATGGTGATCCCCGAGGTCCAGGAC
GTGCTGGCCGAGGCCACCGA

Product: precorrin-2 C20-methyltransferase

Products: NA

Alternate protein names: S-adenosyl-L-methionine--precorrin-2 methyltransferase; SP2MT [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MNVPKAGKVICAGLGPGDPELMSVKSWRALQGATHVAYFRKAGRAGQARAIVEGLLPAGVTEYPMEYPVTTEIHFSDPEY
NRQLAAFYDQWADTLAEIAATQTVVVLCEGDPFLYGSFMHLHTRLEGRAEVEIIPGITGMSGCWTATGQPITWGDDVLTV
AMATLSEDELTQRIRQTDALVVMKIGRNLPKLRRALEAAGRLQDAWLVERGTMPAQTVQKLTDVDGEVPYFSIVILHGEG
RRP

Sequences:

>Translated_243_residues
MNVPKAGKVICAGLGPGDPELMSVKSWRALQGATHVAYFRKAGRAGQARAIVEGLLPAGVTEYPMEYPVTTEIHFSDPEY
NRQLAAFYDQWADTLAEIAATQTVVVLCEGDPFLYGSFMHLHTRLEGRAEVEIIPGITGMSGCWTATGQPITWGDDVLTV
AMATLSEDELTQRIRQTDALVVMKIGRNLPKLRRALEAAGRLQDAWLVERGTMPAQTVQKLTDVDGEVPYFSIVILHGEG
RRP
>Mature_243_residues
MNVPKAGKVICAGLGPGDPELMSVKSWRALQGATHVAYFRKAGRAGQARAIVEGLLPAGVTEYPMEYPVTTEIHFSDPEY
NRQLAAFYDQWADTLAEIAATQTVVVLCEGDPFLYGSFMHLHTRLEGRAEVEIIPGITGMSGCWTATGQPITWGDDVLTV
AMATLSEDELTQRIRQTDALVVMKIGRNLPKLRRALEAAGRLQDAWLVERGTMPAQTVQKLTDVDGEVPYFSIVILHGEG
RRP

Specific function: Methylates precorrin-2 at the C-20 position to produce precorrin-3A [H]

COG id: COG2243

COG function: function code H; Precorrin-2 methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR012382
- InterPro:   IPR006364
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.130 [H]

Molecular weight: Translated: 26624; Mature: 26624

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVPKAGKVICAGLGPGDPELMSVKSWRALQGATHVAYFRKAGRAGQARAIVEGLLPAGV
CCCCCCCCEEEECCCCCCHHHEEHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCCC
TEYPMEYPVTTEIHFSDPEYNRQLAAFYDQWADTLAEIAATQTVVVLCEGDPFLYGSFMH
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEHHHH
LHTRLEGRAEVEIIPGITGMSGCWTATGQPITWGDDVLTVAMATLSEDELTQRIRQTDAL
HHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCE
VVMKIGRNLPKLRRALEAAGRLQDAWLVERGTMPAQTVQKLTDVDGEVPYFSIVILHGEG
EEEECCCCCHHHHHHHHHHCCCCHHHEEECCCCCHHHHHHHHCCCCCCCEEEEEEEECCC
RRP
CCC
>Mature Secondary Structure
MNVPKAGKVICAGLGPGDPELMSVKSWRALQGATHVAYFRKAGRAGQARAIVEGLLPAGV
CCCCCCCCEEEECCCCCCHHHEEHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCCC
TEYPMEYPVTTEIHFSDPEYNRQLAAFYDQWADTLAEIAATQTVVVLCEGDPFLYGSFMH
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEHHHH
LHTRLEGRAEVEIIPGITGMSGCWTATGQPITWGDDVLTVAMATLSEDELTQRIRQTDAL
HHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCE
VVMKIGRNLPKLRRALEAAGRLQDAWLVERGTMPAQTVQKLTDVDGEVPYFSIVILHGEG
EEEECCCCCHHHHHHHHHHCCCCHHHEEECCCCCHHHHHHHHCCCCCCCEEEEEEEECCC
RRP
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521 [H]