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The map label for this gene is tas [H]

Identifier: 99082030

GI number: 99082030

Start: 2299874

End: 2300920

Strand: Reverse

Name: tas [H]

Synonym: TM1040_2190

Alternate gene names: 99082030

Gene position: 2300920-2299874 (Counterclockwise)

Preceding gene: 99082032

Following gene: 99082028

Centisome position: 71.88

GC content: 59.31

Gene sequence:

>1047_bases
ATGAAGAAGAACCGGCTTGGCCGCACAGATATGATGGTGACCGATCTGTGCCTTGGGACCATGACCTATGGCACTCAGAC
CGATGAAGCGGATGCGCATGCGCAGATCGACATGGCGCTGGAAGCGGGGATCAACTTCCTCGATACCGCTGAGATGTATC
CAGTGAACCCCATTCGGGCGGAGACCCTTGGTCTGAGCGAAGAGATCATCGGCAACTGGAACCAAAAGACCGGCCGCCGG
AAGGACTATATCCTTGCGACAAAACACTCAGGCGAGGGCTCCGTGGCGCGCGACGGGGCGCCGATCACAGGCAAAACCAT
TGCGGCGACCGTTGAGGCATCGTTGAAGCGGCTCAAGACCGACTACATCGACCTTTATCAGTTTCACTGGCCAAACCGCG
GCAGCTACATGTTCCGCAAGAACTGGAGTTATGATCCGACCGCTTCTTCTTATAATCGCGCGCAGGTGATCGCGGATATG
GAAGAATGCCTCGCCGCGTTGCAGGCGCAAGTCGAAAAGGGCAACATCCGCGCCTTTGGGCTTTCCAATGAAAGCGCCTG
GGGCACTGCGCAATGGCTGCGTCTGGCGGAAGAGGGCAAGGGCCCGCGGGTTGCCTCGATCCAGAACGAATACTCTTTGC
TGTGCAGGCTTTATGACACGGACCTGGCAGAGCTGAGCCACTATGAGGATGTTGGCTTGCTGTCGTTCTCTCCTTTGGGG
GCCGGGTATCTCACCGGGAAATATCAAGAGGGTGCGGTGCCGGAAAAGTCGCGCAAGTCGATCAACCCGGAGATGGGCGG
GCGGCAGTCTGATCGGGTAGAGGCGGCCGTCGCGGCCTACCTGACGATCGCGGCCGATCATGGGCTGGATCCGGTGCATA
TGGCGCTGGGGTGGTGCCGGACACGGCCGTTTATGGCTTCGGCGATCTTTGGTGCGACCGATGTGGCGCAGCTCGCGCAT
ATCCTTGAAGGTGCGGATCTTGAACTGGCGCCCGAAGTTCTGGCTCAGATCGATCAGGCCCATCGCGCCCATGCGATGCC
GTACTGA

Upstream 100 bases:

>100_bases
AAAGGGTGGGCAACGCGCCCCAGGAGCGCCGTTCAATGACTTGCATCCGCTCCCCGGCGGGCTAGGGTCCGCGAGGAACA
GAACATCAGGAGAGCGCGAG

Downstream 100 bases:

>100_bases
GGCCAACGGAGGGGGCGCTGCCCCCTCTTGCCCTGATCGGGCAATTCACCCCCGGGATATTTGTGAGAAGATGAAGGGCT
AGTTGGTGCTGTGGCTGGCG

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MKKNRLGRTDMMVTDLCLGTMTYGTQTDEADAHAQIDMALEAGINFLDTAEMYPVNPIRAETLGLSEEIIGNWNQKTGRR
KDYILATKHSGEGSVARDGAPITGKTIAATVEASLKRLKTDYIDLYQFHWPNRGSYMFRKNWSYDPTASSYNRAQVIADM
EECLAALQAQVEKGNIRAFGLSNESAWGTAQWLRLAEEGKGPRVASIQNEYSLLCRLYDTDLAELSHYEDVGLLSFSPLG
AGYLTGKYQEGAVPEKSRKSINPEMGGRQSDRVEAAVAAYLTIAADHGLDPVHMALGWCRTRPFMASAIFGATDVAQLAH
ILEGADLELAPEVLAQIDQAHRAHAMPY

Sequences:

