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The map label for this gene is argM [C]

Identifier: 99081871

GI number: 99081871

Start: 2140200

End: 2141552

Strand: Direct

Name: argM [C]

Synonym: TM1040_2031

Alternate gene names: 99081871

Gene position: 2140200-2141552 (Clockwise)

Preceding gene: 99081869

Following gene: 99081873

Centisome position: 66.86

GC content: 62.01

Gene sequence:

>1353_bases
ATGGCGAGCGTGATCTACCCGACGACGAATTTCACCGCGACGGAGCAGCTCTGCATCACCCACGGTGAGGGGATCTACGT
CTATGACGACACCGGCAAACAATATATCGAAGGCCTCGCGGGCCTGTGGTGTACCTCGCTGGGCTATTCCAACACCGAGG
TGGTCGAGGCCATCACCGAGCAGTTGAAACGCCTGCCCTTCCAGCACACGTTTGGCGGCAAGACCCACGCGCCGGTGATG
GAGTTGGCCGAAAAGCTGAAGGCAATGGTGCCGGTCGAGGACGCCTATTTCTTCTTTGGCAATTCCGGCTCGGACGCAAA
CGACAGCCACTACAAGATGCTGCGCTATTACTTCAACGCGATCGGCAAGCCGCACAAGCGCAAGATCATCACTCGCGAGC
GCGGCTATCACGGCGTGACCGTGGCGGCGGGATCGCTGACCTCCCTGCCTGCGAACCTCGCCCATTTCGACGCCCCGCTT
GAGGCGCTCTCGATCCTGCGCACCGATGCGCCGCATTATTACACCGGCCGCCAAGGCAATGAGACCGAAGCGCAGTTTGT
CGAGCGCATCCTGCAAAACCTCGAAGACCAGATCCTCGCCGAGGACCCCGACACGATCGCCGCGATGATCATCGAGCCGA
TCACCGGCGCCTCCGGTGTAATCGTGCCCCCCGAAGGCTACTACGAGGGGCTGCAGGCGCTTTTGCGCAAACATGGCATC
CTGATCTGGGCGGATGAGGTCATCTGCGGCTTTGGTCGCACAGGCGCCGATTTTGGCTGCACCACCATGGGCATCAAACC
GGACCTCATGACCTTTGCCAAGCAGCTGTCTTCGGCCTATTTCCCGATCTCCGCCTCCGTCATTCCCGGCTGGATGTACA
AGGCGATGGTGGATCAGACCAATGAGGTCGGCGTCTTTGGCCATGGCTACACCTACTCGGGCCACCCCGCCGCCTGTGCT
GCGGCCCTGAAGACGCTCGAAATCTACGAGCGCGACAAGATCTTTGACCACGCCGCCGAGGTCGGCACCTACCTGCAAGA
GCAACTGCGCGCGACCTTCACCGATCACCCGCTGGTGGGCGAGGTGCGCGGCAAAGGCCTGATCGCCGCGCTCGAACTGG
TTTCAAACAAGACCACCGGCGCCACCATCGCAGGCGGCAAGGGTGGTGCTGCCGCAGTCAAAGCCTGCCAGACCGAGGGC
GTGATCCTGCGCGCGGTGGCCGGCAATGCGCTGGCCTTCTGCCCGCCGCTCATCATCACAAAGCCAGAGGTGGACGAGAT
GCTCAAACGCACCAAGGCCGGTGTCGATGCTGCCTACGAGGCCCTGAGATCCGAAGGCCTCCTGAACAGCTGA

Upstream 100 bases:

>100_bases
TATTGAACAAAGACTTGCGACTTTTGATCAAAACCCTTTGACTGCCCCGCAAATGCACGCCAATCCTAACGCCAACCTGT
GACAGCAAAGGATTGGCCAG

Downstream 100 bases:

>100_bases
TCCAAAACAAAAGGCGCCGCGATCGAATCGGGCGCCTTTTCATCTTCTTACAAATATCCCGGAGCGCGAGGCAGCGCCTC
GCAACAGGCTTTTCCCATAG

Product: aminotransferase

Products: L-glutamate; N2-succinylglutamic-semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MASVIYPTTNFTATEQLCITHGEGIYVYDDTGKQYIEGLAGLWCTSLGYSNTEVVEAITEQLKRLPFQHTFGGKTHAPVM
ELAEKLKAMVPVEDAYFFFGNSGSDANDSHYKMLRYYFNAIGKPHKRKIITRERGYHGVTVAAGSLTSLPANLAHFDAPL
EALSILRTDAPHYYTGRQGNETEAQFVERILQNLEDQILAEDPDTIAAMIIEPITGASGVIVPPEGYYEGLQALLRKHGI
LIWADEVICGFGRTGADFGCTTMGIKPDLMTFAKQLSSAYFPISASVIPGWMYKAMVDQTNEVGVFGHGYTYSGHPAACA
AALKTLEIYERDKIFDHAAEVGTYLQEQLRATFTDHPLVGEVRGKGLIAALELVSNKTTGATIAGGKGGAAAVKACQTEG
VILRAVAGNALAFCPPLIITKPEVDEMLKRTKAGVDAAYEALRSEGLLNS

Sequences:

>Translated_450_residues
MASVIYPTTNFTATEQLCITHGEGIYVYDDTGKQYIEGLAGLWCTSLGYSNTEVVEAITEQLKRLPFQHTFGGKTHAPVM
ELAEKLKAMVPVEDAYFFFGNSGSDANDSHYKMLRYYFNAIGKPHKRKIITRERGYHGVTVAAGSLTSLPANLAHFDAPL
EALSILRTDAPHYYTGRQGNETEAQFVERILQNLEDQILAEDPDTIAAMIIEPITGASGVIVPPEGYYEGLQALLRKHGI
LIWADEVICGFGRTGADFGCTTMGIKPDLMTFAKQLSSAYFPISASVIPGWMYKAMVDQTNEVGVFGHGYTYSGHPAACA
AALKTLEIYERDKIFDHAAEVGTYLQEQLRATFTDHPLVGEVRGKGLIAALELVSNKTTGATIAGGKGGAAAVKACQTEG
VILRAVAGNALAFCPPLIITKPEVDEMLKRTKAGVDAAYEALRSEGLLNS
>Mature_449_residues
ASVIYPTTNFTATEQLCITHGEGIYVYDDTGKQYIEGLAGLWCTSLGYSNTEVVEAITEQLKRLPFQHTFGGKTHAPVME
LAEKLKAMVPVEDAYFFFGNSGSDANDSHYKMLRYYFNAIGKPHKRKIITRERGYHGVTVAAGSLTSLPANLAHFDAPLE
ALSILRTDAPHYYTGRQGNETEAQFVERILQNLEDQILAEDPDTIAAMIIEPITGASGVIVPPEGYYEGLQALLRKHGIL
IWADEVICGFGRTGADFGCTTMGIKPDLMTFAKQLSSAYFPISASVIPGWMYKAMVDQTNEVGVFGHGYTYSGHPAACAA
ALKTLEIYERDKIFDHAAEVGTYLQEQLRATFTDHPLVGEVRGKGLIAALELVSNKTTGATIAGGKGGAAAVKACQTEGV
ILRAVAGNALAFCPPLIITKPEVDEMLKRTKAGVDAAYEALRSEGLLNS

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=430, Percent_Identity=27.6744186046512, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI24119277, Length=450, Percent_Identity=26.8888888888889, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4557809, Length=424, Percent_Identity=26.8867924528302, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI37574042, Length=443, Percent_Identity=26.410835214447, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI226442705, Length=443, Percent_Identity=26.1851015801354, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI226442709, Length=395, Percent_Identity=27.0886075949367, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI284507298, Length=335, Percent_Identity=28.6567164179104, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI188536080, Length=279, Percent_Identity=22.5806451612903, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI38679950, Length=279, Percent_Identity=22.5806451612903, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI38679946, Length=279, Percent_Identity=22.5806451612903, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788044, Length=419, Percent_Identity=30.5489260143198, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI145693181, Length=353, Percent_Identity=30.5949008498584, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1789016, Length=422, Percent_Identity=30.3317535545024, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1786991, Length=440, Percent_Identity=29.5454545454545, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789759, Length=410, Percent_Identity=26.5853658536585, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1787560, Length=426, Percent_Identity=28.4037558685446, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=431, Percent_Identity=30.8584686774942, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI25144271, Length=420, Percent_Identity=27.6190476190476, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=439, Percent_Identity=25.5125284738041, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25144274, Length=338, Percent_Identity=28.698224852071, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17541228, Length=315, Percent_Identity=23.8095238095238, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324432, Length=447, Percent_Identity=26.1744966442953, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323470, Length=435, Percent_Identity=25.5172413793103, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324386, Length=436, Percent_Identity=27.0642201834862, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321456, Length=414, Percent_Identity=23.9130434782609, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=29.9303944315545, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28574759, Length=422, Percent_Identity=30.5687203791469, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21357415, Length=419, Percent_Identity=25.2983293556086, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21356575, Length=431, Percent_Identity=25.9860788863109, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281366494, Length=455, Percent_Identity=21.978021978022, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24667139, Length=455, Percent_Identity=21.978021978022, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24667143, Length=455, Percent_Identity=21.978021978022, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.- [C]

Molecular weight: Translated: 48721; Mature: 48590

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVIYPTTNFTATEQLCITHGEGIYVYDDTGKQYIEGLAGLWCTSLGYSNTEVVEAITE
CCEEEECCCCCCCCHHEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QLKRLPFQHTFGGKTHAPVMELAEKLKAMVPVEDAYFFFGNSGSDANDSHYKMLRYYFNA
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
IGKPHKRKIITRERGYHGVTVAAGSLTSLPANLAHFDAPLEALSILRTDAPHYYTGRQGN
HCCCHHHHHHHHCCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ETEAQFVERILQNLEDQILAEDPDTIAAMIIEPITGASGVIVPPEGYYEGLQALLRKHGI
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCE
LIWADEVICGFGRTGADFGCTTMGIKPDLMTFAKQLSSAYFPISASVIPGWMYKAMVDQT
EEEECHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCEECHHCCHHHHHHHHCCC
NEVGVFGHGYTYSGHPAACAAALKTLEIYERDKIFDHAAEVGTYLQEQLRATFTDHPLVG
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
EVRGKGLIAALELVSNKTTGATIAGGKGGAAAVKACQTEGVILRAVAGNALAFCPPLIIT
CCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHCCCCEEEEEECCCCHHHCCCCEEE
KPEVDEMLKRTKAGVDAAYEALRSEGLLNS
CCCHHHHHHHHHCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ASVIYPTTNFTATEQLCITHGEGIYVYDDTGKQYIEGLAGLWCTSLGYSNTEVVEAITE
CEEEECCCCCCCCHHEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QLKRLPFQHTFGGKTHAPVMELAEKLKAMVPVEDAYFFFGNSGSDANDSHYKMLRYYFNA
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
IGKPHKRKIITRERGYHGVTVAAGSLTSLPANLAHFDAPLEALSILRTDAPHYYTGRQGN
HCCCHHHHHHHHCCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ETEAQFVERILQNLEDQILAEDPDTIAAMIIEPITGASGVIVPPEGYYEGLQALLRKHGI
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCE
LIWADEVICGFGRTGADFGCTTMGIKPDLMTFAKQLSSAYFPISASVIPGWMYKAMVDQT
EEEECHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCEECHHCCHHHHHHHHCCC
NEVGVFGHGYTYSGHPAACAAALKTLEIYERDKIFDHAAEVGTYLQEQLRATFTDHPLVG
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
EVRGKGLIAALELVSNKTTGATIAGGKGGAAAVKACQTEGVILRAVAGNALAFCPPLIIT
CCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHCCCCEEEEEECCCCHHHCCCCEEE
KPEVDEMLKRTKAGVDAAYEALRSEGLLNS
CCCHHHHHHHHHCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-alpha-acetylornithine; 2-oxoglutarate [C]

Specific reaction: N-alpha-acetylornithine + 2-oxoglutarate = N-acetylglutamate semialdehyde + L-glutamate N2-succinylornithine + 2-oxoglutarate = N2-succinylglutamic-semialdehyde + L-glutamate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]