Click here to switch to the map view.

The map label for this gene is hmrR [H]

Identifier: 99081921

GI number: 99081921

Start: 2186594

End: 2186947

Strand: Reverse

Name: hmrR [H]

Synonym: TM1040_2081

Alternate gene names: 99081921

Gene position: 2186947-2186594 (Counterclockwise)

Preceding gene: 99081923

Following gene: 99081920

Centisome position: 68.32

GC content: 59.89

Gene sequence:

>354_bases
ATGTTGAAAATCGGGGATCTGGCACAGCGCACCGGGGTCAGCGCGGATGCGCTTCGGCTCTATGAGCGGCGGGGGTTGAT
CCGCTCTGAACGTATGGCCAACGGCTATCGCGTGTTTGATCCCGAGATGGAGCGGCTGGTGAAACTGATCCGACTGGGCC
AGAGCATCGGCTTTACCCTGCGCGAGATGGAGCATGTGATAGCGACCCTGTCGAGTCGCGATCTGAGTGCCGCACAAACC
GCCACATTGATCCAGGATCGGATTGACGCGGTCGATGTCAAACTGGCTGAGCTCACCGAGCTGCGACGCCTGCTTGTGGA
TCTTCAGGATCAAGCCTGCCCGCTCAGAGGGTGA

Upstream 100 bases:

>100_bases
GGTAGACCTTTTTGTTCATCCCATCGCAAAACATGATTCTTCCTTTCCTGTTGCGTTGGGGCTCGGTATAGAGGTTGGAC
TATAGTCTAAGGTCAAGCAG

Downstream 100 bases:

>100_bases
CCGGGGCAGCGGGTGTCCTGCTGCCCACCGGCGCAAAATCTTCCCTCGGGGCAGGGTAATTCACCCAATATGGCGTGTTG
TGGGAAAAATCTCATATTCC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 117; Mature: 117

Protein sequence:

>117_residues
MLKIGDLAQRTGVSADALRLYERRGLIRSERMANGYRVFDPEMERLVKLIRLGQSIGFTLREMEHVIATLSSRDLSAAQT
ATLIQDRIDAVDVKLAELTELRRLLVDLQDQACPLRG

Sequences:

>Translated_117_residues
MLKIGDLAQRTGVSADALRLYERRGLIRSERMANGYRVFDPEMERLVKLIRLGQSIGFTLREMEHVIATLSSRDLSAAQT
ATLIQDRIDAVDVKLAELTELRRLLVDLQDQACPLRG
>Mature_117_residues
MLKIGDLAQRTGVSADALRLYERRGLIRSERMANGYRVFDPEMERLVKLIRLGQSIGFTLREMEHVIATLSSRDLSAAQT
ATLIQDRIDAVDVKLAELTELRRLLVDLQDQACPLRG

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=116, Percent_Identity=28.448275862069, Blast_Score=60, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 13224; Mature: 13224

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIGDLAQRTGVSADALRLYERRGLIRSERMANGYRVFDPEMERLVKLIRLGQSIGFTL
CCCCCHHHHHHCCCHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHCHHH
REMEHVIATLSSRDLSAAQTATLIQDRIDAVDVKLAELTELRRLLVDLQDQACPLRG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLKIGDLAQRTGVSADALRLYERRGLIRSERMANGYRVFDPEMERLVKLIRLGQSIGFTL
CCCCCHHHHHHCCCHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHCHHH
REMEHVIATLSSRDLSAAQTATLIQDRIDAVDVKLAELTELRRLLVDLQDQACPLRG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]