>Translated_348_residues
MKKNRLGRTDMMVTDLCLGTMTYGTQTDEADAHAQIDMALEAGINFLDTAEMYPVNPIRAETLGLSEEIIGNWNQKTGRR
KDYILATKHSGEGSVARDGAPITGKTIAATVEASLKRLKTDYIDLYQFHWPNRGSYMFRKNWSYDPTASSYNRAQVIADM
EECLAALQAQVEKGNIRAFGLSNESAWGTAQWLRLAEEGKGPRVASIQNEYSLLCRLYDTDLAELSHYEDVGLLSFSPLG
AGYLTGKYQEGAVPEKSRKSINPEMGGRQSDRVEAAVAAYLTIAADHGLDPVHMALGWCRTRPFMASAIFGATDVAQLAH
ILEGADLELAPEVLAQIDQAHRAHAMPY
>Mature_348_residues
MKKNRLGRTDMMVTDLCLGTMTYGTQTDEADAHAQIDMALEAGINFLDTAEMYPVNPIRAETLGLSEEIIGNWNQKTGRR
KDYILATKHSGEGSVARDGAPITGKTIAATVEASLKRLKTDYIDLYQFHWPNRGSYMFRKNWSYDPTASSYNRAQVIADM
EECLAALQAQVEKGNIRAFGLSNESAWGTAQWLRLAEEGKGPRVASIQNEYSLLCRLYDTDLAELSHYEDVGLLSFSPLG
AGYLTGKYQEGAVPEKSRKSINPEMGGRQSDRVEAAVAAYLTIAADHGLDPVHMALGWCRTRPFMASAIFGATDVAQLAH
ILEGADLELAPEVLAQIDQAHRAHAMPY

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436964, Length=362, Percent_Identity=26.7955801104972, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI27436971, Length=355, Percent_Identity=27.3239436619718, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4504825, Length=343, Percent_Identity=25.9475218658892, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI27436966, Length=362, Percent_Identity=27.0718232044199, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI27436969, Length=348, Percent_Identity=25.8620689655172, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI27436962, Length=356, Percent_Identity=26.9662921348315, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI41327764, Length=233, Percent_Identity=27.4678111587983, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1789199, Length=352, Percent_Identity=43.4659090909091, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI87081735, Length=358, Percent_Identity=29.8882681564246, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1788070, Length=350, Percent_Identity=26.8571428571429, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789375, Length=356, Percent_Identity=25.8426966292135, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788081, Length=314, Percent_Identity=25.1592356687898, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323998, Length=346, Percent_Identity=22.8323699421965, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319951, Length=365, Percent_Identity=23.5616438356164, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319958, Length=324, Percent_Identity=22.2222222222222, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322615, Length=239, Percent_Identity=22.1757322175732, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644950, Length=316, Percent_Identity=24.6835443037975, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 38314; Mature: 38314

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNRLGRTDMMVTDLCLGTMTYGTQTDEADAHAQIDMALEAGINFLDTAEMYPVNPIRA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCH
ETLGLSEEIIGNWNQKTGRRKDYILATKHSGEGSVARDGAPITGKTIAATVEASLKRLKT
HHCCCCHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
DYIDLYQFHWPNRGSYMFRKNWSYDPTASSYNRAQVIADMEECLAALQAQVEKGNIRAFG
HHHHHHEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LSNESAWGTAQWLRLAEEGKGPRVASIQNEYSLLCRLYDTDLAELSHYEDVGLLSFSPLG
CCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCHHHHHCCCCCCCEEECCCC
AGYLTGKYQEGAVPEKSRKSINPEMGGRQSDRVEAAVAAYLTIAADHGLDPVHMALGWCR
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TRPFMASAIFGATDVAQLAHILEGADLELAPEVLAQIDQAHRAHAMPY
CCHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKNRLGRTDMMVTDLCLGTMTYGTQTDEADAHAQIDMALEAGINFLDTAEMYPVNPIRA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCH
ETLGLSEEIIGNWNQKTGRRKDYILATKHSGEGSVARDGAPITGKTIAATVEASLKRLKT
HHCCCCHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
DYIDLYQFHWPNRGSYMFRKNWSYDPTASSYNRAQVIADMEECLAALQAQVEKGNIRAFG
HHHHHHEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LSNESAWGTAQWLRLAEEGKGPRVASIQNEYSLLCRLYDTDLAELSHYEDVGLLSFSPLG
CCCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCHHHHHCCCCCCCEEECCCC
AGYLTGKYQEGAVPEKSRKSINPEMGGRQSDRVEAAVAAYLTIAADHGLDPVHMALGWCR
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TRPFMASAIFGATDVAQLAHILEGADLELAPEVLAQIDQAHRAHAMPY
CCHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9560382; 9278503 [H]