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The map label for this gene is clpA [C]

Identifier: 99081932

GI number: 99081932

Start: 2195880

End: 2198258

Strand: Direct

Name: clpA [C]

Synonym: TM1040_2092

Alternate gene names: 99081932

Gene position: 2195880-2198258 (Clockwise)

Preceding gene: 99081931

Following gene: 99081938

Centisome position: 68.6

GC content: 61.29

Gene sequence:

>2379_bases
GTGGCGGACGATCCCCATAACCCAAGACAGAGGAGCACGCCCGTGCCTTCATTCTCGAGCACACTGGAACAAGCCATTCA
CGCGGCGCTGGCGCTGGCGAATGAACGGCGTCACGAATTTGCAACCCTAGAGCACCTGCTTTTGGCCCTCACCGAGGAGC
CGGATGCCGCACGCGTCATGCGTGCCTGCAGCGTGAACCTCGACGAGCTGCGATCGACCCTGCTGGAATTTGTCGACGAG
GATCTGGCCAATCTGGTCACCGACATCGACGGTTCCGAAGCCGTGCCCACCGCAGCCTTCCAGCGCGTGATTCAACGCGC
AGCCATCCATGTTCAGTCCTCCGGCCGCACCGAAGTGACCGGCGCGAACGTGCTGGTGGCAATCTTTGCCGAGCGCGAGA
GCGACGCGGCCTTCTTCCTGCAGGACCAGGACATGACACGCTATGACGCGGTGAACTTCATCGCGCACGGCGTTGCCAAA
GATCCCGCCTACGGCGAGAACCGCCCCGTGACAGGCGCCAGCGAATCCGAAGAAGAAATCGGCGGCGGTCCGTCCATGGG
CAGCCCAGAGGGCGAACAAAAAGAGTCGGCTCTGGCGAAATACTGCGTCGACCTCAACGCCAAATCCCGCGAAGGCGACA
TCGATCCCCTGATCGGGCGCGACAGCGAAGTCGAGCGCTGCATCCAGGTGCTCTGCCGCCGCCGCAAGAACAACCCGCTT
TTGGTGGGGGATCCCGGCGTTGGTAAAACCGCCATCGCTGAAGGTCTCGCCCGCAAGGTCGTGCAGGGCGAAGTCCCCGA
GGTTCTGTCGGAAACCACCATCTACTCGCTCGACATGGGCGCGCTTTTGGCCGGCACACGCTATCGCGGTGACTTCGAAG
AGCGCCTTAAGGCCGTGGTGACCGAGCTTGAAGAACATCCCGATGCGGTGCTGTTCATCGACGAGATCCACACCGTGATC
GGTGCAGGTGCCACCTCGGGTGGGGCAATGGATGCGTCAAACCTGCTGAAGCCTGCCCTGCAGGGCGGCAAGCTGCGCAC
CATGGGATCCACCACCTACAAGGAGTTCCGTCAACATTTTGAGAAGGACCGCGCGCTGTCGCGTCGCTTCCAGAAGATCG
ACGTAAACGAGCCTTCGGTCGAAGACAGCATCGCGATCCTCAAAGGGCTGAAACCCTACTTTGAGGACCATCACTCGATC
AAATTCACATCGGATGCGATCAAATCCGCGGTGGAACTTTCGGCGCGCTACATCAACGACCGCAAGCTGCCGGACAAGGC
CATCGACGTAATCGACGAAGCCGGCGCCGCGCAGCACCTTGTGGCCGAGAGCAAGCGCCGCAAGACCATCGGCGTCAAGG
AGATTGAGGCCGTGGTGGCCAAGATCGCCCGCATCCCGCCGAAAAACGTCTCCAAGGACGATGCCGAGGTGCTGAAGGAC
CTCGAGGCGAGCCTGAAGCGCGTGGTCTTTGGTCAGGACGCAGCCATCGATGCGCTGTCTTCAGCGATCAAACTGGCCCG
TGCCGGGCTGCGCGAGCCGGAAAAACCCATCGGGAACTATCTCTTTGCGGGCCCCACCGGTGTCGGCAAAACCGAGGTGG
CCAAGCAGCTCGCAGATACGCTTGGGGTGGAACTCCTGCGCTTTGACATGTCGGAGTACATGGAGAAACACGCGGTCTCC
CGCCTGATCGGCGCGCCTCCGGGCTATGTCGGCTTTGACCAGGGTGGTCTTCTGACAGATGGCGTCGACCAGCATCCCCA
CTGCGTGCTGCTTCTCGACGAGATCGAGAAAGCGCACCCGGATGTGTTCAATATCCTCCTGCAGGTAATGGACAATGGCC
AGCTCACGGATCACAACGGCCGCACGGTCAATTTCCGCAACGTGGTTCTGATCATGACCTCCAACGCGGGCGCCTCGGAA
CTGGCGAAATCCGCCATCGGCTTTGGCCGCGACCGGCGCGAGGGTGAAGACACAGCTGCCATCGAGCGCACCTTCAGCCC
CGAATTCCGCAACCGTCTGGATGCCACGATTTCCTTTGGGCCGCTGCCCAAGGAGGTCATCCTGCAGGTGGTCGAGAAGT
TCGTTCTGCAGCTTGAGGCGCAGCTCATGGACCGCAACGTCTCGATTGAGCTTACCCGCAAGGCAGCTGAATGGCTCGCG
GACAAAGGCTATGATGACAAGATGGGTGCGCGCCCCTTGGGCCGCGTCATCCAGGAGCACATCAAGAAGCCGCTTGCAGA
AGAGCTCTTGTTCGGCAAGCTCTCCAAGGGCGGTGTGGTTCAGGTCGGCATCAAGGACGGCAAACTTGATCTTCGGATCG
AGGGTCCAGGCAAGCCCCGCCTGAGCGGCAACAAACCACCGCTCCTGACTGCGGAATAG

Upstream 100 bases:

>100_bases
TTGTGACCACAATCGCGCAAAAAGCCCTTGAAGCTTACGATCTATCAACCAAACTCTAACACTATGAGGACACGGTTATG
GGACAGGACCGGCCCGCCCG

Downstream 100 bases:

>100_bases
CGCTGCTTCGGCACCACACAGCAAGATCACGCGCCCGCCTCTGACCTCAGACGGCGGGCGTTCTCTTACGCACGGCTCAA
ATGCCTCAGGCCCTCAACTG

Product: ATP-dependent Clp protease ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 792; Mature: 791

Protein sequence:

>792_residues
MADDPHNPRQRSTPVPSFSSTLEQAIHAALALANERRHEFATLEHLLLALTEEPDAARVMRACSVNLDELRSTLLEFVDE
DLANLVTDIDGSEAVPTAAFQRVIQRAAIHVQSSGRTEVTGANVLVAIFAERESDAAFFLQDQDMTRYDAVNFIAHGVAK
DPAYGENRPVTGASESEEEIGGGPSMGSPEGEQKESALAKYCVDLNAKSREGDIDPLIGRDSEVERCIQVLCRRRKNNPL
LVGDPGVGKTAIAEGLARKVVQGEVPEVLSETTIYSLDMGALLAGTRYRGDFEERLKAVVTELEEHPDAVLFIDEIHTVI
GAGATSGGAMDASNLLKPALQGGKLRTMGSTTYKEFRQHFEKDRALSRRFQKIDVNEPSVEDSIAILKGLKPYFEDHHSI
KFTSDAIKSAVELSARYINDRKLPDKAIDVIDEAGAAQHLVAESKRRKTIGVKEIEAVVAKIARIPPKNVSKDDAEVLKD
LEASLKRVVFGQDAAIDALSSAIKLARAGLREPEKPIGNYLFAGPTGVGKTEVAKQLADTLGVELLRFDMSEYMEKHAVS
RLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHPDVFNILLQVMDNGQLTDHNGRTVNFRNVVLIMTSNAGASE
LAKSAIGFGRDRREGEDTAAIERTFSPEFRNRLDATISFGPLPKEVILQVVEKFVLQLEAQLMDRNVSIELTRKAAEWLA
DKGYDDKMGARPLGRVIQEHIKKPLAEELLFGKLSKGGVVQVGIKDGKLDLRIEGPGKPRLSGNKPPLLTAE

Sequences:

>Translated_792_residues
MADDPHNPRQRSTPVPSFSSTLEQAIHAALALANERRHEFATLEHLLLALTEEPDAARVMRACSVNLDELRSTLLEFVDE
DLANLVTDIDGSEAVPTAAFQRVIQRAAIHVQSSGRTEVTGANVLVAIFAERESDAAFFLQDQDMTRYDAVNFIAHGVAK
DPAYGENRPVTGASESEEEIGGGPSMGSPEGEQKESALAKYCVDLNAKSREGDIDPLIGRDSEVERCIQVLCRRRKNNPL
LVGDPGVGKTAIAEGLARKVVQGEVPEVLSETTIYSLDMGALLAGTRYRGDFEERLKAVVTELEEHPDAVLFIDEIHTVI
GAGATSGGAMDASNLLKPALQGGKLRTMGSTTYKEFRQHFEKDRALSRRFQKIDVNEPSVEDSIAILKGLKPYFEDHHSI
KFTSDAIKSAVELSARYINDRKLPDKAIDVIDEAGAAQHLVAESKRRKTIGVKEIEAVVAKIARIPPKNVSKDDAEVLKD
LEASLKRVVFGQDAAIDALSSAIKLARAGLREPEKPIGNYLFAGPTGVGKTEVAKQLADTLGVELLRFDMSEYMEKHAVS
RLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHPDVFNILLQVMDNGQLTDHNGRTVNFRNVVLIMTSNAGASE
LAKSAIGFGRDRREGEDTAAIERTFSPEFRNRLDATISFGPLPKEVILQVVEKFVLQLEAQLMDRNVSIELTRKAAEWLA
DKGYDDKMGARPLGRVIQEHIKKPLAEELLFGKLSKGGVVQVGIKDGKLDLRIEGPGKPRLSGNKPPLLTAE
>Mature_791_residues
ADDPHNPRQRSTPVPSFSSTLEQAIHAALALANERRHEFATLEHLLLALTEEPDAARVMRACSVNLDELRSTLLEFVDED
LANLVTDIDGSEAVPTAAFQRVIQRAAIHVQSSGRTEVTGANVLVAIFAERESDAAFFLQDQDMTRYDAVNFIAHGVAKD
PAYGENRPVTGASESEEEIGGGPSMGSPEGEQKESALAKYCVDLNAKSREGDIDPLIGRDSEVERCIQVLCRRRKNNPLL
VGDPGVGKTAIAEGLARKVVQGEVPEVLSETTIYSLDMGALLAGTRYRGDFEERLKAVVTELEEHPDAVLFIDEIHTVIG
AGATSGGAMDASNLLKPALQGGKLRTMGSTTYKEFRQHFEKDRALSRRFQKIDVNEPSVEDSIAILKGLKPYFEDHHSIK
FTSDAIKSAVELSARYINDRKLPDKAIDVIDEAGAAQHLVAESKRRKTIGVKEIEAVVAKIARIPPKNVSKDDAEVLKDL
EASLKRVVFGQDAAIDALSSAIKLARAGLREPEKPIGNYLFAGPTGVGKTEVAKQLADTLGVELLRFDMSEYMEKHAVSR
LIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHPDVFNILLQVMDNGQLTDHNGRTVNFRNVVLIMTSNAGASEL
AKSAIGFGRDRREGEDTAAIERTFSPEFRNRLDATISFGPLPKEVILQVVEKFVLQLEAQLMDRNVSIELTRKAAEWLAD
KGYDDKMGARPLGRVIQEHIKKPLAEELLFGKLSKGGVVQVGIKDGKLDLRIEGPGKPRLSGNKPPLLTAE

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=319, Percent_Identity=32.2884012539185, Blast_Score=170, Evalue=6e-42,
Organism=Escherichia coli, GI1787109, Length=754, Percent_Identity=58.8859416445623, Blast_Score=908, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=273, Percent_Identity=54.5787545787546, Blast_Score=304, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6320464, Length=326, Percent_Identity=46.319018404908, Blast_Score=278, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6323002, Length=249, Percent_Identity=47.3895582329317, Blast_Score=249, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 86420; Mature: 86289

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDPHNPRQRSTPVPSFSSTLEQAIHAALALANERRHEFATLEHLLLALTEEPDAARVM
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RACSVNLDELRSTLLEFVDEDLANLVTDIDGSEAVPTAAFQRVIQRAAIHVQSSGRTEVT
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEC
GANVLVAIFAERESDAAFFLQDQDMTRYDAVNFIAHGVAKDPAYGENRPVTGASESEEEI
CCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHC
GGGPSMGSPEGEQKESALAKYCVDLNAKSREGDIDPLIGRDSEVERCIQVLCRRRKNNPL
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
LVGDPGVGKTAIAEGLARKVVQGEVPEVLSETTIYSLDMGALLAGTRYRGDFEERLKAVV
EEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHEEEECHHHHHHCCCCCCCHHHHHHHHH
TELEEHPDAVLFIDEIHTVIGAGATSGGAMDASNLLKPALQGGKLRTMGSTTYKEFRQHF
HHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHH
EKDRALSRRFQKIDVNEPSVEDSIAILKGLKPYFEDHHSIKFTSDAIKSAVELSARYIND
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHCCCCEEECHHHHHHHHHHHHHHHCC
RKLPDKAIDVIDEAGAAQHLVAESKRRKTIGVKEIEAVVAKIARIPPKNVSKDDAEVLKD
CCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LEASLKRVVFGQDAAIDALSSAIKLARAGLREPEKPIGNYLFAGPTGVGKTEVAKQLADT
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCEEEECCCCCCHHHHHHHHHHH
LGVELLRFDMSEYMEKHAVSRLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCC
DVFNILLQVMDNGQLTDHNGRTVNFRNVVLIMTSNAGASELAKSAIGFGRDRREGEDTAA
HHHHHHHHHHCCCCEECCCCCEEEECEEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHH
IERTFSPEFRNRLDATISFGPLPKEVILQVVEKFVLQLEAQLMDRNVSIELTRKAAEWLA
HHHCCCHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHH
DKGYDDKMGARPLGRVIQEHIKKPLAEELLFGKLSKGGVVQVGIKDGKLDLRIEGPGKPR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEECCCCCCC
LSGNKPPLLTAE
CCCCCCCCCCCC
>Mature Secondary Structure 
ADDPHNPRQRSTPVPSFSSTLEQAIHAALALANERRHEFATLEHLLLALTEEPDAARVM
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RACSVNLDELRSTLLEFVDEDLANLVTDIDGSEAVPTAAFQRVIQRAAIHVQSSGRTEVT
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEC
GANVLVAIFAERESDAAFFLQDQDMTRYDAVNFIAHGVAKDPAYGENRPVTGASESEEEI
CCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHC
GGGPSMGSPEGEQKESALAKYCVDLNAKSREGDIDPLIGRDSEVERCIQVLCRRRKNNPL
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
LVGDPGVGKTAIAEGLARKVVQGEVPEVLSETTIYSLDMGALLAGTRYRGDFEERLKAVV
EEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHEEEECHHHHHHCCCCCCCHHHHHHHHH
TELEEHPDAVLFIDEIHTVIGAGATSGGAMDASNLLKPALQGGKLRTMGSTTYKEFRQHF
HHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHH
EKDRALSRRFQKIDVNEPSVEDSIAILKGLKPYFEDHHSIKFTSDAIKSAVELSARYIND
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHCCCCEEECHHHHHHHHHHHHHHHCC
RKLPDKAIDVIDEAGAAQHLVAESKRRKTIGVKEIEAVVAKIARIPPKNVSKDDAEVLKD
CCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LEASLKRVVFGQDAAIDALSSAIKLARAGLREPEKPIGNYLFAGPTGVGKTEVAKQLADT
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCEEEECCCCCCHHHHHHHHHHH
LGVELLRFDMSEYMEKHAVSRLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCC
DVFNILLQVMDNGQLTDHNGRTVNFRNVVLIMTSNAGASELAKSAIGFGRDRREGEDTAA
HHHHHHHHHHCCCCEECCCCCEEEECEEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHH
IERTFSPEFRNRLDATISFGPLPKEVILQVVEKFVLQLEAQLMDRNVSIELTRKAAEWLA
HHHCCCHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHH
DKGYDDKMGARPLGRVIQEHIKKPLAEELLFGKLSKGGVVQVGIKDGKLDLRIEGPGKPR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEECCCCCCC
LSGNKPPLLTAE
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]