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The map label for this gene is hbd [H]

Identifier: 99082026

GI number: 99082026

Start: 2295598

End: 2297073

Strand: Reverse

Name: hbd [H]

Synonym: TM1040_2186

Alternate gene names: 99082026

Gene position: 2297073-2295598 (Counterclockwise)

Preceding gene: 99082027

Following gene: 99082025

Centisome position: 71.76

GC content: 62.06

Gene sequence:

>1476_bases
ATGACAAAAACAGCAGCAATCATTGGCGGTGGCGTTATCGGCGGCGGTTGGGCCGCGCGGTTCTTGCTCAATGGCTGGGA
TGTGCGGGTCTTTGACCCGGATCCCGAAGCCGAGCGCAAGATTGGCGATGTTCTTGCCAATGCCCGCCGCAGCCTGCCCG
GGCTTGGCAATGTGGCGCTGCCACCCGAAGGAAGTCTGAGCTATCATGAGACCCTCGCGGAAACCGTGCAGGGCGTCGAC
TGGGTACAGGAGAGCGTGCCCGAGCGGCTCGATCTGAAACAGAAAGTATACGCAGAGCTCGAGGCGCATGCGCCCGGGGG
CGCGGTGATTGGTTCGTCGACCTCGGGCTACAAGCCCTCGCAATTGCAGGACGGGTTCACCAACGCCGCACAGATCGTTG
TGGCGCATCCTTTCAATCCGGTCTACCTCATGCCGCTGGTGGAGGTGGTCACAACTGATGTGAACACGCCCGAGATGATT
GCCAAGGCCAAGGCGATCATCACCGAAATCGGCATGTATCCCTTGCACTTGAAAAAGGAAATCGACGCTCATGTGGCGGA
CCGGTTCCTTGAGGCGGTCTGGCGCGAGGCGCTGTGGCTGGTAAAAGATGGCATCGCCACCACCGAAGAGATCGACAACG
CGATCCGCTATGGCTTTGGCATCCGCTGGGCGCAGATGGGGCTGTTTGAAACCTACCGCGTTGCGGGCGGCGAGGCGGGC
ATGAAGCATTTCATGGCGCAGTTCGGCCCGGCTCTCAGCTGGCCCTGGACCAAACTGATGGATGTACCCGAGTATAATGA
TGCGTTGGTCGACCTGATCGCAGGCCAGTCGGACGCACAGTCAGGGCAGTATTCCATCCGCGAGCTCGAGCGTATCCGCG
ATGACAACCTCGTGGGGATGATGCGGGCGCTGGGCGCAAACAACTGGGGTGCCGGGGCGCTTCAGAATGCTCATGACGCC
GCGCGCCTGTCAGAGGCGGGGCTTGCGCGCAGCATGGAGGACGTTGCCGATCTGTCGCAGCCCATCCTCACCCAGAGCCG
CGTCGTGCCGCTCGATTGGACCGACTACAACGGCCACATGACCGAGAGCCGCTATCTGGATGCCTTTGCCCAATCCACTG
ACCGGCTGATGGAGATCATCGGCTGTGACGCCGACTATATCGCCTCAGGCGGCAGCTACTTCACCGCCGAGACCCATATC
CGCCATATCGACGAGGTCCACGCGGGCCACCCGGTCCAAGTCCGAACGCGGGTCATAATGGGCGCGGGTAAGAAGATGCA
CCTCTGGCACGAGATGTATGAAGGCGACCGCCTCCTGGCGACCGGCGAGCATATGCTCTTGCATGTGGATCTGAAAACCC
GCCGCTCGGCACCGCCGGCCGCGCATATCGAGGCCAATCTTGTGAAGCTCGCCGAGGCACATGCGGCGTTGCCCGCACCC
GAAGGGCTGGGTCGCGCCATCGGTGCGCCTCGCTAA

Upstream 100 bases:

>100_bases
CAGCGCGACAGAGCTGGAGGCTGCAAAAGCGGTCCTGCGCAAGAATGGATATGACACCGGGGCCCTGGAGATGGTGCCCC
AGAACTAGGGACAACGGGAT

Downstream 100 bases:

>100_bases
TGCGCGTTCTGGTGACGGCGGGCGCGTCCGGTATCGGGCGCGCCATGGCAGAGGGCTTTGTCGCGACGGGCGCCGAAGTC
TGGGTTTCCGATGTGGATCG

Product: bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MTKTAAIIGGGVIGGGWAARFLLNGWDVRVFDPDPEAERKIGDVLANARRSLPGLGNVALPPEGSLSYHETLAETVQGVD
WVQESVPERLDLKQKVYAELEAHAPGGAVIGSSTSGYKPSQLQDGFTNAAQIVVAHPFNPVYLMPLVEVVTTDVNTPEMI
AKAKAIITEIGMYPLHLKKEIDAHVADRFLEAVWREALWLVKDGIATTEEIDNAIRYGFGIRWAQMGLFETYRVAGGEAG
MKHFMAQFGPALSWPWTKLMDVPEYNDALVDLIAGQSDAQSGQYSIRELERIRDDNLVGMMRALGANNWGAGALQNAHDA
ARLSEAGLARSMEDVADLSQPILTQSRVVPLDWTDYNGHMTESRYLDAFAQSTDRLMEIIGCDADYIASGGSYFTAETHI
RHIDEVHAGHPVQVRTRVIMGAGKKMHLWHEMYEGDRLLATGEHMLLHVDLKTRRSAPPAAHIEANLVKLAEAHAALPAP
EGLGRAIGAPR

Sequences:

>Translated_491_residues
MTKTAAIIGGGVIGGGWAARFLLNGWDVRVFDPDPEAERKIGDVLANARRSLPGLGNVALPPEGSLSYHETLAETVQGVD
WVQESVPERLDLKQKVYAELEAHAPGGAVIGSSTSGYKPSQLQDGFTNAAQIVVAHPFNPVYLMPLVEVVTTDVNTPEMI
AKAKAIITEIGMYPLHLKKEIDAHVADRFLEAVWREALWLVKDGIATTEEIDNAIRYGFGIRWAQMGLFETYRVAGGEAG
MKHFMAQFGPALSWPWTKLMDVPEYNDALVDLIAGQSDAQSGQYSIRELERIRDDNLVGMMRALGANNWGAGALQNAHDA
ARLSEAGLARSMEDVADLSQPILTQSRVVPLDWTDYNGHMTESRYLDAFAQSTDRLMEIIGCDADYIASGGSYFTAETHI
RHIDEVHAGHPVQVRTRVIMGAGKKMHLWHEMYEGDRLLATGEHMLLHVDLKTRRSAPPAAHIEANLVKLAEAHAALPAP
EGLGRAIGAPR
>Mature_490_residues
TKTAAIIGGGVIGGGWAARFLLNGWDVRVFDPDPEAERKIGDVLANARRSLPGLGNVALPPEGSLSYHETLAETVQGVDW
VQESVPERLDLKQKVYAELEAHAPGGAVIGSSTSGYKPSQLQDGFTNAAQIVVAHPFNPVYLMPLVEVVTTDVNTPEMIA
KAKAIITEIGMYPLHLKKEIDAHVADRFLEAVWREALWLVKDGIATTEEIDNAIRYGFGIRWAQMGLFETYRVAGGEAGM
KHFMAQFGPALSWPWTKLMDVPEYNDALVDLIAGQSDAQSGQYSIRELERIRDDNLVGMMRALGANNWGAGALQNAHDAA
RLSEAGLARSMEDVADLSQPILTQSRVVPLDWTDYNGHMTESRYLDAFAQSTDRLMEIIGCDADYIASGGSYFTAETHIR
HIDEVHAGHPVQVRTRVIMGAGKKMHLWHEMYEGDRLLATGEHMLLHVDLKTRRSAPPAAHIEANLVKLAEAHAALPAPE
GLGRAIGAPR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=283, Percent_Identity=32.5088339222615, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI296179429, Length=252, Percent_Identity=26.5873015873016, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI68989263, Length=259, Percent_Identity=25.8687258687259, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI261878539, Length=259, Percent_Identity=25.8687258687259, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI296179427, Length=269, Percent_Identity=24.907063197026, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1787661, Length=223, Percent_Identity=25.1121076233184, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=276, Percent_Identity=23.9130434782609, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193203623, Length=276, Percent_Identity=23.9130434782609, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17563036, Length=229, Percent_Identity=27.0742358078603, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17549919, Length=294, Percent_Identity=25.5102040816327, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17553560, Length=276, Percent_Identity=23.5507246376812, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45549573, Length=251, Percent_Identity=32.6693227091633, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI20129993, Length=312, Percent_Identity=28.2051282051282, Blast_Score=131, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 53664; Mature: 53532

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTAAIIGGGVIGGGWAARFLLNGWDVRVFDPDPEAERKIGDVLANARRSLPGLGNVAL
CCCCEEEECCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC
PPEGSLSYHETLAETVQGVDWVQESVPERLDLKQKVYAELEAHAPGGAVIGSSTSGYKPS
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCH
QLQDGFTNAAQIVVAHPFNPVYLMPLVEVVTTDVNTPEMIAKAKAIITEIGMYPLHLKKE
HHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
IDAHVADRFLEAVWREALWLVKDGIATTEEIDNAIRYGFGIRWAQMGLFETYRVAGGEAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
MKHFMAQFGPALSWPWTKLMDVPEYNDALVDLIAGQSDAQSGQYSIRELERIRDDNLVGM
HHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHH
MRALGANNWGAGALQNAHDAARLSEAGLARSMEDVADLSQPILTQSRVVPLDWTDYNGHM
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCC
TESRYLDAFAQSTDRLMEIIGCDADYIASGGSYFTAETHIRHIDEVHAGHPVQVRTRVIM
CHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEHHHHHHHHHHHCCCCCCEEEEEEEC
GAGKKMHLWHEMYEGDRLLATGEHMLLHVDLKTRRSAPPAAHIEANLVKLAEAHAALPAP
CCCCHHHHHHHHHCCCEEEEECCEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
EGLGRAIGAPR
HHHHHHCCCCC
>Mature Secondary Structure 
TKTAAIIGGGVIGGGWAARFLLNGWDVRVFDPDPEAERKIGDVLANARRSLPGLGNVAL
CCCEEEECCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC
PPEGSLSYHETLAETVQGVDWVQESVPERLDLKQKVYAELEAHAPGGAVIGSSTSGYKPS
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCH
QLQDGFTNAAQIVVAHPFNPVYLMPLVEVVTTDVNTPEMIAKAKAIITEIGMYPLHLKKE
HHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
IDAHVADRFLEAVWREALWLVKDGIATTEEIDNAIRYGFGIRWAQMGLFETYRVAGGEAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
MKHFMAQFGPALSWPWTKLMDVPEYNDALVDLIAGQSDAQSGQYSIRELERIRDDNLVGM
HHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHH
MRALGANNWGAGALQNAHDAARLSEAGLARSMEDVADLSQPILTQSRVVPLDWTDYNGHM
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCC
TESRYLDAFAQSTDRLMEIIGCDADYIASGGSYFTAETHIRHIDEVHAGHPVQVRTRVIM
CHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEHHHHHHHHHHHCCCCCCEEEEEEEC
GAGKKMHLWHEMYEGDRLLATGEHMLLHVDLKTRRSAPPAAHIEANLVKLAEAHAALPAP
CCCCHHHHHHHHHCCCEEEEECCEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
EGLGRAIGAPR
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA