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The map label for this gene is hisE

Identifier: 99081882

GI number: 99081882

Start: 2148721

End: 2149038

Strand: Direct

Name: hisE

Synonym: TM1040_2042

Alternate gene names: 99081882

Gene position: 2148721-2149038 (Clockwise)

Preceding gene: 99081881

Following gene: 99081888

Centisome position: 67.13

GC content: 59.75

Gene sequence:

>318_bases
ATGACCTTGCTGCACGACCTCGAACAGACCATTCTGTCCCGCAAGGGCACCGATCCCGACACCAGCTGGACCGCGAAGCT
CTTGTCCAAGGGGCCGGAGAAATGCGCCGAAAAATTTGGCGAAGAAGCCATCGAAGCCATCATCGAAGCGGTGAAGGACG
ACAAAGCCAAGCTCGCCTCTGAGGGCGCGGATGTGCTCTACCATTTTCTGGTGATGCTGGCAGCGCGGGATGTGGCGTTG
GACGATGTTCTGACTGTGCTTGCTGAGCGGCAGGGTCTGAGCGGCCTTGCGGAGAAAGCCGCCCGTCCCAAAGGCTAG

Upstream 100 bases:

>100_bases
CCAGCGCGGTGCTGGCGGCCTCGATCTTCCACTTTGGCGAATACACGGTGCAAGAAGCCAAGGAACACATGATCGCCAAT
GGCATCCCGATGAGGCTCCA

Downstream 100 bases:

>100_bases
GCGCAAAAGCGTCGGGGCCAAGCGCGCGGCCCAAAGCGGACCGAGTGCAAAGCCGCCTATTCCACGGCCCAGATCACCCT
CTGCAGACCCGCGAGTCGTG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MTLLHDLEQTILSRKGTDPDTSWTAKLLSKGPEKCAEKFGEEAIEAIIEAVKDDKAKLASEGADVLYHFLVMLAARDVAL
DDVLTVLAERQGLSGLAEKAARPKG

Sequences:

>Translated_105_residues
MTLLHDLEQTILSRKGTDPDTSWTAKLLSKGPEKCAEKFGEEAIEAIIEAVKDDKAKLASEGADVLYHFLVMLAARDVAL
DDVLTVLAERQGLSGLAEKAARPKG
>Mature_104_residues
TLLHDLEQTILSRKGTDPDTSWTAKLLSKGPEKCAEKFGEEAIEAIIEAVKDDKAKLASEGADVLYHFLVMLAARDVALD
DVLTVLAERQGLSGLAEKAARPKG

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=39.3258426966292, Blast_Score=73, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_SILST (Q1GEZ2)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614036.1
- ProteinModelPortal:   Q1GEZ2
- SMR:   Q1GEZ2
- STRING:   Q1GEZ2
- GeneID:   4077969
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2042
- NMPDR:   fig|292414.1.peg.414
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   SSP292414:TM1040_2042-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11335; Mature: 11204

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLHDLEQTILSRKGTDPDTSWTAKLLSKGPEKCAEKFGEEAIEAIIEAVKDDKAKLAS
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGADVLYHFLVMLAARDVALDDVLTVLAERQGLSGLAEKAARPKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCC
>Mature Secondary Structure 
TLLHDLEQTILSRKGTDPDTSWTAKLLSKGPEKCAEKFGEEAIEAIIEAVKDDKAKLAS
CHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGADVLYHFLVMLAARDVALDDVLTVLAERQGLSGLAEKAARPKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA