Click here to switch to the map view.

The map label for this gene is hisB

Identifier: 99081873

GI number: 99081873

Start: 2142137

End: 2142724

Strand: Direct

Name: hisB

Synonym: TM1040_2033

Alternate gene names: 99081873

Gene position: 2142137-2142724 (Clockwise)

Preceding gene: 99081871

Following gene: 99081874

Centisome position: 66.92

GC content: 63.1

Gene sequence:

>588_bases
ATGCGCACAGCCCAGGTTTCCCGCTCCACCGCCGAGACGGAGATCTCCGTCTCCGTCAACCTCGATGGCAGCGGCACATA
TGACAATCAGACCGGCGTTGGCTTTTTTGACCATATGCTCGACCAGTTGTCGCGCCACTCTCTGATTGACATGACCATCC
GCGCCAAGGGCGACTACCACATCGACGACCACCATACCGTCGAGGACACCGGCATCGCACTGGGTCAGGCCCTGGTGCAG
GCGCTTGGCGACAAAAAAGGCATCAACCGCTACGGCGAGTGTCACCTGCCGATGGATGACGCGCAGGTGCGCGCGGCGCT
CGATCTCTCCGCCCGGCCTTTCCTTGTCTGGAATGTGGATCTGCCCACGCAGAAGATCGGCAGCTTTGACACCGAACTCG
TCCGCGAGTTCTTTCAGGCGCTGGCGACCCATGGTGGCATCACCCTGCATATCGACCAGATCCATGGGGTGAACAGCCAC
CACATCGCCGAGGCCGCCTTCAAGGCCGTGGCCCGCGCGCTGCGCACCGCGGTTGAGGTCGACCCCCGCAAGGCCGACGC
CGTCCCTTCCACCAAAGGCGCGCTCTGA

Upstream 100 bases:

>100_bases
CCGATCGCGACACCACATCCCCCCGACAATCGGCGCTGCCCCCTTGAGCCTGAGCACCTCTCAGCCCTATAAGCCTAGCC
AACAGATTGAGGATTTCGCC

Downstream 100 bases:

>100_bases
CACGCTCCAGAAGAGCCCCCAGGCTCTCGCCCGCTTTTGCCTCGCCCAGACGCGTGCCCTAAGAGGGCTGCCGGGCCGGG
GCGCATAAGATCCCGAGGAT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRTAQVSRSTAETEISVSVNLDGSGTYDNQTGVGFFDHMLDQLSRHSLIDMTIRAKGDYHIDDHHTVEDTGIALGQALVQ
ALGDKKGINRYGECHLPMDDAQVRAALDLSARPFLVWNVDLPTQKIGSFDTELVREFFQALATHGGITLHIDQIHGVNSH
HIAEAAFKAVARALRTAVEVDPRKADAVPSTKGAL

Sequences:

>Translated_195_residues
MRTAQVSRSTAETEISVSVNLDGSGTYDNQTGVGFFDHMLDQLSRHSLIDMTIRAKGDYHIDDHHTVEDTGIALGQALVQ
ALGDKKGINRYGECHLPMDDAQVRAALDLSARPFLVWNVDLPTQKIGSFDTELVREFFQALATHGGITLHIDQIHGVNSH
HIAEAAFKAVARALRTAVEVDPRKADAVPSTKGAL
>Mature_195_residues
MRTAQVSRSTAETEISVSVNLDGSGTYDNQTGVGFFDHMLDQLSRHSLIDMTIRAKGDYHIDDHHTVEDTGIALGQALVQ
ALGDKKGINRYGECHLPMDDAQVRAALDLSARPFLVWNVDLPTQKIGSFDTELVREFFQALATHGGITLHIDQIHGVNSH
HIAEAAFKAVARALRTAVEVDPRKADAVPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=50.5154639175258, Blast_Score=188, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=39.9082568807339, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_SILST (Q1GF01)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614027.1
- ProteinModelPortal:   Q1GF01
- SMR:   Q1GF01
- STRING:   Q1GF01
- GeneID:   4077960
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2033
- NMPDR:   fig|292414.1.peg.8
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q1GF01
- ProtClustDB:   PRK00951
- BioCyc:   SSP292414:TM1040_2033-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21238; Mature: 21238

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTAQVSRSTAETEISVSVNLDGSGTYDNQTGVGFFDHMLDQLSRHSLIDMTIRAKGDYH
CCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCEE
IDDHHTVEDTGIALGQALVQALGDKKGINRYGECHLPMDDAQVRAALDLSARPFLVWNVD
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCEEEEECC
LPTQKIGSFDTELVREFFQALATHGGITLHIDQIHGVNSHHIAEAAFKAVARALRTAVEV
CCHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
DPRKADAVPSTKGAL
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MRTAQVSRSTAETEISVSVNLDGSGTYDNQTGVGFFDHMLDQLSRHSLIDMTIRAKGDYH
CCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCEE
IDDHHTVEDTGIALGQALVQALGDKKGINRYGECHLPMDDAQVRAALDLSARPFLVWNVD
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCEEEEECC
LPTQKIGSFDTELVREFFQALATHGGITLHIDQIHGVNSHHIAEAAFKAVARALRTAVEV
CCHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
DPRKADAVPSTKGAL
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA