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The map label for this gene is ribB [H]

Identifier: 99081969

GI number: 99081969

Start: 2234044

End: 2235168

Strand: Reverse

Name: ribB [H]

Synonym: TM1040_2129

Alternate gene names: 99081969

Gene position: 2235168-2234044 (Counterclockwise)

Preceding gene: 99081970

Following gene: 99081968

Centisome position: 69.83

GC content: 60.27

Gene sequence:

>1125_bases
ATGAGCTATGAGACGCCCGGTCCAGTCGAGTCTGAGTTGCGCGACGCCATCAGTCCGATTGAAGAGATCATCGACGCCGC
GCGCGCGGGCAAGATGTATATTCTTGTCGATCATGAGGACCGCGAAAACGAGGGTGATCTGATCATCCCGGCGGAGTTTG
CCGACGCGGATGCGATCAACTTTATGGCCACCTATGGGCGTGGACTCATCTGCCTCCCAATGACGGCCGAGCGCATTGAT
CGTTTGGGCTTGCCGATGATGGCGGTGAACAATTCCTCGCGTCACGAGACGGCCTTTACCGTGTCGATCGAGGCGCGCGA
AGGGGTCGATACCGGGATTTCCGCCGCGGATCGTGCGCTGACCGTGGCCACGGCGATCAATGAGCAAAATACCATGGCGG
CGATTGCAACGCCGGGCCATGTTTTCCCGCTGCGCGCAAAACGCGGCGGGGTTCTGGTCCGGGCCGGGCACACCGAGGCC
TCTGTCGATATTTCGCGCATCGCGGGCTGTCACCCATCGGCCGTGATCTGCGAGATCATGAAAGACGATGGCACCATGGC
GCGACTGCCGGATCTGGTGGAATTTGCAAAAACCCACGATATGAAAATCGGCACCATCTCGGATCTCATCGCCTACCGCG
CCAAGAACGACAACCTCGTGGATGAGACCGCCCGCTCTACCGTTACCTCGGAATATGGGGGCGACTGGGAGATGCGGATC
TTCACCGATCAGACCCATGATGTGGAGCATGTTGTCCTGATCAAGGGCGACATCACCACGCCAGAGCCGGTGCTGACTCG
CACTCATGCGCTGCATGAGGCGTCCGACTTGCTGGGGCTTGGTCCCAAACCCGCTGGGGAACTGCCGCGCGCGATGGAAT
TGATCGCCGACGAGGGGCGCGGGATCGTCTGCCTGTTCCGCCAGCCGCGCAACGCGCTCTATGCCTCCGACGAGGAAGGG
GTGCGCACCATCAAACAGACCGGTCTCGGGGCGCAAATTCTGAATAAACTCGGCGTTGAGGAACTGATCCTGCTCACCGA
CTCGCCGCAAACCAAATATGTTGGGCTGGATGCCTATGGGCTGTCGATTGTCGGCACCCGTCCCATCCTGTCCCGAGACA
GCTAA

Upstream 100 bases:

>100_bases
TGGTATTTGCACAGCGCGTGGTCTATCCCGGCAGGGACGACAGCGGCGCGGGCAAGGGCTTCTTGACCGTGCGGCCCCAC
GAGCGAAAGGCCTGTTGCAT

Downstream 100 bases:

>100_bases
AGGAGTCCTCCGCCATGGCCGGACAAGAAAGCCACTACATCCTGCCGCGCCCTGAGTTTGACAAGCCGGTAAAGCTGCTC
ATCGTGGTCTCGCCCTATTA

Product: GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSYETPGPVESELRDAISPIEEIIDAARAGKMYILVDHEDRENEGDLIIPAEFADADAINFMATYGRGLICLPMTAERID
RLGLPMMAVNNSSRHETAFTVSIEAREGVDTGISAADRALTVATAINEQNTMAAIATPGHVFPLRAKRGGVLVRAGHTEA
SVDISRIAGCHPSAVICEIMKDDGTMARLPDLVEFAKTHDMKIGTISDLIAYRAKNDNLVDETARSTVTSEYGGDWEMRI
FTDQTHDVEHVVLIKGDITTPEPVLTRTHALHEASDLLGLGPKPAGELPRAMELIADEGRGIVCLFRQPRNALYASDEEG
VRTIKQTGLGAQILNKLGVEELILLTDSPQTKYVGLDAYGLSIVGTRPILSRDS

Sequences:

>Translated_374_residues
MSYETPGPVESELRDAISPIEEIIDAARAGKMYILVDHEDRENEGDLIIPAEFADADAINFMATYGRGLICLPMTAERID
RLGLPMMAVNNSSRHETAFTVSIEAREGVDTGISAADRALTVATAINEQNTMAAIATPGHVFPLRAKRGGVLVRAGHTEA
SVDISRIAGCHPSAVICEIMKDDGTMARLPDLVEFAKTHDMKIGTISDLIAYRAKNDNLVDETARSTVTSEYGGDWEMRI
FTDQTHDVEHVVLIKGDITTPEPVLTRTHALHEASDLLGLGPKPAGELPRAMELIADEGRGIVCLFRQPRNALYASDEEG
VRTIKQTGLGAQILNKLGVEELILLTDSPQTKYVGLDAYGLSIVGTRPILSRDS
>Mature_373_residues
SYETPGPVESELRDAISPIEEIIDAARAGKMYILVDHEDRENEGDLIIPAEFADADAINFMATYGRGLICLPMTAERIDR
LGLPMMAVNNSSRHETAFTVSIEAREGVDTGISAADRALTVATAINEQNTMAAIATPGHVFPLRAKRGGVLVRAGHTEAS
VDISRIAGCHPSAVICEIMKDDGTMARLPDLVEFAKTHDMKIGTISDLIAYRAKNDNLVDETARSTVTSEYGGDWEMRIF
TDQTHDVEHVVLIKGDITTPEPVLTRTHALHEASDLLGLGPKPAGELPRAMELIADEGRGIVCLFRQPRNALYASDEEGV
RTIKQTGLGAQILNKLGVEELILLTDSPQTKYVGLDAYGLSIVGTRPILSRDS

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=49.4949494949495, Blast_Score=202, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=39.6135265700483, Blast_Score=157, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 40530; Mature: 40398

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYETPGPVESELRDAISPIEEIIDAARAGKMYILVDHEDRENEGDLIIPAEFADADAIN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCHHH
FMATYGRGLICLPMTAERIDRLGLPMMAVNNSSRHETAFTVSIEAREGVDTGISAADRAL
HHHHHCCCEEEECCCHHHHHHCCCCEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHEE
TVATAINEQNTMAAIATPGHVFPLRAKRGGVLVRAGHTEASVDISRIAGCHPSAVICEIM
EEEEEECCCCCEEEEECCCCEEEEEECCCCEEEEECCCCCCCCHHHHCCCCCCCEEHEEC
KDDGTMARLPDLVEFAKTHDMKIGTISDLIAYRAKNDNLVDETARSTVTSEYGGDWEMRI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEE
FTDQTHDVEHVVLIKGDITTPEPVLTRTHALHEASDLLGLGPKPAGELPRAMELIADEGR
EECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
GIVCLFRQPRNALYASDEEGVRTIKQTGLGAQILNKLGVEELILLTDSPQTKYVGLDAYG
CEEEEEECCCCCEECCCHHHHHHHHHCCCCHHHHHHCCCEEEEEEECCCCCEEEEEEECC
LSIVGTRPILSRDS
EEEEECCCCCCCCC
>Mature Secondary Structure 
SYETPGPVESELRDAISPIEEIIDAARAGKMYILVDHEDRENEGDLIIPAEFADADAIN
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCHHH
FMATYGRGLICLPMTAERIDRLGLPMMAVNNSSRHETAFTVSIEAREGVDTGISAADRAL
HHHHHCCCEEEECCCHHHHHHCCCCEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHEE
TVATAINEQNTMAAIATPGHVFPLRAKRGGVLVRAGHTEASVDISRIAGCHPSAVICEIM
EEEEEECCCCCEEEEECCCCEEEEEECCCCEEEEECCCCCCCCHHHHCCCCCCCEEHEEC
KDDGTMARLPDLVEFAKTHDMKIGTISDLIAYRAKNDNLVDETARSTVTSEYGGDWEMRI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEE
FTDQTHDVEHVVLIKGDITTPEPVLTRTHALHEASDLLGLGPKPAGELPRAMELIADEGR
EECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCC
GIVCLFRQPRNALYASDEEGVRTIKQTGLGAQILNKLGVEELILLTDSPQTKYVGLDAYG
CEEEEEECCCCCEECCCHHHHHHHHHCCCCHHHHHHCCCEEEEEEECCCCCEEEEEEECC
LSIVGTRPILSRDS
EEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]